| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bolun Li, Jie Shi, Boris A Gutman, Leslie C Baxter, Paul M Thompson, Richard J Caselli, Yalin Wan. Influence of APOE Genotype on Hippocampal Atrophy over Time - An N=1925 Surface-Based ADNI Study. PloS one. vol 11. issue 4. 2016-08-25. PMID:27065111. |
in the alzheimer's disease neuroimaging initiative (adni) cohort, we previously reported significant baseline structural differences in apoe e4 carriers relative to non-carriers, involving the left hippocampus more than the right--a difference more pronounced in e4 homozygotes than heterozygotes. |
2016-08-25 |
2023-08-13 |
human |
| Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Gala. Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo. Neurobiology of disease. vol 82. 2016-08-24. PMID:26385829. |
the accumulation of dna and rna oxidative damage is observed in cortical and hippocampal neurons from alzheimer's disease (ad) brains at early stages of pathology. |
2016-08-24 |
2023-08-13 |
mouse |
| Aránzazu Perianes-Cachero, Sandra Canelles, David Aguado-Llera, Laura M Frago, María Val Toledo-Lobo, Iván Carrera, Ramón Cacabelos, Julie A Chowen, Jesús Argente, Eduardo Arilla-Ferreiro, Vicente Barrio. Reduction in Aβ-induced cell death in the hippocampus of 17β-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone. Journal of neurochemistry. vol 135. issue 6. 2016-08-22. PMID:26442993. |
as alterations in somatostatin have been demonstrated in alzheimer's disease, we examined whether e2 prevents changes in the hippocampal somatostatinergic system induced by aβ25-35 and cell death, as well as the possible involvement of leptin and insulin-like growth factor (igf)-i signaling. |
2016-08-22 |
2023-08-13 |
rat |
| M Dolores Muñoz, Mónica Antolín-Vallespín, Silvia Tapia-González, Amelia Sánchez-Capel. Smad3 deficiency inhibits dentate gyrus LTP by enhancing GABAA neurotransmission. Journal of neurochemistry. vol 137. issue 2. 2016-08-22. PMID:26826552. |
alteration of gaba neurotransmission is thought to produce hippocampal cognitive dysfunction in down's syndrome or alzheimer's disease, and here we provide new insights into the hippocampal changes in an animal model of parkinson's disease. |
2016-08-22 |
2023-08-13 |
mouse |
| Naftali Raz, Ana M Daugherty, Andrew R Bender, Cheryl L Dahle, Susan Lan. Volume of the hippocampal subfields in healthy adults: differential associations with age and a pro-inflammatory genetic variant. Brain structure & function. vol 220. issue 5. 2016-08-19. PMID:24947882. |
we examined the associations of hippocampal subfield volumes with age, a vascular risk factor (hypertension), and genetic polymorphisms associated with variation in pro-inflammatory cytokines levels (il-1β c-511t and il-6 c-174g) and risk for alzheimer's disease (apoeε4) in healthy adult volunteers (n = 80; age = 22-82 years). |
2016-08-19 |
2023-08-13 |
human |
| Melissa J Alldred, Sang Han Lee, Eva Petkova, Stephen D Ginsber. Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). Brain structure & function. vol 220. issue 5. 2016-08-19. PMID:25031177. |
down syndrome (ds) is caused by the triplication of human chromosome 21 (hsa21) and is the most common genetic cause of intellectual disability, with individuals having deficits in cognitive function including hippocampal learning and memory and neurodegeneration of cholinergic basal forebrain neurons, a pathological hallmark of alzheimer's disease (ad). |
2016-08-19 |
2023-08-13 |
mouse |
| Mohamady El-Gaby, Olivia A Shipton, Ole Paulse. Synaptic Plasticity and Memory: New Insights from Hippocampal Left-Right Asymmetries. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 21. issue 5. 2016-08-19. PMID:25239943. |
finally, we outline the potential implications of this left-right asymmetry for human hippocampal function, as well as dysfunction in memory disorders such as alzheimer's disease. |
2016-08-19 |
2023-08-13 |
mouse |
| Sebastian Palmqvist, Niklas Mattsson, Oskar Hansso. Cerebrospinal fluid analysis detects cerebral amyloid-β accumulation earlier than positron emission tomography. Brain : a journal of neurology. vol 139. issue Pt 4. 2016-08-18. PMID:26936941. |
those with both abnormal cerebrospinal fluid and positron emission tomography deteriorated more in memory and hippocampal volume compared with the other groups (p < 0.001), indicating that they were closer to alzheimer's disease dementia. |
2016-08-18 |
2023-08-13 |
human |
| Matthew D Cykowski, Hidehiro Takei, Linda J Van Eldik, Frederick A Schmitt, Gregory A Jicha, Suzanne Z Powell, Peter T Nelso. Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons. Journal of neuropathology and experimental neurology. vol 75. issue 5. 2016-08-18. PMID:26971127. |
hippocampal sclerosis but not normal aging or alzheimer disease is associated with tdp-43 pathology in the basal forebrain of aged persons. |
2016-08-18 |
2023-08-13 |
Not clear |
| Matthew D Cykowski, Hidehiro Takei, Linda J Van Eldik, Frederick A Schmitt, Gregory A Jicha, Suzanne Z Powell, Peter T Nelso. Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons. Journal of neuropathology and experimental neurology. vol 75. issue 5. 2016-08-18. PMID:26971127. |
as expected, many of these brains had comorbid pathologies including those of alzheimer disease (ad), lewy body disease (lbd), and/or hippocampal sclerosis of aging (hs-aging). |
2016-08-18 |
2023-08-13 |
Not clear |
| E J Mufson, L Mahady, D Waters, S E Counts, S E Perez, S T DeKosky, S D Ginsberg, M D Ikonomovic, S W Scheff, L I Binde. Hippocampal plasticity during the progression of Alzheimer's disease. Neuroscience. vol 309. 2016-08-09. PMID:25772787. |
hippocampal plasticity during the progression of alzheimer's disease. |
2016-08-09 |
2023-08-13 |
human |
| Dong Hyun Kim, Dahm Lee, Eun Hyuk Chang, Ji Hyun Kim, Jung Won Hwang, Ju-Yeon Kim, Jae Won Kyung, Sung Hyun Kim, Jeong Su Oh, Sang Mi Shim, Duk Lyul Na, Wonil Oh, Jong Wook Chan. GDF-15 secreted from human umbilical cord blood mesenchymal stem cells delivered through the cerebrospinal fluid promotes hippocampal neurogenesis and synaptic activity in an Alzheimer's disease model. Stem cells and development. vol 24. issue 20. 2016-08-09. PMID:26154268. |
gdf-15 secreted from human umbilical cord blood mesenchymal stem cells delivered through the cerebrospinal fluid promotes hippocampal neurogenesis and synaptic activity in an alzheimer's disease model. |
2016-08-09 |
2023-08-13 |
mouse |
| Dong Hyun Kim, Dahm Lee, Eun Hyuk Chang, Ji Hyun Kim, Jung Won Hwang, Ju-Yeon Kim, Jae Won Kyung, Sung Hyun Kim, Jeong Su Oh, Sang Mi Shim, Duk Lyul Na, Wonil Oh, Jong Wook Chan. GDF-15 secreted from human umbilical cord blood mesenchymal stem cells delivered through the cerebrospinal fluid promotes hippocampal neurogenesis and synaptic activity in an Alzheimer's disease model. Stem cells and development. vol 24. issue 20. 2016-08-09. PMID:26154268. |
our previous studies demonstrated that transplantation of human umbilical cord blood-derived mesenchymal stem cells (hucb-mscs) into the hippocampus of a transgenic mouse model of alzheimer's disease (ad) reduced amyloid-β (aβ) plaques and enhanced cognitive function through paracrine action. |
2016-08-09 |
2023-08-13 |
mouse |
| T Bartsch, P Wulf. The hippocampus in aging and disease: From plasticity to vulnerability. Neuroscience. vol 309. 2016-08-09. PMID:26241337. |
considering this framework of plasticity and vulnerability, we here review basic principles of hippocampal anatomy and neuroplasticity on various levels as well as recent findings regarding the functional organization of the hippocampus in light of the regional vulnerability in alzheimer's disease, ischemia, epilepsy, neuroinflammation and aging. |
2016-08-09 |
2023-08-13 |
human |
| Robin de Flores, Renaud La Joie, Gaël Chétela. Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease. Neuroscience. vol 309. 2016-08-09. PMID:26306871. |
structural imaging of hippocampal subfields in healthy aging and alzheimer's disease. |
2016-08-09 |
2023-08-13 |
Not clear |
| Robin de Flores, Renaud La Joie, Gaël Chétela. Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease. Neuroscience. vol 309. 2016-08-09. PMID:26306871. |
hippocampal atrophy, as evidenced using magnetic resonance imaging (mri), is one of the most validated, easily accessible and widely used biomarkers of alzheimer's disease (ad). |
2016-08-09 |
2023-08-13 |
Not clear |
| Hee Ra Park, Ju Yeon Kim, Yujeong Lee, Hye Jeong Chun, Young Whan Choi, Hwa Kyoung Shin, Byung Tae Choi, Cheol Min Kim, Jaewon Le. PMC-12, a traditional herbal medicine, enhances learning memory and hippocampal neurogenesis in mice. Neuroscience letters. vol 617. 2016-08-08. PMID:26917101. |
the beneficial effects of traditional korean medicine are recognized during the treatment of neurodegenerative conditions, such as, alzheimer's disease and neurocognitive dysfunction, and recently, hippocampal neurogenesis has been reported to be associated with memory function. |
2016-08-08 |
2023-08-13 |
mouse |
| Shahid Ali Shah, Gwang Ho Yoon, Ashfaq Ahmad, Faheem Ullah, Faiz Ul Amin, Myeong Ok Ki. Nanoscale-alumina induces oxidative stress and accelerates amyloid beta (Aβ) production in ICR female mice. Nanoscale. vol 7. issue 37. 2016-08-05. PMID:26315713. |
most importantly, these nano-particles induced alzheimer disease (ad) neuropathology by enhancing the amyloidogenic pathway of amyloid beta (aβ) production, aggregation and implied the progression of neurodegeneration in the cortex and hippocampus of these mice. |
2016-08-05 |
2023-08-13 |
mouse |
| Jin Wang, Ying Jing, Lili Song, Ying Xin. Neuroprotective effects of Wnt/β-catenin signaling pathway against Aβ -induced tau protein over-phosphorylation in PC12 cells. Biochemical and biophysical research communications. vol 471. issue 4. 2016-08-04. PMID:26809093. |
alzheimer's disease (ad) is a progressive neurodegenerative disease, which is characterized by deposition of senile plaque (sp) and appearance of neurofibrillary tangles (nft) in the cerebral cortex and hippocampus. |
2016-08-04 |
2023-08-13 |
Not clear |
| Lilian Calderón-Garcidueñas, Antonieta Mora-Tiscareño, Gastón Melo-Sánchez, Joel Rodríguez-Díaz, Ricardo Torres-Jardón, Martin Styner, Partha S Mukherjee, Weili Lin, Valerie Jewell. A Critical Proton MR Spectroscopy Marker of Alzheimer's Disease Early Neurodegenerative Change: Low Hippocampal NAA/Cr Ratio Impacts APOE ɛ4 Mexico City Children and Their Parents. Journal of Alzheimer's disease : JAD. vol 48. issue 4. 2016-08-03. PMID:26402110. |
a critical proton mr spectroscopy marker of alzheimer's disease early neurodegenerative change: low hippocampal naa/cr ratio impacts apoe ɛ4 mexico city children and their parents. |
2016-08-03 |
2023-08-13 |
Not clear |