| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dae-Yong Song, Ha-Nul Yu, Chae-Ri Park, Jin-Sook Lee, Ji-Yong Lee, Byung-Gu Park, Ran-Sook Woo, Jung-Tae Han, Byung-Pil Cho, Tai-Kyoung Bai. Down-regulation of microglial activity attenuates axotomized nigral dopaminergic neuronal cell loss. BMC neuroscience. vol 14. 2014-04-07. PMID:24093518. |
there is growing evidence that inflammatory processes of activated microglia could play an important role in the progression of nerve cell damage in neurodegenerative disorders such as parkinson's disease and alzheimer's disease which harbor features of chronic microglial activation, though the precise mechanism is unknown. |
2014-04-07 |
2023-08-12 |
Not clear |
| Paola Forabosco, Adaikalavan Ramasamy, Daniah Trabzuni, Robert Walker, Colin Smith, Jose Bras, Adam P Levine, John Hardy, Jennifer M Pocock, Rita Guerreiro, Michael E Weale, Mina Ryte. Insights into TREM2 biology by network analysis of human brain gene expression data. Neurobiology of aging. vol 34. issue 12. 2014-04-02. PMID:23855984. |
most importantly, we show that the trem2-containing module is significantly enriched for genes genetically implicated in alzheimer's disease, multiple sclerosis, and motor neuron disease, implying that these diseases share common pathways centered on microglia and that among the genes identified are possible new disease-relevant genes. |
2014-04-02 |
2023-08-12 |
human |
| Rodrigo Medeiros, Masashi Kitazawa, Giselle F Passos, David Baglietto-Vargas, David Cheng, David H Cribbs, Frank M LaFerl. Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. The American journal of pathology. vol 182. issue 5. 2014-03-25. PMID:23506847. |
aspirin-triggered lipoxin a4 stimulates alternative activation of microglia and reduces alzheimer disease-like pathology in mice. |
2014-03-25 |
2023-08-12 |
mouse |
| Linjing Mu, Roger Slavik, Adrienne Müller, Kasim Popaj, Stjepko Cermak, Markus Weber, Roger Schibli, Stefanie D Krämer, Simon M Ametame. Synthesis and Preliminary Evaluation of a 2-Oxoquinoline Carboxylic Acid Derivative for PET Imaging the Cannabinoid Type 2 Receptor. Pharmaceuticals (Basel, Switzerland). vol 7. issue 3. 2014-03-25. PMID:24662272. |
cannabinoid receptor subtype 2 (cb2) has been shown to be up-regulated in activated microglia and therefore plays an important role in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis and alzheimer's disease. |
2014-03-25 |
2023-08-12 |
mouse |
| Ke Zhang, Li Tian, Li Liu, Yu Feng, Yan-Bin Dong, Bo Li, De-Shu Shang, Wen-Gang Fang, Yun-Peng Cao, Yu-Hua Che. CXCL1 contributes to β-amyloid-induced transendothelial migration of monocytes in Alzheimer's disease. PloS one. vol 8. issue 8. 2014-03-18. PMID:23967336. |
bone marrow-derived microglia that originates in part from hematopoietic cells, and more particularly from monocytes preferentially attach to amyloid deposition in brains of alzheimer's disease (ad). |
2014-03-18 |
2023-08-12 |
Not clear |
| Yue Yang, Eiron Cudaback, Nikolas L Jorstad, Jake F Hemingway, Catherine E Hagan, Erica J Melief, Xianwu Li, Tom Yoo, Shawn B Khademi, Kathleen S Montine, Thomas J Montine, C Dirk Keen. APOE3, but not APOE4, bone marrow transplantation mitigates behavioral and pathological changes in a mouse model of Alzheimer disease. The American journal of pathology. vol 183. issue 3. 2014-03-12. PMID:23831297. |
apolipoprotein e4 (apoe4) genotype is the strongest genetic risk factor for late-onset alzheimer disease and confers a proinflammatory, neurotoxic phenotype to microglia. |
2014-03-12 |
2023-08-12 |
mouse |
| MinJeong Kim, Yong-Xin Li, Pradeep Dewapriya, BoMi Ryu, Se-Kwon Ki. Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia. BMB reports. vol 46. issue 8. 2014-03-11. PMID:23977987. |
inflammatory conditions mediated by activated microglia lead to chronic neuro-degenerative diseases such as alzheimer's, parkinson's, and huntington's diseases. |
2014-03-11 |
2023-08-12 |
Not clear |
| Isabel Lastres-Becker, Nadia G Innamorato, Tomasz Jaworski, Alberto Rábano, Sebastian Kügler, Fred Van Leuven, Antonio Cuadrad. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a journal of neurology. vol 137. issue Pt 1. 2014-03-11. PMID:24277722. |
the hippocampus of patients with alzheimer's disease also exhibits increased expression of fractalkine in tau-injured neurons that recruit microglia. |
2014-03-11 |
2023-08-12 |
mouse |
| Stephen D Skaper, Laura Facci, Pietro Giust. Intracellular ion channel CLIC1: involvement in microglia-mediated β-amyloid peptide(1-42) neurotoxicity. Neurochemical research. vol 38. issue 9. 2014-03-10. PMID:23743620. |
microglia can exacerbate central nervous system disorders, including stroke and chronic progressive neurodegenerative diseases such as alzheimer disease. |
2014-03-10 |
2023-08-12 |
Not clear |
| Claudia A McCarthy, Robert E Widdop, Devy Deliyanti, Jennifer L Wilkinson-Berk. Brain and retinal microglia in health and disease: an unrecognized target of the renin-angiotensin system. Clinical and experimental pharmacology & physiology. vol 40. issue 8. 2014-02-19. PMID:23601050. |
although microglia are essential for maintaining a healthy cns, paradoxically they may undergo phenotypic changes to influence numerous neurodegenerative disorders, including parkinson's disease and alzheimer's disease. |
2014-02-19 |
2023-08-12 |
Not clear |
| Elisa Ridolfi, Cinzia Barone, Elio Scarpini, Daniela Galimbert. The role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: an eye on microglia. Clinical & developmental immunology. vol 2013. 2014-02-17. PMID:23970926. |
the role of the innate immune system in alzheimer's disease and frontotemporal lobar degeneration: an eye on microglia. |
2014-02-17 |
2023-08-12 |
Not clear |
| Anja Hafner, Gordana Glavan, Nataša Obermajer, Marko Živin, Reinhard Schliebs, Janko Ko. Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X. Aging cell. vol 12. issue 4. 2013-12-16. PMID:23621429. |
neuroprotective role of γ-enolase in microglia in a mouse model of alzheimer's disease is regulated by cathepsin x. |
2013-12-16 |
2023-08-12 |
mouse |
| Oliver Wirths, Antje Hillmann, Laurent Pradier, Wolfgang Härtig, Thomas A Baye. Oligomeric pyroglutamate amyloid-β is present in microglia and a subfraction of vessels in patients with Alzheimer's disease: implications for immunotherapy. Journal of Alzheimer's disease : JAD. vol 35. issue 4. 2013-12-10. PMID:23481684. |
oligomeric pyroglutamate amyloid-β is present in microglia and a subfraction of vessels in patients with alzheimer's disease: implications for immunotherapy. |
2013-12-10 |
2023-08-12 |
mouse |
| Erik Hjorth, Mingqin Zhu, Veronica Cortés Toro, Inger Vedin, Jan Palmblad, Tommy Cederholm, Yvonne Freund-Levi, Gerd Faxen-Irving, Lars-Olof Wahlund, Hans Basun, Maria Eriksdotter, Marianne Schultzber. Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. Journal of Alzheimer's disease : JAD. vol 35. issue 4. 2013-12-10. PMID:23481688. |
omega-3 fatty acids enhance phagocytosis of alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. |
2013-12-10 |
2023-08-12 |
human |
| Erik Hjorth, Mingqin Zhu, Veronica Cortés Toro, Inger Vedin, Jan Palmblad, Tommy Cederholm, Yvonne Freund-Levi, Gerd Faxen-Irving, Lars-Olof Wahlund, Hans Basun, Maria Eriksdotter, Marianne Schultzber. Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. Journal of Alzheimer's disease : JAD. vol 35. issue 4. 2013-12-10. PMID:23481688. |
alzheimer's disease (ad) is associated with inflammation mediated by microglia and astrocytes, and ω3 fas have been proposed as potential treatments for ad. |
2013-12-10 |
2023-08-12 |
human |
| Hui-quan Li, Cong Chen, Ying Dou, Hang-jun Wu, Yi-jun Liu, Hui-Fang Lou, Jian-min Zhang, Xiao-ming Li, Hao Wang, Shumin Dua. P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Molecular and cellular biology. vol 33. issue 21. 2013-12-09. PMID:24001770. |
our results demonstrate a previously unknown function of atp as a "drink me" signal for microglia and p2y4 receptors as a potential therapeutic target for the treatment of alzheimer's disease. |
2013-12-09 |
2023-08-12 |
Not clear |
| Francisca Cornejo, Rommy von Bernhard. Role of scavenger receptors in glia-mediated neuroinflammatory response associated with Alzheimer's disease. Mediators of inflammation. vol 2013. 2013-12-03. PMID:23737655. |
it is widely accepted that cells serving immune functions in the brain, namely, microglia and astrocytes, are important mediators of pathological phenomena observed in alzheimer's disease. |
2013-12-03 |
2023-08-12 |
Not clear |
| Tobias Goldmann, Tuan Leng Tay, Marco Prin. Love and death: microglia, NLRP3 and the Alzheimer's brain. Cell research. vol 23. issue 5. 2013-11-26. PMID:23399597. |
love and death: microglia, nlrp3 and the alzheimer's brain. |
2013-11-26 |
2023-08-12 |
Not clear |
| Kurt M Lucin, Caitlin E O'Brien, Gregor Bieri, Eva Czirr, Kira I Mosher, Rachelle J Abbey, Diego F Mastroeni, Joseph Rogers, Brian Spencer, Eliezer Masliah, Tony Wyss-Cora. Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron. vol 79. issue 5. 2013-11-11. PMID:24012002. |
interestingly, microglia isolated from human alzheimer's disease (ad) brains show significantly reduced beclin 1 and retromer protein levels. |
2013-11-11 |
2023-08-12 |
mouse |
| Cai Song, Ye Zhang, Yilong Don. Acute and subacute IL-1β administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration. Journal of neuroinflammation. vol 10. 2013-11-05. PMID:23651534. |
in alzheimer's disease, stroke and brain injuries, activated microglia can release proinflammatory cytokines, such as interleukin (il)-1β. |
2013-11-05 |
2023-08-12 |
Not clear |