| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelsey E Melah, Sharon Yuan-Fu Lu, Siobhan M Hoscheidt, Andrew L Alexander, Nagesh Adluru, Daniel J Destiche, Cynthia M Carlsson, Henrik Zetterberg, Kaj Blennow, Ozioma C Okonkwo, Carey E Gleason, N Maritza Dowling, Lisa C Bratzke, Howard A Rowley, Mark A Sager, Sanjay Asthana, Sterling C Johnson, Barbara B Bendli. Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 50. issue 3. 2016-10-31. PMID:26836182. |
the immune response in alzheimer's disease (ad) involves activation of microglia which may remove amyloid-β (aβ). |
2016-10-31 |
2023-08-13 |
Not clear |
| Jun-ichi Satoh, Yoshihiro Kino, Naohiro Asahina, Mika Takitani, Junko Miyoshi, Tsuyoshi Ishida, Yuko Sait. TMEM119 marks a subset of microglia in the human brain. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 1. 2016-10-19. PMID:26250788. |
notably, tmem119 immunoreactivity was expressed exclusively on a subset of iba1(+) cd68(+) microglia with ramified and amoeboid morphologies in the brains of neurodegenerative diseases, such as alzheimer's disease (ad), whereas iba1(+) cd68(+) infiltrating macrophages do not express tmem119 in demyelinating lesions of multiple sclerosis and necrotic lesions of cerebral infarction. |
2016-10-19 |
2023-08-13 |
human |
| Richard M Ransohoff, Joseph El Khour. Microglia in Health and Disease. Cold Spring Harbor perspectives in biology. vol 8. issue 1. 2016-10-13. PMID:26354893. |
here, we review recent advances in our understanding of the role of microglia in physiological and pathological processes of the cns with a focus on multiple sclerosis and alzheimer's disease. |
2016-10-13 |
2023-08-13 |
Not clear |
| Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. |
in addition, we demonstrate, for the first time, that microglia colocalize with various forms of tau in postmortem brain tissue of patients with alzheimer's disease and non-demented control subjects. |
2016-10-07 |
2023-08-13 |
mouse |
| Ryan C McCarthy, Dah-Yuu Lu, Ahmed Alkhateeb, Andrew M Gardeck, Chih-Hao Lee, Marianne Wessling-Resnic. Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta. Journal of neuroinflammation. vol 13. 2016-10-05. PMID:26819091. |
alzheimer's disease is associated with amyloid-beta (aβ)-induced microglia activation. |
2016-10-05 |
2023-08-13 |
Not clear |
| Adele Salemme, Anna Rita Togna, Arianna Mastrofrancesco, Vittoria Cammisotto, Monica Ottaviani, Armandodoriano Bianco, Alessandro Venditt. Anti-inflammatory effects and antioxidant activity of dihydroasparagusic acid in lipopolysaccharide-activated microglial cells. Brain research bulletin. vol 120. 2016-09-30. PMID:26592472. |
the activation of microglia and subsequent release of toxic pro-inflammatory factors are crucially associated with neurodegenerative disease, characterized by increased oxidative stress and neuroinflammation, including alzheimer and parkinson diseases and multiple sclerosis. |
2016-09-30 |
2023-08-13 |
rat |
| P Rangarajan, A Karthikeyan, J Lu, E-A Ling, S T Dhee. Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia. Neuroscience. vol 311. 2016-09-14. PMID:26523980. |
chronic activation of microglia has been linked to aging-associated neurodegenerative diseases such as alzheimer's disease (ad) and parkinson's disease (pd) since they produce excessive amounts of ros for a prolonged duration leading to oxidative stress. |
2016-09-14 |
2023-08-13 |
rat |
| Yan Wang, Jizong Lin, Qing-Zhuang Chen, Ning Zhu, De-Qi Jiang, Ming-Xing Li, Yong Wan. Overexpression of mitochondrial Hsp75 protects neural stem cells against microglia-derived soluble factor-induced neurotoxicity by regulating mitochondrial permeability transition pore opening in vitro. International journal of molecular medicine. vol 36. issue 6. 2016-09-12. PMID:26500047. |
microglia (mg)-induced neurotoxicity, a major determinant of alzheimer's disease, is closely related to the survival of neural stem cells (nscs). |
2016-09-12 |
2023-08-13 |
human |
| Lianne Hoeijmakers, Yvonne Heinen, Anne-Marie van Dam, Paul J Lucassen, Aniko Koros. Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics? Frontiers in human neuroscience. vol 10. 2016-08-24. PMID:27555812. |
neuroinflammation is thought to contribute to alzheimer's disease (ad) pathogenesis that is, to a large extent, mediated by microglia. |
2016-08-24 |
2023-08-13 |
Not clear |
| Elizabeth E Spangenberg, Rafael J Lee, Allison R Najafi, Rachel A Rice, Monica R P Elmore, Mathew Blurton-Jones, Brian L West, Kim N Gree. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain : a journal of neurology. vol 139. issue Pt 4. 2016-08-18. PMID:26921617. |
eliminating microglia in alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. |
2016-08-18 |
2023-08-13 |
mouse |
| Elizabeth E Spangenberg, Rafael J Lee, Allison R Najafi, Rachel A Rice, Monica R P Elmore, Mathew Blurton-Jones, Brian L West, Kim N Gree. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain : a journal of neurology. vol 139. issue Pt 4. 2016-08-18. PMID:26921617. |
inflammation in alzheimer's disease is characterized by the presence of reactive astrocytes and activated microglia surrounding amyloid plaques, implicating their role in disease pathogenesis. |
2016-08-18 |
2023-08-13 |
mouse |
| Elizabeth E Spangenberg, Rafael J Lee, Allison R Najafi, Rachel A Rice, Monica R P Elmore, Mathew Blurton-Jones, Brian L West, Kim N Gree. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain : a journal of neurology. vol 139. issue Pt 4. 2016-08-18. PMID:26921617. |
in this study, we set out to determine if chronically activated microglia in the alzheimer's disease brain are also dependent on csf1r signalling, and if so, how these cells contribute to disease pathogenesis. |
2016-08-18 |
2023-08-13 |
mouse |
| Lorraine Hamelin, Julien Lagarde, Guillaume Dorothée, Claire Leroy, Mickael Labit, Robert A Comley, Leonardo Cruz de Souza, Helene Corne, Luce Dauphinot, Maxime Bertoux, Bruno Dubois, Philippe Gervais, Olivier Colliot, Marie Claude Potier, Michel Bottlaender, Marie Sarazi. Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging. Brain : a journal of neurology. vol 139. issue Pt 4. 2016-08-18. PMID:26984188. |
while emerging evidence suggests that neuroinflammation plays a crucial role in alzheimer's disease, the impact of the microglia response in alzheimer's disease remains a matter of debate. |
2016-08-18 |
2023-08-13 |
human |
| Chin Wai Hui, Yang Zhang, Karl Herru. Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System. PloS one. vol 11. issue 1. 2016-08-11. PMID:26788729. |
chronic inflammation is associated with activated microglia and reactive astrocytes and plays an important role in the pathogenesis of neurodegenerative diseases such as alzheimer's. |
2016-08-11 |
2023-08-13 |
mouse |
| Sabine Hellwig, Annette Masuch, Sigrun Nestel, Natalie Katzmarski, Melanie Meyer-Luehmann, Knut Bibe. Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures. Scientific reports. vol 5. 2016-08-08. PMID:26416689. |
the capacity to prevent aβ plaque formation was absent in forebrain microglia from young adult but not juvenile 5xfamilial alzheimer's disease (fad) mice. |
2016-08-08 |
2023-08-13 |
mouse |
| Shi Shi, Dongli Liang, Yi Chen, Yilin Xie, Yingchao Wang, Lianyun Wang, Zhaoxia Wang, Zhongdong Qia. Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO, and PGE2 expression and inhibits NF-κB signaling in a mouse model of Alzheimer's disease. European journal of immunology. vol 46. issue 3. 2016-08-04. PMID:26643273. |
chronic inflammation, which is regulated by overactivated microglia in the brain, accelerates the occurrence and development of alzheimer's disease (ad). |
2016-08-04 |
2023-08-13 |
mouse |
| Roger F Butterwort. Hepatic encephalopathy in alcoholic cirrhosis. Handbook of clinical neurology. vol 125. 2016-07-28. PMID:25307598. |
neuropathologically, he in cirrhosis is principally a disorder of neuroglia characterized by alzheimer type ii astrocytosis and activation of microglia. |
2016-07-28 |
2023-08-13 |
Not clear |
| Gen-Lin He, Zhen Luo, Ju Yang, Ting-Ting Shen, Yi Chen, Xue-Sen Yan. Curcumin Ameliorates the Reduction Effect of PGE2 on Fibrillar β-Amyloid Peptide (1-42)-Induced Microglial Phagocytosis through the Inhibition of EP2-PKA Signaling in N9 Microglial Cells. PloS one. vol 11. issue 1. 2016-07-26. PMID:26824354. |
inflammatory activation of microglia and β amyloid (aβ) deposition are considered to work both independently and synergistically to contribute to the increased risk of alzheimer's disease (ad). |
2016-07-26 |
2023-08-13 |
Not clear |
| Marco Colonna, Yaming Wan. TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nature reviews. Neuroscience. vol 17. issue 4. 2016-07-21. PMID:26911435. |
genome-wide association studies have identified rare variants of the gene that encodes triggering receptor expressed on myeloid cells 2 (trem2) - an immune receptor that is found in brain microglia - as risk factors for non-familial alzheimer disease (ad). |
2016-07-21 |
2023-08-13 |
Not clear |
| Joseph Jebelli, Thomas Piers, Jennifer Pococ. Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester. Journal of visualized experiments : JoVE. issue 101. 2016-07-06. PMID:26275019. |
this approach allows one to assess the relative impact of microglia on experimental data, as well as determine whether microglia are playing a neuroprotective or neurotoxic role in culture models of neurological conditions, such as stroke, alzheimer's or parkinson's disease. |
2016-07-06 |
2023-08-13 |
Not clear |