All Relations between Alzheimer Disease and microglial cell

Publication Sentence Publish Date Extraction Date Species
S M Gentlema. Review: microglia in protein aggregation disorders: friend or foe? Neuropathology and applied neurobiology. vol 39. issue 1. 2013-07-24. PMID:23339288. microglia cells have been implicated, to some extent, in the pathogenesis of all of the common neurodegenerative disorders involving protein aggregation such as alzheimer's disease, parkinson's disease and amyotrophic lateral sclerosis. 2013-07-24 2023-08-12 Not clear
Alberto Serrano-Pozo, Alona Muzikansky, Teresa Gómez-Isla, John H Growdon, Rebecca A Betensky, Matthew P Frosch, Bradley T Hyma. Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 72. issue 6. 2013-07-19. PMID:23656989. differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in alzheimer disease. 2013-07-19 2023-08-12 Not clear
Alberto Serrano-Pozo, Alona Muzikansky, Teresa Gómez-Isla, John H Growdon, Rebecca A Betensky, Matthew P Frosch, Bradley T Hyma. Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 72. issue 6. 2013-07-19. PMID:23656989. although it is clear that astrocytes and microglia cluster around dense-core amyloid plaques in alzheimer disease (ad), whether they are primarily attracted to amyloid deposits or are just reacting to plaque-associated neuritic damage remains elusive. 2013-07-19 2023-08-12 Not clear
Bijay Parajuli, Yoshifumi Sonobe, Jun Kawanokuchi, Yukiko Doi, Mariko Noda, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumur. GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia. Journal of neuroinflammation. vol 9. 2013-07-01. PMID:23234315. microglia are resident macrophage-like cells in the central nervous system (cns) and cause innate immune responses via the lps receptors, toll-like receptor (tlr) 4 and cd14, in a variety of neuroinflammatory disorders including bacterial infection, alzheimer's disease, and amyotrophic lateral sclerosis. 2013-07-01 2023-08-12 Not clear
Rachael L Terry, Daniel R Getts, Celine Deffrasnes, Caryn van Vreden, Iain L Campbell, Nicholas J C Kin. Inflammatory monocytes and the pathogenesis of viral encephalitis. Journal of neuroinflammation. vol 9. 2013-07-01. PMID:23244217. ly6chi/ccr2(hi) inflammatory monocytes have been identified as the circulating precursors of brain macrophages, dendritic cells and arguably microglia in experimental autoimmune encephalomyelitis; alzheimer's disease; stroke; and more recently in cns infection caused by herpes simplex virus, murine hepatitis virus, theiler's murine encephalomyelitis virus, japanese encephalitis virus and west nile virus. 2013-07-01 2023-08-12 human
Jiong Ni, Peijun Wang, Jingfa Zhang, Wei Chen, Limin G. Silencing of the P2X(7) receptor enhances amyloid-β phagocytosis by microglia. Biochemical and biophysical research communications. vol 434. issue 2. 2013-06-28. PMID:23562658. p2x7 receptor (p2x7r) is an atp-gated cation channel that promotes microglia activation and plays a critical role in the pathogenesis of alzheimer's disease. 2013-06-28 2023-08-12 Not clear
Madhumitha Ravikumar, Seema Jain, Robert H Miller, Jeffrey R Capadona, Stephen M Selkir. An organotypic spinal cord slice culture model to quantify neurodegeneration. Journal of neuroscience methods. vol 211. issue 2. 2013-06-26. PMID:22975474. activated microglia cells have been implicated in the neurodegenerative process of alzheimer's disease, parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis; however, the precise roles of microglia in disease progression are unclear. 2013-06-26 2023-08-12 Not clear
Cheryl A Hawkes, LeHua Deng, Daniela Fenili, Mark Nitz, JoAnne McLauri. In vivo uptake of β-amyloid by non-plaque associated microglia. Current Alzheimer research. vol 9. issue 8. 2013-06-21. PMID:22272621. the role of microglia in β-amyloid (aβ) deposition or clearance in the alzheimer's disease (ad) brain remains unclear. 2013-06-21 2023-08-12 mouse
Lalida Rojanathammanee, Kendra L Puig, Colin K Comb. Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease. The Journal of nutrition. vol 143. issue 5. 2013-06-18. PMID:23468550. alzheimer disease (ad) brain is characterized by extracellular plaques of amyloid β (aβ) peptide with reactive microglia. 2013-06-18 2023-08-12 mouse
Carina Halleskog, Jacomijn Petronella Dijksterhuis, Michaela Brita Christina Kilander, Javier Becerril-Ortega, Juan Carlos Villaescusa, Eva Lindgren, Ernest Arenas, Gunnar Schult. Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation. Journal of neuroinflammation. vol 9. 2013-06-17. PMID:22647544. we have previously investigated the inflammatory effects of wnt/β-catenin signaling in microglia in alzheimer's disease. 2013-06-17 2023-08-12 Not clear
Suzanne E Hickman, Joseph El Khour. The neuroimmune system in Alzheimer's disease: the glass is half full. Journal of Alzheimer's disease : JAD. vol 33 Suppl 1. 2013-06-06. PMID:22751176. it is well established that microglia, the neuroimmune cells of the brain, are associated with amyloid-β (aβ) deposits in alzheimer's disease (ad). 2013-06-06 2023-08-12 Not clear
Ke-Wu Zeng, Ming-Bo Zhao, Zhi-Zhong Ma, Yong Jiang, Peng-Fei T. Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. International immunopharmacology. vol 14. issue 4. 2013-06-04. PMID:23000519. during inflammation-mediated neurodegenerative diseases, including alzheimer's disease and parkinson's disease, reactive oxygen species (ros) and nitric oxide (no) are produced by activated microglia, further inducing increased neuronal injury in the brain. 2013-06-04 2023-08-12 Not clear
Stephanie Busch, Liang Wu, Yuxi Feng, Norbert Gretz, Sigrid Hoffmann, Hans-Peter Hamme. Alzheimer's disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 6. 2013-05-29. PMID:23171816. the pathogenesis of alzheimer's disease (ad) is characterized by neuronal injury, activation of microglia and astrocytes, deposition of amyloid-β and secondary vessel degeneration. 2013-05-29 2023-08-12 rat
Sandra Schütze, Tobias Loleit, Moritz Zeretzke, Stephanie Bunkowski, Wolfgang Brück, Sandra Ribes, Roland Na. Additive microglia-mediated neuronal injury caused by amyloid-β and bacterial TLR agonists in murine neuron-microglia co-cultures quantified by an automated image analysis using cognition network technology. Journal of Alzheimer's disease : JAD. vol 31. issue 3. 2013-05-21. PMID:22647259. activated microglia is considered to be involved in the progression of alzheimer's disease (ad). 2013-05-21 2023-08-12 Not clear
Bobby Tan, Rachel Huiyi Choi, Tammy Jing Yee Chin, Charanjit Kaur, Eng-Ang Lin. Manipulation of microglial activity as a therapy for Alzheimer's disease. Frontiers in bioscience (Scholar edition). vol 4. 2013-04-29. PMID:22652882. the review aims to elucidate the potential of microglia as a therapeutic target in alleviating alzheimer's disease (ad). 2013-04-29 2023-08-12 Not clear
Bob Olsson, Clas Malmeström, Hans Basun, Peter Annas, Kina Höglund, Lars Lannfelt, Niels Andreasen, Henrik Zetterberg, Kaj Blenno. Extreme stability of chitotriosidase in cerebrospinal fluid makes it a suitable marker for microglial activation in clinical trials. Journal of Alzheimer's disease : JAD. vol 32. issue 2. 2013-04-23. PMID:22785399. microglia is thought to be important in alzheimer's disease. 2013-04-23 2023-08-12 Not clear
Rubén Martín, Claudia Cordova, Maria L Niet. Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding. Journal of neuroinflammation. vol 9. 2013-04-19. PMID:22747893. activation of microglia, the primary component of the innate immune response in the brain, is a hallmark of neuroinflammation in neurodegenerative disorders, including alzheimer's disease (ad) and other pathological conditions such as stroke or cns infection. 2013-04-19 2023-08-12 Not clear
Di Ma, Yukiko Doi, Shijie Jin, Endong Li, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumur. TGF-β induced by interleukin-34-stimulated microglia regulates microglial proliferation and attenuates oligomeric amyloid β neurotoxicity. Neuroscience letters. vol 529. issue 1. 2013-04-05. PMID:22985514. microglia play critical roles in the pathogenesis of alzheimer's disease (ad). 2013-04-05 2023-08-12 Not clear
Wai T Won. Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation. Frontiers in cellular neuroscience. vol 7. 2013-03-18. PMID:23493481. neurodegenerative diseases such as alzheimer's disease, parkinson's disease, and age-related macular degeneration (amd), share two characteristics in common: (1) a disease prevalence that increases markedly with advancing age, and (2) neuroinflammatory changes in which microglia, the primary resident immune cell of the cns, feature prominently. 2013-03-18 2023-08-12 Not clear
Dongzi Yu, Brian Corbett, Yaping Yan, Guang-Xian Zhang, Peter Reinhart, Seongeun J Cho, Jeannie Chi. Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease. Neurobiology of aging. vol 33. issue 12. 2013-03-12. PMID:22440674. amyloid plaques associated with alzheimer's disease (ad) induce inflammatory responses associated with activated microglia and reactive astrocytes, which exacerbate neurodegeneration through release of inflammatory cytokines, reactive oxygen species, and other factors. 2013-03-12 2023-08-12 mouse