| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aonan Zhao, Fang Fang, Binyin Li, Yan Chen, Yinghui Qiu, Yanli Wu, Wei Xu, Yulei Den. Visual Abnormalities Associate With Hippocampus in Mild Cognitive Impairment and Early Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2021-02-10. PMID:33551787. |
visual abnormalities associate with hippocampus in mild cognitive impairment and early alzheimer's disease. |
2021-02-10 |
2023-08-13 |
Not clear |
| Wei-Ti Hsu, Yi-Hung Chen, Han-Bin Yang, Jaung-Geng Lin, Shih-Ya Hun. Electroacupuncture Improves Motor Symptoms of Parkinson's Disease and Promotes Neuronal Autophagy Activity in Mouse Brain. The American journal of Chinese medicine. vol 48. issue 7. 2021-02-09. PMID:33202151. |
we report that ea improves pd motor symptoms in mice and enhances (1) autophagy initiation (increased beclin 1), (2) autophagosome biogenesis (increased atg5, atg7, atg9a, atg12, atg16l, atg3, and lc3-ii), (3) autophagy flux/substrate degradation (decreased p62), and (4) mitophagy (increased pink1 and dj-1) in neurons of the substantia nigra, striatum, hippocampus, and cortex (affected brain areas of pd, huntington disease, and alzheimer's disease). |
2021-02-09 |
2023-08-13 |
mouse |
| Zhen Qiang Zhang, Christian Hölsche. GIP has neuroprotective effects in Alzheimer and Parkinson's disease models. Peptides. vol 125. 2021-02-08. PMID:31705913. |
in alzheimer's disease models, memory is rescued, synapse numbers and synaptic plasticity in the hippocampus is normalized, amyloid plaque load and the chronic inflammation is reduced. |
2021-02-08 |
2023-08-13 |
mouse |
| Shea J Andrews, Brian Fulton-Howard, Paul O'Reilly, Edoardo Marcora, Alison M Goat. Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome. Annals of neurology. vol 89. issue 1. 2021-02-02. PMID:32996171. |
the purpose of this study was to infer causal relationships between 22 previously reported risk factors for alzheimer's disease (ad) and the "ad phenome": ad, ad age of onset (aaos), hippocampal volume, cortical surface area and thickness, cerebrospinal fluid (csf) levels of amyloid-β (aβ |
2021-02-02 |
2023-08-13 |
Not clear |
| Chuan He, Zhong-Sheng Huang, Hong-Ru Chen, Chao-Chao Yu, Xue-Song Wang, Tao Jiang, Li-Hong Kon. [Effect of pretreatment of acupuncture on learning-memory ability and related protein of NLRP3 inflammasome in hippocampus in Alzheimer's disease like rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 12. 2021-02-01. PMID:33415876. |
[effect of pretreatment of acupuncture on learning-memory ability and related protein of nlrp3 inflammasome in hippocampus in alzheimer's disease like rats]. |
2021-02-01 |
2023-08-13 |
rat |
| Chuan He, Zhong-Sheng Huang, Hong-Ru Chen, Chao-Chao Yu, Xue-Song Wang, Tao Jiang, Li-Hong Kon. [Effect of pretreatment of acupuncture on learning-memory ability and related protein of NLRP3 inflammasome in hippocampus in Alzheimer's disease like rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 12. 2021-02-01. PMID:33415876. |
to observe the effect of pretreatment of acupuncture on the expression of nucleotide-binding oligomerization domain-like receptor 3(nlrp3), caspase-1, interleukin1β(il-1β) and the number of activated microglia (mg) in the hippocampus in alzheimer's disease (ad) like rats, so as to explore the mechanism of pretreatment of acupuncture in preventing and treating ad. |
2021-02-01 |
2023-08-13 |
rat |
| Negar Mehri, Rasool Haddadi, Maziar Ganji, Siamak Shahidi, Sara Soleimani Asl, Masoume Taheri Azandariani, Akram Ranjba. Effects of vitamin D in an animal model of Alzheimer's disease: behavioral assessment with biochemical investigation of Hippocampus and serum. Metabolic brain disease. vol 35. issue 2. 2021-01-29. PMID:31853828. |
effects of vitamin d in an animal model of alzheimer's disease: behavioral assessment with biochemical investigation of hippocampus and serum. |
2021-01-29 |
2023-08-13 |
rat |
| b' Kilian Hett, Vinh-Thong Ta, Gwena\\xc3\\xablle Catheline, Thomas Tourdias, Jos\\xc3\\xa9 V Manj\\xc3\\xb3n, Pierrick Coup\\xc3\\xa. Author Correction: Multimodal hippocampal subfield grading for Alzheimer\'s disease classification. Scientific reports. vol 10. issue 1. 2021-01-27. PMID:32606432.' |
author correction: multimodal hippocampal subfield grading for alzheimer's disease classification. |
2021-01-27 |
2023-08-13 |
Not clear |
| Amanda K Engstrom, Alicia C Walker, Rohitha A Moudgal, Dexter A Myrick, Stephanie M Kyle, Yu Bai, M Jordan Rowley, David J Kat. The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 46. 2021-01-25. PMID:33139560. |
previously, our laboratory implicated the histone demethylase lsd1 in tau-induced neurodegeneration by showing that lsd1 localizes to pathological tau aggregates in alzheimer's disease cases, and that it is continuously required for the survival of hippocampal and cortical neurons in mice. |
2021-01-25 |
2023-08-13 |
mouse |
| Md Habibur Rahman, Rokeya Akter, Tanima Bhattacharya, Mohamed M Abdel-Daim, Saad Alkahtani, Mohammed W Arafah, Norah S Al-Johani, Norah M Alhoshani, Nora Alkeraishan, Alhanof Alhenaky, Omar H Abd-Elkader, Hesham R El-Seedi, Deepak Kaushik, Vineet Mitta. Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease. Frontiers in pharmacology. vol 11. 2021-01-19. PMID:33456444. |
alzheimer's disease (ad) is a progressive cortex and hippocampal neurodegenerative disease which ultimately causes cognitively impaired decline in patients. |
2021-01-19 |
2023-08-13 |
Not clear |
| Lei Xu, Haixiang Yu, Hongbin Sun, Bang Hu, Yi Gen. Dietary Melatonin Therapy Alleviates the Lamina Cribrosa Damages in Patients with Mild Cognitive Impairments: A Double-Blinded, Randomized Controlled Study. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-19. PMID:32376818. |
background alzheimer's disease (ad) is a degenerative disease that is characterized by massive neuron devastations in the hippocampus and cortex. |
2021-01-19 |
2023-08-13 |
Not clear |
| Hong-He Xiao, Ming-Bo Zhang, Jun-Ting Xu, Yan Deng, Ning Li, Peng Gao, Yan Li, Liang Kong, Wan-Yi Li, Ji-Cong Chen, Hong-Yan Li, Guo-Shun Shan, He Tai, Jing-Xian Yan. Icarisid II promotes proliferation and neuronal differentiation of neural stem cells via activating Wnt/β-catenin signaling pathway. Phytotherapy research : PTR. 2021-01-17. PMID:33455039. |
mobilization of hippocampal neurogenesis has been regarded as a promising therapeutic approach to restore injured neurons in neurodegenerative diseases including alzheimer's disease (ad). |
2021-01-17 |
2023-08-13 |
human |
| Fengjin Hao, Yueqin Fen. Cannabidiol (CBD) enhanced the hippocampal immune response and autophagy of APP/PS1 Alzheimer's mice uncovered by RNA-seq. Life sciences. vol 264. 2021-01-15. PMID:33096116. |
cannabidiol (cbd) enhanced the hippocampal immune response and autophagy of app/ps1 alzheimer's mice uncovered by rna-seq. |
2021-01-15 |
2023-08-13 |
mouse |
| Masoomeh Nazifi, Shahrbanoo Oryan, Delaram Eslimi Esfahani, Manoochehr Ashrafpoo. The functional effects of piperine and piperine plus donepezil on hippocampal synaptic plasticity impairment in rat model of Alzheimer's disease. Life sciences. vol 265. 2021-01-13. PMID:33242524. |
the functional effects of piperine and piperine plus donepezil on hippocampal synaptic plasticity impairment in rat model of alzheimer's disease. |
2021-01-13 |
2023-08-13 |
rat |
| Masoomeh Nazifi, Shahrbanoo Oryan, Delaram Eslimi Esfahani, Manoochehr Ashrafpoo. The functional effects of piperine and piperine plus donepezil on hippocampal synaptic plasticity impairment in rat model of Alzheimer's disease. Life sciences. vol 265. 2021-01-13. PMID:33242524. |
the present study investigated the effect of piperine and piperine-donepezil co-administration on cognitive functions and synaptic plasticity at hippocampal perforant pathway (pp) to dentate gyrus (dg) synapses in an experimental model of alzheimer's disease (ad). |
2021-01-13 |
2023-08-13 |
rat |
| Shoma Ishikawa, Fuyuki Ishikaw. Proteostasis failure and cellular senescence in long-term cultured postmitotic rat neurons. Aging cell. vol 19. issue 1. 2021-01-13. PMID:31762159. |
primary rat hippocampal neurons in long-term cultures show molecular changes indicative of both senescence (senescence-associated β-galactosidase, p16, and loss of lamin b1) and proteostasis failure relevant to alzheimer's disease. |
2021-01-13 |
2023-08-13 |
rat |
| Dae Won Moon, Young Ho Park, Sun Young Lee, Heejin Lim, SuHwa Kwak, Minseok S Kim, Hyunmin Kim, Eunjoo Kim, Yebin Jung, Hyang-Sook Hoe, Sungjee Kim, Dong-Kwon Lim, Chul-Hoon Kim, Su-Il I. Multiplex Protein Imaging with Secondary Ion Mass Spectrometry Using Metal Oxide Nanoparticle-Conjugated Antibodies. ACS applied materials & interfaces. vol 12. issue 15. 2021-01-12. PMID:32073828. |
we applied our new imaging technique for the study of hippocampal tissue samples from control and alzheimer's disease (ad) model mice; the proximity of protein clusters in the hippocampus ca1 region showed intriguing dependence on aging and ad progress, suggesting that protein cluster proximity may be helpful for understanding pathological pathways in the microscopic cellular level. |
2021-01-12 |
2023-08-13 |
mouse |
| Xiao-Ling Wang, Yu-Xin Deng, Yu-Mei Gao, Yang-Ting Dong, Fan Wang, Zhi-Zhong Guan, Wei Hong, Xiao-Lan Q. Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway. Aging. vol 12. issue 1. 2021-01-11. PMID:31905173. |
the present study used primary hippocampus cells and appswe/psen1de9 double-transgenic mice models to study the possible therapeutic effect and underlying mechanism of the specific activation of α7 nachr by pnu-282987 in the pathogenesis of alzheimer's disease. |
2021-01-11 |
2023-08-13 |
mouse |
| Meina Quan, Tan Zhao, Yi Tang, Ping Luo, Wei Wang, Qi Qin, Tingting Li, Qigeng Wang, Jiliang Fang, Jianping Ji. Effects of gene mutation and disease progression on representative neural circuits in familial Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-01-11. PMID:31937364. |
although structural and functional changes of the striatum and hippocampus are present in familial alzheimer's disease, little is known about the effects of specific gene mutation or disease progression on their related neural circuits. |
2021-01-11 |
2023-08-13 |
Not clear |
| Hyowon Chung, Kyerl Park, Hyun Jae Jang, Michael M Kohl, Jeehyun Kwa. Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid β oligomers in vivo. Brain structure & function. vol 225. issue 3. 2021-01-08. PMID:32107637. |
accumulation of amyloid β oligomers (aβo) in alzheimer's disease (ad) impairs hippocampal theta and gamma oscillations. |
2021-01-08 |
2023-08-13 |
mouse |