| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin B Fixman, Isaac W Babcock, Laurie S Minamide, Alisa E Shaw, Marina I Oliveira da Silva, Avery M Runyan, Michael T Maloney, Jeffrey J Field, James R Bambur. Modified Roller Tube Method for Precisely Localized and Repetitive Intermittent Imaging During Long-term Culture of Brain Slices in an Enclosed System. Journal of visualized experiments : JoVE. issue 130. 2018-06-19. PMID:29364208. |
examples are shown for the use of this method combined with specific neuronal staining and expression to observe changes in hippocampal slice architecture, viral-mediated neuronal expression of fluorescent proteins, and the development of cofilin pathology, which was previously observed in the hippocampus of alzheimer's disease (ad) in response to slice treatment with oligomers of amyloid-β (aβ) peptide. |
2018-06-19 |
2023-08-13 |
mouse |
| Thais B Fernandes, Micael R Cunha, Renata P Sakata, Thalita M Candido, André R Baby, Maurício T Tavares, Euzébio G Barbosa, Wanda P Almeida, Roberto Parise-Filh. Synthesis, Molecular Modeling, and Evaluation of Novel Sulfonylhydrazones as Acetylcholinesterase Inhibitors for Alzheimer's Disease. Archiv der Pharmazie. vol 350. issue 11. 2018-06-15. PMID:28940630. |
alzheimer's disease (ad) is the most common type of dementia and related to the degeneration of hippocampal cholinergic neurons, which dramatically affects cognitive ability. |
2018-06-15 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Stephanie Rainey-Smith, Yoon Lim, Simon M Laws, Veer Gupta, Tenielle Porter, Pierrick Bourgeat, David Ames, Christopher Fowler, Olivier Salvado, Victor L Villemagne, Christopher C Rowe, Colin L Masters, Xin Fu Zhou, Ralph N Martins, Paul Maruf. BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International psychogeriatrics. vol 29. issue 11. 2018-06-12. PMID:28720165. |
bdnf val66met in preclinical alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mbdnf. |
2018-06-12 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Stephanie Rainey-Smith, Yoon Lim, Simon M Laws, Veer Gupta, Tenielle Porter, Pierrick Bourgeat, David Ames, Christopher Fowler, Olivier Salvado, Victor L Villemagne, Christopher C Rowe, Colin L Masters, Xin Fu Zhou, Ralph N Martins, Paul Maruf. BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International psychogeriatrics. vol 29. issue 11. 2018-06-12. PMID:28720165. |
the brain-derived neurotrophic factor (bdnf) val66met polymorphism met allele exacerbates amyloid (aβ) related decline in episodic memory (em) and hippocampal volume (hv) over 36-54 months in preclinical alzheimer's disease (ad). |
2018-06-12 |
2023-08-13 |
Not clear |
| Christoph Köhler, Vivien Fuhr, Maja Dineko. Distribution of spleen tyrosine kinase and tau phosphorylated at tyrosine 18 in a mouse model of tauopathy and in the human hippocampus. Brain research. vol 1677. 2018-06-11. PMID:28919467. |
it has been proposed that increased immunoreactivity for double-phosphorylated syk in hippocampal neurons of alzheimer's disease cases indicates a not yet defined neurodegenerative process. |
2018-06-11 |
2023-08-13 |
mouse |
| Carolyn Hollands, Matthew Kyle Tobin, Michael Hsu, Kianna Musaraca, Tzong-Shiue Yu, Rachana Mishra, Steven G Kernie, Orly Lazaro. Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer's disease by compromising hippocampal inhibition. Molecular neurodegeneration. vol 12. issue 1. 2018-06-08. PMID:28886753. |
depletion of adult neurogenesis exacerbates cognitive deficits in alzheimer's disease by compromising hippocampal inhibition. |
2018-06-08 |
2023-08-13 |
mouse |
| Carolyn Hollands, Matthew Kyle Tobin, Michael Hsu, Kianna Musaraca, Tzong-Shiue Yu, Rachana Mishra, Steven G Kernie, Orly Lazaro. Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer's disease by compromising hippocampal inhibition. Molecular neurodegeneration. vol 12. issue 1. 2018-06-08. PMID:28886753. |
however, whether impairments in neurogenesis affect the hippocampal circuitry in a way that leads to memory deficits characteristic of alzheimer's disease is unknown. |
2018-06-08 |
2023-08-13 |
mouse |
| Mohsen Khalili-Fomeshi, Mohammad Golparvar Azizi, Mohammad Reza Esmaeili, Mohammad Gol, Sohrab Kazemi, Manouchehr Ashrafpour, Ali Akbar Moghadamnia, Soheila Hosseinzade. Piperine restores streptozotocin-induced cognitive impairments: Insights into oxidative balance in cerebrospinal fluid and hippocampus. Behavioural brain research. vol 337. 2018-06-08. PMID:28939403. |
lipid peroxidation and the ferric reducing antioxidant power (frap) of cerebrospinal fluid (csf) and hippocampus in streptozotocin (stz)-induced experimental dementia of the alzheimer's type was measured. |
2018-06-08 |
2023-08-13 |
rat |
| Florence Clavaguera, Markus Tolnay, Michel Goeder. The Prion-Like Behavior of Assembled Tau in Transgenic Mice. Cold Spring Harbor perspectives in medicine. vol 7. issue 10. 2018-06-07. PMID:27940600. |
the pattern of tau deposition in alzheimer's disease follows a stereotypical progression, with the first lesions appearing in the locus coeruleus and entorhinal cortex, from where they appear to spread to the hippocampus and neocortex. |
2018-06-07 |
2023-08-13 |
mouse |
| Valentina Echeverria, George E Barreto, Marco Avila-Rodriguezc, Vadim V Tarasov, Gjumrakch Alie. Is VEGF a Key Target of Cotinine and Other Potential Therapies Against Alzheimer Disease? Current Alzheimer research. vol 14. issue 11. 2018-06-04. PMID:28356047. |
in animal models, it has been shown that environmental enrichment and exercise, two non-pharmacological interventions that are beneficial decreasing the progression of alzheimer disease (ad) and depressive-like behavior, enhance hippocampal vegf expression and neurogenesis. |
2018-06-04 |
2023-08-13 |
Not clear |
| Lianne Hoeijmakers, Gideon F Meerhoff, Janneke W de Vries, Silvie R Ruigrok, Anne-Marie van Dam, Fred van Leuven, Aniko Korosi, Paul J Lucasse. The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis. Neurobiology of aging. vol 61. 2018-06-04. PMID:29059594. |
in alzheimer's disease, the hippocampus is characterized by abundant deposition of amyloid peptides (amyloid β [aβ]) and neuroinflammation. |
2018-06-04 |
2023-08-13 |
mouse |
| Theresa M Harrison, Donald G McLaren, Teena D Moody, Jamie D Feusner, Susan Y Bookheime. Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease. Journal of visualized experiments : JoVE. issue 129. 2018-06-01. PMID:29286444. |
in the present study, we used this type of associative memory task and a generalized ppi (gppi) analysis to compare changes in hippocampal connectivity in older adults who are carriers of the alzheimer's disease (ad) genetic risk factor apolipoprotein-e epsilon-4 (apoeε4). |
2018-06-01 |
2023-08-13 |
human |
| Min Kim, Alejo Nevado-Holgado, Luke Whiley, Stuart G Snowden, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Madhav Thambisetty, Richard J B Dobson, John F Powell, Michelle K Lupton, Andy Simmons, Latha Velayudhan, Simon Lovestone, Petroula Proitsi, Cristina Legido-Quigle. Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 60. issue 3. 2018-05-30. PMID:27911300. |
association between plasma ceramides and phosphatidylcholines and hippocampal brain volume in late onset alzheimer's disease. |
2018-05-30 |
2023-08-13 |
human |
| Yan-Na Geng, Yi-Jun Wu, Wen-Xin Zhan. [Effect of hyperforin on learning and memory abilities and Aβ₁₋₄₂, βAPP and BACE1 protein expressions in hippocampus of Alzheimer's disease model mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 15. 2018-05-22. PMID:28914032. |
[effect of hyperforin on learning and memory abilities and aβ₁₋₄₂, βapp and bace1 protein expressions in hippocampus of alzheimer's disease model mice]. |
2018-05-22 |
2023-08-13 |
mouse |
| Débora Lanznaster, Josiel M Mack, Victor Coelho, Marcelo Ganzella, Roberto F Almeida, Tharine Dal-Cim, Gisele Hansel, Eduardo R Zimmer, Diogo O Souza, Rui D Prediger, Carla I Tasc. Guanosine Prevents Anhedonic-Like Behavior and Impairment in Hippocampal Glutamate Transport Following Amyloid-β Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27599498. |
guanosine prevents anhedonic-like behavior and impairment in hippocampal glutamate transport following amyloid-β amyloid-beta (aβ) peptides are the major neuropathological hallmarks related with alzheimer's disease (ad). |
2018-05-18 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
kunming mice were selected and established a mouse model of alzheimer's by intraperitoneal injection of d-galactose and sodium nitrite, continued intragastric 4 weeks, using the ability of learning and memory in morris water maze test to evaluate the animals in each group; the content of bdnf in the hippocampus of mice with western blotting detected; elisa method for the detection of each group of mice hippocampal tau protein,p-tau protein, aβ,ach,ache and serum nt-probnp levels. |
2018-05-15 |
2023-08-13 |
mouse |
| Zhixiong Ma, Weiliang Jiang, Eric Erquan Zhan. Orexin signaling regulates both the hippocampal clock and the circadian oscillation of Alzheimer's disease-risk genes. Scientific reports. vol 6. 2018-05-14. PMID:27796320. |
orexin signaling regulates both the hippocampal clock and the circadian oscillation of alzheimer's disease-risk genes. |
2018-05-14 |
2023-08-13 |
mouse |
| N A Kraskovskaya, E O Kukanova, N S Lin'kova, E A Popugaeva, V Kh Khavinso. Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer's Disease. Bulletin of experimental biology and medicine. vol 163. issue 4. 2018-05-14. PMID:28853087. |
in primary culture of mouse hippocampal neurons, peptide edr (200 ng/ml) under conditions of amyloid synaptotoxicity (a model of alzheimer's disease) increased the number of mushroom spines by 71% and returned this parameter to the normal level. |
2018-05-14 |
2023-08-13 |
mouse |
| Bo Yang, Zi-An Xia, Bingwu Zhong, Xingui Xiong, Chenxia Sheng, Yang Wang, Wei Gong, Yucheng Cao, Zhe Wang, Weijun Pen. Distinct Hippocampal Expression Profiles of Long Non-coding RNAs in an Alzheimer's Disease Model. Molecular neurobiology. vol 54. issue 7. 2018-05-10. PMID:27501805. |
distinct hippocampal expression profiles of long non-coding rnas in an alzheimer's disease model. |
2018-05-10 |
2023-08-13 |
rat |
| Lan Zhao, Chunlei Zhou, Li Li, Jianwei Liu, Huiyan Shi, Bohong Kan, Zhen Li, Yunzhu Li, Jingxian Han, Jianchun Y. Acupuncture Improves Cerebral Microenvironment in Mice with Alzheimer's Disease Treated with Hippocampal Neural Stem Cells. Molecular neurobiology. vol 54. issue 7. 2018-05-10. PMID:27558235. |
acupuncture improves cerebral microenvironment in mice with alzheimer's disease treated with hippocampal neural stem cells. |
2018-05-10 |
2023-08-13 |
mouse |