| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hwan Goo Lee, Sun Mi Won, Byoung Joo Gwag, Yong Beom Le. Microglial P2X₇ receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease. Experimental & molecular medicine. vol 43. issue 1. 2011-05-19. PMID:21088470. |
the possibility that p2x₇ receptor (p2x₇r) expression in microglia would mediate neuronal damage via reactive oxygen species (ros) production was examined in the appswe/ps1de9 mouse model of alzheimer's disease (ad). |
2011-05-19 |
2023-08-12 |
mouse |
| Masamichi Yokokura, Norio Mori, Shunsuke Yagi, Etsuji Yoshikawa, Mitsuru Kikuchi, Yujiro Yoshihara, Tomoyasu Wakuda, Genichi Sugihara, Kiyokazu Takebayashi, Shiro Suda, Yasuhide Iwata, Takatoshi Ueki, Kenji J Tsuchiya, Katsuaki Suzuki, Kazuhiko Nakamura, Yasuomi Ouch. In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 38. issue 2. 2011-04-28. PMID:20844871. |
amyloid β protein (aβ) is known as a pathological substance in alzheimer's disease (ad) and is assumed to coexist with a degree of activated microglia in the brain. |
2011-04-28 |
2023-08-12 |
Not clear |
| Sungho Lee, Nicholas H Varvel, Megan E Konerth, Guixiang Xu, Astrid E Cardona, Richard M Ransohoff, Bruce T Lam. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. The American journal of pathology. vol 177. issue 5. 2011-03-21. PMID:20864679. |
microglia, the primary immune effector cells in the brain, continually monitor the tissue parenchyma for pathological alterations and become activated in alzheimer's disease. |
2011-03-21 |
2023-08-12 |
mouse |
| Izumi Maezawa, Pavel I Zimin, Heike Wulff, Lee-Way Ji. Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. The Journal of biological chemistry. vol 286. issue 5. 2011-03-21. PMID:20971854. |
neuroinflammation and associated neuronal dysfunction mediated by activated microglia play an important role in the pathogenesis of alzheimer disease (ad). |
2011-03-21 |
2023-08-12 |
Not clear |
| Emilio Badoe. Microglia: activation in acute and chronic inflammatory states and in response to cardiovascular dysfunction. The international journal of biochemistry & cell biology. vol 42. issue 10. 2011-03-09. PMID:20638485. |
microglia are activated in many conditions that involve chronic inflammation such as alzheimer's and parkinson's diseases and in neuropathic pain. |
2011-03-09 |
2023-08-12 |
Not clear |
| Tiziana Bisogno, Vincenzo Di Marz. Cannabinoid receptors and endocannabinoids: role in neuroinflammatory and neurodegenerative disorders. CNS & neurological disorders drug targets. vol 9. issue 5. 2011-03-01. PMID:20632970. |
whilst cb₁ receptors are mostly expressed in neurons, where they regulate neurotransmitter release and synaptic strength, cb₂ receptors are found mostly in glial cells and microglia, which become activated and over-express these receptors during disorders such as alzheimer's disease, multiple sclerosis, amyotropic lateral sclerosis, parkinson's disease, and huntington's chorea. |
2011-03-01 |
2023-08-12 |
Not clear |
| Carina Halleskog, Jan Mulder, Jenny Dahlström, Ken Mackie, Tibor Hortobágyi, Heikki Tanila, Lakshman Kumar Puli, Katrin Färber, Tibor Harkany, Gunnar Schult. WNT signaling in activated microglia is proinflammatory. Glia. vol 59. issue 1. 2011-02-25. PMID:20967887. |
here, we report increased β-catenin expression, a central intracellular component of wnt signaling, in microglia undergoing a proinflammatory morphogenic transformation under pathogenic conditions associated with neuroinflammation such as alzheimer's disease. |
2011-02-25 |
2023-08-12 |
mouse |
| Zhiqiang Liu, Carlo Condello, Aaron Schain, Roa Harb, Jaime Grutzendle. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159979. |
in alzheimer's disease (ad), amyloid-β (aβ) deposits are frequently surrounded by activated microglia but the precise role of these cells in disease progression remains unclear. |
2011-02-09 |
2023-08-12 |
mouse |
| Zhiqiang Liu, Carlo Condello, Aaron Schain, Roa Harb, Jaime Grutzendle. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159979. |
to study the specific effects of microglia activation on amyloid pathology in vivo, we crossbred mice lacking cx3cr1 with the alzheimer's mouse model crnd8. |
2011-02-09 |
2023-08-12 |
mouse |
| Wenlin Hao, Yang Liu, Shirong Liu, Silke Walter, Marcus O Grimm, Amanda J Kiliaan, Botond Penke, Tobias Hartmann, Claudia E Rübe, Michael D Menger, Klaus Fassbende. Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology. Brain : a journal of neurology. vol 134. issue Pt 1. 2011-01-21. PMID:21115468. |
for this reason, we investigated the effects of myeloid differentiation factor 88-deficient bone marrow cells on alzheimer's disease-related symptoms and pathology by establishing bone marrow chimeric amyloid β peptide precursor transgenic mice, in which bone marrow cells differentiate into microglia and are recruited to amyloid β peptide deposits. |
2011-01-21 |
2023-08-12 |
mouse |
| V Wee Yon. Inflammation in neurological disorders: a help or a hindrance? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 16. issue 4. 2011-01-07. PMID:20817918. |
even when there is no significant inflammatory infiltrates, such as in parkinson or alzheimer disease, there is intense activation of microglia with resultant elevation of many inflammatory mediators within the cns. |
2011-01-07 |
2023-08-12 |
Not clear |
| Martina M Hughes, Robert H Field, V Hugh Perry, Carol L Murray, Colm Cunningha. Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation. Glia. vol 58. issue 16. 2011-01-06. PMID:20878768. |
despite the phagocytic machinery available to microglia the aberrant amyloid proteins produced during alzheimer's and prion disease, amyloid-β and prp(sc), are inefficiently cleared. |
2011-01-06 |
2023-08-12 |
Not clear |
| Kalliopi Thanopoulou, Apostolia Fragkouli, Fotini Stylianopoulou, Spiros Georgopoulo. Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 48. 2011-01-05. PMID:21076037. |
sr-bi has been identified on astrocytes and vascular smooth muscle cells in alzheimer's disease brain and has been shown to mediate adhesion of microglia to fibrillar amyloid-β (aβ). |
2011-01-05 |
2023-08-12 |
mouse |
| Philipp Spitzer, Martin Herrmann, Hans-Wolfgang Klafki, Alexander Smirnov, Piotr Lewczuk, Johannes Kornhuber, Jens Wiltfang, Juan Manuel Male. Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes. Journal of neuroinflammation. vol 7. 2010-12-06. PMID:20929546. |
the classic neuritic β-amyloid plaque of alzheimer's disease (ad) is typically associated with activated microglia and neuroinflammation. |
2010-12-06 |
2023-08-12 |
human |
| Simon McArthur, Enrico Cristante, Mario Paterno, Helen Christian, Federico Roncaroli, Glenda E Gillies, Egle Solit. Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 10. 2010-12-02. PMID:20962261. |
we have identified anxa1 to be sparingly expressed in microglia of normally aged human brains and to be more strongly expressed in alzheimer's disease. |
2010-12-02 |
2023-08-12 |
mouse |
| Lih-Fen Lue, Yu-Min Kuo, Thomas Beach, Douglas G Walke. Microglia activation and anti-inflammatory regulation in Alzheimer's disease. Molecular neurobiology. vol 41. issue 2-3. 2010-10-08. PMID:20195797. |
microglia activation and anti-inflammatory regulation in alzheimer's disease. |
2010-10-08 |
2023-08-12 |
Not clear |
| Vincenzo Bramanti, Daniele Tomassoni, Marcello Avitabile, Francesco Amenta, Roberto Avol. Biomarkers of glial cell proliferation and differentiation in culture. Frontiers in bioscience (Scholar edition). vol 2. 2010-09-30. PMID:20036968. |
the role of s100b in astrocytes, neurons, and microglia is particularly studied in alzheimer's disease. |
2010-09-30 |
2023-08-12 |
Not clear |
| Colin K Comb. Inflammation and microglia actions in Alzheimer's disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 4. issue 4. 2010-08-16. PMID:19669893. |
inflammation and microglia actions in alzheimer's disease. |
2010-08-16 |
2023-08-12 |
mouse |
| Colin K Comb. Inflammation and microglia actions in Alzheimer's disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 4. issue 4. 2010-08-16. PMID:19669893. |
a variety of studies have documented increased presence of reactive microglia in the brains of not only alzheimer's disease (ad) patients but its transgenic mouse models. |
2010-08-16 |
2023-08-12 |
mouse |
| Wolfgang J Streit, Qing-Shan Xu. Life and death of microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 4. issue 4. 2010-08-16. PMID:19680817. |
cytorrhexis of microglia is infrequent in the normally aged human brain and non-detectable in aged rodents, but its occurrence increases dramatically during neurodegenerative conditions, including alzheimer's disease (ad) in humans and motoneuron disease in transgenic rats. |
2010-08-16 |
2023-08-12 |
human |