| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher S Casley, Viktor Lakics, Hyoung-gon Lee, Lisa M Broad, Theresa A Day, Tricia Cluett, Mark A Smith, Michael J O'Neill, Ann E Kingsto. Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide. Brain research. vol 1260. 2015-03-30. PMID:19401173. |
the changes observed in vitro were consistent with results obtained from human alzheimer's disease (ad) patients.immunostaining for mglu5 receptors was increased on astrocytes which were colocalized with aβ plaques in hippocampal tissue from ad patients compared to age-matched controls. |
2015-03-30 |
2023-08-12 |
human |
| Rong Zhao, Stephanie W Fowler, Angie C A Chiang, Daoyun Ji, Joanna L Jankowsk. Impairments in experience-dependent scaling and stability of hippocampal place fields limit spatial learning in a mouse model of Alzheimer's disease. Hippocampus. vol 24. issue 8. 2015-03-30. PMID:24752989. |
impairments in experience-dependent scaling and stability of hippocampal place fields limit spatial learning in a mouse model of alzheimer's disease. |
2015-03-30 |
2023-08-13 |
mouse |
| Rasoul Ghasemi, Asadollah Zarifkar, Karim Rastegar, Nader maghsoudi, Maryam Moosav. Insulin protects against Aβ-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption. Neuropharmacology. vol 85. 2015-03-30. PMID:24881967. |
alzheimer disease (ad) is a progressive neurodegenerative disease characterized by extracellular deposits of beta amyloid (aβ) and neuronal loss particularly in the hippocampus. |
2015-03-30 |
2023-08-13 |
rat |
| Selvaraju Subash, Musthafa Mohamed Essa, Abdullah Al-Asmi, Samir Al-Adawi, Ragini Vaishna. Chronic dietary supplementation of 4% figs on the modification of oxidative stress in Alzheimer's disease transgenic mouse model. BioMed research international. vol 2014. 2015-03-30. PMID:25050360. |
we assessed the changes in the plasma aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of alzheimer's disease (ad) transgenic mice (tg2576) after dietary supplementation of omani figs fruits for 15 months along with spatial memory and learning test. |
2015-03-30 |
2023-08-13 |
mouse |
| Katherine A Price, Merina Varghese, Allison Sowa, Frank Yuk, Hannah Brautigam, Michelle E Ehrlich, Dara L Dickstei. Altered synaptic structure in the hippocampus in a mouse model of Alzheimer's disease with soluble amyloid-β oligomers and no plaque pathology. Molecular neurodegeneration. vol 9. 2015-03-30. PMID:25312309. |
altered synaptic structure in the hippocampus in a mouse model of alzheimer's disease with soluble amyloid-β oligomers and no plaque pathology. |
2015-03-30 |
2023-08-13 |
mouse |
| Jing Jiang, Kai Gao, Yuan Zhou, Anping Xu, Suhua Shi, Gang Liu, Zhigang L. Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer's Disease: Using Morris Water Maze and Micro-PET. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-03-30. PMID:25821477. |
alzheimer's disease (ad) causes progressive hippocampus dysfunctions leading to the impairment of learning and memory ability and low level of uptake rate of glucose in hippocampus. |
2015-03-30 |
2023-08-13 |
mouse |
| Ying Liu, Jin-Tai Yu, Hui-Fu Wang, Pei-Ran Han, Chen-Chen Tan, Chong Wang, Xiang-Fei Meng, Shannon L Risacher, Andrew J Saykin, Lan Ta. APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis. Journal of neurology, neurosurgery, and psychiatry. vol 86. issue 2. 2015-03-27. PMID:24838911. |
we aimed to examine the association of apolipoprotein e (apoe) ɛ4 genotype with neuroimaging markers of alzheimer's disease: hippocampal volume, brain amyloid deposition and cerebral metabolism. |
2015-03-27 |
2023-08-13 |
Not clear |
| Ping Zhang, Gangyong Zhao, Xianjiang Kang, Likai S. Effects of lateral ventricular transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene on cognition in a rat model of Alzheimer's disease. Neural regeneration research. vol 7. issue 4. 2015-03-25. PMID:25806063. |
results indicate that transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene can significantly improve cognitive function in a rat model of alzheimer's disease, possibly by increasing the levels of brain-derived neurotrophic factor and tyrosine kinase b in the hippocampus. |
2015-03-25 |
2023-08-13 |
rat |
| Kevin Richetin, Clémence Leclerc, Nicolas Toni, Thierry Gallopin, Stéphane Pech, Laurent Roybon, Claire Rampo. Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer's disease. Brain : a journal of neurology. vol 138. issue Pt 2. 2015-03-23. PMID:25518958. |
genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of alzheimer's disease. |
2015-03-23 |
2023-08-13 |
mouse |
| Kevin Richetin, Clémence Leclerc, Nicolas Toni, Thierry Gallopin, Stéphane Pech, Laurent Roybon, Claire Rampo. Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer's disease. Brain : a journal of neurology. vol 138. issue Pt 2. 2015-03-23. PMID:25518958. |
when tested in an appxps1 mouse model of alzheimer's disease, directed expression of neurod1 in cycling hippocampal progenitors conspicuously reduced dendritic spine density deficits on new hippocampal neurons, to the same level as that observed in healthy age-matched control animals. |
2015-03-23 |
2023-08-13 |
mouse |
| Holly C Hunsberger, Carolyn C Rudy, Seth R Batten, Greg A Gerhardt, Miranda N Ree. P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway. Journal of neurochemistry. vol 132. issue 2. 2015-03-16. PMID:25319522. |
individuals at risk of developing alzheimer's disease (ad) often exhibit hippocampal hyperexcitability. |
2015-03-16 |
2023-08-13 |
mouse |
| Yinghong Li, Zhengzhi Wu, Yu Jin, Anmin Wu, Meiqun Cao, Kehuan Sun, Xiuqin Jia, Manyin Che. Analysis of hippocampal gene expression profile of Alzheimer's disease model rats using genome chip bioinformatics. Neural regeneration research. vol 7. issue 5. 2015-03-16. PMID:25774171. |
analysis of hippocampal gene expression profile of alzheimer's disease model rats using genome chip bioinformatics. |
2015-03-16 |
2023-08-13 |
rat |
| Yinghong Li, Zhengzhi Wu, Yu Jin, Anmin Wu, Meiqun Cao, Kehuan Sun, Xiuqin Jia, Manyin Che. Analysis of hippocampal gene expression profile of Alzheimer's disease model rats using genome chip bioinformatics. Neural regeneration research. vol 7. issue 5. 2015-03-16. PMID:25774171. |
in this study, an alzheimer's disease model was established in rats through stereotactic injection of condensed amyloid beta 1-40 into the bilateral hippocampus, and the changes of gene expression profile in the hippocampus of rat models and sham-operated rats were compared by genome expression profiling analysis. |
2015-03-16 |
2023-08-13 |
rat |
| Yinghong Li, Zhengzhi Wu, Yu Jin, Anmin Wu, Meiqun Cao, Kehuan Sun, Xiuqin Jia, Manyin Che. Analysis of hippocampal gene expression profile of Alzheimer's disease model rats using genome chip bioinformatics. Neural regeneration research. vol 7. issue 5. 2015-03-16. PMID:25774171. |
results showed that the expression of 50 genes was significantly up-regulated (fold change ≥ 2), while 21 genes were significantly down-regulated in the hippocampus of alzheimer's disease model rats (fold change ≤ 0.5) compared with the sham-operation group. |
2015-03-16 |
2023-08-13 |
rat |
| Yinghong Li, Zhengzhi Wu, Yu Jin, Anmin Wu, Meiqun Cao, Kehuan Sun, Xiuqin Jia, Manyin Che. Analysis of hippocampal gene expression profile of Alzheimer's disease model rats using genome chip bioinformatics. Neural regeneration research. vol 7. issue 5. 2015-03-16. PMID:25774171. |
our findings indicate that several genes were abnormally expressed in the metabolic and signal transduction pathways in the hippocampus of amyloid beta 1-40-induced rat model of alzheimer's disease, thereby affecting the hippocampal and brain functions. |
2015-03-16 |
2023-08-13 |
rat |
| J C Gant, E M Blalock, K-C Chen, I Kadish, N M Porter, C M Norris, O Thibault, P W Landfiel. FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation? European journal of pharmacology. vol 739. 2015-03-13. PMID:24291098. |
moreover, in microarray studies, we found fkbp1b gene expression was downregulated in hippocampus of aging rats and early-stage alzheimer's disease subjects. |
2015-03-13 |
2023-08-12 |
human |
| Davide Vito Morett. Electroencephalography reveals lower regional blood perfusion and atrophy of the temporoparietal network associated with memory deficits and hippocampal volume reduction in mild cognitive impairment due to Alzheimer's disease. Neuropsychiatric disease and treatment. vol 11. 2015-03-09. PMID:25750526. |
electroencephalography reveals lower regional blood perfusion and atrophy of the temporoparietal network associated with memory deficits and hippocampal volume reduction in mild cognitive impairment due to alzheimer's disease. |
2015-03-09 |
2023-08-13 |
human |
| Davide Vito Morett. Electroencephalography reveals lower regional blood perfusion and atrophy of the temporoparietal network associated with memory deficits and hippocampal volume reduction in mild cognitive impairment due to Alzheimer's disease. Neuropsychiatric disease and treatment. vol 11. 2015-03-09. PMID:25750526. |
an increased electroencephalographic (eeg) upper/lower alpha power ratio has been associated with less regional blood perfusion, atrophy of the temporoparietal region of the brain, and reduction of hippocampal volume in subjects affected by mild cognitive impairment due to alzheimer's disease as compared with subjects who do not develop the disease. |
2015-03-09 |
2023-08-13 |
human |
| Min Chen, Jing Wang, Cairong Min. Buyuan Congnao decoction decreases hippocampal beta-amyloid expression in a rat model of Alzheimer's disease. Neural regeneration research. vol 7. issue 9. 2015-03-06. PMID:25745460. |
buyuan congnao decoction decreases hippocampal beta-amyloid expression in a rat model of alzheimer's disease. |
2015-03-06 |
2023-08-13 |
rat |
| Min Chen, Jing Wang, Cairong Min. Buyuan Congnao decoction decreases hippocampal beta-amyloid expression in a rat model of Alzheimer's disease. Neural regeneration research. vol 7. issue 9. 2015-03-06. PMID:25745460. |
a mixture of ibotenic acid and β-amyloid 1-42 was injected into the hippocampus of a rat model of alzheimer's disease, followed by intragastric administration of a traditional chinese medicine buyuan congnao decoction (main components included radix astragali, radix polygoni multiflori preparata, rhizoma acori talarinowii, radix polygalae, fructus alpiniae oxyphyllae, and radix glycyrrhizae preparata) and a piracetam suspension. |
2015-03-06 |
2023-08-13 |
rat |