| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J West, C H Kawas, L J Martin, J C Troncos. The CA1 region of the human hippocampus is a hot spot in Alzheimer's disease. Annals of the New York Academy of Sciences. vol 908. 2000-08-17. PMID:10911964. |
data from an ongoing study of differences in the total number of neurons in the five major subdivisions of the hippocampal regions of the brains of patients with alzheimer's disease (ad) and normal age-matched controls confirm an earlier finding from our laboratories of a pronounced loss of ca1 neurons associated with ad. |
2000-08-17 |
2023-08-12 |
human |
| A Takeuchi, M C Irizarry, K Duff, T C Saido, K Hsiao Ashe, M Hasegawa, D M Mann, B T Hyman, T Iwatsub. Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. The American journal of pathology. vol 157. issue 1. 2000-08-08. PMID:10880403. |
to analyze the relationship between the deposition of amyloid beta peptides (abeta) and neuronal loss in transgenic models of alzheimer's disease (ad), we examined the frontal neocortex (fc) and ca1 portion of hippocampus (ca1) in psapp mice doubly expressing ad-associated mutant presenilin 1 (ps1) and swedish-type mutant beta amyloid precursor protein (appsw) by morphometry of abeta burden and neuronal counts. |
2000-08-08 |
2023-08-12 |
mouse |
| S D Ginsberg, S E Hemby, V M Lee, J H Eberwine, J Q Trojanowsk. Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Annals of neurology. vol 48. issue 1. 2000-07-31. PMID:10894219. |
expression profile of transcripts in alzheimer's disease tangle-bearing ca1 neurons. |
2000-07-31 |
2023-08-12 |
Not clear |
| M Z Smith, Z Nagy, M M Esir. Cell cycle-related protein expression in vascular dementia and Alzheimer's disease. Neuroscience letters. vol 271. issue 1. 1999-10-19. PMID:10471210. |
however, cyclin b1 expression was significantly elevated in the ca1 of patients suffering from cerebro-vascular disease alone, while cyclin e expression was significantly higher in the ca4 subfield in patients suffering from mixed alzheimer's and cerebro-vascular diseases compared to subjects in other categories. |
1999-10-19 |
2023-08-12 |
human |
| A Parent, D J Linden, S S Sisodia, D R Borchel. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1. Neurobiology of disease. vol 6. issue 1. 1999-05-06. PMID:10078973. |
ps1 is expressed in a variety of neuronal and peripheral tissues, including neuronal populations known to be at risk in alzheimer's disease such as ca1 hippocampal neurons. |
1999-05-06 |
2023-08-12 |
mouse |
| M Bobinski, M J de Leon, M Tarnawski, J Wegiel, B Reisberg, D C Miller, H M Wisniewsk. Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease. Brain research. vol 805. issue 1-2. 1998-11-25. PMID:9733982. |
neuronal and volume loss in ca1 of the hippocampal formation uniquely predicts duration and severity of alzheimer disease. |
1998-11-25 |
2023-08-12 |
Not clear |
| M Bobinski, M J de Leon, M Tarnawski, J Wegiel, B Reisberg, D C Miller, H M Wisniewsk. Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease. Brain research. vol 805. issue 1-2. 1998-11-25. PMID:9733982. |
in a series of multiple regression models predicting either duration or severity of alzheimer disease (ad) patients, significant linear correlations were found consistently for the volume of ca1, the subiculum, and the entorhinal cortex. |
1998-11-25 |
2023-08-12 |
Not clear |
| M Bobinski, J Wegiel, M Tarnawski, M J de Leon, B Reisberg, D C Miller, H M Wisniewsk. Duration of neurofibrillary changes in the hippocampal pyramidal neurons. Brain research. vol 799. issue 1. 1998-09-11. PMID:9666111. |
the total number of neurons with and without neurofibrillary changes in sectors ca1 to ca4, subiculum, and dentate gyrus of 16 subjects with alzheimer disease (ad) was estimated. |
1998-09-11 |
2023-08-12 |
human |
| A Salehi, J M Bakker, M Mulder, D F Swaa. Limited effect of neuritic plaques on neuronal density in the hippocampal CA1 area of Alzheimer patients. Alzheimer disease and associated disorders. vol 12. issue 2. 1998-09-08. PMID:9651135. |
limited effect of neuritic plaques on neuronal density in the hippocampal ca1 area of alzheimer patients. |
1998-09-08 |
2023-08-12 |
Not clear |
| Y Ihar. [beta-amyloidogenesis]. Rinsho shinkeigaku = Clinical neurology. vol 37. issue 12. 1998-07-01. PMID:9577656. |
from consecutive autopsy cases (n = 76; age range: 24-92 years) and confirmed alzheimer's disease cases (n = 7; age range: 60-79 years), hippocampus ca1 and occipitotemporal cortex t4 were sampled for a beta quantitation. |
1998-07-01 |
2023-08-12 |
Not clear |
| E Aronica, D W Dickson, Y Kress, J H Morrison, R S Zuki. Non-plaque dystrophic dendrites in Alzheimer hippocampus: a new pathological structure revealed by glutamate receptor immunocytochemistry. Neuroscience. vol 82. issue 4. 1998-03-26. PMID:9466422. |
alzheimer's disease is a progressive dementia characterized by a pronounced neurodegeneration in the entorhinal cortex, hippocampal ca1, and subiculum. |
1998-03-26 |
2023-08-12 |
human |
| P Giannakopoulos, P R Hof, J P Michel, J Guimon, C Boura. Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts. Brain research. Brain research reviews. vol 25. issue 2. 1998-01-15. PMID:9403139. |
moreover, alzheimer's disease symptomatology is characterized in these very old patients by high neurofibrillary tangle densities in the anterior ca1 field, but not in the entorhinal cortex and inferior temporal cortex. |
1998-01-15 |
2023-08-12 |
human |
| J Ulas, C W Cotma. Decreased expression of N-methyl-D-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain. Neuroscience. vol 79. issue 4. 1997-10-23. PMID:9219960. |
the analysis of emulsion-dipped tissue revealed a trend toward a decrease in the number of silver grains overlying individual neurons in the ca1, entorhinal cortex, and granule cell layer of some alzheimer patients. |
1997-10-23 |
2023-08-12 |
human |
| C P Mauriz. Loss of intraventricular fluid melatonin can explain the neuropathology of Alzheimer's disease. Medical hypotheses. vol 49. issue 2. 1997-10-07. PMID:9278927. |
loss of intraventricular fluid melatonin explains why alzheimer's disease neuropathology has a laminar, regional and neural-system-specific pattern, which includes the entorhinal cortex, ca1 of the hippocampus, the dorsal raphe nucleus and the locus ceruleus. |
1997-10-07 |
2023-08-12 |
Not clear |
| E Braak, H Braa. Alzheimer's disease: transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon's horn. Acta neuropathologica. vol 93. issue 4. 1997-06-17. PMID:9113196. |
alzheimer's disease: transiently developing dendritic changes in pyramidal cells of sector ca1 of the ammon's horn. |
1997-06-17 |
2023-08-12 |
Not clear |
| A J Harding, A Wong, M Svoboda, J J Kril, G M Hallida. Chronic alcohol consumption does not cause hippocampal neuron loss in humans. Hippocampus. vol 7. issue 1. 1997-05-05. PMID:9138671. |
neuron loss occurred exclusively from the ca1 and subiculum subregions of the hippocampus in alzheimer's disease. |
1997-05-05 |
2023-08-12 |
human |
| B Connor, D Young, P Lawlor, W Gai, H Waldvogel, R L Faull, M Draguno. Trk receptor alterations in Alzheimer's disease. Brain research. Molecular brain research. vol 42. issue 1. 1997-03-25. PMID:8915574. |
alzheimer's disease hippocampi displayed an increase in trka receptor levels in astrocytes in the ca1 region, some of which were associated with beta-amyloid-positive plaques. |
1997-03-25 |
2023-08-12 |
human |
| J W Geddes, Z Pang, D H Wile. Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease. Molecular and chemical neuropathology. vol 28. issue 1-3. 1997-01-23. PMID:8871943. |
to determine if impaired energy metabolism might contribute to some aspects of alzheimer disease (ad), including the vulnerability of the ca1 region of the hippocampal formation and the altered cytoskeleton evident in neurofibrillary tangles, we examined the effects of metabolic poisons on neuronal damage and cytoskeletal disruption in the hippocampal formation. |
1997-01-23 |
2023-08-12 |
Not clear |
| P Giannakopoulos, P R Hof, P G Vallet, A S Giannakopoulos, Y Charnay, C Boura. Quantitative analysis of neuropathologic changes in the cerebral cortex of centenarians. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 4. 1996-03-22. PMID:8588057. |
furthermore, they indicate that both the neurofibrillary tangle densities in the ca1 field and senile plaque densities in the superficial layers of the neocortex must be considered for the neuropathological diagnosis of alzheimer's disease in this age group. |
1996-03-22 |
2023-08-12 |
Not clear |
| M Yamazaki, I Nakano, O Imazu, A Terash. Paired helical filaments and straight tubules in astrocytes: an electron microscopic study in dementia of the Alzheimer type. Acta neuropathologica. vol 90. issue 1. 1995-11-22. PMID:7572076. |
ultrastructural investigation of the hippocampal ca1 and ca4 of nine autopsy-proven cases of dementia of the alzheimer type (duration of disease: 3-16 years; age: 76-92 years) revealed paired helical filaments (phfs) and straight tubules (sts) in astrocytes of three advanced cases of long duration (> 13 years). |
1995-11-22 |
2023-08-12 |
Not clear |