| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiqing Chai, Weina Kong, Lingyun Liu, Wenguo Yu, Zhenqing Zhang, Yimin Su. A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis. Neural regeneration research. vol 9. issue 11. 2014-09-10. PMID:25206774. |
single raav-hif-1α administration resulted in decreased apoptosis of hippocampal neurons in an alzheimer's disease rat model established by intracerebroventricular injection of aggregated amyloid-beta protein (25-35). |
2014-09-10 |
2023-08-13 |
human |
| Dongming Yu, Wenjuan Fan, Ping Wu, Jiexin Deng, Jing Liu, Yanli Niu, Mingshan Li, Jinbo Den. Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease (Tg2576). Neural regeneration research. vol 9. issue 4. 2014-09-10. PMID:25206826. |
characterization of hippocampal cajal-retzius cells during development in a mouse model of alzheimer's disease (tg2576). |
2014-09-10 |
2023-08-13 |
mouse |
| Lei Zhang, Shuai Dong, Guixiang Zhao, Yu M. 7.0T nuclear magnetic resonance evaluation of the amyloid beta (1-40) animal model of Alzheimer's disease: comparison of cytology verification. Neural regeneration research. vol 9. issue 4. 2014-09-10. PMID:25206831. |
in this study, 7.0t magnetic resonance spectroscopy showed that in the hippocampus of alzheimer's disease rats, the n-acetylaspartate wave crest was reduced, and the creatine and choline wave crest was elevated. |
2014-09-10 |
2023-08-13 |
rat |
| Lei Zhang, Shuai Dong, Guixiang Zhao, Yu M. 7.0T nuclear magnetic resonance evaluation of the amyloid beta (1-40) animal model of Alzheimer's disease: comparison of cytology verification. Neural regeneration research. vol 9. issue 4. 2014-09-10. PMID:25206831. |
overall, the results revealed that 7.0t high-field nuclear magnetic resonance spectroscopy detected the lesions and functional changes in hippocampal neurons of alzheimer's disease rats in vivo, allowing the possibility for assessing the success rate and grading of the amyloid beta (1-40) animal model of alzheimer's disease. |
2014-09-10 |
2023-08-13 |
rat |
| Yufang Yan, Tuo Ma, Kai Gong, Qiang Ao, Xiufang Zhang, Yandao Gon. Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice. Neural regeneration research. vol 9. issue 8. 2014-09-10. PMID:25206892. |
immunofluorescence staining revealed that the number of newly generated (brdu(+)) cells in the subgranular zone of the dentate gyrus in the hippocampus was significantly higher in alzheimer's disease mice after adipose-derived mesenchymal stem cell transplantation, and there was also a significant increase in the number of brdu(+)/dcx(+) neuroblasts in these animals. |
2014-09-10 |
2023-08-13 |
mouse |
| Hua Zhou, Guojie Sun, Lihong Kong, Yanjun Du, Feng Shen, Shuju Wang, Bangguo Chen, Xiaoling Zen. Acupuncture and moxibustion reduces neuronal edema in Alzheimer's disease rats. Neural regeneration research. vol 9. issue 9. 2014-09-10. PMID:25206919. |
to examine the possible correlation of aberrant wnt signaling and pathological changes in alzheimer's disease, we established a rat model of alzheimer's disease and measured axin and β-catenin expression in the hippocampus. |
2014-09-10 |
2023-08-13 |
rat |
| Xiaoqi Hong, Jie Liu, Guoqi Zhu, YingHan Zhuang, Haiyun Suo, Pan Wang, Dongping Huang, Jing Xu, Yufang Huang, Mei Yu, MinJuan Bian, Zhejin Sheng, Jian Fei, Houyan Song, Thomas Behnisch, Fang Huan. Parkin overexpression ameliorates hippocampal long-term potentiation and β-amyloid load in an Alzheimer's disease mouse model. Human molecular genetics. vol 23. issue 4. 2014-09-09. PMID:24105468. |
parkin overexpression ameliorates hippocampal long-term potentiation and β-amyloid load in an alzheimer's disease mouse model. |
2014-09-09 |
2023-08-12 |
mouse |
| Xue-Qin Hou, Rong Yan, Cong Yang, Lei Zhang, Ru-Yu Su, Si-Jun Liu, Shi-Jie Zhang, Wen-Qing He, Shu-Huan Fang, Shu-Yi Cheng, Zi-Ren Su, Yun-Bo Chen, Qi Wan. A novel assay for high-throughput screening of anti-Alzheimer's disease drugs to determine their efficacy by real-time monitoring of changes in PC12 cell proliferation. International journal of molecular medicine. vol 33. issue 3. 2014-09-09. PMID:24378397. |
alzheimer's disease (ad) is a neurodegenerative disease that is characterized by the accumulation of senile plaque and neurofibrilary tangle formation in the brain, including the cerebral cortex and hippocampus. |
2014-09-09 |
2023-08-12 |
Not clear |
| Ling-Li Ma, Jiang-Rong Ou, Wei Zhang, Fu-Rong Sun, Jin-Tai Yu, Lan Ta. Single nucleotide polymorphism rs7294919 on chromosome 12q24.22 is associated with late-onset Alzheimer's disease in Han Chinese. Neuroscience letters. vol 560. 2014-09-08. PMID:24361131. |
recently, two large genome-wide association studies (gwass) have identified several variants at 12q14 and 12q24 which are associated with hippocampal volume, one of the most important biological markers of alzheimer's disease (ad). |
2014-09-08 |
2023-08-12 |
Not clear |
| Noriyuki Matsukaw. [The involvement of hippocampal cholinergic neurostimulating peptide and its precursor in Alzheimer pathogenesis]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 34. issue 3. 2014-09-08. PMID:25076779. |
[the involvement of hippocampal cholinergic neurostimulating peptide and its precursor in alzheimer pathogenesis]. |
2014-09-08 |
2023-08-13 |
mouse |
| Noriyuki Matsukaw. [The involvement of hippocampal cholinergic neurostimulating peptide and its precursor in Alzheimer pathogenesis]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 34. issue 3. 2014-09-08. PMID:25076779. |
crmp-2 is one of microtubule-associated proteins such as tau protein, and its phosphorylated form increased in the hippocampus of alzheimer brains. |
2014-09-08 |
2023-08-13 |
mouse |
| Jing Du, Yu Liang, Feng Xu, Bing Sun, Zhao Wan. Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice. The Journal of pharmacy and pharmacology. vol 65. issue 12. 2014-09-05. PMID:24236985. |
alzheimer's disease (ad) is well characterized by the accumulated aβ plaque in hippocampus and cerebral cortex concomitant with markedly reduced study and learning ability. |
2014-09-05 |
2023-08-12 |
mouse |
| Leslie M Tong, Biljana Djukic, Christine Arnold, Anna K Gillespie, Seo Yeon Yoon, Max M Wang, Olivia Zhang, Johanna Knoferle, John L R Rubenstein, Arturo Alvarez-Buylla, Yadong Huan. Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 29. 2014-09-05. PMID:25031394. |
apolipoprotein (apo) e4 and amyloid-β (aβ) peptides, two major players in alzheimer's disease (ad), cause inhibitory interneuron impairments and aberrant neuronal activity in the hippocampal dentate gyrus in ad-related mouse models and humans, leading to learning and memory deficits. |
2014-09-05 |
2023-08-13 |
mouse |
| Claudia Niemann, Ben Godde, Claudia Voelcker-Rehag. Not only cardiovascular, but also coordinative exercise increases hippocampal volume in older adults. Frontiers in aging neuroscience. vol 6. 2014-08-28. PMID:25165446. |
this is particularly true for the hippocampus, a brain structure that plays an important role in learning and memory, and whose decline has been related to the development of alzheimer's disease. |
2014-08-28 |
2023-08-13 |
Not clear |
| Roberto F Villa, Federica Ferrari, Antonella Gorin. Functional proteomics related to energy metabolism of synaptosomes from different neuronal systems of rat hippocampus during aging. Journal of proteome research. vol 12. issue 12. 2014-08-27. PMID:24200092. |
the results show that "large" and "small" synaptosomes possess specific and independent metabolic features coherently with the selective vulnerability of the respective hippocampal subfields to alzheimer's disease and cerebral ischemia. |
2014-08-27 |
2023-08-12 |
rat |
| Wenfeng Yu, Mathilde Bonnet, Mark Farso, Keran Ma, Jean-Guy Chabot, Elisabeth Martin, Alicia Torriglia, Zhizhong Guan, JoAnne McLaurin, Rémi Quirion, Slavica Kranti. The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease. BMC neuroscience. vol 15. 2014-08-27. PMID:24915960. |
the expression of apoptosis inducing factor (aif) is associated with aging-related cell death in the cortex but not in the hippocampus in the tgcrnd8 mouse model of alzheimer's disease. |
2014-08-27 |
2023-08-13 |
mouse |
| Donald M Lyall, Natalie A Royle, Sarah E Harris, Mark E Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W Lutz, Ann M Saunders, Allen D Roses, Maria C del Valdés Hernández, John M Starr, David J Porteous, Joanna M Wardlaw, Ian J Dear. Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936. PloS one. vol 8. issue 11. 2014-08-26. PMID:24260406. |
alzheimer's disease susceptibility genes apoe and tomm40, and hippocampal volumes in the lothian birth cohort 1936. |
2014-08-26 |
2023-08-12 |
human |
| Markus P Kummer, Thea Hammerschmidt, Ana Martinez, Dick Terwel, Gregor Eichele, Anika Witten, Stefanie Figura, Monika Stoll, Stephanie Schwartz, Hans-Christian Pape, Joachim L Schultze, David Weinshenker, Michael T Heneka, Inga Urba. Ear2 deletion causes early memory and learning deficits in APP/PS1 mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 26. 2014-08-21. PMID:24966384. |
to assess the consequences of locus ceruleus (lc) degeneration and subsequent noradrenaline (na) deficiency in early alzheimer's disease (ad), mice overexpressing mutant amyloid precursor protein and presenilin-1 (app/ps1) were crossed with ear2(-/-) mice that have a severe loss of lc neurons projecting to the hippocampus and neocortex. |
2014-08-21 |
2023-08-13 |
mouse |
| Takayuki Nemoto, Fumiyo Toyoshima-Aoyama, Toshihiko Yanagita, Toyoaki Maruta, Hiroshi Fujita, Tomohiro Koshida, Tetsu Yonaha, Akihiko Wada, Akira Sawaguchi, Manabu Murakam. New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: amyloid-β1-42-induced reduction of proinsulin level via glycogen synthase kinase-3β. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269535. |
the reduction of insulin levels in hippocampal areas is associated with alzheimer's disease. |
2014-08-18 |
2023-08-12 |
rat |
| Takayuki Nemoto, Fumiyo Toyoshima-Aoyama, Toshihiko Yanagita, Toyoaki Maruta, Hiroshi Fujita, Tomohiro Koshida, Tetsu Yonaha, Akihiko Wada, Akira Sawaguchi, Manabu Murakam. New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: amyloid-β1-42-induced reduction of proinsulin level via glycogen synthase kinase-3β. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269535. |
these results demonstrate that synthesized insulin is secreted from rat hippocampal and cortical neuron's dense-core vesicles, and that activation of gsk-3β in aβ(1-42)-induced alzheimer's model hippocampal neurons decreases the insulin synthesis. |
2014-08-18 |
2023-08-12 |
rat |