| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Srinivas Ayyadevara, Meenakshisundaram Balasubramaniam, Paul A Parcon, Steven W Barger, W Sue T Griffin, Ramani Alla, Alan J Tackett, Samuel G Mackintosh, Emanuel Petricoin, Weidong Zhou, Robert J Shmookler Rei. Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls. Aging cell. vol 15. issue 5. 2017-06-05. PMID:27448508. |
compact hippocampal aggregates were purified from alzheimer's and control-subject pools using magnetic-bead immunoaffinity pulldowns. |
2017-06-05 |
2023-08-13 |
human |
| Cyril Laurent, Guillaume Dorothée, Stéphane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, François-Pierre Légeron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, Kévin Carvalho, Raphaëlle Caillierez, Nadège Zommer, Dominique Demeyer, Nathalie Jouy, Veronique Sazdovitch, Susanna Schraen-Maschke, Cécile Delarasse, Luc Buée, David Blu. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain : a journal of neurology. vol 140. issue 1. 2017-06-05. PMID:27818384. |
altogether, these data support an instrumental role of hippocampal t cell infiltration in tau-driven pathophysiology and cognitive impairments in alzheimer's disease and other tauopathies. |
2017-06-05 |
2023-08-13 |
mouse |
| Gamze Balci Camsari, Melissa E Murray, Neill R Graff-Radfor. Case Studies Illustrating Focal Alzheimer's, Fluent Aphasia, Late-Onset Memory Loss, and Rapid Dementia. Neurologic clinics. vol 34. issue 3. 2017-06-01. PMID:27445249. |
these include focal cortical presentations of alzheimer's disease (ad; posterior cortical atrophy and corticobasal syndrome [cbs]), fluent aphasia (semantic dementia and logopenic aphasia), late-onset slowly progressive dementia (hippocampal sclerosis and limbic predominant ad) and rapidly progressive dementia (creutzfeldt-jakob disease and limbic encephalitis). |
2017-06-01 |
2023-08-13 |
Not clear |
| Yan Liu, Yanfeng Xu, Ling Zhang, Lan Huang, Pin Yu, Hua Zhu, Wei Deng, Chuan Qi. Down-Regulated Drebrin Aggravates Cognitive Impairments in a Mouse Model of Alzheimer's Disease. International journal of molecular sciences. vol 18. issue 4. 2017-06-01. PMID:28398234. |
a noticeable decline of this protein has been found in the hippocampus and cortex of patients with alzheimer's disease (ad), yet the relationship between dbn and ad has not been fully understood. |
2017-06-01 |
2023-08-13 |
mouse |
| Brian A Gordon, Tyler Blazey, Yi Su, Anne M Fagan, David M Holtzman, John C Morris, Tammie L S Benzinge. Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non-Alzheimer Disease Pathophysiology. JAMA neurology. vol 73. issue 10. 2017-05-29. PMID:27548756. |
longitudinal β-amyloid deposition and hippocampal volume in preclinical alzheimer disease and suspected non-alzheimer disease pathophysiology. |
2017-05-29 |
2023-08-13 |
Not clear |
| Sandro Alves, Guillaume Churlaud, Mickael Audrain, Kristin Michaelsen-Preusse, Romain Fol, Benoit Souchet, Jérôme Braudeau, Martin Korte, David Klatzmann, Nathalie Cartie. Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28003243. |
interleukin-2 (il-2)-deficient mice have cytoarchitectural hippocampal modifications and impaired learning and memory ability reminiscent of alzheimer's disease. |
2017-05-29 |
2023-08-13 |
mouse |
| Sandro Alves, Guillaume Churlaud, Mickael Audrain, Kristin Michaelsen-Preusse, Romain Fol, Benoit Souchet, Jérôme Braudeau, Martin Korte, David Klatzmann, Nathalie Cartie. Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28003243. |
therefore, we investigated il-2 levels in hippocampal biopsies of patients with alzheimer's disease relative to age-matched control individuals. |
2017-05-29 |
2023-08-13 |
mouse |
| Sandro Alves, Guillaume Churlaud, Mickael Audrain, Kristin Michaelsen-Preusse, Romain Fol, Benoit Souchet, Jérôme Braudeau, Martin Korte, David Klatzmann, Nathalie Cartie. Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28003243. |
we first found decreased il-2 levels in hippocampal biopsies of patients with alzheimer's disease. |
2017-05-29 |
2023-08-13 |
mouse |
| Patricia A Boyle, Jingyun Yang, Lei Yu, Sue E Leurgans, Ana W Capuano, Julie A Schneider, Robert S Wilson, David A Bennet. Varied effects of age-related neuropathologies on the trajectory of late life cognitive decline. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28082297. |
alzheimer's disease pathology, macroscopic infarcts, lewy bodies, tdp-43 pathology, and hippocampal sclerosis were associated with progressive cognitive decline, with their deleterious effects increasing over time. |
2017-05-29 |
2023-08-13 |
human |
| Luca Passamonti, Patricia Vázquez Rodríguez, Young T Hong, Kieren S J Allinson, David Williamson, Robin J Borchert, Saber Sami, Thomas E Cope, W Richard Bevan-Jones, P Simon Jones, Robert Arnold, Ajenthan Surendranathan, Elijah Mak, Li Su, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Row. 18F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28122879. |
more specifically, 18f-av-1451 binding was significantly increased in patients with alzheimer's disease, relative to patients with progressive supranuclear palsy and with control subjects, in the hippocampus and in occipital, parietal, temporal, and frontal cortices (t's > 2.2, p's < 0.04). |
2017-05-29 |
2023-08-13 |
human |
| Huimin Zhou, Rui Zhang, Kang Lu, Wenjun Yu, Bing Xie, Dongsheng Cui, Lei Jiang, Qingfu Zhang, Shunjiang X. Deregulation of miRNA-181c potentially contributes to the pathogenesis of AD by targeting collapsin response mediator protein 2 in mice. Journal of the neurological sciences. vol 367. 2017-05-17. PMID:27423553. |
taken together, these findings suggested that crmp2 is a target of mir-181c and that the abnormally low expression of mir-181c in the hippocampus of samp8 mice could lead to an increase of the crmp2 protein level in ad mice, which might potentially play a role in the pathogenesis of alzheimer's disease. |
2017-05-17 |
2023-08-13 |
mouse |
| Cátia F Lourenço, Ana Ledo, Rui M Barbosa, João Laranjinh. Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling. Experimental neurology. vol 291. 2017-05-16. PMID:28161255. |
in this work, we aimed at investigating whether and to what extent neuronal-derived no signaling and related neurovascular coupling are impaired along aging in the hippocampus of the triple transgenic mouse model of alzheimer's disease (3xtg-ad). |
2017-05-16 |
2023-08-13 |
mouse |
| Kejal Kantarci, Timothy Lesnick, Tanis J Ferman, Scott A Przybelski, Bradley F Boeve, Glenn E Smith, Walter K Kremers, David S Knopman, Clifford R Jack, Ronald C Peterse. Hippocampal volumes predict risk of dementia with Lewy bodies in mild cognitive impairment. Neurology. vol 87. issue 22. 2017-05-12. PMID:27807186. |
to predict the risk of probable dementia with lewy bodies (dlb) competing with alzheimer disease (ad) dementia by hippocampal volume (hv) in patients with mild cognitive impairment (mci) with impairments in amnestic or nonamnestic cognitive domains. |
2017-05-12 |
2023-08-13 |
Not clear |
| John P Aggleton, Agathe Pralus, Andrew J D Nelson, Michael Hornberge. Thalamic pathology and memory loss in early Alzheimer's disease: moving the focus from the medial temporal lobe to Papez circuit. Brain : a journal of neurology. vol 139. issue Pt 7. 2017-05-10. PMID:27190025. |
consequently, research into the causes of memory loss in alzheimer's disease continues to centre on hippocampal dysfunction and how disease-modifying therapies in this region can potentially alleviate memory symptomology. |
2017-05-10 |
2023-08-13 |
Not clear |
| Jin Gyu Choi, Namkwon Kim, Eugene Huh, Hwan Lee, Myeong Hwan Oh, Jong Dae Park, Mi Kyung Pyo, Myung Sook O. White Ginseng Protects Mouse Hippocampal Cells Against Amyloid-Beta Oligomer Toxicity. Phytotherapy research : PTR. vol 31. issue 3. 2017-05-09. PMID:28112442. |
these results suggest that wge reverses memory impairment in alzheimer's disease by attenuating neuronal damage and neuroinflammation in the aβo-injected mouse hippocampus. |
2017-05-09 |
2023-08-13 |
mouse |
| Marta Nesteruk, Tomasz Nesteruk, Maria Styczyńska, Monika Mandecka, Anna Barczak, Maria Barcikowsk. Combined use of biochemical and volumetric biomarkers to assess the risk of conversion of mild cognitive impairment to Alzheimer's disease. Folia neuropathologica. vol 54. issue 4. 2017-05-09. PMID:28139818. |
the aim of our study was to evaluate the usefulness of several biomarkers in predicting the conversion of mild cognitive impairment (mci) to alzheimer's disease (ad): β-amyloid and tau proteins in cerebrospinal fluid and the volumetric evaluation of brain structures including the hippocampus in magnetic resonance imaging (mri). |
2017-05-09 |
2023-08-13 |
Not clear |
| François-Laurent De Winter, Louise Emsell, Filip Bouckaert, Lene Claes, Saurabh Jain, Gill Farrar, Thibo Billiet, Stephan Evers, Jan Van den Stock, Pascal Sienaert, Jasmien Obbels, Stefan Sunaert, Katarzyna Adamczuk, Rik Vandenberghe, Koen Van Laere, Mathieu Vandenbulck. No Association of Lower Hippocampal Volume With Alzheimer's Disease Pathology in Late-Life Depression. The American journal of psychiatry. vol 174. issue 3. 2017-05-01. PMID:27539488. |
no association of lower hippocampal volume with alzheimer's disease pathology in late-life depression. |
2017-05-01 |
2023-08-13 |
Not clear |
| François-Laurent De Winter, Louise Emsell, Filip Bouckaert, Lene Claes, Saurabh Jain, Gill Farrar, Thibo Billiet, Stephan Evers, Jan Van den Stock, Pascal Sienaert, Jasmien Obbels, Stefan Sunaert, Katarzyna Adamczuk, Rik Vandenberghe, Koen Van Laere, Mathieu Vandenbulck. No Association of Lower Hippocampal Volume With Alzheimer's Disease Pathology in Late-Life Depression. The American journal of psychiatry. vol 174. issue 3. 2017-05-01. PMID:27539488. |
the purpose of this prospective study was to examine whether lower hippocampal volume in late-life depression is associated with alzheimer's disease pathology. |
2017-05-01 |
2023-08-13 |
Not clear |
| Perla Moreno-Castilla, Rodrigo Pérez-Ortega, Valeria Violante-Soria, Israela Balderas, Federico Bermúdez-Ratton. Hippocampal release of dopamine and norepinephrine encodes novel contextual information. Hippocampus. vol 27. issue 5. 2017-04-25. PMID:28176408. |
the significance of catecholaminergic function may be extended to the clinical field as it has been reported that innervation of hippocampus by the noradrenergic and dopaminergic system is reduced and atrophied in aging and alzheimer's disease brain. |
2017-04-25 |
2023-08-13 |
mouse |
| Alessia Giuliano, Graziella Donatelli, Mirco Cosottini, Michela Tosetti, Alessandra Retico, Maria Evelina Fantacc. Hippocampal subfields at ultra high field MRI: An overview of segmentation and measurement methods. Hippocampus. vol 27. issue 5. 2017-04-25. PMID:28188659. |
studying the morphometry of the hippocampus is crucial in neuroimaging research because changes in volume and thickness of hippocampal subregions may be relevant in the early assessment of pathological cognitive decline and alzheimer's disease (ad). |
2017-04-25 |
2023-08-13 |
Not clear |