| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyo Jin Lim, Hyun-Sun Lee, Jae-Ha Ry. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression by tussilagone from Farfarae flos in BV-2 microglial cells. Archives of pharmacal research. vol 31. issue 5. 2008-08-22. PMID:18481023. |
activated microglia produce diverse neurotoxic factors such as nitric oxide (no) and prostaglandin e(2) (pge(2)) that may cause neurodegenerative diseases, including alzheimer's disease and parkinson's disease. |
2008-08-22 |
2023-08-12 |
Not clear |
| Claudia Schwab, Patrick L McGee. Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders. Journal of Alzheimer's disease : JAD. vol 13. issue 4. 2008-08-07. PMID:18487845. |
alzheimer and a number of other neurodegenerative diseases are characterized by the presence of reactive microglia and reactive astrocytes in association with the lesions. |
2008-08-07 |
2023-08-12 |
Not clear |
| Karine L Richard, Mohammed Filali, Paul Préfontaine, Serge Rives. Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 22. 2008-07-01. PMID:18509040. |
microglia are the immune cells of the brain, they are activated in the brain of alzheimer's disease (ad) patients and mouse models of ad, and they express the innate immune receptor toll-like receptor 2 (tlr2). |
2008-07-01 |
2023-08-12 |
mouse |
| Huayan Liu, Jun Wang, Atsuo Sekiyama, Takeshi Tabir. Juzen-taiho-to, an herbal medicine, activates and enhances phagocytosis in microglia/macrophages. The Tohoku journal of experimental medicine. vol 215. issue 1. 2008-07-01. PMID:18509234. |
involvement of activated microglia in the pathogenesis has been demonstrated in several neurological diseases including alzheimer's disease (ad). |
2008-07-01 |
2023-08-12 |
mouse |
| Long Tai Zheng, Jiyeon Ock, Byoung-Mog Kwon, Kyoungho Su. Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity. International immunopharmacology. vol 8. issue 3. 2008-04-08. PMID:18279803. |
activation of microglia plays an important role in the processes of several neurodegenerative diseases including alzheimer's disease, parkinson's disease, and hiv dementia. |
2008-04-08 |
2023-08-12 |
Not clear |
| Assunta Dal Bianco, Monika Bradl, Josa Frischer, Alexandra Kutzelnigg, Kurt Jellinger, Hans Lassman. Multiple sclerosis and Alzheimer's disease. Annals of neurology. vol 63. issue 2. 2008-04-03. PMID:17924575. |
chronic inflammation with microglia activation is thought to play a major role in the formation or clearance of alzheimer's disease (ad) lesions, as well as in the induction of demyelination in multiple sclerosis (ms). |
2008-04-03 |
2023-08-12 |
Not clear |
| V A Campbell, A Gowra. Alzheimer's disease; taking the edge off with cannabinoids? British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17828287. |
targeting cannabinoid receptors on microglia may reduce the neuroinflammation that is a feature of alzheimer's disease, without causing psychoactive effects. |
2008-02-25 |
2023-08-12 |
Not clear |
| Rita Barone, Stefano Sotgiu, Salvatore Musumec. Plasma chitotriosidase in health and pathology. Clinical laboratory. vol 53. issue 5-6. 2008-01-24. PMID:17605408. |
after a wide range of unwanted stimuli such as those occurring in stroke, multiple sclerosis, and alzheimer's disease, resident cells like microglia and a few other cell types promptly activate a complex immune cascade which then might be monitored also by measuring chit activity. |
2008-01-24 |
2023-08-12 |
Not clear |
| R Bryan Rock, Phillip K Peterso. Microglia as a pharmacological target in infectious and inflammatory diseases of the brain. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 1. issue 2. 2007-12-27. PMID:18040778. |
results of a large number of in vitro studies, using isolated microglial cells or glial/neuronal cell cultures, and parallel findings emerging from animal models and clinical studies have demonstrated that activated microglia produce a myriad of inflammatory mediators that both serve important defense functions against invading neurotropic pathogens and have been implicated in brain damage in infectious as well as neuroinflammatory/neurodegenerative diseases, such as multiple sclerosis, alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis. |
2007-12-27 |
2023-08-12 |
Not clear |
| Ramin Raouf, Anne-Julie Chabot-Doré, Ariel R Ase, Dominique Blais, Philippe Séguél. Differential regulation of microglial P2X4 and P2X7 ATP receptors following LPS-induced activation. Neuropharmacology. vol 53. issue 4. 2007-12-20. PMID:17675190. |
activation of microglia has been implicated in many neurological conditions including alzheimer's disease and neuropathic pain. |
2007-12-20 |
2023-08-12 |
Not clear |
| Joseph El Khoury, Michelle Toft, Suzanne E Hickman, Terry K Means, Kinya Terada, Changiz Geula, Andrew D Luste. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nature medicine. vol 13. issue 4. 2007-11-21. PMID:17351623. |
however, the role of microglia in alzheimer disease has not been resolved. |
2007-11-21 |
2023-08-12 |
mouse |
| Birgit Kraus, Horst Wolff, Jörg Heilmann, Erich F Elstne. Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells. Life sciences. vol 81. issue 11. 2007-10-26. PMID:17725929. |
as immunocompetent cells of the brain, microglia are able to counteract the damaging effects of amyloid-beta in alzheimer's disease by phagocytosis-mediated clearance of protein aggregates. |
2007-10-26 |
2023-08-12 |
Not clear |
| Robert E Mrak, W Sue T Griffi. Common inflammatory mechanisms in Lewy body disease and Alzheimer disease. Journal of neuropathology and experimental neurology. vol 66. issue 8. 2007-10-26. PMID:17882012. |
activated microglia are found in association with alpha-synuclein-containing neurons and glia in parkinson disease, in dementia with lewy bodies, and in multiple system atrophy, and these associations are reminiscent of microglial associations with neurofibrillary tangle-containing neurons in alzheimer disease. |
2007-10-26 |
2023-08-12 |
Not clear |
| Oleg Butovsky, Gilad Kunis, Maya Koronyo-Hamaoui, Michal Schwart. Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. The European journal of neuroscience. vol 26. issue 2. 2007-10-25. PMID:17623022. |
we have recently shown that the ability of microglia to effectively fight off aggregated beta-amyloid plaque formation and cognitive loss in transgenic mouse models of alzheimer's disease (tg-ad), is augmented in response to t-cell-based immunization, using glatiramer acetate (ga). |
2007-10-25 |
2023-08-12 |
mouse |
| Shabnam Baig, Gordon K Wilcock, Seth Lov. Loss of perineuronal net N-acetylgalactosamine in Alzheimer's disease. Acta neuropathologica. vol 110. issue 4. 2007-10-19. PMID:16133543. |
we have investigated the relative preservation of wisteria floribunda agglutinin (wfa)-positive pns and parvalbumin-positive neurons in alzheimer's disease (ad), and the relationship of wfa-positive pns to parenchymal tau, amyloid beta-peptide (abeta) and mhc class ii antigen (a marker of activated microglia), in paraffin sections of 100 cases with ad and 45 controls. |
2007-10-19 |
2023-08-12 |
Not clear |
| Yong-Ki Park, Yoo Sun Chung, Yoon Seong Kim, O-Yoon Kwon, Tong H Jo. Inhibition of gene expression and production of iNOS and TNF-alpha in LPS-stimulated microglia by methanol extract of Phellodendri cortex. International immunopharmacology. vol 7. issue 7. 2007-10-04. PMID:17499198. |
activation of microglia has been increasingly associated with the pathogenesis of several neurodegenerative disorders including parkinson's and alzheimer's diseases, and the suppression of microglial activation may lead to alleviation of the progression of neurodegeneration in these diseases. |
2007-10-04 |
2023-08-12 |
mouse |
| Pablo Iribarren, Keqiang Chen, Wanghua Gong, Edward H Cho, Stephen Lockett, Badarch Uranchimeg, Ji Ming Wan. Interleukin 10 and TNFalpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microglia. Neurobiology of disease. vol 27. issue 1. 2007-09-06. PMID:17544285. |
this chemoattractant receptor mediates microglial cell chemotaxis in response to a variety of peptides, including amyloid beta peptide (abeta(42)), a major pathogenic factor in alzheimer's disease (ad). |
2007-09-06 |
2023-08-12 |
human |
| Joseph Rogers, Diego Mastroeni, Brian Leonard, Jeffrey Joyce, Andrew Grove. Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? International review of neurobiology. vol 82. 2007-09-05. PMID:17678964. |
neuroinflammation in alzheimer's disease and parkinson's disease: are microglia pathogenic in either disorder? |
2007-09-05 |
2023-08-12 |
human |
| Carol A Colton, Ryan T Mott, Hayley Sharpe, Qing Xu, William E Van Nostrand, Michael P Vite. Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD. Journal of neuroinflammation. vol 3. 2007-07-23. PMID:17005052. |
microglia are associated with neuritic plaques in alzheimer disease (ad) and serve as a primary component of the innate immune response in the brain. |
2007-07-23 |
2023-08-12 |
mouse |
| Aiste Jekabsone, Palwinder K Mander, Anna Tickler, Martyn Sharpe, Guy C Brow. Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study. Journal of neuroinflammation. vol 3. 2007-07-20. PMID:16959029. |
alzheimer's disease is characterized by the accumulation of neuritic plaques, containing activated microglia and beta-amyloid peptides (abeta). |
2007-07-20 |
2023-08-12 |
Not clear |