| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rachel A Multz, Callen Spencer, Arleen Matos, Kaouther Ajroud, Carlos Zamudio, Eileen Bigio, Qinwen Mao, Rose A Medeiros, Jared T Ahrendsen, Rudolph J Castellani, Margaret E Flanaga. What every neuropathologist needs to know: condensed protocol work-up for clinical dementia syndromes. Journal of neuropathology and experimental neurology. 2022-12-02. PMID:36458947. |
for this reason, we designed and validated a condensed protocol for the neuropathologic diagnoses of alzheimer disease neuropathologic change, lewy body disease neuropathologic change, as well as chronic microvascular lesions, hippocampal sclerosis of aging, and cerebral amyloid angiopathy. |
2022-12-02 |
2023-08-14 |
Not clear |
| Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei H. Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease? Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453396. |
do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of alzheimer's disease? |
2022-12-01 |
2023-08-14 |
Not clear |
| Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei H. Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease? Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453396. |
cognitive decline in alzheimer's disease correlates with the extent of tau pathology, in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the hippocampus. |
2022-12-01 |
2023-08-14 |
Not clear |
| Carlo Abbate, Pietro D Trimarchi, Giorgio G Fumagalli, Alessia Gallucci, Emanuele Tomasini, Stefania Fracchia, Isabella Rebecchi, Elisabetta Morello, Anna Fontanella, Paola M R Parisi, Federica Tartarone, Fabrizio Giunco, Simona Ciccone, Paola Nicolini, Tiziano Lucchi, Beatrice Arosio, Silvia Inglese, Paolo D Ross. Diencephalic versus Hippocampal Amnesia in Alzheimer's Disease: The Possible Confabulation-Misidentification Phenotype. Journal of Alzheimer's disease : JAD. 2022-11-28. PMID:36442200. |
diencephalic versus hippocampal amnesia in alzheimer's disease: the possible confabulation-misidentification phenotype. |
2022-11-28 |
2023-08-14 |
Not clear |
| Ximeng Yang, Chihiro Tohd. Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1. Molecular neurobiology. 2022-11-27. PMID:36437381. |
in the pfc, the expression of gal-1 in axonal shafts and terminals of hippocampal neurons was decreased in the 5xfad mouse model of alzheimer's disease (ad). |
2022-11-27 |
2023-08-14 |
mouse |
| Kuldeep Kaur, Bharti Devi, Vishal Agrawal, Rajnish Kumar, Rajat Sandhi. Identification of potential inhibitors of brain-specific CYP46A1 from phytoconstituents in Indian traditional medicinal plants. Journal of proteins and proteomics. 2022-11-21. PMID:36404953. |
the inhibition of cyp46a1 with several synthetic molecules has been investigated extensively for treatment of alzheimer's disease, huntington's disease, glaucoma, and in hippocampal neurons from aged mice. |
2022-11-21 |
2023-08-14 |
mouse |
| Harshita Agrawal, Ashok M Mehendal. A Review of Proteins Associated With Neuroprotection and Regeneration in Alzheimer's Disease. Cureus. vol 14. issue 10. 2022-11-21. PMID:36407141. |
in alzheimer's disease, the destruction of neurons and the interconnection between them in the cortical region and the hippocampus is the beginning, after which the disease proceeds. |
2022-11-21 |
2023-08-14 |
Not clear |
| Yinzhong Lu, Kejia Xu, Dongyang Lin, Shuyan Wang, Rao Fu, Xiaobei Deng, Giorgia Croppi, Junjie Zhan. Multi-omics analysis reveals neuroinflammation, activated glial signaling, and dysregulated synaptic signaling and metabolism in the hippocampus of aged mice. Frontiers in aging neuroscience. vol 14. 2022-11-21. PMID:36408109. |
the hippocampus has long been known to be critically associated with cognitive impairment, dementia, and alzheimer's disease during aging; however, the underlying mechanisms remain largely unknown. |
2022-11-21 |
2023-08-14 |
mouse |
| Younghun Jung, Jonathan Lopez-Benitez, Christina M Tognoni, Isabel Carreras, Alpaslan Dedeogl. Dysregulation of Sphingosine-1-Phosphate (S1P) and S1P Receptor 1 Signaling in the 5xFAD Mouse Model of Alzheimer's Disease. Brain research. 2022-11-21. PMID:36410428. |
our recent studies have shown that treatment with fingolimod, an analog of sphingosine, provides neuroprotective effects in five familiar alzheimer disease (5xfad) transgenic mice, resulting in the reduction of amyloid-β (aβ) neurotoxicity, inhibition of activation of microglia and astrocytes, increased hippocampal neurogenesis, and improved learning and memory. |
2022-11-21 |
2023-08-14 |
mouse |
| Zhi-Hang Huang, Hai Wang, Dong-Mei Wang, Xiu-Yun Zhao, Wen-Wen Liu, Xin Zhong, Dong-Mei He, Ben-Rong Mu, Mei-Hong L. Identification of core genes in prefrontal cortex and hippocampus of Alzheimer's disease based on mRNA-miRNA network. Journal of cellular and molecular medicine. 2022-11-19. PMID:36401602. |
identification of core genes in prefrontal cortex and hippocampus of alzheimer's disease based on mrna-mirna network. |
2022-11-19 |
2023-08-14 |
mouse |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
the hippocampal sparing subtype of alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. |
2022-11-15 |
2023-08-14 |
human |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
neuropathology and neuroimaging studies have identified several subtypes of alzheimer's disease (ad): hippocampal sparing ad, typical ad, and limbic predominant ad. |
2022-11-15 |
2023-08-14 |
human |
| Nikita Zernov, Alexander V Veselovsky, Vladimir V Poroikov, Daria Melentieva, Anastasia Bolshakova, Elena Popugaev. New Positive TRPC6 Modulator Penetrates Blood-Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362339. |
we suggest that c20 might be recognized as the novel trpc6-selective drug suitable to treat synaptic deficiency in alzheimer's disease-affected hippocampal neurons. |
2022-11-11 |
2023-08-14 |
mouse |
| Pulak R Manna, Arubala P Reddy, Jangampalli Adi Pradeepkiran, Sudhir Kshirsagar, P Hemachandra Redd. Regulation of retinoid mediated StAR transcription and steroidogenesis in hippocampal neuronal cells: Implications for StAR in protecting Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2022-11-10. PMID:36356843. |
regulation of retinoid mediated star transcription and steroidogenesis in hippocampal neuronal cells: implications for star in protecting alzheimer's disease. |
2022-11-10 |
2023-08-14 |
mouse |
| Lloyd Prosser, Amy MacDougall, Carole H Sudre, Emily N Manning, Ian B Malone, Phoebe Walsh, Olivia Goodkin, Hugh Pemberton, Frederik Barkhof, Geert Jan Biessels, David M Cash, Josephine Barne. Predicting Cognitive Decline in Nondemented Elders Using Baseline Metrics of AD Pathologies, Cerebrovascular Disease, and Neurodegeneration. Neurology. 2022-11-10. PMID:36357185. |
here we compared the ability of baseline, single time-point biomarkers (csf amyloid 1-42, csf ptau-181, white matter hyperintensities (wmh), cerebral microbleeds (cmb), whole-brain volume, and hippocampal volume) to predict decline in cognitively normal individuals who later converted to mild cognitive impairment (mci) (cntomci), and those with mci who later converted to an alzheimer's disease (ad) diagnosis (mcitoad). |
2022-11-10 |
2023-08-14 |
Not clear |
| Kengo Suzuki, Yoshiaki Ohi, Toyohiro Sato, Yo Tsuda, Yuta Madokoro, Masayuki Mizuno, Kenichi Adachi, Yuto Uchida, Akira Haji, Kosei Ojika, Noriyuki Matsukaw. Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice. Scientific reports. vol 12. issue 1. 2022-11-10. PMID:36357544. |
cholinergic activation can enhance glutamatergic activity in the hippocampus under pathologic conditions, such as alzheimer's disease. |
2022-11-10 |
2023-08-14 |
mouse |
| David C Zhu, Chih-Ying Gwo, An-Wen Deng, Norman Scheel, Mari A Dowling, Rong Zhan. Hippocampus shape characterization with 3D Zernike transformation in clinical Alzheimer's disease progression. Human brain mapping. 2022-11-08. PMID:36346203. |
hippocampus shape characterization with 3d zernike transformation in clinical alzheimer's disease progression. |
2022-11-08 |
2023-08-14 |
human |
| Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J Laukka, Bengt Winblad, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-07. PMID:36341691. |
in the subsamples, we measured plasma amyloid beta (aβ)40, aβ42, total tau, and neurofilament light chain (nfl; n = 1054); and quantified hippocampal, entorhinal cortex, and white matter hyperintensity (wmh) volumes, and alzheimer's disease (ad)-signature cortical thickness (n = 917). |
2022-11-07 |
2023-08-14 |
human |
| Selene Tomassini, Agnese Sbrollini, Giacomo Covella, Paolo Sernani, Nicola Falcionelli, Henning Müller, Micaela Morettini, Laura Burattini, Aldo Franco Dragon. Brain-on-Cloud for automatic diagnosis of Alzheimer's disease from 3D structural magnetic resonance whole-brain scans. Computer methods and programs in biomedicine. vol 227. 2022-11-06. PMID:36335750. |
cortical and hippocampal atrophy caused by alzheimer's disease can be appreciated easily from a t1-weighted structural magnetic resonance scan. |
2022-11-06 |
2023-08-14 |
human |
| Kausalia Vijayaragavan, Bryan J Cannon, Dmitry Tebaykin, Marc Bossé, Alex Baranski, J P Oliveria, Syed A Bukhari, Dunja Mrdjen, M Ryan Corces, Erin F McCaffrey, Noah F Greenwald, Yari Sigal, Diana Marquez, Zumana Khair, Trevor Bruce, Mako Goldston, Anusha Bharadwaj, Kathleen S Montine, R Michael Angelo, Thomas J Montine, Sean C Bendal. Single-cell spatial proteomic imaging for human neuropathology. Acta neuropathologica communications. vol 10. issue 1. 2022-11-05. PMID:36333818. |
customized analysis strategies identified cell types and proteopathies in the hippocampus across stages of alzheimer's disease (ad) neuropathologic change. |
2022-11-05 |
2023-08-14 |
human |