| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Ho Han, Won Sup Lee, Arulkumar Nagappan, Su Hyun Hong, Ji Hyun Jung, Cheol Park, Hye Jung Kim, Gi-Young Kim, GonSup Kim, Jin-Myung Jung, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Cho. Flavonoids Isolated from Flowers of Lonicera japonica Thunb. Inhibit Inflammatory Responses in BV2 Microglial Cells by Suppressing TNF-α and IL-β Through PI3K/Akt/NF-kb Signaling Pathways. Phytotherapy research : PTR. vol 30. issue 11. 2017-04-03. PMID:27534446. |
the cytokines release from microglia is closely linked to various chronic neurodegenerative diseases like alzheimer's disease and parkinson's disease. |
2017-04-03 |
2023-08-13 |
Not clear |
| Alexandra Grubman, Katja M Kanninen, Tarja Mal. Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets. Journal of molecular neuroscience : MN. vol 60. issue 3. 2017-03-23. PMID:27660215. |
multitasking microglia and alzheimer's disease: diversity, tools and therapeutic targets. |
2017-03-23 |
2023-08-13 |
Not clear |
| Alexandra Grubman, Katja M Kanninen, Tarja Mal. Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets. Journal of molecular neuroscience : MN. vol 60. issue 3. 2017-03-23. PMID:27660215. |
the impairment of microglia in alzheimer's disease has been demonstrated on genetic, epigenetic, transcriptional and functional levels using unbiased systems level approaches. |
2017-03-23 |
2023-08-13 |
Not clear |
| Alexandra Grubman, Katja M Kanninen, Tarja Mal. Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets. Journal of molecular neuroscience : MN. vol 60. issue 3. 2017-03-23. PMID:27660215. |
furthermore, we highlight recent advances on the role, heterogeneity and dysfunction of microglia in alzheimer's disease and discuss the potential for therapeutic interventions targeting microglia. |
2017-03-23 |
2023-08-13 |
Not clear |
| Marta Bolós, Juan Ramón Perea, Jesús Avil. Alzheimer's disease as an inflammatory disease. Biomolecular concepts. vol 8. issue 1. 2017-03-20. PMID:28231054. |
alzheimer's disease (ad) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. |
2017-03-20 |
2023-08-13 |
Not clear |
| Fan Su, Feng Bai, Zhijun Zhan. Inflammatory Cytokines and Alzheimer's Disease: A Review from the Perspective of Genetic Polymorphisms. Neuroscience bulletin. vol 32. issue 5. 2017-02-27. PMID:27568024. |
neuroinflammatory processes are a central feature of alzheimer's disease (ad) in which microglia are over-activated, resulting in the increased production of pro-inflammatory cytokines. |
2017-02-27 |
2023-08-13 |
Not clear |
| Yutaro Kobayashi, Hiroyuki Inagawa, Chie Kohchi, Katsuichiro Okazaki, Ran Zhang, Gen-Ichiro Som. Effect of Lipopolysaccharide Derived from Pantoea agglomerans on the Phagocytic Activity of Amyloid β by Primary Murine Microglial Cells. Anticancer research. vol 36. issue 7. 2017-01-26. PMID:27354642. |
monophosphoryl lipid a, lipopolysaccharide (lps)-derived toll-like receptor (tlr) 4 agonist, has been shown to be effective in the prevention of alzheimer's disease (ad) by enhancing phagocytosis of amyloid β (aβ) by brain microglia. |
2017-01-26 |
2023-08-13 |
Not clear |
| Yasdani B Shaik-Dasthagirisaheb, Pio Cont. The Role of Mast Cells in Alzheimer's Disease. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 25. issue 4. 2017-01-13. PMID:27629855. |
cytokines/chemokines, which are generated mostly by microglia and astrocytes in alzheimer's disease, contribute to nearly every aspect of neuroinflammation and amyloid â-protein plaque aggregates may induce in mast cells the release of a plethora of mediators, including pro-inflammatory cytokines/chemokines such as interleukin-1, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-alpha, vascular endothelial growth factor, transforming growth factor beta, cxcl8 and ccl2-3-4. |
2017-01-13 |
2023-08-13 |
Not clear |
| Marie-Christine Pardon, Maria Yanez Lopez, Ding Yuchun, Małgorzata Marjańska, Malcolm Prior, Christopher Brignell, Samira Parhizkar, Alessandra Agostini, Li Bai, Dorothee P Auer, Henryk M Faa. Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models. Scientific reports. vol 6. 2017-01-06. PMID:26813748. |
microglia activation has emerged as a potential key factor in the pathogenesis of alzheimer's disease. |
2017-01-06 |
2023-08-13 |
mouse |
| Marie-Christine Pardon, Maria Yanez Lopez, Ding Yuchun, Małgorzata Marjańska, Malcolm Prior, Christopher Brignell, Samira Parhizkar, Alessandra Agostini, Li Bai, Dorothee P Auer, Henryk M Faa. Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models. Scientific reports. vol 6. 2017-01-06. PMID:26813748. |
using mrs, we monitored the brain metabolic response to lipopolysaccharides (lps)-induced microglia activation in vivo in a transgenic mouse model of alzheimer's disease (app/ps1) and healthy controls (wild-type (wt) littermates) over 4 hours. |
2017-01-06 |
2023-08-13 |
mouse |
| Emiliano Peña-Altamira, Federica Prati, Francesca Massenzio, Marco Virgili, Antonio Contestabile, Maria Laura Bolognesi, Barbara Mont. Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation. Expert opinion on therapeutic targets. vol 20. issue 5. 2016-12-30. PMID:26568363. |
the importance of microglia in most neurodegenerative pathologies, from parkinson's disease to amyotrophic lateral sclerosis and alzheimer's disease, is increasingly recognized. |
2016-12-30 |
2023-08-13 |
Not clear |
| Katherine A Southam, Adele J Vincent, David H Smal. Do Microglia Default on Network Maintenance in Alzheimer's Disease? Journal of Alzheimer's disease : JAD. vol 51. issue 3. 2016-12-19. PMID:26890782. |
do microglia default on network maintenance in alzheimer's disease? |
2016-12-19 |
2023-08-13 |
Not clear |
| Mami Nod. Dysfunction of Glutamate Receptors in Microglia May Cause Neurodegeneration. Current Alzheimer research. vol 13. issue 4. 2016-12-15. PMID:26567741. |
thus, dysfunction or decreased expression of glua2 reported in patients with neurodegenerative diseases such as alzheimer's and creutzfeldt-jakob disease may accelerate glu neurotoxicity via excess release of proinflammatory cytokines from microglia, causing more neuronal death. |
2016-12-15 |
2023-08-13 |
Not clear |
| José Joaquín Merino, Vilma Muñetón-Gómez, María-Isabel Alvárez, Adolfo Toledano-Día. Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer's Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD? Current Alzheimer research. vol 13. issue 4. 2016-12-15. PMID:26567742. |
microglia and astrocytes are the major source of cytokines in alzheimer,s disease (ad). |
2016-12-15 |
2023-08-13 |
mouse |
| Dario Tejera, Michael T Henek. Microglia in Alzheimer's disease: the good, the bad and the ugly. Current Alzheimer research. vol 13. issue 4. 2016-12-15. PMID:26567746. |
microglia in alzheimer's disease: the good, the bad and the ugly. |
2016-12-15 |
2023-08-13 |
Not clear |
| Maria Pannell, Maria Almut Meier, Frank Szulzewsky, Vitali Matyash, Matthias Endres, Golo Kronenberg, Vincent Prinz, Sonia Waiczies, Susanne A Wolf, Helmut Kettenman. The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer's disease. Brain structure & function. vol 221. issue 2. 2016-12-14. PMID:25523105. |
the subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and alzheimer's disease. |
2016-12-14 |
2023-08-13 |
mouse |
| Namki Cho, Eun Hye Moon, Hyun Woo Kim, Jaewoo Hong, John A Beutler, Sang Hyun Sun. Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus. Molecules (Basel, Switzerland). vol 21. issue 4. 2016-12-14. PMID:27070561. |
it is well known that activated microglia produce nitric oxide (no), which has an important role in the pathophysiology of several neurodegenerative diseases such as alzheimer's disease. |
2016-12-14 |
2023-08-13 |
Not clear |
| Simon Beggs, Michael W Salte. SnapShot: Microglia in Disease. Cell. vol 165. issue 5. 2016-11-09. PMID:27203115. |
by contrast, dysregulation of microglia contributes to the pathology of neurodevelopmental disorders such as autism spectrum disorders; neurodegenerative disorders such as alzheimer's disease; and schizophrenia and chronic neuropathic pain. |
2016-11-09 |
2023-08-13 |
Not clear |
| Nevenka Dudvarski Stankovic, Marcin Teodorczyk, Robert Ploen, Frauke Zipp, Mirko H H Schmid. Microglia-blood vessel interactions: a double-edged sword in brain pathologies. Acta neuropathologica. vol 131. issue 3. 2016-11-08. PMID:26711460. |
such reactive microglia have been reported to even escalate the damage of the brain parenchyma as is the case in ischemic injuries, brain tumors, multiple sclerosis, alzheimer's and parkinson's disease. |
2016-11-08 |
2023-08-13 |
Not clear |
| Marie Christine Pardo. Lipopolysaccharide hyporesponsiveness: protective or damaging response to the brain? Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 56. issue 3. 2016-11-07. PMID:26662122. |
and while reduced tlr4 signaling reduces the risk of neurodegenerative diseases, up-regulation of anti-inflammatory cytokines associated with lps hyporesponsiveness can have deleterious consequences to the brain by inhibiting the protective phenotype of microglia, aggravating the progression of some neurodegenerative conditions such as alzheimer's disease. |
2016-11-07 |
2023-08-13 |
Not clear |