| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takahiro Kato, Akira Monji, Sadayuki Hashioka, Shigenobu Kanb. Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro. Schizophrenia research. vol 92. issue 1-3. 2007-07-03. PMID:17363222. |
microglia has thus been reported to play an important role in the pathology of neurodegenerative disease, such as alzheimer's disease (ad) and parkinson's disease (pd). |
2007-07-03 |
2023-08-12 |
Not clear |
| Amanda McRae, Ralph N Martins, Justine Fonte, Rudolf Kraftsik, Lorenz Hirt, Judith Mikloss. Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: a putative marker of an ongoing inflammatory process. Experimental gerontology. vol 42. issue 4. 2007-06-29. PMID:17140756. |
immunocompetent microglia play an important role in the pathogenesis of alzheimer's disease (ad). |
2007-06-29 |
2023-08-12 |
Not clear |
| Atoosa Familian, Piet Eikelenboom, Robert Veerhui. Minocycline does not affect amyloid beta phagocytosis by human microglial cells. Neuroscience letters. vol 416. issue 1. 2007-06-19. PMID:17317005. |
activated microglia accumulate in amyloid beta (abeta) plaques containing amyloid associated factors sap and c1q in alzheimer's disease (ad) brain. |
2007-06-19 |
2023-08-12 |
human |
| Amitabha Majumdar, Dana Cruz, Nikiya Asamoah, Adina Buxbaum, Istvan Sohar, Peter Lobel, Frederick R Maxfiel. Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. Molecular biology of the cell. vol 18. issue 4. 2007-06-04. PMID:17314396. |
activation of microglia acidifies lysosomes and leads to degradation of alzheimer amyloid fibrils. |
2007-06-04 |
2023-08-12 |
mouse |
| Amitabha Majumdar, Dana Cruz, Nikiya Asamoah, Adina Buxbaum, Istvan Sohar, Peter Lobel, Frederick R Maxfiel. Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. Molecular biology of the cell. vol 18. issue 4. 2007-06-04. PMID:17314396. |
microglia are the main immune cells of the brain, and under some circumstances they can play an important role in removal of fibrillar alzheimer amyloid beta peptide (fabeta). |
2007-06-04 |
2023-08-12 |
mouse |
| Patrick L McGeer, Edith G McGee. NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies. Neurobiology of aging. vol 28. issue 5. 2007-05-31. PMID:16697488. |
activated microglia, along with a spectrum of inflammatory mediators, have been identified in association with the lesions of alzheimer disease (ad), suggesting that antiinflammatory agents such as nsaids should protect against the disease. |
2007-05-31 |
2023-08-12 |
mouse |
| Shaohua Wang, Jing Li, Wei Xia, Meiyu Gen. A marine-derived acidic oligosaccharide sugar chain specifically inhibits neuronal cell injury mediated by beta-amyloid-induced astrocyte activation in vitro. Neurological research. vol 29. issue 1. 2007-05-29. PMID:17427283. |
in alzheimer's disease (ad), beta-amyloid (abeta) plaques are surrounded by activated astrocytes and microglia. |
2007-05-29 |
2023-08-12 |
Not clear |
| Jon Infante, Javier Llorca, Ignacio Mateo, Eloy Rodríguez-Rodríguez, Coro Sánchez-Quintana, Pascual Sánchez-Juan, Carlos Fernández-Viadero, Nicolás Peña, José Berciano, Onofre Combarro. Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 23. issue 4. 2007-05-24. PMID:17290104. |
excessive release of proinflammatory cytokines by activated microglia surrounding senile plaques might contribute to the neurodegeneration associated with alzheimer's disease (ad). |
2007-05-24 |
2023-08-12 |
Not clear |
| Sadayuki Hashioka, Youn-Hee Han, Shunsuke Fujii, Takahiro Kato, Akira Monji, Hideo Utsumi, Makoto Sawada, Hiroshi Nakanishi, Shigenobu Kanb. Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation. Free radical biology & medicine. vol 42. issue 7. 2007-05-10. PMID:17349923. |
there is increasing evidence that microglial activation is one of the major pathogenic factors for alzheimer's disease (ad) and the inhibition of the inflammatory activation of the microglia thus appears to be neuroprotective and a potentially useful treatment for ad. |
2007-05-10 |
2023-08-12 |
Not clear |
| E Boelen, H W M Steinbusch, I Pronk, G Grauls, P Rennert, V Bailly, C A Bruggeman, F R M Stasse. Inflammatory responses following Chlamydia pneumoniae infection of glial cells. The European journal of neuroscience. vol 25. issue 3. 2007-05-02. PMID:17313571. |
here, we examined the inflammatory responses in murine microglial cell (mmc) and murine astrocyte cell (mac) lines following infection with chlamydia pneumoniae (cpn), a pathogen that has recently been associated with alzheimer's disease. |
2007-05-02 |
2023-08-12 |
Not clear |
| Jacques Boddaert, Kiyoka Kinugawa, Jean-Charles Lambert, Fatiha Boukhtouche, Joffrey Zoll, Régine Merval, Olivier Blanc-Brude, David Mann, Claudine Berr, José Vilar, Béatrice Garabedian, Nathalie Journiac, Dominique Charue, Jean-Sébastien Silvestre, Charles Duyckaerts, Philippe Amouyel, Jean Mariani, Alain Tedgui, Ziad Malla. Evidence of a role for lactadherin in Alzheimer's disease. The American journal of pathology. vol 170. issue 3. 2007-05-01. PMID:17322377. |
cells involved in alzheimer's disease, including vascular smooth muscle cells, astrocytes, and microglia, showed a time-related increase in lactadherin production in culture. |
2007-05-01 |
2023-08-12 |
human |
| Anna Chiarini, Ilaria Dal Pra, James F Whitfield, Ubaldo Armat. The killing of neurons by beta-amyloid peptides, prions, and pro-inflammatory cytokines. Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia. vol 111. issue 4. 2007-04-27. PMID:17385278. |
reportedly, beta-amyloid peptides (abeta40 and abeta42) induce the neurodegenerative changes of alzheimer's disease (ad) both directly by interacting with components of the cell surface to trigger apoptogenic signaling and indirectly by activating astrocytes and microglia to produce excess amounts of inflammatory cytokines. |
2007-04-27 |
2023-08-12 |
human |
| Claudie Hooper, Jennifer M Pococ. Chromogranin A activates diverse pathways mediating inducible nitric oxide expression and apoptosis in primary microglia. Neuroscience letters. vol 413. issue 3. 2007-04-24. PMID:17267111. |
these findings provide insights into the way microglia are activated by cga and the microglial signalling mechanisms associated with neurological disorders such as alzheimer's disease. |
2007-04-24 |
2023-08-12 |
rat |
| Milena Damjanac, Agnès Rioux Bilan, Laurence Barrier, Raymond Pontcharraud, Cantereau Anne, Jacques Hugon, Guylène Pag. Fluoro-Jade B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's disease. Brain research. vol 1128. issue 1. 2007-03-27. PMID:17125750. |
fluoro-jade b staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of alzheimer's disease. |
2007-03-27 |
2023-08-12 |
mouse |
| Milena Damjanac, Agnès Rioux Bilan, Laurence Barrier, Raymond Pontcharraud, Cantereau Anne, Jacques Hugon, Guylène Pag. Fluoro-Jade B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's disease. Brain research. vol 1128. issue 1. 2007-03-27. PMID:17125750. |
in this study, we analyzed the staining of fluoro-jade b alone or combined with specific markers for detection of glial fibrillary acidic protein (gfap) or activated cd68 microglia in the double app(sl)/ps1 ki transgenic mice of alzheimer's disease (ad), which display a massive neuronal loss in the ca1 region of the hippocampus. |
2007-03-27 |
2023-08-12 |
mouse |
| S Leone, A Ottani, A Bertolin. Dual acting anti-inflammatory drugs. Current topics in medicinal chemistry. vol 7. issue 3. 2007-03-26. PMID:17305569. |
in addition, the dual inhibition of both cox and 5-lox is neuroprotective by suppressing toxic actions of reactive microglia and macrophages, that are increased in aging brain and in age-related degenerative conditions, particularly alzheimer's and parkinson's diseases. |
2007-03-26 |
2023-08-12 |
Not clear |
| Masaru Yamamoto, Tomomi Kiyota, Masahide Horiba, James L Buescher, Shannon M Walsh, Howard E Gendelman, Tsuneya Ikez. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. The American journal of pathology. vol 170. issue 2. 2007-03-21. PMID:17255335. |
reactive astrocytes and microglia in alzheimer's disease surround amyloid plaques and secrete proinflammatory cytokines that affect neuronal function. |
2007-03-21 |
2023-08-12 |
mouse |
| L Gerardino, P Papaleo, A Flex, E Gaetani, G Fioroni, P Pola, R Pol. Coagulation factor XIII Val34Leu gene polymorphism and Alzheimer's disease. Neurological research. vol 28. issue 8. 2007-03-21. PMID:17288735. |
fxiiia subunit was immunohistochemically detected in a subpopulation of reactive microglia in alzheimer's disease (ad). |
2007-03-21 |
2023-08-12 |
Not clear |
| Sriram Venneti, Brian J Lopresti, Clayton A Wile. The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging. Progress in neurobiology. vol 80. issue 6. 2007-03-15. PMID:17156911. |
microglia constitute the primary resident immune surveillance cell in the brain and are thought to play a significant role in the pathogenesis of several neurodegenerative disorders, such as alzheimer's disease, multiple sclerosis, parkinson's disease and hiv-associated dementia. |
2007-03-15 |
2023-08-12 |
Not clear |
| Anil Kumar, Neha Seghal, Satyanaryana Venketeshwara Padi, Pattipati Sreenivaslu Naid. Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. European journal of pharmacology. vol 551. issue 1-3. 2007-02-08. PMID:17027965. |
inflammatory cells, such as astrocytes and microglia, are activated in areas of the brain affected by amyloid plaques and inflammatory mediators including cytokines, chemokines, prostaglandins, oxygen free radicals and reactive nitrogen species may have a crucial role in alzheimer's disease pathogenesis. |
2007-02-08 |
2023-08-12 |
rat |