Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Hsiao-Wen Lin, Steven W Leviso. Context-dependent IL-6 potentiation of interferon- gamma-induced IL-12 secretion and CD40 expression in murine microglia. Journal of neurochemistry. vol 111. issue 3. 2009-11-06. PMID:19712053. |
interleukin-6 (il-6) is produced by neurons, astrocytes, and microglia, and elevated levels of il-6 within the cns have been documented in multiple neurological disorders including alzheimer's disease, stroke, epilepsy, attention deficit disorder, cerebral palsy, and multiple sclerosis. |
2009-11-06 |
2023-08-12 |
Not clear |
Erin G Reed-Geaghan, Julie C Savage, Amy G Hise, Gary E Landret. CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 38. 2009-10-09. PMID:19776284. |
microglia are the brain's tissue macrophages and are found in an activated state surrounding beta-amyloid plaques in the alzheimer's disease brain. |
2009-10-09 |
2023-08-12 |
Not clear |
Vincent Boissonneault, Mohammed Filali, Martine Lessard, Jane Relton, Gordon Wong, Serge Rives. Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19151372. |
together these results provide compelling evidence that systemic m-csf administration is a powerful treatment to stimulate bone marrow-derived microglia, degrade abeta and prevent or improve the cognitive decline associated with abeta burden in a mouse model of alzheimer's disease. |
2009-10-01 |
2023-08-12 |
mouse |
Anusorn Thampithak, Yamaratee Jaisin, Benjawan Meesarapee, Sukumal Chongthammakun, Pawinee Piyachaturawat, Piyarat Govitrapong, Porntip Supavilai, Yupin Sanvarind. Transcriptional regulation of iNOS and COX-2 by a novel compound from Curcuma comosa in lipopolysaccharide-induced microglial activation. Neuroscience letters. vol 462. issue 2. 2009-10-01. PMID:19583997. |
overproduction of pro-inflammatory mediators resulting from chronic activation of microglia has been implicated in many neurodegenerative disorders, such as parkinson's disease and alzheimer's disease. |
2009-10-01 |
2023-08-12 |
rat |
Ken-ichi Isobe, Naomi Nishio, Sachiko It. [Age-related decline of immune function and age-related diseases]. Nihon rinsho. Japanese journal of clinical medicine. vol 67. issue 7. 2009-09-03. PMID:19591280. |
for example, the pathogenesis of atherosclerosis and alzheimer disease are related to macrophages (microglia). |
2009-09-03 |
2023-08-12 |
Not clear |
Sriram Venneti, Brian J Lopresti, Guoji Wang, Ronald L Hamilton, Chester A Mathis, William E Klunk, Udayan M Apte, Clayton A Wile. PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET. Neurobiology of aging. vol 30. issue 8. 2009-08-31. PMID:18178291. |
pk11195 labels activated microglia in alzheimer's disease and in vivo in a mouse model using pet. |
2009-08-31 |
2023-08-12 |
mouse |
Sriram Venneti, Brian J Lopresti, Guoji Wang, Ronald L Hamilton, Chester A Mathis, William E Klunk, Udayan M Apte, Clayton A Wile. PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET. Neurobiology of aging. vol 30. issue 8. 2009-08-31. PMID:18178291. |
activated microglia may promote neurodegeneration in alzheimer's disease (ad) and may also help in amyloid clearance in immunization therapies. |
2009-08-31 |
2023-08-12 |
mouse |
Lisette T Arnaud, Natura Myeku, Maria E Figueiredo-Pereir. Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells. Journal of neurochemistry. vol 110. issue 1. 2009-08-21. PMID:19457109. |
alzheimer's disease brains also exhibit signs of inflammation manifested by activated astrocytes and microglia, which produce cytotoxic agents among them prostaglandins. |
2009-08-21 |
2023-08-12 |
human |
Ji Yeon Kim, Tae Hyong Kim, Soung Soo Ki. NSA9, a human prothrombin kringle-2-derived peptide, acts as an inhibitor of kringle-2-induced activation in EOC2 microglia. BMB reports. vol 42. issue 6. 2009-08-12. PMID:19558798. |
in neurodegenerative diseases, such as alzheimer's and parkinson's, microglial cell activation is thought to contribute to cns injury by producing neurotoxic compounds. |
2009-08-12 |
2023-08-12 |
human |
Akiko Yamada, Hidetoshi Akimoto, Syota Kagawa, Gilles J Guillemin, Osamu Takikaw. Proinflammatory cytokine interferon-gamma increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid beta peptide 1-42: implications for the pathogenesis of Alzheimer's disease. Journal of neurochemistry. vol 110. issue 3. 2009-08-07. PMID:19457071. |
in the tg2576 mouse model of alzheimer's disease, systemic inflammation induced by lipopolysaccharide leads to an increase in ido expression and quin production in microglia surrounding amyloid plaques. |
2009-08-07 |
2023-08-12 |
mouse |
Sun Seek Min, Hui Yan Quan, Jinhua Ma, Jung-Soo Han, Byeong Hwa Jeon, Geun Hee Seo. Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area. Neuroscience letters. vol 456. issue 1. 2009-07-15. PMID:19429126. |
neuroinflammation plays an important role in the progression of alzheimer's disease (ad) and is characterized by the presence of activated microglia. |
2009-07-15 |
2023-08-12 |
rat |
Adrian P Mundt, Christine Winter, Susanne Mueller, Jens Wuerfel, Eva Tysiak, Jörg Schnorr, Matthias Taupitz, Andreas Heinz, Georg Jucke. Targeting activated microglia in Alzheimer's pathology by intraventricular delivery of a phagocytosable MRI contrast agent in APP23 transgenic mice. NeuroImage. vol 46. issue 2. 2009-06-24. PMID:19385010. |
targeting activated microglia in alzheimer's pathology by intraventricular delivery of a phagocytosable mri contrast agent in app23 transgenic mice. |
2009-06-24 |
2023-08-12 |
mouse |
Joseph El Khoury, Andrew D Luste. Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends in pharmacological sciences. vol 29. issue 12. 2009-06-23. PMID:18835047. |
mechanisms of microglia accumulation in alzheimer's disease: therapeutic implications. |
2009-06-23 |
2023-08-12 |
mouse |
Joseph El Khoury, Andrew D Luste. Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends in pharmacological sciences. vol 29. issue 12. 2009-06-23. PMID:18835047. |
in alzheimer's disease (ad), and other conditions affecting integrity of the blood-brain barrier, microglia can originate in the bone marrow, migrate into the blood and enter the brain in a chemokine-dependent manner. |
2009-06-23 |
2023-08-12 |
mouse |
I Napoli, H Neuman. Microglial clearance function in health and disease. Neuroscience. vol 158. issue 3. 2009-05-08. PMID:18644426. |
insufficient clearance by microglia appears to be prevalent in neurodegenerative diseases such as alzheimer's disease. |
2009-05-08 |
2023-08-12 |
Not clear |
Wei-Chao Huang, Feng-Chang Yen, Young-Ji Shiao, Feng-Shiun Shie, Jin-Lieh Chan, Cheng-Ning Yang, Yen-Jen Sung, Fong-Lee Huang, Huey-Jen Tsa. Enlargement of Abeta aggregates through chemokine-dependent microglial clustering. Neuroscience research. vol 63. issue 4. 2009-05-04. PMID:19367788. |
the number of microglia surrounding senile plaques is correlated with the size of plaques in alzheimer's disease (ad). |
2009-05-04 |
2023-08-12 |
Not clear |
Balázs Gulyás, Boglárka Makkai, Péter Kása, Károly Gulya, Lidia Bakota, Szilvia Várszegi, Zsuzsa Beliczai, Jan Andersson, László Csiba, Andrea Thiele, Thomas Dyrks, Tetsua Suhara, Kazutoshi Suzuki, Makato Higuchi, Christer Halldi. A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system. Neurochemistry international. vol 54. issue 1. 2009-04-24. PMID:18984021. |
compared with age-matched control brains, specific binding in several brain structures (temporal and parietal lobes, thalamus and white matter) in alzheimer brains was significantly higher, indicating that the radioligands can effectively label-activated microglia and the up-regulated pbr/tspo system in ad. |
2009-04-24 |
2023-08-12 |
human |
Jennifer C Roberts, Sarah L Friel, Shilina Roman, Marion Perren, Alex Harper, John B Davis, Jill C Richardson, David Virley, Andrew D Medhurs. Autoradiographical imaging of PPARgamma agonist effects on PBR/TSPO binding in TASTPM mice. Experimental neurology. vol 216. issue 2. 2009-04-15. PMID:19320004. |
chronic inflammation is known to occur in the brains of alzheimer's disease (ad) patients, including the presence of activated microglia close to amyloid plaques. |
2009-04-15 |
2023-08-12 |
mouse |
Juana M Sanz, Paola Chiozzi, Davide Ferrari, Marilena Colaianna, Marco Idzko, Simonetta Falzoni, Renato Fellin, Luigia Trabace, Francesco Di Virgili. Activation of microglia by amyloid {beta} requires P2X7 receptor expression. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 7. 2009-04-14. PMID:19299738. |
release of this and other nucleotides modulates microglia responses via p2y and p2x receptors, among which the p2x(7) subtype stands out for its proinflammatory activity and for up-regulation in a transgenic model of alzheimer disease and in brains from alzheimer disease patients. |
2009-04-14 |
2023-08-12 |
mouse |
Juana M Sanz, Paola Chiozzi, Davide Ferrari, Marilena Colaianna, Marco Idzko, Simonetta Falzoni, Renato Fellin, Luigia Trabace, Francesco Di Virgili. Activation of microglia by amyloid {beta} requires P2X7 receptor expression. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 7. 2009-04-14. PMID:19299738. |
identification of the p2x(7) receptor as a non-dispensable factor of abeta-mediated microglia stimulation may open new avenues for the treatment of alzheimer disease. |
2009-04-14 |
2023-08-12 |
mouse |