| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Branden Stansley, Jan Post, Kenneth Hensle. A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease. Journal of neuroinflammation. vol 9. 2013-01-17. PMID:22651808. |
over the past two decades, it has become increasingly apparent that alzheimer's disease neuropathology is characterized by activated microglia (brain resident macrophages) as well as the classic features of amyloid plaques and neurofibrillary tangles. |
2013-01-17 |
2023-08-12 |
human |
| Branden Stansley, Jan Post, Kenneth Hensle. A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease. Journal of neuroinflammation. vol 9. 2013-01-17. PMID:22651808. |
this review summarizes several of the most common microglial cell culture systems currently being employed in alzheimer's research including primary microglia; bv2 and n9 retroviral immortalized microglia; human immortalized microglia (hmo6); and spontaneously immortalized rodent microglial lines (eoc lines and hapi cells). |
2013-01-17 |
2023-08-12 |
human |
| Andressa Bernardi, Rudimar L Frozza, André Meneghetti, Juliana B Hoppe, Ana Maria O Battastini, Adriana R Pohlmann, Sílvia S Guterres, Christianne G Salbeg. Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer's disease models. International journal of nanomedicine. vol 7. 2013-01-17. PMID:23028221. |
neuroinflammation, characterized by the accumulation of activated microglia and reactive astrocytes, is believed to modulate the development and/or progression of alzheimer's disease (ad). |
2013-01-17 |
2023-08-12 |
Not clear |
| Lee-Way Ji. Microglia in Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-12-20. PMID:23251825. |
microglia in alzheimer's disease. |
2012-12-20 |
2023-08-12 |
Not clear |
| Banafsheh Amiraslani, Farzaneh Sabouni, Shahsanam Abbasi, Habiballah Nazem, Mohammadsadegh Sabe. Recognition of betaine as an inhibitor of lipopolysaccharide-induced nitric oxide production in activated microglial cells. Iranian biomedical journal. vol 16. issue 2. 2012-11-13. PMID:22801281. |
neuroinflammation, as a major outcome of microglia activation, is an important factor for progression of neurodegenerative disorders including alzheimer's disease and parkinson's disease. |
2012-11-13 |
2023-08-12 |
Not clear |
| Tatiana Veremeyko, Sarah-Christine Starossom, Howard L Weiner, Eugene D Ponomare. Detection of microRNAs in microglia by real-time PCR in normal CNS and during neuroinflammation. Journal of visualized experiments : JoVE. issue 65. 2012-11-02. PMID:22872097. |
the described method will be useful to measure the level of expression of micrornas in microglia in normal cns or during neuroinflammation associated with various pathologies including ms, stroke, traumatic injury, alzheimer's disease and brain tumors. |
2012-11-02 |
2023-08-12 |
mouse |
| Barbara Biscaro, Olle Lindvall, Giuseppina Tesco, Christine T Ekdahl, Roger M Nitsc. Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease. Neuro-degenerative diseases. vol 9. issue 4. 2012-10-23. PMID:22584394. |
activated microglia with macrophage-like functions invade and surround β-amyloid (aβ) plaques in alzheimer's disease (ad), possibly contributing to the turnover of aβ, but they can also secrete proinflammatory factors that may be involved in the pathogenesis of ad. |
2012-10-23 |
2023-08-12 |
mouse |
| Jong Kil Lee, Edward H Schuchman, Hee Kyung Jin, Jae-sung Ba. Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses. Stem cells (Dayton, Ohio). vol 30. issue 7. 2012-10-19. PMID:22570192. |
soluble ccl5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses. |
2012-10-19 |
2023-08-12 |
mouse |
| Jong Kil Lee, Edward H Schuchman, Hee Kyung Jin, Jae-sung Ba. Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses. Stem cells (Dayton, Ohio). vol 30. issue 7. 2012-10-19. PMID:22570192. |
microglia have the ability to eliminate amyloid β (aβ) by a cell-specific phagocytic mechanism, and bone marrow (bm) stem cells have shown a beneficial effect through endogenous microglia activation in the brains of alzheimer's disease (ad) mice. |
2012-10-19 |
2023-08-12 |
mouse |
| b' Zorica Jovanovi\\xc4\\x8. [Mechanisms of neurodegeneration in Alzheimer\'s disease]. Medicinski pregled. vol 65. issue 7-8. 2012-10-05. PMID:22924250.' |
microglial activation and nicotinamide adenine dinucleotide phosphate oxidase in alzheimer's disease: there is a wealth of evidence demonstrating that microglia, the resident innate immune cells in the brain, can become deleterious and damage neurons. |
2012-10-05 |
2023-08-12 |
Not clear |
| Egle Solito, Magdalena Sastr. Microglia function in Alzheimer's disease. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22363284. |
microglia function in alzheimer's disease. |
2012-10-02 |
2023-08-12 |
Not clear |
| Egle Solito, Magdalena Sastr. Microglia function in Alzheimer's disease. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22363284. |
it is known that inflammation has an essential role in the progression of alzheimer's disease (ad), since amyloid-β (aβ) is able to activate microglia, initiating an inflammatory response, which could have different consequences for neuronal survival. |
2012-10-02 |
2023-08-12 |
Not clear |
| P Sozio, M Rapino, V Di Valerio, S Laserra, S Pacella, A Di Stefano, A Catald. pPKCα-mediated effect on in vitro Aβ production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes. Journal of biological regulators and homeostatic agents. vol 26. issue 2. 2012-09-21. PMID:22824752. |
alzheimer's disease implies memory and cognitive impairment due to beta amyloid accumulation, presence of reactive microglia and astrocytes, loss of synapses, neural network dysfunctions and modifications of neuronal signalling. |
2012-09-21 |
2023-08-12 |
rat |
| Shai Abutbul, Jenny Shapiro, Irit Szaingurten-Solodkin, Nitzan Levy, Yaron Carmy, Rona Baron, Steffen Jung, Alon Monsoneg. TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment. Glia. vol 60. issue 7. 2012-09-20. PMID:22511296. |
our study suggests that the abundant expression of tgf-β within the cns during development and various inflammatory processes plays a key role in promoting the quiescent phenotype of microglia and may thus serve as a target for therapeutic strategies aimed at modulating the function of microglia in neurodegenerative diseases such as alzheimer's and prion. |
2012-09-20 |
2023-08-12 |
Not clear |
| Makoto Higuchi, Bin Ji, Jun Maeda, Masahiro Maruyama, Maiko Ono, Makoto Sawada, Tetsuya Suhar. [Alzheimer's disease and microglia]. Rinsho shinkeigaku = Clinical neurology. vol 51. issue 11. 2012-09-18. PMID:22277469. |
[alzheimer's disease and microglia]. |
2012-09-18 |
2023-08-12 |
Not clear |
| Kazuyuki Takata, Yoshihisa Kitamur. Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease: tangle formation, amyloid-β, and microglia in Alzheimer's disease. Journal of pharmacological sciences. vol 118. issue 3. 2012-09-10. PMID:22382659. |
molecular approaches to the treatment, prophylaxis, and diagnosis of alzheimer's disease: tangle formation, amyloid-β, and microglia in alzheimer's disease. |
2012-09-10 |
2023-08-12 |
Not clear |
| Helen Crehan, John Hardy, Jennifer Pococ. Microglia, Alzheimer's disease, and complement. International journal of Alzheimer's disease. vol 2012. 2012-09-10. PMID:22957298. |
microglia, alzheimer's disease, and complement. |
2012-09-10 |
2023-08-12 |
Not clear |
| Helen Crehan, John Hardy, Jennifer Pococ. Microglia, Alzheimer's disease, and complement. International journal of Alzheimer's disease. vol 2012. 2012-09-10. PMID:22957298. |
microglia, the immune cell of the brain, are implicated in cascades leading to neuronal loss and cognitive decline in alzheimer's disease (ad). |
2012-09-10 |
2023-08-12 |
Not clear |
| Gaëlle Naert, Serge Rives. Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. Molecular medicine (Cambridge, Mass.). vol 18. 2012-09-04. PMID:22160221. |
monocytes emigrate from bone marrow, can infiltrate into brain, differentiate into microglia and clear amyloid β (aβ) from the brain of mouse models of alzheimer's disease (ad). |
2012-09-04 |
2023-08-12 |
mouse |
| Michael J Surace, Michelle L Bloc. Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors. Cellular and molecular life sciences : CMLS. vol 69. issue 14. 2012-09-04. PMID:22581365. |
here, we describe the evidence denoting the role of nox2 in microglia-mediated neurotoxicity with an emphasis on alzheimer's and parkinson's disease, describe available inhibitors that have been tested, and detail evidence of the neuroprotective and therapeutic potential of targeting this enzyme complex to regulate microglia. |
2012-09-04 |
2023-08-12 |
Not clear |