| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Max Stevenson, Rency Varghese, Michaeline L Hebron, Xiaoguang Liu, Nick Ratliff, Amelia Smith, R Scott Turner, Charbel Mouss. Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer's disease. Journal of neuroinflammation. vol 20. issue 1. 2023-05-16. PMID:37194065. |
individuals diagnosed with mild-moderate alzheimer's disease (ad) treated with nilotinib (versus placebo) for 12 months showed reduction of amyloid plaque and cerebrospinal fluid (csf) amyloid, and attenuation of hippocampal volume loss. |
2023-05-16 |
2023-08-14 |
Not clear |
| Sara Calafate, Gökhan Özturan, Nicola Thrupp, Jeroen Vanderlinden, Luísa Santa-Marinha, Rafaela Morais-Ribeiro, Antonella Ruggiero, Ivan Bozic, Thomas Rusterholz, Blanca Lorente-Echeverría, Marcelo Dias, Wei-Ting Chen, Mark Fiers, Ashley Lu, Ine Vlaeminck, Eline Creemers, Katleen Craessaerts, Joris Vandenbempt, Luuk van Boekholdt, Suresh Poovathingal, Kristofer Davie, Dietmar Rudolf Thal, Keimpe Wierda, Tiago Gil Oliveira, Inna Slutsky, Antoine Adamantidis, Bart De Strooper, Joris de Wi. Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease. Nature neuroscience. 2023-05-15. PMID:37188873. |
early alzheimer's disease (ad) is associated with hippocampal hyperactivity and decreased sleep quality. |
2023-05-15 |
2023-08-14 |
mouse |
| Zhi Huang, Gennifer E Merrihew, Eric B Larson, Jea Park, Deanna Plubell, Edward J Fox, Kathleen S Montine, Caitlin S Latimer, C Dirk Keene, James Y Zou, Michael J MacCoss, Thomas J Montin. Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-05-14. PMID:37173305. |
here we assessed 43 research participants meeting stringent criteria, 11 healthy controls, 12 resilience to alzheimer's disease and 20 alzheimer's disease with dementia and analyzed matched isocortical regions, hippocampus, and caudate nucleus by mass spectrometry-based proteomics. |
2023-05-14 |
2023-08-14 |
human |
| Zhi Huang, Gennifer E Merrihew, Eric B Larson, Jea Park, Deanna Plubell, Edward J Fox, Kathleen S Montine, Caitlin S Latimer, C Dirk Keene, James Y Zou, Michael J MacCoss, Thomas J Montin. Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-05-14. PMID:37173305. |
of 7115 differentially expressed soluble proteins, lower isocortical and hippocampal soluble aβ levels is a significant feature of resilience when compared to healthy control and alzheimer's disease dementia groups. |
2023-05-14 |
2023-08-14 |
human |
| Evangelia Thanou, Frank Koopmans, Débora Pita-Illobre, Remco V Klaassen, Berna Özer, Ioannis Charalampopoulos, August B Smit, Ka Wan L. Suspension TRAPping Filter (sTRAP) Sample Preparation for Quantitative Proteomics in the Low µg Input Range Using a Plasmid DNA Micro-Spin Column: Analysis of the Hippocampus from the 5xFAD Alzheimer's Disease Mouse Model. Cells. vol 12. issue 9. 2023-05-14. PMID:37174641. |
suspension trapping filter (strap) sample preparation for quantitative proteomics in the low µg input range using a plasmid dna micro-spin column: analysis of the hippocampus from the 5xfad alzheimer's disease mouse model. |
2023-05-14 |
2023-08-14 |
mouse |
| Evangelia Thanou, Frank Koopmans, Débora Pita-Illobre, Remco V Klaassen, Berna Özer, Ioannis Charalampopoulos, August B Smit, Ka Wan L. Suspension TRAPping Filter (sTRAP) Sample Preparation for Quantitative Proteomics in the Low µg Input Range Using a Plasmid DNA Micro-Spin Column: Analysis of the Hippocampus from the 5xFAD Alzheimer's Disease Mouse Model. Cells. vol 12. issue 9. 2023-05-14. PMID:37174641. |
we applied strap for the analysis of the hippocampal proteome from the 5xfad mouse model of alzheimer's disease and their wildtype littermates, and revealed 121 up- and 54 down-regulated proteins. |
2023-05-14 |
2023-08-14 |
mouse |
| Kazuki Nakanishi, Kosuke Norimatsu, Akira Tani, Teruki Matsuoka, Ryoma Matsuzaki, Syogo Kakimoto, Nao Nojima, Yuta Tachibe, Yuki Kato, Masaki Inadome, Riho Kitazato, Shotaro Otsuka, Seiya Takada, Megumi Sumizono, Harutoshi Sakakim. Effects of early exercise intervention and exercise cessation on neuronal loss and neuroinflammation in a senescence-accelerated mouse prone 8. Neuroscience letters. 2023-05-14. PMID:37182575. |
physical exercise is beneficial for preventing alzheimer's disease (ad) and cognitive decline through several mechanisms, including suppression of neuroinflammation and neuronal loss in the hippocampus. |
2023-05-14 |
2023-08-14 |
mouse |
| Titis Nurmasitoh, Dwi Cahyani Ratna Sari, Rina Susilowat. Moderate-Intensity Intermittent Exercise Prevents Memory Deficit, Hippocampal Neuron Loss, and Elevated Level of Alzheimer's Dementia Markers in the Hippocampus of Trimethyltin-Induced Rats. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2023-05-14. PMID:37182815. |
moderate-intensity intermittent exercise prevents memory deficit, hippocampal neuron loss, and elevated level of alzheimer's dementia markers in the hippocampus of trimethyltin-induced rats. |
2023-05-14 |
2023-08-14 |
rat |
| Erica S Brady, Jessica Griffiths, Lilya Andrianova, Monika Bielska, Takashi Saito, Takaomi C Saido, Andrew D Randall, Francesco Tamagnini, Jonathan Witton, Michael T Crai. Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal - medial prefrontal cortex circuit during natural sleep in App Neurobiology of disease. 2023-05-12. PMID:37172910. |
alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal - medial prefrontal cortex circuit during natural sleep in app in the early stages of alzheimer's disease (ad), the accumulation of the peptide amyloid-β (aβ) damages synapses and disrupts neuronal activity, leading to the disruption of neuronal oscillations associated with cognition. |
2023-05-12 |
2023-08-14 |
mouse |
| Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Grønning Hansen, Tessa de Vries, Anna Sancho-Balsells, Kaspar Russ, Ekaterina Savchenko, Anna Collin, Ana Rita Vaz, Silvia Bagnoli, Benedetta Nacmias, Claire Rampon, Sandro Sorbi, Dora Brites, György Marko-Varga, Zaal Kokaia, Melinda Rezeli, Gunnar K Gouras, Laurent Roybo. Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies. Stem cell reports. vol 18. issue 5. 2023-05-10. PMID:37163981. |
human ipsc-derived hippocampal spheroids: an innovative tool for stratifying alzheimer disease patient-specific cellular phenotypes and developing therapies. |
2023-05-10 |
2023-08-14 |
human |
| Zhengwu Zhang, Yuexuan Wu, Di Xiong, Joseph G Ibrahim, Anuj Srivastava, Hongtu Zh. LESA: Longitudinal Elastic Shape Analysis of Brain Subcortical Structures. Journal of the American Statistical Association. vol 118. issue 541. 2023-05-09. PMID:37153845. |
in particular, with the alzheimer's disease neuroimaging initiative (adni) data, we found that the alzheimer's disease (ad) can significantly speed the shape change of ventricle and hippocampus from 60 to 75 years old compared with normal aging. |
2023-05-09 |
2023-08-14 |
human |
| Qiyao Wang, Chenglong Xia, An Zhu, Yongjie Bao, Jiani Lu, Yuan Chen, Jiayi Xu, Binbin Wang, C Benjamin Naman, Liping Li, Qinwen Wang, Hao Liu, Hongze Liang, Wei Cu. Discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of APP/PS1 and MAPT×P301S transgenic mice at the early stage of Alzheimer's disease. Metabolic brain disease. 2023-05-09. PMID:37160613. |
discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of app/ps1 and mapt×p301s transgenic mice at the early stage of alzheimer's disease. |
2023-05-09 |
2023-08-14 |
mouse |
| Teresa Juárez-Cedillo, Nancy Martínez-Rodríguez, José Manuel Fragoso, Valentin Islas-Pérez, Amara López-Martínez, Antonio Valle-Medin. Multifactor Dimensionality Reduction Analysis to Evaluate the Association of Dopamine Beta-Hydroxylase (DΒH) Polymorphisms with Susceptibility to Dementia (SADEM Study). Molecular neurobiology. 2023-05-06. PMID:37148523. |
since the activity of dopamine b hydroxylase (dβh) is reduced in the hippocampus and neocortex in the brain, changes in the physiological status of dopamine have been reported in alzheimer's disease (ad) induced by this enzyme. |
2023-05-06 |
2023-08-14 |
Not clear |
| Ye Ji Lee, Ye Ji Jeong, Eun Ji Kang, Beom Seok Kang, Song Hee Lee, You Jin Kim, Seong Su Kang, Sang Won Suh, Eun Hee Ah. GAP-43 closely interacts with BDNF in hippocampal neurons and is associated with Alzheimer's disease progression. Frontiers in molecular neuroscience. vol 16. 2023-05-05. PMID:37143467. |
gap-43 closely interacts with bdnf in hippocampal neurons and is associated with alzheimer's disease progression. |
2023-05-05 |
2023-08-14 |
Not clear |
| Pulak R Manna, Sudhir Kshirsagar, Jangampalli Adi Pradeepkiran, Priyanka Rawat, Subodh Kumar, Arubala P Reddy, P Hemachandra Redd. Protective function of StAR in amyloid-β accumulated hippocampal neurotoxicity and neurosteroidogenesis: Mechanistic insights into Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-05-04. PMID:37142132. |
protective function of star in amyloid-β accumulated hippocampal neurotoxicity and neurosteroidogenesis: mechanistic insights into alzheimer's disease. |
2023-05-04 |
2023-08-14 |
Not clear |
| Anchalee Prasansuklab, Suporn Sukjamnong, Atsadang Theerasri, Valerie W Hu, Tewarit Sarachana, Tewin Tencomna. Transcriptomic analysis of glutamate-induced HT22 neurotoxicity as a model for screening anti-Alzheimer's drugs. Scientific reports. vol 13. issue 1. 2023-05-04. PMID:37142620. |
glutamate-induced neurotoxicity in the ht22 mouse hippocampal neuronal cell line has been recognized as a valuable cell model for the study of neurotoxicity associated with neurodegenerative diseases including alzheimer's disease (ad). |
2023-05-04 |
2023-08-14 |
mouse |
| Daniel Zvi Press, Christian Sandøe Musaeus, Li Zhao, Jocelyn Breton, Mouhsin M Shafi, Weiying Dai, David C Also. Levetiracetam Increases Hippocampal Blood Flow in Alzheimer's Disease as Measured by Arterial Spin Labelling MRI. Journal of Alzheimer's disease : JAD. 2023-05-01. PMID:37125545. |
levetiracetam increases hippocampal blood flow in alzheimer's disease as measured by arterial spin labelling mri. |
2023-05-01 |
2023-08-14 |
Not clear |
| Yu Chen, Hailin Yue, Hulin Kuang, Jianxin Wan. RBS-Net: Hippocampus segmentation using multi-layer feature learning with the region, boundary and structure loss. Computers in biology and medicine. vol 160. 2023-04-30. PMID:37120987. |
hippocampus has great influence over the alzheimer's disease (ad) research because of its essential role as a biomarker in the human brain. |
2023-04-30 |
2023-08-14 |
human |
| Mengjin Dong, Long Xie, Sandhitsu R Das, Jiancong Wang, Laura E M Wisse, Robin deFlores, David A Wolk, Paul A Yushkevic. Regional Deep Atrophy: a Self-Supervised Learning Method to Automatically Identify Regions Associated With Alzheimer's Disease Progression From Longitudinal MRI. ArXiv. 2023-04-24. PMID:37090239. |
longitudinal assessment of brain atrophy, particularly in the hippocampus, is a well-studied biomarker for neurodegenerative diseases, such as alzheimer's disease (ad). |
2023-04-24 |
2023-08-14 |
Not clear |
| Yaqiong Xiao, Liangjun Liao, Kaiyu Huang, Shun Yao, Lei Ga. Coupling Between Hippocampal Parenchymal Fraction and Cortical Grey Matter Atrophy at Different Stages of Cognitive Decline. Journal of Alzheimer's disease : JAD. 2023-04-24. PMID:37092228. |
hippocampal atrophy is a significant brain marker of pathology in alzheimer's disease (ad). |
2023-04-24 |
2023-08-14 |
Not clear |