| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Midori Suenaga, Akiko Furuta, Koichi Wakabayashi, Toshiji Saibara, Yoichi Matsunag. Monocytic elastase-mediated apolipoprotein-E degradation: Potential involvement of microglial elastase-like proteases in apolipoprotein-E proteolysis in brains with Alzheimers disease. Biochimica et biophysica acta. vol 1854. issue 8. 2015-08-21. PMID:25956321. |
impaired clearance of soluble aβ (amyloid-β) promotes aβ aggregation in brains with alzheimer's disease (ad), while apolipoprotein-e (apoe) in microglia mediates aβ clearance. |
2015-08-21 |
2023-08-13 |
mouse |
| Lusine Danielyan, Sandra Beer-Hammer, Alexandra Stolzing, Richard Schäfer, Georg Siegel, Claire Fabian, Philipp Kahle, Tilo Biedermann, Ali Lourhmati, Marine Buadze, Ana Novakovic, Barbara Proksch, Christoph H Gleiter, William H Frey, Matthias Schwa. Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's disease. Cell transplantation. vol 23 Suppl 1. 2015-08-19. PMID:25302802. |
intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of alzheimer's and parkinson's disease. |
2015-08-19 |
2023-08-13 |
mouse |
| Lusine Danielyan, Sandra Beer-Hammer, Alexandra Stolzing, Richard Schäfer, Georg Siegel, Claire Fabian, Philipp Kahle, Tilo Biedermann, Ali Lourhmati, Marine Buadze, Ana Novakovic, Barbara Proksch, Christoph H Gleiter, William H Frey, Matthias Schwa. Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's disease. Cell transplantation. vol 23 Suppl 1. 2015-08-19. PMID:25302802. |
the present study examined delivery of bone marrow-derived mscs, macrophages, and microglia to the brain in a transgenic model of pd [(thy1)-h[a30p] αs] and an app/ps1 model of alzheimer's disease (ad) via intranasal application (ina). |
2015-08-19 |
2023-08-13 |
mouse |
| Mingqin Zhu, Xiuzhe Wang, Marianne Schultzberg, Erik Hjort. Differential regulation of resolution in inflammation induced by amyloid-β42 and lipopolysaccharides in human microglia. Journal of Alzheimer's disease : JAD. vol 43. issue 4. 2015-08-18. PMID:25147114. |
chronic inflammation mediated by microglia is a feature of alzheimer's disease (ad) and can be a pathogenic factor in which both treatment targets and diagnostic markers may be found. |
2015-08-18 |
2023-08-13 |
human |
| Daisuke Umebayashi, Atsushi Natsume, Hideyuki Takeuchi, Masahito Hara, Yusuke Nishimura, Ryuichi Fukuyama, Naoyuki Sumiyoshi, Toshihiko Wakabayash. Blockade of gap junction hemichannel protects secondary spinal cord injury from activated microglia-mediated glutamate exitoneurotoxicity. Journal of neurotrauma. vol 31. issue 24. 2015-08-03. PMID:24588281. |
we previously demonstrated that activated microglia release excessive glutamate through gap junction hemichannels and identified a novel gap junction hemichannel blocker, ini-0602, that was proven to penetrate the blood-brain barrier and be an effective treatment in mouse models of amyotrophic lateral sclerosis and alzheimer disease. |
2015-08-03 |
2023-08-12 |
mouse |
| Maria Neus Bosch, Marco Pugliese, Carmen Andrade, Javier Gimeno-Bayón, Nicole Mahy, Manuel J Rodrigue. Amyloid-β immunotherapy reduces amyloid plaques and astroglial reaction in aged domestic dogs. Neuro-degenerative diseases. vol 15. issue 1. 2015-07-30. PMID:25531153. |
alzheimer's disease (ad) is characterized by the dynamic accumulation of extracellular amyloid deposits from the interplay between amyloid-β (aβ) plaques, reactive astrocytes and activated microglia. |
2015-07-30 |
2023-08-13 |
Not clear |
| Chul Hyoung Lyoo, Masamichi Ikawa, Jeih-San Liow, Sami S Zoghbi, Cheryl L Morse, Victor W Pike, Masahiro Fujita, Robert B Innis, William Charles Kreis. Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 5. 2015-07-24. PMID:25766898. |
alzheimer disease (ad) is associated with an increase in the brain of the 18-kda translocator protein (tspo), which is overexpressed in activated microglia and reactive astrocytes. |
2015-07-24 |
2023-08-13 |
Not clear |
| Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Ta. Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease. Annals of translational medicine. vol 3. issue 10. 2015-07-24. PMID:26207229. |
role of pro-inflammatory cytokines released from microglia in alzheimer's disease. |
2015-07-24 |
2023-08-13 |
Not clear |
| Tara M Weitz, David Gate, Kavon Rezai-Zadeh, Terrence Tow. MyD88 is dispensable for cerebral amyloidosis and neuroinflammation in APP/PS1 transgenic mice. The American journal of pathology. vol 184. issue 11. 2015-07-21. PMID:25174876. |
activated microglia are associated with amyloid plaques in transgenic mouse models of cerebral amyloidosis and in human alzheimer disease; yet, their implication in alzheimer disease pathogenesis remains unclear. |
2015-07-21 |
2023-08-13 |
mouse |
| Mrinmay Chakrabarti, Azizul Haque, Naren L Banik, Prakash Nagarkatti, Mitzi Nagarkatti, Swapan K Ra. Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration. Brain research bulletin. vol 109. 2015-07-10. PMID:25245209. |
neurodegenerative processes in several cns disorders including spinal cord injury (sci), multiple sclerosis (ms), parkinson's disease (pd), and alzheimer's disease (ad) are associated with activation of microglia and astrocytes, which drive the resident neuroinflammatory response. |
2015-07-10 |
2023-08-13 |
Not clear |
| Emanuel Monteiro Candeias, Inês Carolina Sebastião, Susana Maria Cardoso, Sónia Catarina Correia, Cristina Isabel Carvalho, Ana Isabel Plácido, Maria Sancha Santos, Catarina Resende Oliveira, Paula Isabel Moreira, Ana Isabel Duart. Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide. World journal of diabetes. vol 6. issue 6. 2015-07-01. PMID:26131323. |
importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against t2d, stroke and alzheimer disease (ad), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in ad biomarkers. |
2015-07-01 |
2023-08-13 |
Not clear |
| Ying Li, Meng-Shan Tan, Teng Jiang, Lan Ta. Microglia in Alzheimer's disease. BioMed research international. vol 2014. 2015-06-29. PMID:25197646. |
microglia in alzheimer's disease. |
2015-06-29 |
2023-08-13 |
Not clear |
| Thomas J Anastasi. Computational identification of potential multi-drug combinations for reduction of microglial inflammation in Alzheimer disease. Frontiers in pharmacology. vol 6. 2015-06-22. PMID:26097457. |
like other neurodegenerative diseases, alzheimer disease (ad) has a prominent inflammatory component mediated by brain microglia. |
2015-06-22 |
2023-08-13 |
Not clear |
| I L Han Choo, Stephen F Carter, Michael L Schöll, Agneta Nordber. Astrocytosis measured by ¹¹C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer's patients. European journal of nuclear medicine and molecular imaging. vol 41. issue 11. 2015-06-16. PMID:25077930. |
the alzheimer's disease (ad) pathology is characterized by fibrillar amyloid deposits and neurofibrillary tangles, as well as the activation of astrocytosis, microglia activation, atrophy, dysfunctional synapse, and cognitive impairments. |
2015-06-16 |
2023-08-13 |
Not clear |
| Nathalie Cartier, Coral-Ann Lewis, Regan Zhang, Fabio M V Ross. The role of microglia in human disease: therapeutic tool or target? Acta neuropathologica. vol 128. issue 3. 2015-06-08. PMID:25107477. |
here, we review how our understanding of microglia's involvement in promoting or limiting the pathogenesis of diseases such as amyotrophic lateral sclerosis, alzheimer's disease, huntington's disease, multiple sclerosis, x-linked adrenoleukodystrophy (x-ald) and lysosomal storage diseases (lsd) has changed over time. |
2015-06-08 |
2023-08-13 |
human |
| Danira Toral-Rios, Diana Franco-Bocanegra, Oscar Rosas-Carrasco, Francisco Mena-Barranco, Rosa Carvajal-García, Marco Antonio Meraz-Ríos, Victoria Campos-Peñ. Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer's disease: a pilot study. Frontiers in cellular neuroscience. vol 9. 2015-06-04. PMID:26041990. |
amyloid peptide is able to promote the activation of microglia and astrocytes in alzheimer's disease (ad), and this stimulates the production of pro-inflammatory cytokines. |
2015-06-04 |
2023-08-13 |
human |
| Augusta Pisanu, Daniela Lecca, Giovanna Mulas, Jadwiga Wardas, Gabriella Simbula, Saturnino Spiga, Anna R Cart. Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease. Neurobiology of disease. vol 71. 2015-06-02. PMID:25134730. |
a skewed m1 activation over m2 has been related to disease progression in alzheimer disease, and modulation of microglia polarization may be a therapeutic target for neuroprotection. |
2015-06-02 |
2023-08-13 |
mouse |
| Jean-Philippe Michaud, Serge Rives. Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology. Neuron. vol 85. issue 3. 2015-05-22. PMID:25654250. |
anti-inflammatory signaling in microglia exacerbates alzheimer's disease-related pathology. |
2015-05-22 |
2023-08-13 |
mouse |
| Jean-Philippe Michaud, Serge Rives. Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology. Neuron. vol 85. issue 3. 2015-05-22. PMID:25654250. |
(2015) reveal that the anti-inflammatory cytokine il-10 inhibits aβ clearance by microglia, worsening cognitive decline in mouse models of alzheimer's disease (ad). |
2015-05-22 |
2023-08-13 |
mouse |
| Yikui Hu, Chengyan Li, Wei She. Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 34. issue 4. 2015-05-11. PMID:24661139. |
alzheimer's disease (ad) is a progressive, neurodegenerative disease, characterized by excessive accumulation of amyloid-beta (aβ) and activation of microglia cells and astrocytes. |
2015-05-11 |
2023-08-12 |
mouse |