All Relations between Alzheimer Disease and microglial cell

Publication Sentence Publish Date Extraction Date Species
Hsiao-Wen Lin, Steven W Leviso. Context-dependent IL-6 potentiation of interferon- gamma-induced IL-12 secretion and CD40 expression in murine microglia. Journal of neurochemistry. vol 111. issue 3. 2009-11-06. PMID:19712053. interleukin-6 (il-6) is produced by neurons, astrocytes, and microglia, and elevated levels of il-6 within the cns have been documented in multiple neurological disorders including alzheimer's disease, stroke, epilepsy, attention deficit disorder, cerebral palsy, and multiple sclerosis. 2009-11-06 2023-08-12 Not clear
Erin G Reed-Geaghan, Julie C Savage, Amy G Hise, Gary E Landret. CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 38. 2009-10-09. PMID:19776284. microglia are the brain's tissue macrophages and are found in an activated state surrounding beta-amyloid plaques in the alzheimer's disease brain. 2009-10-09 2023-08-12 Not clear
Vincent Boissonneault, Mohammed Filali, Martine Lessard, Jane Relton, Gordon Wong, Serge Rives. Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19151372. together these results provide compelling evidence that systemic m-csf administration is a powerful treatment to stimulate bone marrow-derived microglia, degrade abeta and prevent or improve the cognitive decline associated with abeta burden in a mouse model of alzheimer's disease. 2009-10-01 2023-08-12 mouse
Anusorn Thampithak, Yamaratee Jaisin, Benjawan Meesarapee, Sukumal Chongthammakun, Pawinee Piyachaturawat, Piyarat Govitrapong, Porntip Supavilai, Yupin Sanvarind. Transcriptional regulation of iNOS and COX-2 by a novel compound from Curcuma comosa in lipopolysaccharide-induced microglial activation. Neuroscience letters. vol 462. issue 2. 2009-10-01. PMID:19583997. overproduction of pro-inflammatory mediators resulting from chronic activation of microglia has been implicated in many neurodegenerative disorders, such as parkinson's disease and alzheimer's disease. 2009-10-01 2023-08-12 rat
Ken-ichi Isobe, Naomi Nishio, Sachiko It. [Age-related decline of immune function and age-related diseases]. Nihon rinsho. Japanese journal of clinical medicine. vol 67. issue 7. 2009-09-03. PMID:19591280. for example, the pathogenesis of atherosclerosis and alzheimer disease are related to macrophages (microglia). 2009-09-03 2023-08-12 Not clear
Sriram Venneti, Brian J Lopresti, Guoji Wang, Ronald L Hamilton, Chester A Mathis, William E Klunk, Udayan M Apte, Clayton A Wile. PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET. Neurobiology of aging. vol 30. issue 8. 2009-08-31. PMID:18178291. pk11195 labels activated microglia in alzheimer's disease and in vivo in a mouse model using pet. 2009-08-31 2023-08-12 mouse
Sriram Venneti, Brian J Lopresti, Guoji Wang, Ronald L Hamilton, Chester A Mathis, William E Klunk, Udayan M Apte, Clayton A Wile. PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET. Neurobiology of aging. vol 30. issue 8. 2009-08-31. PMID:18178291. activated microglia may promote neurodegeneration in alzheimer's disease (ad) and may also help in amyloid clearance in immunization therapies. 2009-08-31 2023-08-12 mouse
Lisette T Arnaud, Natura Myeku, Maria E Figueiredo-Pereir. Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells. Journal of neurochemistry. vol 110. issue 1. 2009-08-21. PMID:19457109. alzheimer's disease brains also exhibit signs of inflammation manifested by activated astrocytes and microglia, which produce cytotoxic agents among them prostaglandins. 2009-08-21 2023-08-12 human
Ji Yeon Kim, Tae Hyong Kim, Soung Soo Ki. NSA9, a human prothrombin kringle-2-derived peptide, acts as an inhibitor of kringle-2-induced activation in EOC2 microglia. BMB reports. vol 42. issue 6. 2009-08-12. PMID:19558798. in neurodegenerative diseases, such as alzheimer's and parkinson's, microglial cell activation is thought to contribute to cns injury by producing neurotoxic compounds. 2009-08-12 2023-08-12 human
Akiko Yamada, Hidetoshi Akimoto, Syota Kagawa, Gilles J Guillemin, Osamu Takikaw. Proinflammatory cytokine interferon-gamma increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid beta peptide 1-42: implications for the pathogenesis of Alzheimer's disease. Journal of neurochemistry. vol 110. issue 3. 2009-08-07. PMID:19457071. in the tg2576 mouse model of alzheimer's disease, systemic inflammation induced by lipopolysaccharide leads to an increase in ido expression and quin production in microglia surrounding amyloid plaques. 2009-08-07 2023-08-12 mouse
Sun Seek Min, Hui Yan Quan, Jinhua Ma, Jung-Soo Han, Byeong Hwa Jeon, Geun Hee Seo. Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area. Neuroscience letters. vol 456. issue 1. 2009-07-15. PMID:19429126. neuroinflammation plays an important role in the progression of alzheimer's disease (ad) and is characterized by the presence of activated microglia. 2009-07-15 2023-08-12 rat
Adrian P Mundt, Christine Winter, Susanne Mueller, Jens Wuerfel, Eva Tysiak, Jörg Schnorr, Matthias Taupitz, Andreas Heinz, Georg Jucke. Targeting activated microglia in Alzheimer's pathology by intraventricular delivery of a phagocytosable MRI contrast agent in APP23 transgenic mice. NeuroImage. vol 46. issue 2. 2009-06-24. PMID:19385010. targeting activated microglia in alzheimer's pathology by intraventricular delivery of a phagocytosable mri contrast agent in app23 transgenic mice. 2009-06-24 2023-08-12 mouse
Joseph El Khoury, Andrew D Luste. Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends in pharmacological sciences. vol 29. issue 12. 2009-06-23. PMID:18835047. mechanisms of microglia accumulation in alzheimer's disease: therapeutic implications. 2009-06-23 2023-08-12 mouse
Joseph El Khoury, Andrew D Luste. Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends in pharmacological sciences. vol 29. issue 12. 2009-06-23. PMID:18835047. in alzheimer's disease (ad), and other conditions affecting integrity of the blood-brain barrier, microglia can originate in the bone marrow, migrate into the blood and enter the brain in a chemokine-dependent manner. 2009-06-23 2023-08-12 mouse
I Napoli, H Neuman. Microglial clearance function in health and disease. Neuroscience. vol 158. issue 3. 2009-05-08. PMID:18644426. insufficient clearance by microglia appears to be prevalent in neurodegenerative diseases such as alzheimer's disease. 2009-05-08 2023-08-12 Not clear
Wei-Chao Huang, Feng-Chang Yen, Young-Ji Shiao, Feng-Shiun Shie, Jin-Lieh Chan, Cheng-Ning Yang, Yen-Jen Sung, Fong-Lee Huang, Huey-Jen Tsa. Enlargement of Abeta aggregates through chemokine-dependent microglial clustering. Neuroscience research. vol 63. issue 4. 2009-05-04. PMID:19367788. the number of microglia surrounding senile plaques is correlated with the size of plaques in alzheimer's disease (ad). 2009-05-04 2023-08-12 Not clear
Balázs Gulyás, Boglárka Makkai, Péter Kása, Károly Gulya, Lidia Bakota, Szilvia Várszegi, Zsuzsa Beliczai, Jan Andersson, László Csiba, Andrea Thiele, Thomas Dyrks, Tetsua Suhara, Kazutoshi Suzuki, Makato Higuchi, Christer Halldi. A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system. Neurochemistry international. vol 54. issue 1. 2009-04-24. PMID:18984021. compared with age-matched control brains, specific binding in several brain structures (temporal and parietal lobes, thalamus and white matter) in alzheimer brains was significantly higher, indicating that the radioligands can effectively label-activated microglia and the up-regulated pbr/tspo system in ad. 2009-04-24 2023-08-12 human
Jennifer C Roberts, Sarah L Friel, Shilina Roman, Marion Perren, Alex Harper, John B Davis, Jill C Richardson, David Virley, Andrew D Medhurs. Autoradiographical imaging of PPARgamma agonist effects on PBR/TSPO binding in TASTPM mice. Experimental neurology. vol 216. issue 2. 2009-04-15. PMID:19320004. chronic inflammation is known to occur in the brains of alzheimer's disease (ad) patients, including the presence of activated microglia close to amyloid plaques. 2009-04-15 2023-08-12 mouse
Juana M Sanz, Paola Chiozzi, Davide Ferrari, Marilena Colaianna, Marco Idzko, Simonetta Falzoni, Renato Fellin, Luigia Trabace, Francesco Di Virgili. Activation of microglia by amyloid {beta} requires P2X7 receptor expression. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 7. 2009-04-14. PMID:19299738. release of this and other nucleotides modulates microglia responses via p2y and p2x receptors, among which the p2x(7) subtype stands out for its proinflammatory activity and for up-regulation in a transgenic model of alzheimer disease and in brains from alzheimer disease patients. 2009-04-14 2023-08-12 mouse
Juana M Sanz, Paola Chiozzi, Davide Ferrari, Marilena Colaianna, Marco Idzko, Simonetta Falzoni, Renato Fellin, Luigia Trabace, Francesco Di Virgili. Activation of microglia by amyloid {beta} requires P2X7 receptor expression. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 7. 2009-04-14. PMID:19299738. identification of the p2x(7) receptor as a non-dispensable factor of abeta-mediated microglia stimulation may open new avenues for the treatment of alzheimer disease. 2009-04-14 2023-08-12 mouse