| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amitabha Majumdar, Estibaliz Capetillo-Zarate, Dana Cruz, Gunnar K Gouras, Frederick R Maxfiel. Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes. Molecular biology of the cell. vol 22. issue 10. 2011-09-06. PMID:21441306. |
incomplete lysosomal acidification in microglia inhibits the degradation of fibrillar forms of alzheimer's amyloid β peptide (faβ). |
2011-09-06 |
2023-08-12 |
Not clear |
| Harshvardhan Rolyan, Annika Scheffold, Annette Heinrich, Yvonne Begus-Nahrmann, Britta Heike Langkopf, Sabine M Hölter, Daniela M Vogt-Weisenhorn, Birgit Liss, Wolfgang Wurst, Dieter Chichung Lie, Dietmar Rudolf Thal, Knut Biber, Karl Lenhard Rudolp. Telomere shortening reduces Alzheimer's disease amyloid pathology in mice. Brain : a journal of neurology. vol 134. issue Pt 7. 2011-08-26. PMID:21672962. |
together, these results provide the first experimental evidence that telomere shortening, despite impairing adult neurogenesis and maintenance of post-mitotic neurons, can slow down the progression of amyloid plaque pathology in alzheimer's disease, possibly involving telomere-dependent effects on microglia activation. |
2011-08-26 |
2023-08-12 |
mouse |
| Feng Huang, Hua-Ming Deng, Miao-Miao Zhu, Fei Xiao, Li Yang, Zai-Jun Zhang, Ying Xiao, Hong Ni. [Inhibitory effect of ferulic acid on inflammatory response in microglia induced by lipopolysaccharides]. Dong wu xue yan jiu = Zoological research. vol 32. issue 3. 2011-08-25. PMID:21698798. |
activated microglia mediated neuronal immunity contributes to the neurodegeneration associated with alzheimer's disease. |
2011-08-25 |
2023-08-12 |
Not clear |
| G Naert, S Rives. The role of microglial cell subsets in Alzheimer's disease. Current Alzheimer research. vol 8. issue 2. 2011-08-12. PMID:21418002. |
the role of microglial cell subsets in alzheimer's disease. |
2011-08-12 |
2023-08-12 |
mouse |
| Stephen D Skape. Ion channels on microglia: therapeutic targets for neuroprotection. CNS & neurological disorders drug targets. vol 10. issue 1. 2011-07-29. PMID:21143139. |
because some microglia functions can exacerbate cns disorders, including stroke, traumatic brain injury, progressive neurodegenerative disorders such as alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis, and several retinal diseases, controlling their activation might ameliorate immune-mediated cns disorders. |
2011-07-29 |
2023-08-12 |
mouse |
| Stephen D Skape. Ion channels on microglia: therapeutic targets for neuroprotection. CNS & neurological disorders drug targets. vol 10. issue 1. 2011-07-29. PMID:21143139. |
for example, the atp-gated p2x7 purinergic receptor cation channel is up-regulated around amyloid β-peptide plaques in transgenic mouse models of alzheimer's disease and co-localizes to microglia and astrocytes. |
2011-07-29 |
2023-08-12 |
mouse |
| Balázs Gulyás, Adám Vas, Miklós Tóth, Akihiro Takano, Andrea Varrone, Zsolt Cselényi, Martin Schain, Patrik Mattsson, Christer Halldi. Age and disease related changes in the translocator protein (TSPO) system in the human brain: positron emission tomography measurements with [11C]vinpocetine. NeuroImage. vol 56. issue 3. 2011-07-25. PMID:21320609. |
the main objectives of the present study were (i) to measure density changes of activated microglia and the peripheral benzodiazepine receptor/translocator protein (tspo) system during normal ageing in the human brain with positron emission tomography (pet) using the tspo molecular imaging biomarker [(11)c]vinpocetine and (ii) to compare the level and pattern of tspo in alzheimer (ad) patients with age matched healthy subjects, in order to assess the biomarker's usefulness as a diagnostic imaging marker in normal (ageing) and pathological (ad) up-regulation of microglia. |
2011-07-25 |
2023-08-12 |
human |
| Xiao-Guang Luo, Jian-Qing Ding, Sheng-Di Che. Microglia in the aging brain: relevance to neurodegeneration. Molecular neurodegeneration. vol 5. 2011-07-14. PMID:20334662. |
in parkinson's disease and alzheimer's disease, over-activation of microglia may play an active role in the pathogenesis because microglia senescence primes them to be neurotoxic during the development of the diseases. |
2011-07-14 |
2023-08-12 |
Not clear |
| Daniela L Krause, Norbert Mülle. Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer's disease. International journal of Alzheimer's disease. vol 2010. 2011-07-14. PMID:20798769. |
neuroinflammation, microglia and implications for anti-inflammatory treatment in alzheimer's disease. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jean-Philippe Michaud, Karine L Richard, Serge Rives. MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease. Molecular neurodegeneration. vol 6. issue 1. 2011-07-14. PMID:21235801. |
alzheimer's disease (ad) is an age-related neurodegenerative disorder associated with brain innate immune activation mainly mediated by microglia. |
2011-07-14 |
2023-08-12 |
mouse |
| Jan Mulder, Misha Zilberter, Susana J Pasquaré, Alán Alpár, Gunnar Schulte, Samira G Ferreira, Attila Köfalvi, Ana M Martín-Moreno, Erik Keimpema, Heikki Tanila, Masahiko Watanabe, Ken Mackie, Tibor Hortobágyi, Maria L de Ceballos, Tibor Harkan. Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. Brain : a journal of neurology. vol 134. issue Pt 4. 2011-07-01. PMID:21459826. |
hippocampal protein concentrations for the sn-1-diacylglycerol lipase α and β isoforms, synthesizing 2-arachidonoyl glycerol, significantly increased in definite alzheimer's (braak stage vi), with ectopic sn-1-diacylglycerol lipase β expression found in microglia accumulating near senile plaques and apposing cb(1) cannabinoid receptor-positive presynapses. |
2011-07-01 |
2023-08-12 |
mouse |
| Jan Mulder, Misha Zilberter, Susana J Pasquaré, Alán Alpár, Gunnar Schulte, Samira G Ferreira, Attila Köfalvi, Ana M Martín-Moreno, Erik Keimpema, Heikki Tanila, Masahiko Watanabe, Ken Mackie, Tibor Hortobágyi, Maria L de Ceballos, Tibor Harkan. Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. Brain : a journal of neurology. vol 134. issue Pt 4. 2011-07-01. PMID:21459826. |
we found that microglia, expressing two 2-arachidonoyl glycerol-degrading enzymes, serine hydrolase α/β-hydrolase domain-containing 6 and monoacylglycerol lipase, begin to surround senile plaques in probable alzheimer's disease (braak stage iii). |
2011-07-01 |
2023-08-12 |
mouse |
| Gaëlle Naert, Serge Rives. CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 16. 2011-06-30. PMID:21508244. |
circulating monocytoid cells have the ability to infiltrate nervous tissue, differentiate into microglia, and clear amyloid-β (aβ) from the brain of mouse models of alzheimer's disease. |
2011-06-30 |
2023-08-12 |
mouse |
| J J Rodríguez, J Witton, M Olabarria, H N Noristani, A Verkhratsk. Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease. Cell death & disease. vol 1. 2011-06-23. PMID:21364611. |
increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of alzheimer's disease. |
2011-06-23 |
2023-08-12 |
Not clear |
| Miguel A Burguillos, Tomas Deierborg, Edel Kavanagh, Annette Persson, Nabil Hajji, Albert Garcia-Quintanilla, Josefina Cano, Patrik Brundin, Elisabet Englund, Jose L Venero, Bertrand Josep. Caspase signalling controls microglia activation and neurotoxicity. Nature. vol 472. issue 7343. 2011-06-23. PMID:21389984. |
we observe that these caspases are activated in microglia in the ventral mesencephalon of parkinson's disease (pd) and the frontal cortex of individuals with alzheimer's disease (ad). |
2011-06-23 |
2023-08-12 |
Not clear |
| Lin-Lin Yin, Wei Li, Yan-Qi Chu, Lin L. ERK pathway activation is required for amyloid-β(1-40)(-)induced neurotoxicity of THP-1 human monocytes towards SK-N-SH neuroblastoma. Brain research. vol 1378. 2011-06-13. PMID:21241676. |
alzheimer's disease (ad) is characterized by amyloid-β peptide deposition, increased activated microglia, and progressive loss of neurons in the brain. |
2011-06-13 |
2023-08-12 |
human |
| Yan-Ying Liu, Jin-Song Bia. Hydrogen sulfide protects amyloid-β induced cell toxicity in microglia. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930302. |
alzheimer's disease (ad) is pathologically characterized by the accumulation of senile plaques, containing activated microglia and amyloid-β peptides (aβ). |
2011-05-25 |
2023-08-12 |
Not clear |
| Hwan Goo Lee, Sun Mi Won, Byoung Joo Gwag, Yong Beom Le. Microglial P2X₇ receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease. Experimental & molecular medicine. vol 43. issue 1. 2011-05-19. PMID:21088470. |
the possibility that p2x₇ receptor (p2x₇r) expression in microglia would mediate neuronal damage via reactive oxygen species (ros) production was examined in the appswe/ps1de9 mouse model of alzheimer's disease (ad). |
2011-05-19 |
2023-08-12 |
mouse |
| Masamichi Yokokura, Norio Mori, Shunsuke Yagi, Etsuji Yoshikawa, Mitsuru Kikuchi, Yujiro Yoshihara, Tomoyasu Wakuda, Genichi Sugihara, Kiyokazu Takebayashi, Shiro Suda, Yasuhide Iwata, Takatoshi Ueki, Kenji J Tsuchiya, Katsuaki Suzuki, Kazuhiko Nakamura, Yasuomi Ouch. In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 38. issue 2. 2011-04-28. PMID:20844871. |
amyloid β protein (aβ) is known as a pathological substance in alzheimer's disease (ad) and is assumed to coexist with a degree of activated microglia in the brain. |
2011-04-28 |
2023-08-12 |
Not clear |
| Sungho Lee, Nicholas H Varvel, Megan E Konerth, Guixiang Xu, Astrid E Cardona, Richard M Ransohoff, Bruce T Lam. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. The American journal of pathology. vol 177. issue 5. 2011-03-21. PMID:20864679. |
microglia, the primary immune effector cells in the brain, continually monitor the tissue parenchyma for pathological alterations and become activated in alzheimer's disease. |
2011-03-21 |
2023-08-12 |
mouse |