| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao Gao, Jingwen Jiang, Yuyan Tan, Shengdi Che. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-22. PMID:37735487. |
here we comprehensively review the biology of microglia and the roles of microglia in neurodegenerative diseases, including alzheimer's disease, parkinson's disease, multiple system atrophy, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, dementia with lewy bodies and huntington's disease. |
2023-09-22 |
2023-10-07 |
Not clear |
| Xiaoyu Yang, Jia Wen, Han Yang, Ian R Jones, Xiaodong Zhu, Weifang Liu, Bingkun Li, Claire D Clelland, Wenjie Luo, Man Ying Wong, Xingjie Ren, Xiekui Cui, Michael Song, Hongjiang Liu, Cady Chen, Nicolas Eng, Mirunalini Ravichandran, Yang Sun, David Lee, Eric Van Buren, Min-Zhi Jiang, Candace S Y Chan, Chun Jimmie Ye, Rushika M Perera, Li Gan, Yun Li, Yin She. Functional characterization of Alzheimer's disease genetic variants in microglia. Nature genetics. 2023-09-21. PMID:37735198. |
functional characterization of alzheimer's disease genetic variants in microglia. |
2023-09-21 |
2023-10-07 |
Not clear |
| Xiaoyu Yang, Jia Wen, Han Yang, Ian R Jones, Xiaodong Zhu, Weifang Liu, Bingkun Li, Claire D Clelland, Wenjie Luo, Man Ying Wong, Xingjie Ren, Xiekui Cui, Michael Song, Hongjiang Liu, Cady Chen, Nicolas Eng, Mirunalini Ravichandran, Yang Sun, David Lee, Eric Van Buren, Min-Zhi Jiang, Candace S Y Chan, Chun Jimmie Ye, Rushika M Perera, Li Gan, Yun Li, Yin She. Functional characterization of Alzheimer's disease genetic variants in microglia. Nature genetics. 2023-09-21. PMID:37735198. |
candidate cis-regulatory elements (ccres) in microglia demonstrate the most substantial enrichment for alzheimer's disease (ad) heritability compared to other brain cell types. |
2023-09-21 |
2023-10-07 |
Not clear |
| Katsura Takano-Kawabe, Kazuyuki Matoba, Yoichi Nakamura, Mitsuaki Moriyam. Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia. Neurochemical research. 2023-09-13. PMID:37702891. |
activation of glial cells, astrocytes and microglia, has been observed in neurodegenerative diseases including alzheimer's disease (ad). |
2023-09-13 |
2023-10-07 |
mouse |
| Lin Wei, Xiaowen Yang, Jie Wang, Zhixiao Wang, Qiguang Wang, Yan Ding, Aiqing Y. H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway. Journal of neuroinflammation. vol 20. issue 1. 2023-09-11. PMID:37697347. |
h3k18 lactylation of senescent microglia potentiates brain aging and alzheimer's disease through the nfκb signaling pathway. |
2023-09-11 |
2023-10-07 |
mouse |
| Daniel C Shippy, Tyler K Ullan. Lipid metabolism transcriptomics of murine microglia in Alzheimer's disease and neuroinflammation. Scientific reports. vol 13. issue 1. 2023-09-08. PMID:37684405. |
lipid metabolism transcriptomics of murine microglia in alzheimer's disease and neuroinflammation. |
2023-09-08 |
2023-10-07 |
mouse |
| Bijay Parajuli, Schuichi Koizum. [Microglia: a potential target for neurological disorder]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 158. issue 5. 2023-09-06. PMID:37673609. |
these microglia mediated tissue damage plays an important role in pathogenesis of various neurological disorders like alzheimer's disease and parkinson's disease. |
2023-09-06 |
2023-10-07 |
Not clear |
| Yiyuan Xia, Yifan Xiao, Zhi-Hao Wang, Xia Liu, Ashfaqul M Alam, John P Haran, Beth A McCormick, Xiji Shu, Xiaochuan Wang, Keqiang Y. Bacteroides Fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice. Nature communications. vol 14. issue 1. 2023-09-06. PMID:37673907. |
bacteroides fragilis in the gut microbiomes of alzheimer's disease activates microglia and triggers pathogenesis in neuronal c/ebpβ transgenic mice. |
2023-09-06 |
2023-10-07 |
mouse |
| Juliana R Lopes, Xiaoming Zhang, Julia Mayrink, Bruna K Tatematsu, Lydia Guo, Danielle S LeServe, Hadi Abou-El-Hassan, Felipe Rong, Maria J Dalton, Marilia G Oliveira, Toby B Lanser, Lei Liu, Oleg Butovsky, Rafael M Rezende, Howard L Weine. Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 37. 2023-09-05. PMID:37669383. |
emerging evidence suggests that dysregulation of neuroinflammation, particularly that orchestrated by microglia, plays a significant role in the pathogenesis of alzheimer's disease (ad). |
2023-09-05 |
2023-10-07 |
mouse |
| Andy P Tsai, Chuanpeng Dong, Peter Bor-Chian Lin, Adrian L Oblak, Gonzalo Viana Di Prisco, Nian Wang, Nicole Hajicek, Adam J Carr, Emma K Lendy, Oliver Hahn, Micaiah Atkins, Aulden G Foltz, Jheel Patel, Guixiang Xu, Miguel Moutinho, John Sondek, Qisheng Zhang, Andrew D Mesecar, Yunlong Liu, Brady K Atwood, Tony Wyss-Coray, Kwangsik Nho, Stephanie J Bissel, Bruce T Lamb, Gary E Landret. Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease. Immunity. 2023-09-02. PMID:37659412. |
genetic variants of phospholipase c-γ2 alter the phenotype and function of microglia and confer differential risk for alzheimer's disease. |
2023-09-02 |
2023-09-07 |
Not clear |
| Makis Tzioras, Michael J D Daniels, Caitlin Davies, Paul Baxter, Declan King, Sean McKay, Balazs Varga, Karla Popovic, Madison Hernandez, Anna J Stevenson, Jack Barrington, Elizabeth Drinkwater, Julia Borella, Rebecca K Holloway, Jane Tulloch, Jonathan Moss, Clare Latta, Jothy Kandasamy, Drahoslav Sokol, Colin Smith, Veronique E Miron, Ragnhildur Thóra Káradóttir, Giles E Hardingham, Christopher M Henstridge, Paul M Brennan, Barry W McColl, Tara L Spires-Jone. Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8. Cell reports. Medicine. 2023-08-31. PMID:37652017. |
human astrocytes and microglia show augmented ingestion of synapses in alzheimer's disease via mfg-e8. |
2023-08-31 |
2023-09-07 |
mouse |
| Keita Saeki, Richard Pan, Eunju Lee, Daisuke Kurotaki, Keiko Ozat. IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645844. |
constitutive irf8 deletion led to the loss of microglia identity gene expression and aberrant induction of alzheimer's disease and neurodegeneration associated genes. |
2023-08-30 |
2023-09-07 |
mouse |
| Xuezhen Chen, Yue Zhao, Yimin Huang, Kaichuan Zhu, Fan Zeng, Junyi Zhao, Huaqiu Zhang, Xinzhou Zhu, Helmut Kettenmann, Xianyuan Xian. TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages. Glia. 2023-08-29. PMID:37641212. |
triggering receptor expressed on myeloid cell 2 (trem2), a myeloid cell-specific signaling molecule, controls essential functions of microglia and impacts on the pathogenesis of alzheimer's disease and other neurodegenerative disorders. |
2023-08-29 |
2023-09-07 |
Not clear |
| Yingying Wu, Ulrich L M Eise. Microglia-Astrocyte Communication in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-08-28. PMID:37638434. |
microglia and astrocytes are regarded as active participants in the central nervous system under various neuropathological conditions, including alzheimer's disease (ad). |
2023-08-28 |
2023-09-07 |
human |
| Jialun Yang, Shunling Yuan, Ye Jian, Yong Lei, Zelin Hu, Qiming Yang, Xinjun Yan, Lan Zheng, Jianghua Li, Wenfeng Li. Aerobic exercise regulates GPR81 signal pathway and mediates complement- microglia axis homeostasis on synaptic protection in the early stage of Alzheimer's disease. Life sciences. 2023-08-27. PMID:37634815. |
aerobic exercise regulates gpr81 signal pathway and mediates complement- microglia axis homeostasis on synaptic protection in the early stage of alzheimer's disease. |
2023-08-27 |
2023-09-07 |
Not clear |
| Edward S Wickstea. Using Stems to Bear Fruit: Deciphering the Role of Alzheimer's Disease Risk Loci in Human-Induced Pluripotent Stem Cell-Derived Microglia. Biomedicines. vol 11. issue 8. 2023-08-26. PMID:37626736. |
using stems to bear fruit: deciphering the role of alzheimer's disease risk loci in human-induced pluripotent stem cell-derived microglia. |
2023-08-26 |
2023-09-07 |
Not clear |
| Carla Usai, Lourdes Mateu, Christian Brander, Júlia Vergara-Alert, Joaquim Segalé. Animal models to study the neurological manifestations of the post-COVID-19 condition. Lab animal. 2023-08-24. PMID:37620562. |
interestingly, the proinflammatory transcriptomic profile observed in the central nervous system of sars-cov-2-inoculated mice partially overlaps with the pathological changes that affect microglia in humans during alzheimer's disease and aging, suggesting shared mechanisms between these conditions. |
2023-08-24 |
2023-09-07 |
mouse |
| Xin Zhao, Pingyuan Ge, Shaohua Lei, Siqi Guo, Peng Zhou, Li Zhao, Yiyu Qi, Xiaotong Wei, Weizhen Wu, Ningjing Wang, Rui Guo, Nianyun Yang, Qingqing Xiao, Qichun Zhang, Huaxu Zh. An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer's Disease with Berberine and Palmatine. Drug design, development and therapy. vol 17. 2023-08-23. PMID:37609432. |
neuroinflammation is one of the major pathogeneses in alzheimer's disease (ad) and mainly involves abnormal inflammatory activation of microglia by multiple pathological stimuli. |
2023-08-23 |
2023-09-07 |
Not clear |
| Junhua Li, Lin Wang, Qinhua Zeng, Jing He, Qing Tang, Kejian Wang, Guiqiong H. MKP-1 regulates the inflammatory activation of microglia against Alzheimer's disease. CNS neuroscience & therapeutics. 2023-08-21. PMID:37602891. |
mkp-1 regulates the inflammatory activation of microglia against alzheimer's disease. |
2023-08-21 |
2023-09-07 |
Not clear |
| Maria Olmedillas, Bianca Brawek, Kaizhen Li, Cris Richter, Olga Garaschu. Plaque vicinity as a hotspot of microglial turnover in a mouse model of Alzheimer's disease. Glia. 2023-08-19. PMID:37596829. |
by using microrna-9 regulated viral vectors for multicolor labeling and longitudinal in vivo monitoring of individual microglia, we followed their fate in the cortex of healthy adult mice and at the onset of amyloidosis in a mouse model of alzheimer's disease. |
2023-08-19 |
2023-10-07 |
mouse |