| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Olmedillas, Bianca Brawek, Kaizhen Li, Cris Richter, Olga Garaschu. Plaque vicinity as a hotspot of microglial turnover in a mouse model of Alzheimer's disease. Glia. 2023-08-19. PMID:37596829. |
by using microrna-9 regulated viral vectors for multicolor labeling and longitudinal in vivo monitoring of individual microglia, we followed their fate in the cortex of healthy adult mice and at the onset of amyloidosis in a mouse model of alzheimer's disease. |
2023-08-19 |
2023-10-07 |
mouse |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. 2023-08-17. PMID:37589745. |
correction: apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. |
2023-08-17 |
2023-09-07 |
Not clear |
| Moris Sangineto, Martina Ciarnelli, Tommaso Cassano, Antonio Radesco, Archana Moola, Vidyasagar Naik Bukke, Antonino Romano, Rosanna Villani, Hina Kanwal, Nazzareno Capitanio, Loren Duda, Carlo Avolio, Gaetano Serviddi. Metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in Alzheimer's disease. Redox biology. vol 66. 2023-08-16. PMID:37586250. |
metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in alzheimer's disease. |
2023-08-16 |
2023-09-07 |
mouse |
| Moris Sangineto, Martina Ciarnelli, Tommaso Cassano, Antonio Radesco, Archana Moola, Vidyasagar Naik Bukke, Antonino Romano, Rosanna Villani, Hina Kanwal, Nazzareno Capitanio, Loren Duda, Carlo Avolio, Gaetano Serviddi. Metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in Alzheimer's disease. Redox biology. vol 66. 2023-08-16. PMID:37586250. |
microglia activation drives the pro-inflammatory activity in the early stages of alzheimer's disease (ad). |
2023-08-16 |
2023-09-07 |
mouse |
| Sarah R Ocañas, Kevin D Pham, Jillian E J Cox, Alex W Keck, Sunghwan Ko, Felix A Ampadu, Hunter L Porter, Victor A Ansere, Adam Kulpa, Collyn M Kellogg, Adeline H Machalinski, Manu A Thomas, Zsabre Wright, Ana J Chucair-Elliott, Willard M Freema. Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease. Journal of neuroinflammation. vol 20. issue 1. 2023-08-16. PMID:37587511. |
microglia, the brain's principal immune cells, have been implicated in the pathogenesis of alzheimer's disease (ad), a condition shown to affect more females than males. |
2023-08-16 |
2023-09-07 |
mouse |
| He Li, Tianyuan Ye, Xingyang Liu, Rui Guo, Xiuzhao Yang, Yangyi Li, Dongmei Qi, Yihua Wei, Yifan Zhu, Lei Wen, Xiaorui Chen. The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease. Journal of pharmaceutical analysis. vol 13. issue 7. 2023-08-14. PMID:37577391. |
the role of signaling crosstalk of microglia in hippocampus on progression of ageing and alzheimer's disease. |
2023-08-14 |
2023-08-16 |
mouse |
| He Li, Tianyuan Ye, Xingyang Liu, Rui Guo, Xiuzhao Yang, Yangyi Li, Dongmei Qi, Yihua Wei, Yifan Zhu, Lei Wen, Xiaorui Chen. The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease. Journal of pharmaceutical analysis. vol 13. issue 7. 2023-08-14. PMID:37577391. |
based on single-cell sequencing of the hippocampi of 5× familiar alzheimer's disease (5× fad) and wild type mice at 2-, 12-, and 24-month of age, we found an increased percentage of microglia in aging and alzheimer's disease (ad) mice. |
2023-08-14 |
2023-08-16 |
mouse |
| Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Diel. Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569296. |
in this review, we focus on the role of cells (microglia, astrocytes, and oligodendrocytes) and molecules (trem2, tau, and β-amyloid) of the innate immune system in the pathogenesis of alzheimer's disease and their possible exploitation as disease biomarkers and targets of therapeutical approaches. |
2023-08-12 |
2023-08-16 |
Not clear |
| Zhengrong Zhang, Kaiwen Yu, Yang You, Peizhou Jiang, Zhiping Wu, Michael A DeTure, Dennis W Dickson, Seiko Ikezu, Junmin Peng, Tsuneya Ikez. Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. Journal of extracellular vesicles. vol 12. issue 8. 2023-08-11. PMID:37563857. |
in contrast, mage samples were more enriched in molecules related to lipoproteins, cell-substrate junction and microglia, whereas sec samples were highly enriched in molecules related to extracellular matrix, alzheimer's disease and astrocytes. |
2023-08-11 |
2023-08-16 |
human |
| Priyanka Mishra, Alexander Silva, Jay Sharma, Jacqueline Nguyen, Donald P Pizzo, Denise Hinz, Debashis Sahoo, Stephanie Cherqu. Rescue of Alzheimer's disease phenotype in a mouse model by transplantation of wild-type hematopoietic stem and progenitor cells. Cell reports. vol 42. issue 8. 2023-08-10. PMID:37561625. |
alzheimer's disease (ad) is the most prevalent cause of dementia; microglia have been implicated in ad pathogenesis, but their role is still matter of debate. |
2023-08-10 |
2023-08-16 |
mouse |
| Renlong Zhang, Ting Zhou, Soham Samanta, Ziyi Luo, Shaowei Li, Hao Xu, Junle Q. Synergistic photobiomodulation with 808-nm and 1064-nm lasers to reduce the β-amyloid neurotoxicity in the Frontiers in neuroimaging. vol 1. 2023-08-09. PMID:37555169. |
synergistic photobiomodulation with 808-nm and 1064-nm lasers to reduce the β-amyloid neurotoxicity in the in alzheimer's disease (ad), the deposition of β-amyloid (aβ) plaques is closely associated with the neuronal apoptosis and activation of microglia, which may result in the functional impairment of neurons through pro-inflammation and over-pruning of the neurons. |
2023-08-09 |
2023-08-16 |
Not clear |
| Li Lin, Rashmita Basu, Debolina Chatterjee, Andrew T Templin, Jonathan N Flak, Travis S Johnso. Disease-associated astrocytes and microglia markers are upregulated in mice fed high fat diet. Scientific reports. vol 13. issue 1. 2023-08-09. PMID:37558676. |
we hypothesize gene expression changes in disease-associated astrocytes (daa), disease-associated microglia and human alzheimer's microglia exist in diabetic and obese individuals before ad development. |
2023-08-09 |
2023-08-16 |
mouse |
| Pei Y Ng, Cheng Zhang, Hu Li, Darren J Bake. Senescent Microglia Represent a Subset of Disease-Associated Microglia in P301S Mice. Journal of Alzheimer's disease : JAD. 2023-08-07. PMID:37545233. |
the existence and contribution of microglia with senescent-like alterations in the pathogenesis of age-related neurodegenerative diseases like alzheimer's disease (ad) have been suggested in recent years. |
2023-08-07 |
2023-08-14 |
mouse |
| Michael S Haney, Róbert Pálovics, Christy Nicole Munson, Chris Long, Patrik Johansson, Oscar Yip, Wentao Dong, Eshaan Rawat, Elizabeth West, Johannes Cm Schlachetzki, Andy Tsai, Ian Hunter Guldner, Bhawika S Lamichhane, Amanda Smith, Nicholas Schaum, Kruti Calcuttawala, Andrew Shin, Yung-Hua Wang, Chengzhong Wang, Nicole Koutsodendris, Geidy E Serrano, Thomas G Beach, Eric M Reiman, Christopher K Glass, Monther Abu-Remaileh, Annika Enejder, Yadong Huang, Tony Wyss-Cora. APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546938. |
apoe4/4 is linked to damaging lipid droplets in alzheimer's microglia. |
2023-08-07 |
2023-08-14 |
Not clear |
| Joseph D Quick, Cristian Silva, Jia Hui Wong, Kah Leong Lim, Richard Reynolds, Anna M Barron, Jialiu Zeng, Chih Hung L. Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration. Journal of neuroinflammation. vol 20. issue 1. 2023-08-05. PMID:37543564. |
reacidification of impaired lysosomes in microglia has been shown to reverse neurodegenerative pathology in alzheimer's disease. |
2023-08-05 |
2023-08-14 |
Not clear |
| Peng Jiang, Mengmeng Ji. Replacing microglia to treat Alzheimer's disease. Cell stem cell. vol 30. issue 8. 2023-08-04. PMID:37541204. |
replacing microglia to treat alzheimer's disease. |
2023-08-04 |
2023-08-14 |
Not clear |
| Mariane C Vicente, Julia L Paneghini, Angelita M Stabile, Mateus Amorim, Conceição E Anibal Silva, Luis Gustavo A Patrone, Thiago M Cunha, Kênia C Bícego, Maria C Almeida, Daniel C Carrettiero, Luciane H Gargaglion. Inhibition of Pro-Inflammatory Microglia with Minocycline Improves Cognitive and Sleep-Wake Dysfunction Under Respiratory Stress in a Sporadic Model for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-07-31. PMID:37522205. |
inhibition of pro-inflammatory microglia with minocycline improves cognitive and sleep-wake dysfunction under respiratory stress in a sporadic model for alzheimer's disease. |
2023-07-31 |
2023-08-14 |
Not clear |
| Mariane C Vicente, Julia L Paneghini, Angelita M Stabile, Mateus Amorim, Conceição E Anibal Silva, Luis Gustavo A Patrone, Thiago M Cunha, Kênia C Bícego, Maria C Almeida, Daniel C Carrettiero, Luciane H Gargaglion. Inhibition of Pro-Inflammatory Microglia with Minocycline Improves Cognitive and Sleep-Wake Dysfunction Under Respiratory Stress in a Sporadic Model for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-07-31. PMID:37522205. |
neuroinflammation in alzheimer's disease (ad) can occur due to excessive activation of microglia in response to the accumulation of amyloid-β peptide (aβ). |
2023-07-31 |
2023-08-14 |
Not clear |
| Hans-Gert Bernstein, Karl-Heinz Smalla, Gerburg Keilhoff, Henrik Dobrowolny, Michael R Kreutz, Johann Steine. The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the Healthy Brain, Dysregulated in Numerous Brain Disorders. Journal of chemical neuroanatomy. 2023-07-31. PMID:37524128. |
in the healthy cns, they occur in neurons and non-neuronal cells (oligodendrocytes, astrocytes, microglia, and endothelial cells) and fulfill pivotal functions in brain development and aging, the regulation of brain metabolism, maintenance of structural integrity, synapse formation, aminoacidergic neurotransmission and, probably, regulation of brain action of certain hypothalamic-pituitary hormones.with regard to the diseased brain there is increasing evidence that prohibitins are prominently involved in numerous major diseases of the cns, which are summarized and discussed in the present review (brain tumors, neurotropic viruses, alzheimer disease, down syndrome, fronto-temporal and vascular dementia, dementia with lewy bodies, parkinson disease, huntington disease, multiple sclerosis, amyotrophic lateral sclerosis, stroke, alcohol use disorder, schizophrenia and autism). |
2023-07-31 |
2023-08-14 |
Not clear |
| Chunrong Li, Kangding Liu, Jie Zhu, Feiqi Zh. The effects of high plasma levels of Aβ Immunity & ageing : I & A. vol 20. issue 1. 2023-07-31. PMID:37525137. |
the effects of high plasma levels of aβ more and more evidences are proving that microglia play a crucial role in the pathogenesis of alzheimer's disease (ad) and the plasma aβ |
2023-07-31 |
2023-08-14 |
Not clear |