| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Puzzo, Carla Loreto, Salvatore Giunta, Giuseppe Musumeci, Giuseppina Frasca, Maria Vittoria Podda, Ottavio Arancio, Agostino Palmer. Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice. Neurobiology of aging. vol 35. issue 3. 2014-09-29. PMID:24112792. |
because it has been previously demonstrated that phosphodiesterase-5 inhibitors (pde5-is) protect against hippocampal synaptic dysfunction and memory deficits in mouse models of alzheimer's disease and physiological aging, we investigated the effect of a treatment with the pde5-i, sildenafil, on cell death, pro- and antiapoptotic molecules, and aβ production. |
2014-09-29 |
2023-08-12 |
mouse |
| Stefan Teipel, Helmut Heinsen, Edson Amaro, Lea T Grinberg, Bernd Krause, Michel Groth. Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease. Neurobiology of aging. vol 35. issue 3. 2014-09-29. PMID:24176625. |
we compared accuracy of hippocampus and basal forebrain cholinergic system (bfcs) atrophy to predict cortical amyloid burden in 179 cognitively normal subjects (cn), 269 subjects with early stages of mild cognitive impairment (mci), 136 subjects with late stages of mci, and 86 subjects with alzheimer's disease (ad) dementia retrieved from the alzheimer's disease neuroimaging initiative database. |
2014-09-29 |
2023-08-12 |
human |
| Peng Yu, Jia Sun, Robin Wolz, Diane Stephenson, James Brewer, Nick C Fox, Patricia E Cole, Clifford R Jack, Derek L G Hill, Adam J Schwar. Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size. Neurobiology of aging. vol 35. issue 4. 2014-09-29. PMID:24211008. |
we evaluated the enrichment performance of 4 widely used hippocampal segmentation algorithms (freesurfer, hippocampus multi-atlas propagation and segmentation (hmaps), learning embeddings atlas propagation (leap), and neuroquant) in terms of 2-year changes in mini-mental state examination (mmse), alzheimer's disease assessment scale-cognitive subscale (adas-cog), and clinical dementia rating sum of boxes (cdr-sb). |
2014-09-29 |
2023-08-12 |
human |
| A E Ramírez, C R Pacheco, L G Aguayo, C M Opaz. Rapamycin protects against Aβ-induced synaptotoxicity by increasing presynaptic activity in hippocampal neurons. Biochimica et biophysica acta. vol 1842. issue 9. 2014-09-25. PMID:24794719. |
under these conditions, rapamycin-treated hippocampal neurons are resistant to the synaptotoxic effect induced by aβ oligomers, suggesting that enhancers of presynaptic activity can be therapeutic agents for alzheimer's disease. |
2014-09-25 |
2023-08-13 |
rat |
| Ignacio Pedrós, Dmitry Petrov, Michael Allgaier, Francesc Sureda, Emma Barroso, Carlos Beas-Zarate, Carme Auladell, Mercè Pallàs, Manuel Vázquez-Carrera, Gemma Casadesús, Jaume Folch, Antoni Camin. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease. Biochimica et biophysica acta. vol 1842. issue 9. 2014-09-25. PMID:24887203. |
early alterations in energy metabolism in the hippocampus of appswe/ps1de9 mouse model of alzheimer's disease. |
2014-09-25 |
2023-08-13 |
mouse |
| Ignacio Pedrós, Dmitry Petrov, Michael Allgaier, Francesc Sureda, Emma Barroso, Carlos Beas-Zarate, Carme Auladell, Mercè Pallàs, Manuel Vázquez-Carrera, Gemma Casadesús, Jaume Folch, Antoni Camin. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease. Biochimica et biophysica acta. vol 1842. issue 9. 2014-09-25. PMID:24887203. |
the present study had focused on the behavioral phenotype and gene expression profile of molecules related to insulin receptor signaling in the hippocampus of 3 and 6 month-old appswe/ps1de9 (app/ps1) transgenic mouse model of alzheimer's disease (ad). |
2014-09-25 |
2023-08-13 |
mouse |
| Daniela Bianchi, Pasquale De Michele, Cristina Marchetti, Brunello Tirozzi, Salvatore Cuomo, Hélène Marie, Michele Miglior. Effects of increasing CREB-dependent transcription on the storage and recall processes in a hippocampal CA1 microcircuit. Hippocampus. vol 24. issue 2. 2014-09-23. PMID:24123649. |
the involvement of the hippocampus in learning processes and major brain diseases makes it an ideal candidate to investigate possible ways to devise effective therapies for memory-related pathologies like alzheimer's disease (ad). |
2014-09-23 |
2023-08-12 |
Not clear |
| Katsuyoshi Mizukami, Eric E Abrahamson, Zhiping Mi, Masanori Ishikawa, Kazushi Watanabe, Setsuo Kinoshita, Takashi Asada, Milos D Ikonomovi. Immunohistochemical analysis of ubiquilin-1 in the human hippocampus: association with neurofibrillary tangle pathology. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 34. issue 1. 2014-09-19. PMID:23869942. |
this post mortem immunohistochemical study examined the localization and distribution of ubiquilin-1 (ubl), a shuttle protein which interacts with ubiquitin and the proteasome, in the hippocampus from alzheimer's disease (ad) dementia cases, and age-matched cases without dementia. |
2014-09-19 |
2023-08-12 |
human |
| Scott A Wilke, Tara Raam, Joseph K Antonios, Eric A Bushong, Edward H Koo, Mark H Ellisman, Anirvan Ghos. Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. PloS one. vol 9. issue 1. 2014-09-18. PMID:24454724. |
specific disruption of hippocampal mossy fiber synapses in a mouse model of familial alzheimer's disease. |
2014-09-18 |
2023-08-12 |
mouse |
| Scott A Wilke, Tara Raam, Joseph K Antonios, Eric A Bushong, Edward H Koo, Mark H Ellisman, Anirvan Ghos. Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. PloS one. vol 9. issue 1. 2014-09-18. PMID:24454724. |
the earliest stages of alzheimer's disease (ad) are characterized by deficits in memory and cognition indicating hippocampal pathology. |
2014-09-18 |
2023-08-12 |
mouse |
| Amy K Y Fu, Kwok-Wang Hung, Huiqian Huang, Shuo Gu, Yang Shen, Elaine Y L Cheng, Fanny C F Ip, Xuhui Huang, Wing-Yu Fu, Nancy Y I. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 27. 2014-09-15. PMID:24958880. |
blockade of epha4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of alzheimer's disease. |
2014-09-15 |
2023-08-13 |
mouse |
| Huimin Liang, Yaozhou Zhang, Xiaoyan Shi, Tianxiang Wei, Jiyu Lo. Role of Notch-1 signaling pathway in PC12 cell apoptosis induced by amyloid beta-peptide (25-35). Neural regeneration research. vol 9. issue 13. 2014-09-15. PMID:25221582. |
recent studies have demonstrated that notch-1 expression is increased in the hippocampus of alzheimer's disease patients. |
2014-09-15 |
2023-08-13 |
Not clear |
| Carlos P Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P Boks, Caroline Biojone, Samia Joca, Harry W M Steinbusch, Katie Lunnon, Diego F Mastroeni, Jonathan Mill, Paul J Lucassen, Paul D Coleman, Daniel L A van den Hove, Bart P F Rutte. Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease. Molecular neurodegeneration. vol 9. 2014-09-12. PMID:24964731. |
these control the expression of specific sets of genes, often including those encoding for small non-coding rnas, indicating a complex interplay between various epigenetic factors and cellular functions.previous studies had indicated that in addition to the neuropathology in alzheimer's disease (ad), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. |
2014-09-12 |
2023-08-13 |
Not clear |
| Changsheng Li, Sufang Liu, Ying Xing, Feng Ta. The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice. Anesthesia and analgesia. vol 119. issue 2. 2014-09-11. PMID:24977637. |
in the present study, we tested our hypothesis that enhanced tau protein phosphorylation in hippocampus contributes to isoflurane-induced cognitive dysfunction in a mouse model of alzheimer disease. |
2014-09-11 |
2023-08-13 |
mouse |
| R Bandopadhyay, J Y W Liu, S M Sisodiya, M Tho. A comparative study of the dentate gyrus in hippocampal sclerosis in epilepsy and dementia. Neuropathology and applied neurobiology. vol 40. issue 2. 2014-09-10. PMID:24028428. |
hippocampal sclerosis (hs) is long-recognized in association with epilepsy (hse ) and more recently in the context of cognitive decline or dementia in the elderly (hsd ), in some cases as a component of neurodegenerative diseases, including alzheimer's disease (ad) and fronto-temporal lobe dementia (ftld). |
2014-09-10 |
2023-08-12 |
Not clear |
| Patrícia Ramos, Agostinho Santos, Nair Rosas Pinto, Ricardo Mendes, Teresa Magalhães, Agostinho Almeid. Iron levels in the human brain: a post-mortem study of anatomical region differences and age-related changes. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 28. issue 1. 2014-09-10. PMID:24075790. |
compared with the age-matched control group, altered iron levels were observed in specific brain areas of one parkinson's disease patient (the basal ganglia) and two alzheimer's disease patients (the hippocampus). |
2014-09-10 |
2023-08-12 |
human |
| Lihua Liu, Saiping Luo, Leping Zeng, Weihong Wang, Liming Yuan, Xiaohong Jia. Degenerative alterations in noradrenergic neurons of the locus coeruleus in Alzheimer's disease. Neural regeneration research. vol 8. issue 24. 2014-09-10. PMID:25206534. |
mice carrying mutant amyloid-β precursor protein and presenilin-1 genes (app/ps1 double transgenic mice) have frequently been used in studies of alzheimer's disease; however, such studies have focused mainly on hippocampal and cortical changes. |
2014-09-10 |
2023-08-13 |
mouse |
| Jie Xiang, Hao Guo, Rui Cao, Hong Liang, Junjie Che. An abnormal resting-state functional brain network indicates progression towards Alzheimer's disease. Neural regeneration research. vol 8. issue 30. 2014-09-10. PMID:25206600. |
brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and alzheimer's disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. |
2014-09-10 |
2023-08-13 |
Not clear |
| Sha Liu, Honghai Wu, Gai Xue, Xin Ma, Jie Wu, Yabin Qin, Yanning Ho. Metabolic alteration of neuroactive steroids and protective effect of progesterone in Alzheimer's disease-like rats. Neural regeneration research. vol 8. issue 30. 2014-09-10. PMID:25206601. |
to our knowledge, this is the first report showing that aβ25-35, a main etiological factor of alzheimer's disease, can alter the level and metabolism of neuroactive steroids in the prefrontal cortex and hippocampus, which are brain regions significantly involved in learning and memory. |
2014-09-10 |
2023-08-13 |
rat |
| Yanjun Du, Ruolan Liu, Guojie Sun, Peiyan Meng, Jie Son. Pre-moxibustion and moxibustion prevent Alzheimer's disease. Neural regeneration research. vol 8. issue 30. 2014-09-10. PMID:25206602. |
results showed no evidence of apoptosis in hippocampal neurons, a significantly reduced apoptosis rate of neurons and improved learning and memory abilities were observed in the alzheimer's disease model. |
2014-09-10 |
2023-08-13 |
rat |