| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minhee Jang, Sun-Hye Choi, Jong Hee Choi, Jinhee Oh, Ra Mi Lee, Na-Eun Lee, Yeon-Jin Cho, Hyewhon Rhim, Hyoung-Chun Kim, Ik-Hyun Cho, Seung-Yeol Na. Ginseng gintonin attenuates the disruptions of brain microvascular permeability and microvascular endothelium junctional proteins in an APPswe/PSEN-1 double-transgenic mouse model of Αlzheimer's disease. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-16. PMID:33717253. |
it has been previously indicated that gintonin, which is a novel exogenous ginseng-derived lysophosphatidic acid (lpa) receptor ligand, restores memory dysfunctions in an appswe/psen-1 double-transgenic mouse model of alzheimer's disease (ad tg mice) by attenuating β-amyloid plaque deposition, recovering cholinergic dysfunctions and upregulating hippocampal neurogenesis in the cortex and hippocampus. |
2021-03-16 |
2023-08-13 |
mouse |
| Dennis van der Meer, Jaroslav Rokicki, Tobias Kaufmann, Aldo Córdova-Palomera, Torgeir Moberget, Dag Alnæs, Francesco Bettella, Oleksandr Frei, Nhat Trung Doan, Ida E Sønderby, Olav B Smeland, Ingrid Agartz, Alessandro Bertolino, Janita Bralten, Christine L Brandt, Jan K Buitelaar, Srdjan Djurovic, Marjolein van Donkelaar, Erlend S Dørum, Thomas Espeseth, Stephen V Faraone, Guillén Fernández, Simon E Fisher, Barbara Franke, Beathe Haatveit, Catharina A Hartman, Pieter J Hoekstra, Asta K Håberg, Erik G Jönsson, Knut K Kolskår, Stephanie Le Hellard, Martina J Lund, Astri J Lundervold, Arvid Lundervold, Ingrid Melle, Jennifer Monereo Sánchez, Linn C Norbom, Jan E Nordvik, Lars Nyberg, Jaap Oosterlaan, Marco Papalino, Andreas Papassotiropoulos, Giulio Pergola, Dominique J F de Quervain, Geneviève Richard, Anne-Marthe Sanders, Pierluigi Selvaggi, Elena Shumskaya, Vidar M Steen, Siren Tønnesen, Kristine M Ulrichsen, Marcel P Zwiers, Ole A Andreassen, Lars T Westly. Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular psychiatry. vol 25. issue 11. 2021-03-15. PMID:30279459. |
these subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often impaired in individuals with brain disorders characterized by reduced hippocampal volume, including alzheimer's disease (ad) and schizophrenia. |
2021-03-15 |
2023-08-13 |
Not clear |
| Alessandra Agostini, Ding Yuchun, Bai Li, David A Kendall, Marie-Christine Pardo. Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Brain, behavior, and immunity. vol 83. 2021-03-08. PMID:31560941. |
sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the appswe/ps1de9 mouse model of alzheimer's disease. |
2021-03-08 |
2023-08-13 |
mouse |
| Lauren C Pawley, Cara M Hueston, James D O'Leary, Danka A Kozareva, John F Cryan, Olivia F O'Leary, Yvonne M Nola. Chronic intrahippocampal interleukin-1β overexpression in adolescence impairs hippocampal neurogenesis but not neurogenesis-associated cognition. Brain, behavior, and immunity. vol 83. 2021-03-08. PMID:31604142. |
the hippocampus is particularly vulnerable to altered concentrations of the pro-inflammatory cytokine interleukin-1β (il-1β), with elevated levels implicated in the aetiology of neurodegenerative disorders such as alzheimer's and parkinson's, and stress-related disorders such as depression. |
2021-03-08 |
2023-08-13 |
rat |
| Paul C Guest, Hassan Rahmoune, Daniel Martins-de-Souz. Proteomic Analysis of Rat Hippocampus for Studies of Cognition and Memory Loss with Aging. Methods in molecular biology (Clifton, N.J.). vol 2138. 2021-03-08. PMID:32219767. |
these could be of interest in further studies of neurological and neurodegenerative disorders linked with hippocampal dysfunction, such as aging, major depression, and alzheimer's disease. |
2021-03-08 |
2023-08-13 |
rat |
| Pierre-François D'Haese, Manish Ranjan, Alexander Song, Marc W Haut, Jeffrey Carpenter, Gerard Dieb, Umer Najib, Peng Wang, Rashi I Mehta, J Levi Chazen, Sally Hodder, Daniel Claassen, Michael Kaplitt, Ali R Reza. β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood-Brain Barrier Opening in Alzheimer's Disease. Frontiers in human neuroscience. vol 14. 2021-03-06. PMID:33132889. |
β-amyloid plaque reduction in the hippocampus after focused ultrasound-induced blood-brain barrier opening in alzheimer's disease. |
2021-03-06 |
2023-08-13 |
human |
| Siddhartha Mondragón-Rodríguez, Benito Ordaz, Erika Orta-Salazar, Sofia Díaz-Cintra, Fernando Peña-Ortega, George Perr. Hippocampal Unicellular Recordings and Hippocampal-dependent Innate Behaviors in an Adolescent Mouse Model of Alzheimer's disease. Bio-protocol. vol 10. issue 4. 2021-03-05. PMID:33654753. |
hippocampal unicellular recordings and hippocampal-dependent innate behaviors in an adolescent mouse model of alzheimer's disease. |
2021-03-05 |
2023-08-13 |
mouse |
| Diedre Carmo, Bruna Silva, Clarissa Yasuda, Letícia Rittner, Roberto Lotuf. Hippocampus segmentation on epilepsy and Alzheimer's disease studies with multiple convolutional neural networks. Heliyon. vol 7. issue 2. 2021-03-05. PMID:33659748. |
hippocampus segmentation on epilepsy and alzheimer's disease studies with multiple convolutional neural networks. |
2021-03-05 |
2023-08-13 |
Not clear |
| Mozhgan Aghajanzadeh, Sina Andalib, Hossein Danafar, Kobra Rostamizadeh, Ali Sharaf. The effect of baicalein-loaded Y-shaped miktoarm copolymer on spatial memory and hippocampal expression of DHCR24, SELADIN and SIRT6 genes in rat model of Alzheimer. International journal of pharmaceutics. vol 586. 2021-03-05. PMID:32544519. |
the effect of baicalein-loaded y-shaped miktoarm copolymer on spatial memory and hippocampal expression of dhcr24, seladin and sirt6 genes in rat model of alzheimer. |
2021-03-05 |
2023-08-13 |
rat |
| Seog-Kyun Mun, Hyunkyu Chae, Xian-Yu Piao, Hyun-Jin Lee, Young-Kook Kim, Seung-Ha Oh, Munyoung Chan. MicroRNAs Related to Cognitive Impairment After Hearing Loss. Clinical and experimental otorhinolaryngology. vol 14. issue 1. 2021-03-05. PMID:32646202. |
our research group has previously demonstrated that hearing loss might be a risk factor for synaptic loss within the hippocampus and impairment of cognition using an animal model of alzheimer disease. |
2021-03-05 |
2023-08-13 |
rat |
| Ting Ye, Xinquan Li, Peng Zhou, Shu Ye, Huawu Gao, Rupeng Hua, Junlong Ma, Yan Wang, Biao Ca. Chrysophanol improves memory ability of d-galactose and Aβ 3 Biotech. vol 10. issue 3. 2021-03-02. PMID:32117672. |
an alzheimer's disease rat model was established using an intraperitoneal injection of d-galactose combined with an intracerebral injection of amyloid-β peptide (25-35), and the effect of chr on the learning and memory ability, the hippocampal neurons change, the ultrastructure of the hippocampal ca1 region, the protein levels of cam, camkk, camkiv, p-camkiv and p-tau in the hippocampus of rats were studied. |
2021-03-02 |
2023-08-13 |
rat |
| Daria Pawlik, Antoine Leuzy, Olof Strandberg, Ruben Smit. Compensating for choroid plexus based off-target signal in the hippocampus using NeuroImage. vol 221. 2021-03-02. PMID:32711062. |
compensating for choroid plexus based off-target signal in the hippocampus using the hippocampus is affected by tau pathology early in alzheimer's disease (ad) development. |
2021-03-02 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
alzheimer's disease is characterized by the presence of amyloid-β and tau deposition in the brain, hippocampal atrophy and increased rates of hippocampal atrophy over time. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
tdp-43 and tau have also been linked to hippocampal atrophy in cases of primary age-related tauopathy, a pathological entity with features that strongly overlap with those of alzheimer's disease. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
at present, it is unclear whether and how tdp-43 and tau are associated with early or late hippocampal atrophy in alzheimer's disease and primary age-related tauopathy, whether either protein is also associated with faster rates of atrophy of other brain regions and whether there is evidence for protein-associated acceleration/deceleration of atrophy rates. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
we therefore aimed to model how these proteins, particularly tdp-43, influence non-linear trajectories of hippocampal and neocortical atrophy in alzheimer's disease and primary age-related tauopathy. |
2021-03-01 |
2023-08-13 |
Not clear |
| Cyrille Sur, James Kost, David Scott, Katarzyna Adamczuk, Nick C Fox, Jeffrey L Cummings, Pierre N Tariot, Paul S Aisen, Bruno Vellas, Tiffini Voss, Erin Mahoney, Yuki Mukai, Matthew E Kennedy, Christopher Lines, David Michelson, Michael F Ega. BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer's disease brain. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33253354. |
in the phase 3 epoch trial (clinicaltrials.gov; nct01739348), treatment with the bace inhibitor verubecestat failed to improve cognition in patients with mild-to-moderate alzheimer's disease, but was associated with reduced hippocampal volume after 78 weeks as assessed by mri. |
2021-03-01 |
2023-08-13 |
human |
| Aydin Saribudak, Adarsha A Subick, Na Hyun Kim, Joshua A Rutta, M Umit Uya. Gene Expressions, Hippocampal Volume Loss, and MMSE Scores in Computation of Progression and Pharmacologic Therapy Effects for Alzheimer's Disease. IEEE/ACM transactions on computational biology and bioinformatics. vol 17. issue 2. 2021-03-01. PMID:31722481. |
gene expressions, hippocampal volume loss, and mmse scores in computation of progression and pharmacologic therapy effects for alzheimer's disease. |
2021-03-01 |
2023-08-13 |
Not clear |
| Aydin Saribudak, Adarsha A Subick, Na Hyun Kim, Joshua A Rutta, M Umit Uya. Gene Expressions, Hippocampal Volume Loss, and MMSE Scores in Computation of Progression and Pharmacologic Therapy Effects for Alzheimer's Disease. IEEE/ACM transactions on computational biology and bioinformatics. vol 17. issue 2. 2021-03-01. PMID:31722481. |
expressions of ad related genes, mini mental state examination (mmse) scores, and hippocampal volume measurements of mci patients are obtained from the alzheimer's disease neuroimaging initiative (adni) database. |
2021-03-01 |
2023-08-13 |
Not clear |
| Sheng-Tao Yang, Min Wang, Veronica Galvin, Yang Yang, Amy F T Arnste. Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance. Psychopharmacology. vol 238. issue 1. 2021-02-26. PMID:32939596. |
metabotropic glutamate type 5 receptor (mglur5) antagonists are under development for treating cognitive disorders such as fragile x syndrome and alzheimer's disease, largely based on success in mouse models, where post-synaptic mglur5 stimulation weakens synaptic functions in hippocampus. |
2021-02-26 |
2023-08-13 |
mouse |