| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bihua Bie, Jiang Wu, Joseph F Foss, Mohamed Nagui. Amyloid fibrils induce dysfunction of hippocampal glutamatergic silent synapses. Hippocampus. vol 28. issue 8. 2019-07-16. PMID:29704282. |
their involvement in the dysfunction of hippocampal glutamatergic transmission in the setting of alzheimer's disease (ad) is unknown. |
2019-07-16 |
2023-08-13 |
rat |
| Claire R Galloway, Kaushik Ravipati, Suyashi Singh, Evan P Lebois, Robert M Cohen, Allan I Levey, Joseph R Mann. Hippocampal place cell dysfunction and the effects of muscarinic M Hippocampus. vol 28. issue 8. 2019-07-16. PMID:29742799. |
hippocampal place cell dysfunction and the effects of muscarinic m alzheimer's disease (ad) is a neurodegenerative disease that disproportionately impacts memory and the hippocampus. |
2019-07-16 |
2023-08-13 |
rat |
| Murat Bilgel, Yang An, Jessica Helphrey, Wendy Elkins, Gabriela Gomez, Dean F Wong, Christos Davatzikos, Luigi Ferrucci, Susan M Resnic. Effects of amyloid pathology and neurodegeneration on cognitive change in cognitively normal adults. Brain : a journal of neurology. vol 141. issue 8. 2019-07-15. PMID:29901697. |
we assessed associations among neuroimaging measures of cerebral amyloid pathology, a hallmark alzheimer's neuropathology, hippocampal atrophy, and prospective cognition among 171 cognitively normal baltimore longitudinal study of aging participants (baseline age 56-95 years, 48% female, 562 cognitive assessments, 3.7 years follow-up). |
2019-07-15 |
2023-08-13 |
human |
| Diana Furcila, Javier DeFelipe, Lidia Alonso-Nanclare. A Study of Amyloid-β and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer's Disease Patients. Journal of Alzheimer's disease : JAD. vol 64. issue 2. 2019-07-15. PMID:29914033. |
a study of amyloid-β and phosphotau in plaques and neurons in the hippocampus of alzheimer's disease patients. |
2019-07-15 |
2023-08-13 |
Not clear |
| Idoia Blanco-Luquin, Miren Altuna, Javier Sánchez-Ruiz de Gordoa, Amaya Urdánoz-Casado, Miren Roldán, María Cámara, Victoria Zelaya, María Elena Erro, Carmen Echavarri, Maite Mendioro. PLD3 epigenetic changes in the hippocampus of Alzheimer's disease. Clinical epigenetics. vol 10. issue 1. 2019-07-15. PMID:30208929. |
pld3 epigenetic changes in the hippocampus of alzheimer's disease. |
2019-07-15 |
2023-08-13 |
human |
| Jiayuan Xu, Qiaojun Li, Wen Qin, Mulin Jun Li, Chuanjun Zhuo, Huaigui Liu, Feng Liu, Junping Wang, Gunter Schumann, Chunshui Y. Neurobiological substrates underlying the effect of genomic risk for depression on the conversion of amnestic mild cognitive impairment. Brain : a journal of neurology. vol 141. issue 12. 2019-07-15. PMID:30445590. |
these cross-scale neurobiological analyses and functional annotations indicate that major depressive disorder-specific genetic variants may increase the conversion from amnestic mild cognitive impairment to alzheimer's disease by modulating the early hippocampal development and amyloid-beta binding. |
2019-07-15 |
2023-08-13 |
Not clear |
| Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto, Kimmo Jokivarsi, Mari Takalo, Mikael Marttinen, Rebekka Wittrahm, Susanna Kemppainen, Reyhaneh Naderi, Adrián Posado-Fernández, Simo Ryhänen, Petra Mäkinen, Kaisa M A Paldanius, Gonçalo Doria, Pekka Poutiainen, Orfeu Flores, Annakaisa Haapasalo, Heikki Tanila, Mikko Hiltune. Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice. Neurobiology of aging. vol 75. 2019-07-11. PMID:30554086. |
intranasal insulin activates akt2 signaling pathway in the hippocampus of wild-type but not in app/ps1 alzheimer model mice. |
2019-07-11 |
2023-08-13 |
mouse |
| Denis S Smirnov, Douglas Galasko, Lawrence A Hansen, Steven D Edland, James B Brewer, David P Salmo. Trajectories of cognitive decline differ in hippocampal sclerosis and Alzheimer's disease. Neurobiology of aging. vol 75. 2019-07-11. PMID:30579145. |
trajectories of cognitive decline differ in hippocampal sclerosis and alzheimer's disease. |
2019-07-11 |
2023-08-13 |
human |
| Denis S Smirnov, Douglas Galasko, Lawrence A Hansen, Steven D Edland, James B Brewer, David P Salmo. Trajectories of cognitive decline differ in hippocampal sclerosis and Alzheimer's disease. Neurobiology of aging. vol 75. 2019-07-11. PMID:30579145. |
hippocampal sclerosis (hs) is a prevalent cause of dementia in the oldest old but is generally misdiagnosed as alzheimer's disease (ad) due to similarities in clinical presentation. |
2019-07-11 |
2023-08-13 |
human |
| Keith S Cover, Ronald A van Schijndel, Paolo Bosco, Soheil Damangir, Alberto Redolf. Can measuring hippocampal atrophy with a fully automatic method be substantially less noisy than manual segmentation over both 1 and 3 years? Psychiatry research. Neuroimaging. vol 280. 2019-07-09. PMID:30149361. |
to quantify the "segmentation noise" of several widely used fully automatic methods for measuring longitudinal hippocampal atrophy in alzheimer's disease and compare the results to the segmentation noise of manual segmentation over both 1 and 3 years. |
2019-07-09 |
2023-08-13 |
human |
| Akinori Nakamura, Pablo Cuesta, Alberto Fernández, Yutaka Arahata, Kaori Iwata, Izumi Kuratsubo, Masahiko Bundo, Hideyuki Hattori, Takashi Sakurai, Koji Fukuda, Yukihiko Washimi, Hidetoshi Endo, Akinori Takeda, Kersten Diers, Ricardo Bajo, Fernando Maestú, Kengo Ito, Takashi Kat. Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 5. 2019-07-08. PMID:29522156. |
the results demonstrated that regional spectral patterns of resting state activity could be separated into several types of meg signatures as follows: (i) the effects of amyloid-β deposition were expressed as the alpha band power augmentation in medial frontal areas; (ii) the delta band power increase in the same region was associated with disease progression within the alzheimer's disease continuum and was correlated with entorhinal atrophy and an alzheimer's disease-like regional decrease in glucose metabolism; and (iii) the global theta power augmentation, which was previously considered to be an alzheimer's disease-related eeg/meg signature, was associated with general cognitive decline and hippocampal atrophy, but was not specific to alzheimer's disease because these changes could be observed in the absence of amyloid-β deposition. |
2019-07-08 |
2023-08-13 |
Not clear |
| Lorraine Hamelin, Julien Lagarde, Guillaume Dorothée, Marie Claude Potier, Fabian Corlier, Bertrand Kuhnast, Fabien Caillé, Bruno Dubois, Ludovic Fillon, Marie Chupin, Michel Bottlaender, Marie Sarazi. Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 6. 2019-07-08. PMID:29608645. |
the positive correlations between change in 18f-dpa-714 binding over time and the three clinical outcome measures (clinical dementia rating, mini-mental state examination, hippocampal atrophy) suggested a detrimental effect on clinical alzheimer's disease progression of increased neuroinflammation after the initial pet examination, without correlation with pib-pet uptake at baseline. |
2019-07-08 |
2023-08-13 |
human |
| Osama Sabri, Philipp M Meyer, Susanne Gräf, Swen Hesse, Stephan Wilke, Georg-Alexander Becker, Michael Rullmann, Marianne Patt, Julia Luthardt, Gudrun Wagenknecht, Alexander Hoepping, Rene Smits, Annegret Franke, Bernhard Sattler, Solveig Tiepolt, Steffen Fischer, Winnie Deuther-Conrad, Ulrich Hegerl, Henryk Barthel, Peter Schönknecht, Peter Brus. Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer's dementia. Brain : a journal of neurology. vol 141. issue 6. 2019-07-08. PMID:29672680. |
analyses revealed that in patients with mild alzheimer's dementia compared to healthy controls, there was significantly lower vt, especially within the hippocampus, fronto-temporal cortices, and basal forebrain, which was similar to comparisons of vs. vt decline in alzheimer's dementia was associated with distinct domains of impaired cognitive functioning, especially episodic memory and executive function/working memory. |
2019-07-08 |
2023-08-13 |
human |
| Ralph Michael, Aufried Lenferink, Gijs F J M Vrensen, Ellen Gelpi, Rafael I Barraquer, Cees Ott. Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer's disease patients. Scientific reports. vol 7. issue 1. 2019-07-05. PMID:29142266. |
we evaluated 12 unstained frontal cortex and hippocampus samples from 3 brain donors with alzheimer's disease and 1 control with hyperspectral raman microscopy on samples of 30 × 30 µm. |
2019-07-05 |
2023-08-13 |
human |
| Luiza K Axelrud, Marcos L Santoro, Daniel S Pine, Fernanda Talarico, Ary Gadelha, Gisele G Manfro, Pedro M Pan, Andrea Jackowski, Felipe Picon, Elisa Brietzke, Rodrigo Grassi-Oliveira, Rodrigo A Bressan, Eurípedes C Miguel, Luis A Rohde, Hakon Hakonarson, Zdenka Pausova, Sintia Belangero, Tomas Paus, Giovanni A Salu. Polygenic Risk Score for Alzheimer's Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life. The American journal of psychiatry. vol 175. issue 6. 2019-07-05. PMID:29495896. |
polygenic risk score for alzheimer's disease: implications for memory performance and hippocampal volumes in early life. |
2019-07-05 |
2023-08-13 |
Not clear |
| Luiza K Axelrud, Marcos L Santoro, Daniel S Pine, Fernanda Talarico, Ary Gadelha, Gisele G Manfro, Pedro M Pan, Andrea Jackowski, Felipe Picon, Elisa Brietzke, Rodrigo Grassi-Oliveira, Rodrigo A Bressan, Eurípedes C Miguel, Luis A Rohde, Hakon Hakonarson, Zdenka Pausova, Sintia Belangero, Tomas Paus, Giovanni A Salu. Polygenic Risk Score for Alzheimer's Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life. The American journal of psychiatry. vol 175. issue 6. 2019-07-05. PMID:29495896. |
the authors evaluate this possibility by examining, in youths, associations among polygenic risk score for alzheimer's disease, cognitive abilities, and hippocampal volume. |
2019-07-05 |
2023-08-13 |
Not clear |
| Ganesh B Chand, Ihab Hajjar, Deqiang Qi. Disrupted interactions among the hippocampal, dorsal attention, and central-executive networks in amnestic mild cognitive impairment. Human brain mapping. vol 39. issue 12. 2019-07-03. PMID:30272830. |
in amnestic mild cognitive impairment (mci) and alzheimer's disease, the hippocampal network (hcn)-a key memory processing system-and its interactions with other networks have gathered central interest. |
2019-07-03 |
2023-08-13 |
Not clear |
| Irene Sánchez-Rodríguez, Agnès Gruart, José María Delgado-García, Lydia Jiménez-Díaz, Juan D Navarro-Lópe. Role of GirK Channels in Long-Term Potentiation of Synaptic Inhibition in an In Vivo Mouse Model of Early Amyloid- International journal of molecular sciences. vol 20. issue 5. 2019-07-01. PMID:30866445. |
role of girk channels in long-term potentiation of synaptic inhibition in an in vivo mouse model of early amyloid- imbalances of excitatory/inhibitory synaptic transmission occur early in the pathogenesis of alzheimer's disease (ad), leading to hippocampal hyperexcitability and causing synaptic, network, and cognitive dysfunctions. |
2019-07-01 |
2023-08-13 |
mouse |
| Hugo Botha, William G Mantyh, Melissa E Murray, David S Knopman, Scott A Przybelski, Heather J Wiste, Jonathan Graff-Radford, Keith A Josephs, Christopher G Schwarz, Walter K Kremers, Bradley F Boeve, Ronald C Petersen, Mary M Machulda, Joseph E Parisi, Dennis W Dickson, Val Lowe, Clifford R Jack, David T Jone. FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis. Brain : a journal of neurology. vol 141. issue 4. 2019-06-28. PMID:29538658. |
for the autopsy cohort, sequential cases with antemortem 18f-fdg-pet were screened and those with tdp-43-negative alzheimer's disease (10 cases) and tdp-43-positive hippocampal sclerosis (eight cases) were included. |
2019-06-28 |
2023-08-13 |
human |
| Hugo Botha, William G Mantyh, Melissa E Murray, David S Knopman, Scott A Przybelski, Heather J Wiste, Jonathan Graff-Radford, Keith A Josephs, Christopher G Schwarz, Walter K Kremers, Bradley F Boeve, Ronald C Petersen, Mary M Machulda, Joseph E Parisi, Dennis W Dickson, Val Lowe, Clifford R Jack, David T Jone. FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis. Brain : a journal of neurology. vol 141. issue 4. 2019-06-28. PMID:29538658. |
in the autopsy series, hippocampal sclerosis cases had greater medial temporal hypometabolism than alzheimer's disease cases, who had more parietal and lateral/inferior temporal hypometabolism. |
2019-06-28 |
2023-08-13 |
human |