All Relations between Alzheimer Disease and hippocampus

Publication Sentence Publish Date Extraction Date Species
Katsuyoshi Mizukami, Eric E Abrahamson, Zhiping Mi, Masanori Ishikawa, Kazushi Watanabe, Setsuo Kinoshita, Takashi Asada, Milos D Ikonomovi. Immunohistochemical analysis of ubiquilin-1 in the human hippocampus: association with neurofibrillary tangle pathology. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 34. issue 1. 2014-09-19. PMID:23869942. this post mortem immunohistochemical study examined the localization and distribution of ubiquilin-1 (ubl), a shuttle protein which interacts with ubiquitin and the proteasome, in the hippocampus from alzheimer's disease (ad) dementia cases, and age-matched cases without dementia. 2014-09-19 2023-08-12 human
Scott A Wilke, Tara Raam, Joseph K Antonios, Eric A Bushong, Edward H Koo, Mark H Ellisman, Anirvan Ghos. Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. PloS one. vol 9. issue 1. 2014-09-18. PMID:24454724. specific disruption of hippocampal mossy fiber synapses in a mouse model of familial alzheimer's disease. 2014-09-18 2023-08-12 mouse
Scott A Wilke, Tara Raam, Joseph K Antonios, Eric A Bushong, Edward H Koo, Mark H Ellisman, Anirvan Ghos. Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. PloS one. vol 9. issue 1. 2014-09-18. PMID:24454724. the earliest stages of alzheimer's disease (ad) are characterized by deficits in memory and cognition indicating hippocampal pathology. 2014-09-18 2023-08-12 mouse
Amy K Y Fu, Kwok-Wang Hung, Huiqian Huang, Shuo Gu, Yang Shen, Elaine Y L Cheng, Fanny C F Ip, Xuhui Huang, Wing-Yu Fu, Nancy Y I. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 27. 2014-09-15. PMID:24958880. blockade of epha4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of alzheimer's disease. 2014-09-15 2023-08-13 mouse
Huimin Liang, Yaozhou Zhang, Xiaoyan Shi, Tianxiang Wei, Jiyu Lo. Role of Notch-1 signaling pathway in PC12 cell apoptosis induced by amyloid beta-peptide (25-35). Neural regeneration research. vol 9. issue 13. 2014-09-15. PMID:25221582. recent studies have demonstrated that notch-1 expression is increased in the hippocampus of alzheimer's disease patients. 2014-09-15 2023-08-13 Not clear
Carlos P Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P Boks, Caroline Biojone, Samia Joca, Harry W M Steinbusch, Katie Lunnon, Diego F Mastroeni, Jonathan Mill, Paul J Lucassen, Paul D Coleman, Daniel L A van den Hove, Bart P F Rutte. Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease. Molecular neurodegeneration. vol 9. 2014-09-12. PMID:24964731. these control the expression of specific sets of genes, often including those encoding for small non-coding rnas, indicating a complex interplay between various epigenetic factors and cellular functions.previous studies had indicated that in addition to the neuropathology in alzheimer's disease (ad), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. 2014-09-12 2023-08-13 Not clear
Changsheng Li, Sufang Liu, Ying Xing, Feng Ta. The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice. Anesthesia and analgesia. vol 119. issue 2. 2014-09-11. PMID:24977637. in the present study, we tested our hypothesis that enhanced tau protein phosphorylation in hippocampus contributes to isoflurane-induced cognitive dysfunction in a mouse model of alzheimer disease. 2014-09-11 2023-08-13 mouse
R Bandopadhyay, J Y W Liu, S M Sisodiya, M Tho. A comparative study of the dentate gyrus in hippocampal sclerosis in epilepsy and dementia. Neuropathology and applied neurobiology. vol 40. issue 2. 2014-09-10. PMID:24028428. hippocampal sclerosis (hs) is long-recognized in association with epilepsy (hse ) and more recently in the context of cognitive decline or dementia in the elderly (hsd ), in some cases as a component of neurodegenerative diseases, including alzheimer's disease (ad) and fronto-temporal lobe dementia (ftld). 2014-09-10 2023-08-12 Not clear
Patrícia Ramos, Agostinho Santos, Nair Rosas Pinto, Ricardo Mendes, Teresa Magalhães, Agostinho Almeid. Iron levels in the human brain: a post-mortem study of anatomical region differences and age-related changes. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 28. issue 1. 2014-09-10. PMID:24075790. compared with the age-matched control group, altered iron levels were observed in specific brain areas of one parkinson's disease patient (the basal ganglia) and two alzheimer's disease patients (the hippocampus). 2014-09-10 2023-08-12 human
Lihua Liu, Saiping Luo, Leping Zeng, Weihong Wang, Liming Yuan, Xiaohong Jia. Degenerative alterations in noradrenergic neurons of the locus coeruleus in Alzheimer's disease. Neural regeneration research. vol 8. issue 24. 2014-09-10. PMID:25206534. mice carrying mutant amyloid-β precursor protein and presenilin-1 genes (app/ps1 double transgenic mice) have frequently been used in studies of alzheimer's disease; however, such studies have focused mainly on hippocampal and cortical changes. 2014-09-10 2023-08-13 mouse
Jie Xiang, Hao Guo, Rui Cao, Hong Liang, Junjie Che. An abnormal resting-state functional brain network indicates progression towards Alzheimer's disease. Neural regeneration research. vol 8. issue 30. 2014-09-10. PMID:25206600. brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and alzheimer's disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. 2014-09-10 2023-08-13 Not clear
Sha Liu, Honghai Wu, Gai Xue, Xin Ma, Jie Wu, Yabin Qin, Yanning Ho. Metabolic alteration of neuroactive steroids and protective effect of progesterone in Alzheimer's disease-like rats. Neural regeneration research. vol 8. issue 30. 2014-09-10. PMID:25206601. to our knowledge, this is the first report showing that aβ25-35, a main etiological factor of alzheimer's disease, can alter the level and metabolism of neuroactive steroids in the prefrontal cortex and hippocampus, which are brain regions significantly involved in learning and memory. 2014-09-10 2023-08-13 rat
Yanjun Du, Ruolan Liu, Guojie Sun, Peiyan Meng, Jie Son. Pre-moxibustion and moxibustion prevent Alzheimer's disease. Neural regeneration research. vol 8. issue 30. 2014-09-10. PMID:25206602. results showed no evidence of apoptosis in hippocampal neurons, a significantly reduced apoptosis rate of neurons and improved learning and memory abilities were observed in the alzheimer's disease model. 2014-09-10 2023-08-13 rat
Zhu Tian, Jia Fan, Yang Zhao, Sheng Bi, Lihui Si, Qun Li. Estrogen receptor beta treats Alzheimer's disease. Neural regeneration research. vol 8. issue 5. 2014-09-10. PMID:25206683. estrogen receptor β lentiviral particles delivered via intraventricular injection increased akt content in the hippocampus, decreased interleukin-1β mrna, tumor necrosis factor α mrna and amyloid β protein levels in the hippocampus, and improved the learning and memory capacities in alzheimer's disease rats. 2014-09-10 2023-08-13 rat
Zhu Tian, Jia Fan, Yang Zhao, Sheng Bi, Lihui Si, Qun Li. Estrogen receptor beta treats Alzheimer's disease. Neural regeneration research. vol 8. issue 5. 2014-09-10. PMID:25206683. these experimental findings indicate that estrogen receptor β, independent from estrogen, can reduce inflammatory reactions and amyloid β deposition in the hippocampus of alzheimer's disease rats, and improve learning and memory capacities. 2014-09-10 2023-08-13 rat
Changhao Yin, Siou Li, Weina Zhao, Jiachun Fen. Brain imaging of mild cognitive impairment and Alzheimer's disease. Neural regeneration research. vol 8. issue 5. 2014-09-10. PMID:25206685. it is extremely important to study early structural and metabolic changes, such as those in the hippocampus, entorhinal cortex, and gray matter structures in the medial temporal lobe, to allow the early detection of mild cognitive impairment and alzheimer's disease. 2014-09-10 2023-08-13 human
Lei Song, Yue Gu, Jing Jie, Xiaoxue Bai, Ying Yang, Chaoying Liu, Qun Li. Dab2 attenuates brain injury in APP/PS1 mice via targeting transforming growth factor-beta/SMAD signaling. Neural regeneration research. vol 9. issue 1. 2014-09-10. PMID:25206742. in this study, we used an adenoviral vector to overexpress the dab2 gene in the mouse hippocampus and investigated the regulatory effect of dab2 protein on tgf-β1/smad signaling in a mouse model of alzheimer's disease, and the potential neuroprotective effect. 2014-09-10 2023-08-13 mouse
Xiqing Chai, Weina Kong, Lingyun Liu, Wenguo Yu, Zhenqing Zhang, Yimin Su. A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis. Neural regeneration research. vol 9. issue 11. 2014-09-10. PMID:25206774. single raav-hif-1α administration resulted in decreased apoptosis of hippocampal neurons in an alzheimer's disease rat model established by intracerebroventricular injection of aggregated amyloid-beta protein (25-35). 2014-09-10 2023-08-13 human
Dongming Yu, Wenjuan Fan, Ping Wu, Jiexin Deng, Jing Liu, Yanli Niu, Mingshan Li, Jinbo Den. Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease (Tg2576). Neural regeneration research. vol 9. issue 4. 2014-09-10. PMID:25206826. characterization of hippocampal cajal-retzius cells during development in a mouse model of alzheimer's disease (tg2576). 2014-09-10 2023-08-13 mouse
Lei Zhang, Shuai Dong, Guixiang Zhao, Yu M. 7.0T nuclear magnetic resonance evaluation of the amyloid beta (1-40) animal model of Alzheimer's disease: comparison of cytology verification. Neural regeneration research. vol 9. issue 4. 2014-09-10. PMID:25206831. in this study, 7.0t magnetic resonance spectroscopy showed that in the hippocampus of alzheimer's disease rats, the n-acetylaspartate wave crest was reduced, and the creatine and choline wave crest was elevated. 2014-09-10 2023-08-13 rat