| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shafiq Ul Rehman, Noha Tarek, Caroline Magdy, Mohammed Kamel, Mohammed Abdelhalim, Alaa Melek, Lamees N Mahmoud, Ibrahim Sade. AI-based tool for early detection of Alzheimer's disease. Heliyon. vol 10. issue 8. 2024-04-22. PMID:38644855. |
the hippocampus, a pivotal early affected region linked to memory, plays a central role in classifying patients into three categories: cognitively normal (cn), representing individuals without cognitive impairment; mild cognitive impairment (mci), indicative of a subtle decline in cognitive abilities; and ad, denoting alzheimer's disease. |
2024-04-22 |
2024-04-24 |
Not clear |
| Ketaki A Katdare, Andrew Kjar, Natasha M O'Brown, Emma H Neal, Alexander G Sorets, Alena Shostak, Wilber Romero-Fernandez, Alexander J Kwiatkowski, Kate Mlouk, Hyosung Kim, Rebecca P Cowell, Katrina R Schwensen, Kensley B Horner, John T Wilson, Matthew S Schrag, Sean G Megason, Ethan S Lippman. IQGAP2 regulates blood-brain barrier immune dynamics. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645082. |
human tissue analyses also reveal that alzheimer's disease is associated with reduced hippocampal iqgap2. |
2024-04-22 |
2024-04-24 |
mouse |
| Gabriel S Stephens, Jin Park, Andrew Eagle, Jason You, Manuel Silva-Pérez, Chia-Hsuan Fu, Sumin Choi, Corey P St Romain, Chiho Sugimoto, Shelly A Buffington, Yi Zheng, Mauro Costa-Mattioli, Yin Liu, A J Robison, Jeannie Chi. Persistent ∆FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice. Progress in neurobiology. 2024-04-20. PMID:38642602. |
recurrent seizures lead to accumulation of the activity-dependent transcription factor ∆fosb in hippocampal dentate granule cells in both mouse models of epilepsy and mouse models of alzheimer's disease (ad), which is also associated with increased incidence of seizures. |
2024-04-20 |
2024-04-23 |
mouse |
| Claudia Dorado-Martínez, Enrique Montiel-Flores, Jose Luis Ordoñez-Librado, Ana Luisa Gutierrez-Valdez, Cesar Alfonso Garcia-Caballero, Javier Sanchez-Betancourt, Leonardo Reynoso-Erazo, Rocio Tron-Alvarez, Vianey Rodríguez-Lara, Maria Rosa Avila-Cost. Histological and Memory Alterations in an Innovative Alzheimer's Disease Animal Model by Vanadium Pentoxide Inhalation. Journal of Alzheimer's disease : JAD. 2024-04-19. PMID:38640149. |
previous work from our group has shown that chronic exposure to vanadium pentoxide (v2o5) causes cytoskeletal alterations suggesting that v2o5 can interact with cytoskeletal proteins through polymerization and tyrosine phosphatases inhibition, causing alzheimer's disease (ad)-like hippocampal cell death. |
2024-04-19 |
2024-04-22 |
Not clear |
| Zhigeng Chen, Sheng Bi, Yi Shan, Bixiao Cui, Hongwei Yang, Zhigang Qi, Zhilian Zhao, Ying Han, Shaozhen Yan, Jie L. Multiparametric hippocampal signatures for early diagnosis of Alzheimer's disease using CNS neuroscience & therapeutics. vol 30. issue 4. 2024-04-15. PMID:38031997. |
multiparametric hippocampal signatures for early diagnosis of alzheimer's disease using this study aimed to explore the utility of hippocampal radiomics using multiparametric simultaneous positron emission tomography (pet)/magnetic resonance imaging (mri) for early diagnosis of alzheimer's disease (ad). |
2024-04-15 |
2024-04-17 |
Not clear |
| Akansh Goal, Khadga Raj, Shamsher Singh, Rimpi Aror. Protective effects of Embelin in Benzo[α]pyrene induced cognitive and memory impairment in experimental model of mice. Current research in neurobiology. vol 6. 2024-04-15. PMID:38616958. |
alzheimer's disease (ad) is a neurodegenerative disease that affects the neurons in the hippocampus, resulting in cognitive and memory impairment. |
2024-04-15 |
2024-04-17 |
mouse |
| Alex Orlowski, Joseph Karippaparambil, Jean-Michel Paumier, Shraddha Ghanta, Eduardo Pallares, Jamuna Tandukar, Ruixuan Gao, Swetha Gowrishanka. Axonal organelle buildup from loss of AP-4 complex function causes exacerbation of amyloid plaque pathology and gliosis in Alzheimer's disease mouse model. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617351. |
our studies examining whether the abnormal axonal lysosome build up resulting from ap-4 loss could lead to amyloidogenesis revealed that the loss of ap-4 complex function in an alzheimer's disease model resulted in a strong increase in size and abundance of amyloid plaques in the hippocampus and corpus callosum as well as increased microglial association with the plaques. |
2024-04-15 |
2024-04-17 |
mouse |
| Peter T Nelson, David W Fardo, Xian Wu, Khine Zin Aung, Matthew D Cykowski, Yuriko Katsumat. Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis. Journal of neuropathology and experimental neurology. 2024-04-13. PMID:38613823. |
although "pure" late-nc is not rare, late-nc often coexists in the same brains with alzheimer disease neuropathologic change, brain arteriolosclerosis, hippocampal sclerosis of aging, and/or age-related tau astrogliopathy (artag). |
2024-04-13 |
2024-04-16 |
human |
| Neda Shafiee, Vladimir Fonov, Mahsa Dadar, R Nathan Spreng, D Louis Collin. Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer's disease progression. Neurobiology of aging. vol 139. 2024-04-12. PMID:38608458. |
nucleus basalis of meynert (nbm), a crucial source of cholinergic projection to the entorhinal cortex (ec) and hippocampus (hc), has shown sensitivity to neurofibrillary degeneration in the early stages of alzheimer's disease. |
2024-04-12 |
2024-04-15 |
human |
| Gavin T Kress, Emily S Popa, David A Merrill, Jennifer E Bramen, Prabha Siddart. The impact of physical exercise on hippocampal atrophy in mild cognitive impairment and Alzheimer's disease: a meta-analysis. Neuroreport. 2024-04-12. PMID:38606637. |
the impact of physical exercise on hippocampal atrophy in mild cognitive impairment and alzheimer's disease: a meta-analysis. |
2024-04-12 |
2024-04-14 |
human |
| Christian Sandøe Musaeus, Troels Wesenberg Kjaer, Ulrich Lindberg, Mark B Vestergaard, Henrik Bo, Wiberg Larsson, Daniel Zvi Press, Birgitte Bo Andersen, Peter Høgh, Preben Kidmose, Martin Christian Hemmsen, Mike Lind Rank, Steen Gregers Hasselbalch, Gunhild Waldemar, Kristian Steen Frederikse. Subclinical epileptiform discharges in Alzheimer's disease are associated with increased hippocampal blood flow. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-12. PMID:38610005. |
subclinical epileptiform discharges in alzheimer's disease are associated with increased hippocampal blood flow. |
2024-04-12 |
2024-04-15 |
Not clear |
| Christian Sandøe Musaeus, Troels Wesenberg Kjaer, Ulrich Lindberg, Mark B Vestergaard, Henrik Bo, Wiberg Larsson, Daniel Zvi Press, Birgitte Bo Andersen, Peter Høgh, Preben Kidmose, Martin Christian Hemmsen, Mike Lind Rank, Steen Gregers Hasselbalch, Gunhild Waldemar, Kristian Steen Frederikse. Subclinical epileptiform discharges in Alzheimer's disease are associated with increased hippocampal blood flow. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-12. PMID:38610005. |
patients with alzheimer's disease (ad) have an increased prevalence of epileptiform discharges and a study using intracranial electrodes have shown that these are very frequent in the hippocampus. |
2024-04-12 |
2024-04-15 |
Not clear |
| Christian Sandøe Musaeus, Troels Wesenberg Kjaer, Ulrich Lindberg, Mark B Vestergaard, Henrik Bo, Wiberg Larsson, Daniel Zvi Press, Birgitte Bo Andersen, Peter Høgh, Preben Kidmose, Martin Christian Hemmsen, Mike Lind Rank, Steen Gregers Hasselbalch, Gunhild Waldemar, Kristian Steen Frederikse. Subclinical epileptiform discharges in Alzheimer's disease are associated with increased hippocampal blood flow. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-12. PMID:38610005. |
the objective of the study was to investigate the association between rcbf in hippocampus and epileptiform discharges as measured with ear-eeg in patients with alzheimer's disease. |
2024-04-12 |
2024-04-15 |
Not clear |
| Corrigendum: Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase IV protein levels in Alzheimer's disease model rats. Neural regeneration research. vol 19. issue 12. 2024-04-10. PMID:38595284. |
corrigendum: genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase iv protein levels in alzheimer's disease model rats. |
2024-04-10 |
2024-04-12 |
rat |
| Jordan N Williamson, Shirley A James, Sean P Mullen, Bradley P Sutton, Tracey Wszalek, Beni Mulyana, Peter Mukli, Andriy Yabluchanskiy, Yuan Yan. Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer's disease. GeroScience. 2024-04-10. PMID:38598069. |
the purpose of this study was to determine if the apoe genotype plays a role in the observed sex differences in hippocampal functional connectivity in alzheimer's disease. |
2024-04-10 |
2024-04-12 |
human |
| Riley H Lochner, Anithachristy S Arumanayagam, Suzanne Z Powell, Joseph C Masdeu, Belen Pascual, Matthew D Cykowsk. Anterior insula is more vulnerable than posterior insula to TDP-43 pathology in common dementias and ALS. Journal of neuropathology and experimental neurology. 2024-04-09. PMID:38591790. |
blinded to clinical and neuropathologic data, phospho-tdp (ptdp) inclusion pathology was assessed in paired anterior and posterior insula samples in 105 autopsied patients with alzheimer disease, lewy body disease, late-nc and hippocampal sclerosis (hs), amyotrophic lateral sclerosis (als), and other conditions. |
2024-04-09 |
2024-04-11 |
Not clear |
| Chanin Sillapachaiyaporn, Chamaiphorn Wongwan, Kuljira Mongkolpobsin, Sunita Nilkhet, Ciro Isidoro, Siriporn Chuchawankul, Tewin Tencomna. Ergosterol promotes neurite outgrowth, inhibits amyloid-beta synthesis, and extends longevity: In vitro neuroblastoma and in vivo Caenorhabditis elegans evidence. Life sciences. 2024-04-04. PMID:38574884. |
alzheimer's disease (ad), the most common neurodegenerative disorder associated with aging, is characterized by amyloid-β (aβ) plaques in the hippocampus. |
2024-04-04 |
2024-04-07 |
caenorhabditis_elegans |
| Orly Lazarov, Muskan Gupta, Pavan Kumar, Zachery Morrissey, Trongha Pha. Memory Circuits in Dementia: The Engram, Hippocampal Neurogenesis and Alzheimer's disease. Progress in neurobiology. 2024-04-03. PMID:38570083. |
memory circuits in dementia: the engram, hippocampal neurogenesis and alzheimer's disease. |
2024-04-03 |
2024-04-06 |
Not clear |
| Orly Lazarov, Muskan Gupta, Pavan Kumar, Zachery Morrissey, Trongha Pha. Memory Circuits in Dementia: The Engram, Hippocampal Neurogenesis and Alzheimer's disease. Progress in neurobiology. 2024-04-03. PMID:38570083. |
here, we provide an in-depth consideration of our current understanding of engrams, spanning from molecular to network levels, and hippocampal neurogenesis, in health and alzheimer's disease (ad). |
2024-04-03 |
2024-04-06 |
Not clear |
| Hai Duc Nguyen, Huong Huong V. Molecular mechanisms implicated in protein changes in the Alzheimer's disease human hippocampus. Mechanisms of ageing and development. 2024-03-30. PMID:38554950. |
molecular mechanisms implicated in protein changes in the alzheimer's disease human hippocampus. |
2024-03-30 |
2024-04-02 |
human |