| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J Moore, T J Lyons, J Gallache. Using path signatures to predict a diagnosis of Alzheimer's disease. PloS one. vol 14. issue 9. 2020-03-12. PMID:31536538. |
while hippocampal and brain volume changes are well known in alzheimer's disease, we demonstrate the power of the path signature in their identification and analysis without manual feature selection. |
2020-03-12 |
2023-08-13 |
Not clear |
| Donald J Joseph, Chunxia Liu, Jun Peng, Ge Liang, Huafeng We. Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner. PloS one. vol 14. issue 10. 2020-03-12. PMID:31600350. |
isoflurane mediated neuropathological and cognitive impairments in the triple transgenic alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner. |
2020-03-12 |
2023-08-13 |
mouse |
| David J Titus, Timothy Johnstone, Nathan H Johnson, Sidney H London, Meghana Chapalamadugu, Derk Hogenkamp, Kelvin W Gee, Coleen M Atkin. Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury. PloS one. vol 14. issue 10. 2020-03-11. PMID:31581202. |
the α7 nicotinic acetylcholine receptor (nachr) is highly expressed in the hippocampus and reduced expression and function of this receptor are linked with cognitive impairments in alzheimer's disease and schizophrenia. |
2020-03-11 |
2023-08-13 |
human |
| Felipe Kenji Sudo, Andrea Silveira de Souza, Claudia Drummond, Naima Assuncao, Alina Teldeschi, Natalia Oliveira, Fernanda Rodrigues, Gustavo Santiago-Bravo, Victor Calil, Gabriel Lima, Pilar Erthal, Gabriel Bernardes, Marina Monteiro, Fernanda Tovar-Moll, Paulo Matto. Inter-method and anatomical correlates of episodic memory tests in the Alzheimer's Disease spectrum. PloS one. vol 14. issue 10. 2020-03-10. PMID:31600312. |
episodic memory impairments have been described as initial clinical findings in the alzheimer's disease (ad) spectrum, which could be associated with the presence of early hippocampal dysfunction. |
2020-03-10 |
2023-08-13 |
Not clear |
| Michael Popiolek, Yael Mandelblat-Cerf, Damon Young, Jonathan Garst-Orozco, Susan M Lotarski, Eda Stark, Melissa Kramer, Christopher R Butler, Rouba Koza. In Vivo Modulation of Hippocampal Excitability by M4 Muscarinic Acetylcholine Receptor Activator: Implications for Treatment of Alzheimer's Disease and Schizophrenic Patients. ACS chemical neuroscience. vol 10. issue 3. 2020-03-05. PMID:30335349. |
in vivo modulation of hippocampal excitability by m4 muscarinic acetylcholine receptor activator: implications for treatment of alzheimer's disease and schizophrenic patients. |
2020-03-05 |
2023-08-13 |
Not clear |
| Michael Popiolek, Yael Mandelblat-Cerf, Damon Young, Jonathan Garst-Orozco, Susan M Lotarski, Eda Stark, Melissa Kramer, Christopher R Butler, Rouba Koza. In Vivo Modulation of Hippocampal Excitability by M4 Muscarinic Acetylcholine Receptor Activator: Implications for Treatment of Alzheimer's Disease and Schizophrenic Patients. ACS chemical neuroscience. vol 10. issue 3. 2020-03-05. PMID:30335349. |
abnormal hippocampal activity has been linked to impaired cognitive performance in alzheimer's disease and schizophrenia, leading to a hypothesis that normalization of this activity may be therapeutically beneficial. |
2020-03-05 |
2023-08-13 |
Not clear |
| E Orta-Salazar, A I Feria-Velasco, S Díaz-Cintr. Primary motor cortex alterations in Alzheimer disease: A study in the 3xTg-AD model. Neurologia (Barcelona, Spain). vol 34. issue 7. 2020-03-02. PMID:28433262. |
in humans and animal models, alzheimer disease (ad) is characterised by accumulation of amyloid-β peptide (aβ) and hyperphosphorylated tau protein, neuronal degeneration, and astrocytic gliosis, especially in vulnerable brain regions (hippocampus and cortex). |
2020-03-02 |
2023-08-13 |
mouse |
| B A Ardekani, S A Hadid, E Blessing, A H Bachma. Sexual Dimorphism and Hemispheric Asymmetry of Hippocampal Volumetric Integrity in Normal Aging and Alzheimer Disease. AJNR. American journal of neuroradiology. vol 40. issue 2. 2020-03-02. PMID:30655257. |
sexual dimorphism and hemispheric asymmetry of hippocampal volumetric integrity in normal aging and alzheimer disease. |
2020-03-02 |
2023-08-13 |
Not clear |
| B A Ardekani, S A Hadid, E Blessing, A H Bachma. Sexual Dimorphism and Hemispheric Asymmetry of Hippocampal Volumetric Integrity in Normal Aging and Alzheimer Disease. AJNR. American journal of neuroradiology. vol 40. issue 2. 2020-03-02. PMID:30655257. |
asymmetric atrophy of the hippocampus is an important clinical finding in normal aging and alzheimer disease. |
2020-03-02 |
2023-08-13 |
Not clear |
| Francesca Rocchio, Laura Tapella, Marcello Manfredi, Mariangela Chisari, Francesca Ronco, Federico Alessandro Ruffinatti, Eleonora Conte, Pier Luigi Canonico, Maria Angela Sortino, Mariagrazia Grilli, Emilio Marengo, Armando A Genazzani, Dmitry Li. Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model. Cell death & disease. vol 10. issue 1. 2020-02-26. PMID:30631041. |
gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an alzheimer's disease mouse model. |
2020-02-26 |
2023-08-13 |
mouse |
| Francesca Rocchio, Laura Tapella, Marcello Manfredi, Mariangela Chisari, Francesca Ronco, Federico Alessandro Ruffinatti, Eleonora Conte, Pier Luigi Canonico, Maria Angela Sortino, Mariagrazia Grilli, Emilio Marengo, Armando A Genazzani, Dmitry Li. Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model. Cell death & disease. vol 10. issue 1. 2020-02-26. PMID:30631041. |
evidence is rapidly growing regarding a role of astroglial cells in the pathogenesis of alzheimer's disease (ad), and the hippocampus is one of the important brain regions affected in ad. |
2020-02-26 |
2023-08-13 |
mouse |
| Kun Zhang, Bin Li, Peifang Li, Xiaoli Yang, Huixian Cui, Xiaoyun Li. Cell-based immunofluorescence assay for screening the neurogenesis potential of new drugs in adult hippocampal neural progenitor cells. Acta neurobiologiae experimentalis. vol 79. issue 3. 2020-02-18. PMID:31587022. |
preclinical studies have suggested that increased adult neurogenesis in the hippocampus might have potential therapeutic effects for alzheimer's disease and depression; therefore, it is a target for the treatment of some brain diseases. |
2020-02-18 |
2023-08-13 |
Not clear |
| Muaz Belviranlı, Nilsel Okuda. Voluntary, involuntary and forced exercises almost equally reverse behavioral impairment by regulating hippocampal neurotrophic factors and oxidative stress in experimental Alzheimer's disease model. Behavioural brain research. vol 364. 2020-02-13. PMID:30790584. |
voluntary, involuntary and forced exercises almost equally reverse behavioral impairment by regulating hippocampal neurotrophic factors and oxidative stress in experimental alzheimer's disease model. |
2020-02-13 |
2023-08-13 |
rat |
| Muaz Belviranlı, Nilsel Okuda. Voluntary, involuntary and forced exercises almost equally reverse behavioral impairment by regulating hippocampal neurotrophic factors and oxidative stress in experimental Alzheimer's disease model. Behavioural brain research. vol 364. 2020-02-13. PMID:30790584. |
the purpose of this study was to compare the neuroprotective effects of voluntary, involuntary, and forced exercise trainings on behavioral impairment as well as hippocampal alzheimer's disease (ad) pathology and oxidative stress markers, and levels of neurotrophic factors in the rat model of ad. |
2020-02-13 |
2023-08-13 |
rat |
| Raphaël Sivera, Hervé Delingette, Marco Lorenzi, Xavier Pennec, Nicholas Ayach. A model of brain morphological changes related to aging and Alzheimer's disease from cross-sectional assessments. NeuroImage. vol 198. 2020-02-12. PMID:31121298. |
in the model, the morphological changes associated with normal aging are mainly found around the ventricles, while the alzheimer's disease specific changes are located in the temporal lobe and the hippocampal area. |
2020-02-12 |
2023-08-13 |
human |
| Katharina Schmidt, Bilal Bari, Martina Ralle, Clorissa Washington-Hughes, Abigael Muchenditsi, Evan Maxey, Svetlana Lutsenk. Localization of the Locus Coeruleus in the Mouse Brain. Journal of visualized experiments : JoVE. issue 145. 2020-01-31. PMID:30907876. |
structural or functional abnormalities of lc impact several brain regions including cortex, hippocampus, and cerebellum and may contribute to depression, bipolar disorder, anxiety, as well as parkinson disease and alzheimer disease. |
2020-01-31 |
2023-08-13 |
mouse |
| Wen-Dan Yang, Wan-Qing Guo, Chang-Hui Qian, Qian Xu, Xue-Hua Zheng, Wei-Guo Don. [Effect of early intervention of electroacupuncture on learning-memory ability and level of hippocampal phosphorylated Tau protein in SAMP8 mice]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 1. 2020-01-29. PMID:31930902. |
to explore the effect of early intervention electroacupuncture (ea) at "baihui" (gv 20), "dazhui" (gv 14) and "shenshu" (bl 23) on the learning-memory ability and the expression of phosphorylated tau protein in the hippocampus of samp8 mice, so as to provide reference for the intervening period of ea for alzheimer's disease (ad). |
2020-01-29 |
2023-08-13 |
mouse |
| Vincent Planche, Pierrick Coupé, Catherine Helmer, Mélanie Le Goff, Helene Amieva, François Tison, Jean-François Dartigues, Gwénaëlle Cathelin. Evolution of brain atrophy subtypes during aging predicts long-term cognitive decline and future Alzheimer's clinical syndrome. Neurobiology of aging. vol 79. 2020-01-27. PMID:31026619. |
in cox proportional-hazards models, "hippocampal predominant atrophy" was associated with an increased risk of developing alzheimer's clinical syndrome over time (hazard ratio = 5.73; 95% ci 2.71-12.15), independently of age and apoe4 genotype, the 2 other significant predictive factors. |
2020-01-27 |
2023-08-13 |
human |
| Vincent Planche, Pierrick Coupé, Catherine Helmer, Mélanie Le Goff, Helene Amieva, François Tison, Jean-François Dartigues, Gwénaëlle Cathelin. Evolution of brain atrophy subtypes during aging predicts long-term cognitive decline and future Alzheimer's clinical syndrome. Neurobiology of aging. vol 79. 2020-01-27. PMID:31026619. |
as a possible surrogate of confined tauopathy and early alzheimer's disease pathology, future studies should consider the definition of "hippocampal predominant atrophy" based on hippocampal-to-cortical volume ratio evolution rather than hippocampal volume alone. |
2020-01-27 |
2023-08-13 |
human |
| Li Wang, Yansong Zheng, Xiaoxiao Gao, Yingchun Liu, Xiaoqing Yo. Retinoid X receptor ligand regulates RXRα/Nur77-dependent apoptosis via modulating its nuclear export and mitochondrial targeting. International journal of clinical and experimental pathology. vol 10. issue 11. 2020-01-26. PMID:31966420. |
thus, we detected the changes of the expression and subcellular localization of rxrα/nur77 and the apoptotic rate of neuroblastoma cells, sh-sy5y cells and nerve cells in c57bl/6 mouse hippocampus in alzheimer's disease pathologic condition, and investigated the effect of rxrα exporting inhibition caused by 9-cis-ra on the apoptosis of neurons. |
2020-01-26 |
2023-08-13 |
mouse |