| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michy P Kell. Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain. Cellular signalling. vol 42. 2018-07-18. PMID:29175000. |
among the most reproducible findings are 1) elevated circulating anp and bnp levels being associated with cognitive dysfunction or dementia independent of cardiovascular effects, 2) reduced basal and/or nmda-stimulated cgmp levels in brain with aging or alzheimer's disease (ad), 3) reduced adenylyl cyclase activity in hippocampus and specific cortical regions with aging or ad, 4) reduced expression/activity of pka in temporal cortex and hippocampus with ad, 5) reduced phosphorylation of creb in hippocampus with aging or ad, 6) reduced expression/activity of the pde4 family in brain with aging, 7) reduced expression of pde10a in the striatum with huntington's disease (hd) or parkinson's disease, and 8) beneficial effects of select pde inhibitors, particularly pde10 inhibitors in hd models and pde4 and pde5 inhibitors in aging and ad models. |
2018-07-18 |
2023-08-13 |
human |
| Yan Liu, Yan-Feng Xu, Ling Zhang, Lan Huang, Pin Yu, Hua Zhu, Wei Deng, Chuan Qi. Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice. CNS neuroscience & therapeutics. vol 23. issue 7. 2018-07-17. PMID:28597477. |
effective expression of drebrin in hippocampus improves cognitive function and alleviates lesions of alzheimer's disease in app (swe)/ps1 (Δe9) mice. |
2018-07-17 |
2023-08-13 |
mouse |
| Huiyoung Kwon, In Ho Jung, Ji Hyun Yi, Jae Hoon Kim, Jung Hoon Park, Seungheon Lee, Ji Wook Jung, Young Choon Lee, Jong Hoon Ryu, Dong Hyun Ki. The Seed of Zizyphus jujuba var. spinosa Attenuates Alzheimer's Disease-Associated Hippocampal Synaptic Deficits through BDNF/TrkB Signaling. Biological & pharmaceutical bulletin. vol 40. issue 12. 2018-07-17. PMID:29199234. |
spinosa attenuates alzheimer's disease-associated hippocampal synaptic deficits through bdnf/trkb signaling. |
2018-07-17 |
2023-08-13 |
mouse |
| Karin Persson, Maria Lage Barca, Lena Cavallin, Anne Brækhus, Anne-Brita Knapskog, Geir Selbæk, Knut Engeda. Comparison of automated volumetry of the hippocampus using NeuroQuant® and visual assessment of the medial temporal lobe in Alzheimer's disease. Acta radiologica (Stockholm, Sweden : 1987). vol 59. issue 8. 2018-07-16. PMID:29172642. |
comparison of automated volumetry of the hippocampus using neuroquant® and visual assessment of the medial temporal lobe in alzheimer's disease. |
2018-07-16 |
2023-08-13 |
Not clear |
| Richard J Wurtma. Synapse formation in the brain can be enhanced by co-administering three specific nutrients. European journal of pharmacology. vol 817. 2018-07-13. PMID:29031899. |
the memory impairments of early alzheimer's disease [ad] are thought to result from a deficiency in synapses within the hippocampus and related brain regions. |
2018-07-13 |
2023-08-13 |
Not clear |
| Li Su, Lawrence Hayes, Soteris Soteriades, Guy Williams, Susannah A E Brain, Michael J Firbank, Giulia Longoni, Robert J Arnold, James B Rowe, John T O'Brie. Hippocampal Stratum Radiatum, Lacunosum, and Moleculare Sparing in Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29171994. |
alzheimer's disease (ad) is associated with atrophy in entorhinal cortex (erc), the hippocampus, and its subfields cornu ammonis 1 (ca1) and subiculum, which predict conversion from mild cognitive impairment (mci) to clinical ad. |
2018-07-13 |
2023-08-13 |
Not clear |
| b' Sinchai Tsao, Niharika Gajawelli, Jiayu Zhou, Jie Shi, Jieping Ye, Yalin Wang, Natasha Lepor\\xc3\\xa. Feature selective temporal prediction of Alzheimer\'s disease progression using hippocampus surface morphometry. Brain and behavior. vol 7. issue 7. 2018-07-09. PMID:28729939.' |
feature selective temporal prediction of alzheimer's disease progression using hippocampus surface morphometry. |
2018-07-09 |
2023-08-13 |
Not clear |
| Lulin Nie, Junxia Xia, Honglian Li, Zaijun Zhang, Ying Yang, Xinfeng Huang, Zhendan He, Jianjun Liu, Xifei Yan. Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer's Disease. Oxidative medicine and cellular longevity. vol 2017. 2018-07-09. PMID:29204248. |
ginsenoside rg1 ameliorates behavioral abnormalities and modulates the hippocampal proteomic change in triple transgenic mice of alzheimer's disease. |
2018-07-09 |
2023-08-13 |
mouse |
| Greg J Elder, Karen Mactier, Sean J Colloby, Rosie Watson, Andrew M Blamire, John T O'Brien, John-Paul Taylo. The influence of hippocampal atrophy on the cognitive phenotype of dementia with Lewy bodies. International journal of geriatric psychiatry. vol 32. issue 11. 2018-07-06. PMID:28425185. |
the level of hippocampal atrophy in dementia with lewy bodies (dlb) is typically less than that observed in alzheimer's disease (ad). |
2018-07-06 |
2023-08-13 |
Not clear |
| Nasrin Hashemi-Firouzi, Alireza Komaki, Sara Soleimani Asl, Siamak Shahid. The effects of the 5-HT7 receptor on hippocampal long-term potentiation and apoptosis in a rat model of Alzheimer's disease. Brain research bulletin. vol 135. 2018-07-05. PMID:28987281. |
the effects of the 5-ht7 receptor on hippocampal long-term potentiation and apoptosis in a rat model of alzheimer's disease. |
2018-07-05 |
2023-08-13 |
rat |
| Carlos Perez, Ghanim Ulla. Reduced cooperativity of voltage-gated sodium channels in the hippocampal interneurons of an aged mouse model of Alzheimer's disease. European biophysics journal : EBJ. vol 47. issue 5. 2018-07-05. PMID:29427204. |
reduced cooperativity of voltage-gated sodium channels in the hippocampal interneurons of an aged mouse model of alzheimer's disease. |
2018-07-05 |
2023-08-13 |
mouse |
| Jin-Yu Zheng, Ke-Shan Liang, Xian-Jun Wang, Xue-Ying Zhou, Jian Sun, Sheng-Nian Zho. Chronic Estradiol Administration During the Early Stage of Alzheimer's Disease Pathology Rescues Adult Hippocampal Neurogenesis and Ameliorates Cognitive Deficits in Aβ Molecular neurobiology. vol 54. issue 10. 2018-07-02. PMID:27838872. |
chronic estradiol administration during the early stage of alzheimer's disease pathology rescues adult hippocampal neurogenesis and ameliorates cognitive deficits in aβ alzheimer's disease (ad) is the leading cause of dementia and has become an important public health concern. |
2018-07-02 |
2023-08-13 |
mouse |
| Ângela G Batista, Edilene S Soares, Monique C P Mendonça, Juliana K da Silva, Ana Paula Dionísio, Cesar R Sartori, Maria Alice da Cruz-Höfling, Mário R Maróstica Júnio. Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. Molecular nutrition & food research. vol 61. issue 10. 2018-07-02. PMID:28544198. |
the hyperphosphorylation of microtubule-associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance and these alterations are related to the development of tauopathies, such as alzheimer's disease. |
2018-07-02 |
2023-08-13 |
mouse |
| Madhuri Chakravarthy, Hadi AlShamaileh, He Huang, Rudi K Tannenberg, Suxiang Chen, Simon Worrall, Peter R Dodd, Rakesh N Veed. Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro. Chemical communications (Cambridge, England). vol 54. issue 36. 2018-07-02. PMID:29670956. |
we have developed a novel functional nucleic acid aptamer to amyloid-β peptide 1-40 (aβ1-40) and investigated its potential to detect aβ peptide fragments in neuropathologically confirmed alzheimer brain hippocampus tissues samples. |
2018-07-02 |
2023-08-13 |
Not clear |
| Madhuri Chakravarthy, Hadi AlShamaileh, He Huang, Rudi K Tannenberg, Suxiang Chen, Simon Worrall, Peter R Dodd, Rakesh N Veed. Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro. Chemical communications (Cambridge, England). vol 54. issue 36. 2018-07-02. PMID:29670956. |
our results demonstrate that the aptamer candidate rnv95 could detect tetrameric/pentameric low-molecular-weight aβ aggregates in autopsy hippocampal tissue from two neuropathologically confirmed alzheimer disease cases. |
2018-07-02 |
2023-08-13 |
Not clear |
| Ying Wang, Lihong Kong, Wei Li, Kangkang Zhang, Feng Shen, Yawen Wang, Hua Zhou, Guojie Su. [Effects and mechanisms of different frequencies of electroacupuncture for learning and memory ability of Alzheimer's rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 37. issue 6. 2018-06-27. PMID:29231506. |
to observe the effects of different frequencies of electroacupuncture (ea) at "baihui (gv 20)" and "shenshu(bl 23)" for the learning and memory ability as well as glycogen synthase kinase-3β (gsk-3β) and growth associated protein-43 (gap-43) in hippocampal tissue of rats with alzheimer's disease(ad), so as to explore the mechanism of different frequencies of ea for the prevention and treatment of ad. |
2018-06-27 |
2023-08-13 |
rat |
| Chao Huang, Paul Thompson, Yalin Wang, Yang Yu, Jingwen Zhang, Dehan Kong, Rivka R Colen, Rebecca C Knickmeyer, Hongtu Zh. FGWAS: Functional genome wide association analysis. NeuroImage. vol 159. 2018-06-22. PMID:28735012. |
we have successfully applied fgwas to large-scale analysis of data from the alzheimer's disease neuroimaging initiative for 708 subjects, 30,000 vertices on the left and right hippocampal surfaces, and 501,584 snps. |
2018-06-22 |
2023-08-13 |
human |
| Elizabeth M Ellison, Melissa A Bradley-Whitman, Mark A Lovel. Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer's Disease Subjects. Journal of molecular neuroscience : MN. vol 63. issue 2. 2018-06-19. PMID:28866733. |
single-base resolution mapping of 5-hydroxymethylcytosine modifications in hippocampus of alzheimer's disease subjects. |
2018-06-19 |
2023-08-13 |
human |
| Elizabeth M Ellison, Melissa A Bradley-Whitman, Mark A Lovel. Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer's Disease Subjects. Journal of molecular neuroscience : MN. vol 63. issue 2. 2018-06-19. PMID:28866733. |
as an initial study to analyze 5-hydroxymethylcytosine (5-hmc) in the alzheimer's disease (ad) genome, reduced representation hydroxymethylation profiling (rrhp) was used to analyze more than 2 million sites of possible modification in hippocampal dna of sporadic ad and normal control subjects. |
2018-06-19 |
2023-08-13 |
human |
| Eugene Huh, Soonmin Lim, Hyo Geun Kim, Sang Keun Ha, Ho-Young Park, Youngbuhm Huh, Myung Sook O. Ginger fermented with Schizosaccharomyces pombe alleviates memory impairment via protecting hippocampal neuronal cells in amyloid beta Food & function. vol 9. issue 1. 2018-06-19. PMID:29171599. |
ginger fermented with schizosaccharomyces pombe alleviates memory impairment via protecting hippocampal neuronal cells in amyloid beta ginger, which has been widely used for dietary condiment, has been reported to improve memory dysfunction in an animal model of alzheimer's disease (ad). |
2018-06-19 |
2023-08-13 |
Not clear |