| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María José Delgado-Cortés, Ana M Espinosa-Oliva, Manuel Sarmiento, Sandro Argüelles, Antonio J Herrera, Raquel Mauriño, Ruth F Villarán, José L Venero, Alberto Machado, Rocío M de Pablo. Synergistic deleterious effect of chronic stress and sodium azide in the mouse hippocampus. Chemical research in toxicology. vol 28. issue 4. 2016-01-22. PMID:25658758. |
our results point out that chronic stress is a risk factor contributing to amplify and accelerate alzheimer's disease features in the hippocampus. |
2016-01-22 |
2023-08-13 |
mouse |
| Fenglei Chao, Lei Zhang, Yanmin Luo, Qian Xiao, Fulin Lv, Qi He, Chunni Zhou, Yi Zhang, Lin Jiang, Rong Jiang, Hengwei Gu, Yong Tan. Running Exercise Reduces Myelinated Fiber Loss in the Dentate Gyrus of the Hippocampus in APP/PS1 Transgenic Mice. Current Alzheimer research. vol 12. issue 4. 2016-01-20. PMID:25817255. |
to investigate the effect of running exercise on myelinated fibers in the dentate gyrus (dg) of the hippocampus during alzheimer's disease (ad), 6-month-old male app/ps1 transgenic mice were randomly assigned to control or running groups. |
2016-01-20 |
2023-08-13 |
mouse |
| Ailin Song, Jingwen Yan, Sungeun Kim, Shannon Leigh Risacher, Aaron K Wong, Andrew J Saykin, Li Shen, Casey S Green. Network-based analysis of genetic variants associated with hippocampal volume in Alzheimer's disease: a study of ADNI cohorts. BioData mining. vol 9. 2016-01-20. PMID:26788126. |
network-based analysis of genetic variants associated with hippocampal volume in alzheimer's disease: a study of adni cohorts. |
2016-01-20 |
2023-08-13 |
Not clear |
| Xiao Wang, Jinhui Wang, Yi He, Huiying Li, Huishu Yuan, Alan Evans, Xin Yu, Yong He, Huali Wan. Apolipoprotein E ε4 Modulates Cognitive Profiles, Hippocampal Volume, and Resting-State Functional Connectivity in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 45. issue 3. 2016-01-19. PMID:25624419. |
apolipoprotein e ε4 modulates cognitive profiles, hippocampal volume, and resting-state functional connectivity in alzheimer's disease. |
2016-01-19 |
2023-08-13 |
Not clear |
| Peng Zhang, Wen Qin, Dawei Wang, Bing Liu, Yunting Zhang, Tianzi Jiang, Chunshui Y. Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults. Brain structure & function. vol 220. issue 3. 2016-01-15. PMID:24578178. |
impacts of picalm and clu variants associated with alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults. |
2016-01-15 |
2023-08-12 |
human |
| Kyung-Ok Uhm, Mi-Jeong Kim, Makoto Kawaguchi, Hiroyasu Akatsu, Yutaka Miura, Sachiyo Misumi, Hideki Hida, Eun-Kyoung Choi, Yong-Sun Kim, Makoto Michikawa, Cha-Gyun Jun. ATBF1 is a novel amyloid-β protein precursor (AβPP) binding protein that affects AβPP expression. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25079792. |
here, we show that atbf1 levels are increased in the cytoplasm of hippocampal neurons in alzheimer's disease (ad) brains compared with non-ad brains. |
2016-01-15 |
2023-08-13 |
mouse |
| Alon Seifan, Karen S Marder, Jesse Mez, James M Noble, Etty P Cortes, Jean Paul Vonsattel, Lawrence S Honi. Hippocampal laminar distribution of tau relates to Alzheimer's disease and age of onset. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25079799. |
hippocampal laminar distribution of tau relates to alzheimer's disease and age of onset. |
2016-01-15 |
2023-08-13 |
Not clear |
| Alon Seifan, Karen S Marder, Jesse Mez, James M Noble, Etty P Cortes, Jean Paul Vonsattel, Lawrence S Honi. Hippocampal laminar distribution of tau relates to Alzheimer's disease and age of onset. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25079799. |
cerebral deposition of phospho-tau in alzheimer's disease (ad) occurs with varying patterns within hippocampus. |
2016-01-15 |
2023-08-13 |
Not clear |
| Xiaoying Tang, Dominic Holland, Anders M Dale, Laurent Younes, Michael I Mille. The diffeomorphometry of regional shape change rates and its relevance to cognitive deterioration in mild cognitive impairment and Alzheimer's disease. Human brain mapping. vol 36. issue 6. 2016-01-15. PMID:25644981. |
we proposed a diffeomorphometry-based statistical pipeline to study the regional shape change rates of the bilateral hippocampus, amygdala, and ventricle in mild cognitive impairment (mci) and alzheimer's disease (ad) compared with healthy controls (hc), using sequential magnetic resonance imaging (mri) scans of 713 subjects (3,123 scans in total). |
2016-01-15 |
2023-08-13 |
human |
| Gerard Ill-Raga, Marta Tajes, Arnau Busquets-García, Eva Ramos-Fernández, Lina M Vargas, Mònica Bosch-Morató, Biuse Guivernau, Victòria Valls-Comamala, Abel Eraso-Pichot, Francesc X Guix, César Fandos, Mark D Rosen, Michael H Rabinowitz, Rafael Maldonado, Alejandra R Alvarez, Andrés Ozaita, Francisco J Muño. Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis. Antioxidants & redox signaling. vol 22. issue 15. 2016-01-15. PMID:25706765. |
however, hippocampus is dramatically compromised in alzheimer's disease due to the accumulation of amyloid β-peptide, whose production is initiated by β-site app cleaving enzyme 1 (bace1). |
2016-01-15 |
2023-08-13 |
Not clear |
| Evelin L Schaeffer, Wagner F Gatta. Chronic inhibition of brain phospholipase A2 in adult rats impairs the survival of newborn mature neurons in the hippocampus. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 5. 2016-01-13. PMID:25160937. |
these findings show that chronic pla2 inhibition in adult rat hippocampus decreases the number of newborn mature neurons in the ventral dg (reflecting in the whole dg), perhaps by impairing neuronal maturation and survival, and suggest that pla2 inhibition reported in the hippocampus of alzheimer disease subjects might partly contribute to the neurogenic abnormalities found in the dg in this disease. |
2016-01-13 |
2023-08-13 |
human |
| Vijay R Varma, Yi-Fang Chuang, Gregory C Harris, Erwin J Tan, Michelle C Carlso. Low-intensity daily walking activity is associated with hippocampal volume in older adults. Hippocampus. vol 25. issue 5. 2016-01-13. PMID:25483019. |
hippocampal atrophy is associated with memory impairment and dementia and serves as a key biomarker in the preclinical stages of alzheimer's disease. |
2016-01-13 |
2023-08-13 |
human |
| Adam D Bachstetter, Linda J Van Eldik, Frederick A Schmitt, Janna H Neltner, Eseosa T Ighodaro, Scott J Webster, Ela Patel, Erin L Abner, Richard J Kryscio, Peter T Nelso. Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging. Acta neuropathologica communications. vol 3. 2016-01-13. PMID:26001591. |
disease-related microglia heterogeneity in the hippocampus of alzheimer's disease, dementia with lewy bodies, and hippocampal sclerosis of aging. |
2016-01-13 |
2023-08-13 |
Not clear |
| Angela Heck, Matthias Fastenrath, David Coynel, Bianca Auschra, Horst Bickel, Virginie Freytag, Leo Gschwind, Francina Hartmann, Frank Jessen, Hanna Kaduszkiewicz, Wolfgang Maier, Annette Milnik, Michael Pentzek, Steffi G Riedel-Heller, Klara Spalek, Christian Vogler, Michael Wagner, Siegfried Weyerer, Steffen Wolfsgruber, Dominique J-F de Quervain, Andreas Papassotiropoulo. Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease. JAMA psychiatry. vol 72. issue 10. 2016-01-12. PMID:26332608. |
genetic analysis of association between calcium signaling and hippocampal activation, memory performance in the young and old, and risk for sporadic alzheimer disease. |
2016-01-12 |
2023-08-13 |
human |
| Angela Heck, Matthias Fastenrath, David Coynel, Bianca Auschra, Horst Bickel, Virginie Freytag, Leo Gschwind, Francina Hartmann, Frank Jessen, Hanna Kaduszkiewicz, Wolfgang Maier, Annette Milnik, Michael Pentzek, Steffi G Riedel-Heller, Klara Spalek, Christian Vogler, Michael Wagner, Siegfried Weyerer, Steffen Wolfsgruber, Dominique J-F de Quervain, Andreas Papassotiropoulo. Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease. JAMA psychiatry. vol 72. issue 10. 2016-01-12. PMID:26332608. |
human episodic memory performance is linked to the function of specific brain regions, including the hippocampus; declines as a result of increasing age; and is markedly disturbed in alzheimer disease (ad), an age-associated neurodegenerative disorder that primarily affects the hippocampus. |
2016-01-12 |
2023-08-13 |
human |
| Charles Duyckaerts, Heiko Braak, Jean-Pierre Brion, Luc Buée, Kelly Del Tredici, Michel Goedert, Glenda Halliday, Manuela Neumann, Maria Grazia Spillantini, Markus Tolnay, Toshiki Uchihar. PART is part of Alzheimer disease. Acta neuropathologica. vol 129. issue 5. 2016-01-11. PMID:25628035. |
it has been proposed that tau aggregation confined to entorhinal cortex and hippocampus, with no or only minimal aβ deposition, should be considered as a 'primary age-related tauopathy' (part) that is not integral to the continuum of sporadic alzheimer disease (ad). |
2016-01-11 |
2023-08-13 |
Not clear |
| Mansi B Parekh, Brian K Rutt, Ryan Purcell, Yuanxin Chen, Michael M Zeine. Ultra-high resolution in-vivo 7.0T structural imaging of the human hippocampus reveals the endfolial pathway. NeuroImage. vol 112. 2016-01-11. PMID:25701699. |
the hippocampus is a very important structure in memory formation and retrieval, as well as in various neurological disorders such as alzheimer's disease, epilepsy and depression. |
2016-01-11 |
2023-08-13 |
human |
| Holly C Hunsberger, Daniel S Weitzner, Carolyn C Rudy, James E Hickman, Eric M Libell, Rebecca R Speer, Greg A Gerhardt, Miranda N Ree. Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26146790. |
hyperexcitability of the hippocampus is a commonly observed phenomenon in the years preceding a diagnosis of alzheimer's disease (ad). |
2016-01-11 |
2023-08-13 |
mouse |
| Tian Ge, Thomas E Nichols, Debashis Ghosh, Elizabeth C Mormino, Jordan W Smoller, Mert R Sabunc. A kernel machine method for detecting effects of interaction between multidimensional variable sets: an imaging genetics application. NeuroImage. vol 109. 2016-01-07. PMID:25600633. |
as a demonstration of application, we applied the method to the data from the alzheimer's disease neuroimaging initiative (adni) to detect the effects of the interactions between candidate alzheimer's disease (ad) risk genes and a collection of cardiovascular disease (cvd) risk factors, on hippocampal volume measurements derived from structural brain magnetic resonance imaging (mri) scans. |
2016-01-07 |
2023-08-13 |
Not clear |
| Xiang-Hua Liu, Zhao Geng, Jing Yan, Ting Li, Qun Chen, Qun-Ye Zhang, Zhe-Yu Che. Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease. Neurobiology of disease. vol 74. 2016-01-06. PMID:25484286. |
moreover, we found that beta-amyloid (aβ) oligomer exposure could impair bdnf-dependent trkb endocytosis and akt activation through enhancing gsk3β activity in cultured hippocampal neurons, which suggested that bdnf-induced trkb endocytosis and the subsequent signaling were impaired in neuronal model of alzheimer's disease (ad). |
2016-01-06 |
2023-08-13 |
mouse |