All Relations between Alzheimer Disease and microglial cell

Publication Sentence Publish Date Extraction Date Species
Jun-Ichi Satoh, Naohiro Asahina, Shouta Kitano, Yoshihiro Kin. A Comprehensive Profile of ChIP-Seq-Based PU.1/Spi1 Target Genes in Microglia. Gene regulation and systems biology. vol 8. 2015-01-09. PMID:25574134. microglia, rapidly activated in response to proinflammatory stimuli, are accumulated in brain lesions of neurodegenerative diseases, such as alzheimer's disease and parkinson's disease. 2015-01-09 2023-08-13 mouse
Sungho Lee, Guixiang Xu, Taylor R Jay, Sabina Bhatta, Ki-Wook Kim, Steffen Jung, Gary E Landreth, Richard M Ransohoff, Bruce T Lam. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 37. 2015-01-07. PMID:25209291. several alzheimer's disease (ad) risk genes are specifically expressed by microglia within the cns. 2015-01-07 2023-08-13 mouse
James G McLarno. Correlated inflammatory responses and neurodegeneration in peptide-injected animal models of Alzheimer's disease. BioMed research international. vol 2014. 2015-01-05. PMID:24822221. animal models of alzheimer's disease (ad) which emphasize activation of microglia may have particular utility in correlating proinflammatory activity with neurodegeneration. 2015-01-05 2023-08-13 rat
Wolfgang J Streit, Qing-Shan Xu. Human CNS immune senescence and neurodegeneration. Current opinion in immunology. vol 29. 2014-12-04. PMID:24908174. on the basis of histopathological observations in human brain, we believe that the ability of microglia to provide neuroprotection deteriorates as our brains get older and that such cns immune senescence is a major factor contributing to the development of aging-related neurodegenerative diseases, notably alzheimer's disease. 2014-12-04 2023-08-13 human
Victoria Ingham, Alun Williams, Clive Bat. Glimepiride reduces CD14 expression and cytokine secretion from macrophages. Journal of neuroinflammation. vol 11. 2014-12-01. PMID:24952384. activated microglia are associated with deposits of aggregated proteins within the brains of patients with alzheimer's disease (ad), parkinson's disease (pd) and prion diseases. 2014-12-01 2023-08-13 Not clear
Deepa Ajit, Lucas T Woods, Jean M Camden, Christina N Thebeau, Farid G El-Sayed, Glen W Greeson, Laurie Erb, Michael J Petris, Douglas C Miller, Grace Y Sun, Gary A Weisma. Loss of P2Y₂ nucleotide receptors enhances early pathology in the TgCRND8 mouse model of Alzheimer's disease. Molecular neurobiology. vol 49. issue 2. 2014-11-21. PMID:24193664. neuroinflammation is a prominent feature in alzheimer's disease (ad) and activation of the brain's innate immune system, particularly microglia, has been postulated to both retard and accelerate ad progression. 2014-11-21 2023-08-12 mouse
Zhiyou Cai, M Delwar Hussain, Liang-Jun Ya. Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease. The International journal of neuroscience. vol 124. issue 5. 2014-11-18. PMID:23930978. microglia, neuroinflammation, and beta-amyloid protein in alzheimer's disease. 2014-11-18 2023-08-12 Not clear
Zhiyou Cai, M Delwar Hussain, Liang-Jun Ya. Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease. The International journal of neuroscience. vol 124. issue 5. 2014-11-18. PMID:23930978. compelling evidence from basic molecular biology has demonstrated the dual roles of microglia in the pathogenesis of alzheimer's disease (ad). 2014-11-18 2023-08-12 Not clear
Taisia Rolova, Lakshman Puli, Johanna Magga, Hiramani Dhungana, Katja Kanninen, Sara Wojciehowski, Antero Salminen, Heikki Tanila, Jari Koistinaho, Tarja Mal. Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit. Neurobiology of disease. vol 64. 2014-11-12. PMID:24345324. our data demonstrates a crucial and complex role p50 subunit of nf-κb in brain inflammation, especially in regulating the phenotype of microglia after acute and chronic inflammatory insults relevant to clinical conditions, contributing to both pro-inflammatory and anti-inflammatory responses of microglia, infiltration of leukocytes, and clearance of aβ in alzheimer's disease. 2014-11-12 2023-08-12 mouse
P Joshi, E Turola, A Ruiz, A Bergami, D D Libera, L Benussi, P Giussani, G Magnani, G Comi, G Legname, R Ghidoni, R Furlan, M Matteoli, C Verderi. Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles. Cell death and differentiation. vol 21. issue 4. 2014-11-04. PMID:24336048. alzheimer's disease (ad) is characterized by extracellular amyloid-β (aβ) deposition, which activates microglia, induces neuroinflammation and drives neurodegeneration. 2014-11-04 2023-08-12 human
Ron Strohmeyer, Jadd Shelton, Christopher Lougheed, Trisia Breitkop. CCAAT-enhancer binding protein-β expression and elevation in Alzheimer's disease and microglial cell cultures. PloS one. vol 9. issue 1. 2014-11-04. PMID:24466171. ccaat-enhancer binding protein-β expression and elevation in alzheimer's disease and microglial cell cultures. 2014-11-04 2023-08-12 Not clear
Ron Strohmeyer, Jadd Shelton, Christopher Lougheed, Trisia Breitkop. CCAAT-enhancer binding protein-β expression and elevation in Alzheimer's disease and microglial cell cultures. PloS one. vol 9. issue 1. 2014-11-04. PMID:24466171. because c/ebps are expressed by rodent astrocytes and microglia, and because they are induced by pro-inflammatory cytokines that are chronically upregulated in the alzheimer's disease (ad) cortex, we have investigated whether c/ebps are expressed and upregulated in the ad cortex. 2014-11-04 2023-08-12 Not clear
Long-Jun W. Microglial voltage-gated proton channel Hv1 in ischemic stroke. Translational stroke research. vol 5. issue 1. 2014-10-27. PMID:24323712. the current understanding of hv1 in ischemic injury through nox-dependent ros production may serve as a common model to reveal the deleterious role of microglia in neurological diseases other than ischemic stroke, such as multiple sclerosis, amyotrophic lateral sclerosis, alzheimer's disease, and neuropathic pain. 2014-10-27 2023-08-12 mouse
Jannis Kountouras, Georgia Deretzi, Emmanouel Gavalas, Christos Zavos, Stergios A Polyzos, Evangelos Kazakos, Evangelia Giartza-Taxidou, Elisabeth Vardaka, Constantinos Kountouras, Panagiotis Katsinelos, Marina Boziki, Olga Gioulem. A proposed role of human defensins in Helicobacter pylori-related neurodegenerative disorders. Medical hypotheses. vol 82. issue 3. 2014-10-27. PMID:24472867. it is proposed that reduction or abnormal elevation of amp expression by cerebral microglia, astrocytes or choroid plexus epithelium might contribute to loss of amp-induced regulation of immune responses, thereby promoting neuronal cell injury and death observed in alzheimer's disease and possibly in other neurodegenerative disorders. 2014-10-27 2023-08-12 human
Dorothy P Schafer, Emily K Lehrman, Christopher T Heller, Beth Steven. An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons. Journal of visualized experiments : JoVE. issue 88. 2014-10-18. PMID:24962472. microglia are the resident immune cells of the central nervous system (cns) whose phagocytic function has been described in a broad range of conditions from neurodegenerative disease (e.g., beta-amyloid clearance in alzheimer's disease) to development of the healthy brain (e.g., synaptic pruning)(1-6). 2014-10-18 2023-08-13 mouse
Feifei Xi, Feng Sang, Chunxiang Zhou, Yun Lin. Protective effects of Lingguizhugan decoction on amyloid-beta peptide (25-35)-induced cell injury: Anti-inflammatory effects. Neural regeneration research. vol 7. issue 36. 2014-10-15. PMID:25317138. in the present study, a human neuroblastoma cell line (sh-sy5y) and bv-2 microglia were treated with amyloid-β peptide (25-35), as a model of alzheimer's disease, to evaluate the protective effects of 10-3-10-8 g/ml lingguizhugan decoction and to examine the underlying anti-inflammatory mechanism. 2014-10-15 2023-08-13 human
Tuo Ma, Kai Gong, Qiang Ao, Yufang Yan, Bo Song, Hongyun Huang, Xiufang Zhang, Yandao Gon. Intracerebral transplantation of adipose-derived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in Alzheimer's disease mice. Cell transplantation. vol 22 Suppl 1. 2014-10-02. PMID:24070198. intracerebral transplantation of adipose-derived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in alzheimer's disease mice. 2014-10-02 2023-08-12 mouse
Deborah Doens, Patricia L Fernánde. Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis. Journal of neuroinflammation. vol 11. 2014-09-16. PMID:24625061. microglia receptors and their implications in the response to amyloid β for alzheimer's disease pathogenesis. 2014-09-16 2023-08-12 Not clear
Zhe Wang, Minghui Wu, Bingwu Zhong, Dongdong Zhang, Mingda H. Effect of Naoling decoction on the expression of microglia and IL-6 in hippocampal CA3 region of rats with synthetic Alzheimer's disease. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 38. issue 2. 2014-09-01. PMID:23456069. effect of naoling decoction on the expression of microglia and il-6 in hippocampal ca3 region of rats with synthetic alzheimer's disease. 2014-09-01 2023-08-12 rat
Zhe Wang, Minghui Wu, Bingwu Zhong, Dongdong Zhang, Mingda H. Effect of Naoling decoction on the expression of microglia and IL-6 in hippocampal CA3 region of rats with synthetic Alzheimer's disease. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 38. issue 2. 2014-09-01. PMID:23456069. to observe the effect of naoling decoction on the learning and memory behaviors and the expression of microglia and il-6 in hippocampal ca3 region of rats with alzheimer's disease (ad), and to elucidate the potential mechanism. 2014-09-01 2023-08-12 rat