| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Huang, Xiu-Hua Ren, Shan-Feng Zhang, Jie-Wen Zhan. [Different doses transplanted microglia effect on β-amyloid protein in rat Alzheimer's models]. Zhonghua yi xue za zhi. vol 91. issue 33. 2016-04-23. PMID:22321752. |
[different doses transplanted microglia effect on β-amyloid protein in rat alzheimer's models]. |
2016-04-23 |
2023-08-12 |
rat |
| Yue Huang, Xiu-Hua Ren, Shan-Feng Zhang, Jie-Wen Zhan. [Different doses transplanted microglia effect on β-amyloid protein in rat Alzheimer's models]. Zhonghua yi xue za zhi. vol 91. issue 33. 2016-04-23. PMID:22321752. |
to explore the effects of different doses of transplanted microglia (mg) on β-amyloid protein (aβ) in rat brain model of alzheimer's disease (ad). |
2016-04-23 |
2023-08-12 |
rat |
| Alena V Savonenko, Tatiana Melnikova, Yuchuan Wang, Hayden Ravert, Yongjun Gao, Jeremy Koppel, Deidre Lee, Olga Pletnikova, Eugenia Cho, Nuzhat Sayyida, Andrew Hiatt, Juan Troncoso, Peter Davies, Robert F Dannals, Martin G Pomper, Andrew G Hort. Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation. PloS one. vol 10. issue 6. 2016-04-14. PMID:26086915. |
in alzheimer's disease (ad), one of the early responses to aβ amyloidosis is recruitment of microglia to areas of new plaque. |
2016-04-14 |
2023-08-13 |
mouse |
| Wenjie Luo, Wencheng Liu, Xiaoyan Hu, Mary Hanna, April Caravaca, Steven M Pau. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody. Scientific reports. vol 5. 2016-04-12. PMID:26057852. |
microglia have been shown to contribute to the clearance of brain amyloid β peptides (aβ), the major component of amyloid plaques, in alzheimer's disease (ad). |
2016-04-12 |
2023-08-13 |
mouse |
| Eun-A Kim, Jiyoung Choi, A Reum Han, Chang Hun Cho, Soo Young Choi, Jee-Yin Ahn, Sung-Woo Ch. 2-Cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride inhibits microglial activation by suppression of nuclear factor-kappa B and mitogen-activated protein kinase signaling. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 4. 2016-03-28. PMID:24752390. |
the activation of microglia is crucially associated with the neurodegeneration observed in many neuroinflammatory pathologies, including multiple sclerosis, parkinson's disease, and alzheimer's disease. |
2016-03-28 |
2023-08-13 |
rat |
| Mario M Dorostkar, Chengyu Zou, Lidia Blazquez-Llorca, Jochen Herm. Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities. Acta neuropathologica. vol 130. issue 1. 2016-03-22. PMID:26063233. |
furthermore, tau hyperphosphorylation and microglia activation, which are thought to be consequences of amyloidosis in alzheimer's disease, may also contribute to spine loss. |
2016-03-22 |
2023-08-13 |
mouse |
| Nabil N Dagher, Allison R Najafi, Kara M Neely Kayala, Monica R P Elmore, Terra E White, Rodrigo Medeiros, Brian L West, Kim N Gree. Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice. Journal of neuroinflammation. vol 12. 2016-03-22. PMID:26232154. |
here, we determined the dose-dependent effects of a specific csf1r inhibitor (plx5622) on microglia in both wild-type and the 3xtg-ad mouse model of alzheimer's disease. |
2016-03-22 |
2023-08-13 |
mouse |
| David S Bouvier, Keith K Mura. Synergistic actions of microglia and astrocytes in the progression of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 45. issue 4. 2016-03-08. PMID:25663025. |
synergistic actions of microglia and astrocytes in the progression of alzheimer's disease. |
2016-03-08 |
2023-08-13 |
Not clear |
| David S Bouvier, Keith K Mura. Synergistic actions of microglia and astrocytes in the progression of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 45. issue 4. 2016-03-08. PMID:25663025. |
in neurodegenerative diseases such as alzheimer's disease, the reciprocal interactions between microglia and astrocytes may be particularly important for the development of neuronal pathology and disease states. |
2016-03-08 |
2023-08-13 |
Not clear |
| Lalida Rojanathammanee, Angela M Floden, Gunjan D Manocha, Colin K Comb. Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition. Journal of neuroinflammation. vol 12. 2016-03-07. PMID:25889879. |
amyloid β (aβ) peptide is hypothesized to stimulate microglia to acquire their characteristic proinflammatory phenotype in alzheimer's disease (ad) brains. |
2016-03-07 |
2023-08-13 |
mouse |
| Christian K E Jung, Kevin Keppler, Sonja Steinbach, Lidia Blazquez-Llorca, Jochen Herm. Fibrillar amyloid plaque formation precedes microglial activation. PloS one. vol 10. issue 3. 2016-03-03. PMID:25799372. |
in alzheimer's disease (ad), hallmark β-amyloid deposits are characterized by the presence of activated microglia around them. |
2016-03-03 |
2023-08-13 |
mouse |
| Zhou Wu, Hiroshi Nakanish. Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer's Disease. Journal of immunology research. vol 2015. 2016-03-03. PMID:26078980. |
lessons from microglia aging for the link between inflammatory bone disorders and alzheimer's disease. |
2016-03-03 |
2023-08-13 |
Not clear |
| Arlan Richardson, Veronica Galvan, Ai-Ling Lin, Salvatore Odd. How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story. Experimental gerontology. vol 68. 2016-02-22. PMID:25481271. |
rapamycin has been shown to prevent (and possibly restore in some cases) the deficit in memory observed in the mouse model of alzheimer's disease (ad-tg) as well as reduce aβ and tau aggregation, restore cerebral blood flow and vascularization, and reduce microglia activation. |
2016-02-22 |
2023-08-13 |
mouse |
| Stefan Prokop, Kelly R Miller, Natalia Drost, Susann Handrick, Vidhu Mathur, Jian Luo, Anja Wegner, Tony Wyss-Coray, Frank L Heppne. Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice. The Journal of experimental medicine. vol 212. issue 11. 2016-02-09. PMID:26458768. |
although central nervous system-resident microglia are believed to be ineffective at phagocytosing and clearing amyloid-β (aβ), a major pathological hallmark of alzheimer's disease (ad), it has been suggested that peripheral myeloid cells constitute a heterogeneous cell population with greater aβ-clearing capabilities. |
2016-02-09 |
2023-08-13 |
mouse |
| Nathan G Skene, Seth G N Gran. Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment. Frontiers in neuroscience. vol 10. 2016-02-09. PMID:26858593. |
genetic susceptibility primarily affected microglia in alzheimer's and multiple sclerosis; was shared between interneurons and pyramidal neurons in autism and schizophrenia; while intellectual disabilities and epilepsy were attributable to a range of cell-types, with the strongest enrichment in interneurons. |
2016-02-09 |
2023-08-13 |
mouse |
| Ping Gan, Li Zhang, Yanke Chen, Yu Zhang, Fali Zhang, Xiang Zhou, Xiaohu Zhang, Bo Gao, Xuechu Zhen, Jian Zhang, Long Tai Zhen. Anti-inflammatory effects of glaucocalyxin B in microglia cells. Journal of pharmacological sciences. vol 128. issue 1. 2016-02-08. PMID:26003084. |
over-activated microglia is involved in various kinds of neurodegenerative process including parkinson, alzheimer and hiv dementia. |
2016-02-08 |
2023-08-13 |
Not clear |
| Julie Audoy-Rémus, Lusine Bozoyan, Aline Dumas, Mohammed Filali, Cynthia Lecours, Steve Lacroix, Serge Rivest, Marie-Eve Tremblay, Luc Vallière. GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease. Brain, behavior, and immunity. vol 46. 2016-02-04. PMID:25637481. |
microglia surrounds the amyloid plaques that form in the brains of patients with alzheimer's disease (ad), but their role is controversial. |
2016-02-04 |
2023-08-13 |
mouse |
| Xiao He, Bing-Gui Su. [Roles of microglia and immune receptors in Alzheimer's disease]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 49. issue 6. 2016-02-02. PMID:25212020. |
[roles of microglia and immune receptors in alzheimer's disease]. |
2016-02-02 |
2023-08-13 |
Not clear |
| Carlo Condello, Peng Yuan, Aaron Schain, Jaime Grutzendle. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nature communications. vol 6. 2016-02-02. PMID:25630253. |
in alzheimer's disease (ad), β-amyloid (aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. |
2016-02-02 |
2023-08-13 |
mouse |
| Ying Jiang, Yingying Liu, Cansheng Zhu, Xiaomeng Ma, Lili Ma, Linli Zhou, Qiling Huang, Lei Cen, Rongbiao Pi, Xiaohong Che. Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice. Neurobiology of learning and memory. vol 121. 2016-01-22. PMID:25838119. |
previous studies have suggested that minocycline can attenuate cognitive deficits in animal models of conditions such as alzheimer's disease and cerebral ischemia through inhibiting microglia associated anti-inflammatory actions. |
2016-01-22 |
2023-08-13 |
mouse |