| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diana Cifuentes, Marine Poittevin, Philippe Bonnin, Anta Ngkelo, Nathalie Kubis, Tatyana Merkulova-Rainon, Bernard I Lév. Inactivation of Nitric Oxide Synthesis Exacerbates the Development of Alzheimer Disease Pathology in APPPS1 Mice (Amyloid Precursor Protein/Presenilin-1). Hypertension (Dallas, Tex. : 1979). vol 70. issue 3. 2019-02-28. PMID:28760945. |
these results suggest that impaired nitric oxide bioavailability exacerbates the pathophysiology of alzheimer disease, essentially impacting amyloid load and cognitive impairment, independently of l-name-induced hypertension. |
2019-02-28 |
2023-08-13 |
mouse |
| Leonardo Pisani, Rosa Maria Iacobazzi, Marco Catto, Mariagrazia Rullo, Roberta Farina, Nunzio Denora, Saverio Cellamare, Cosimo Damiano Altomar. Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors. European journal of medicinal chemistry. vol 161. 2018-12-18. PMID:30366255. |
herein we envisaged the possibility of exploiting alkyl nitrates as precursors of alcohol-bearing dual inhibitors targeting acetylcholinesterase (ache) and monoamine oxidase b (mao b), key enzymes in neurodegenerative syndromes such as alzheimer's disease (ad), through biotransformation unmasking an alcoholic function upon nitric oxide (no) release. |
2018-12-18 |
2023-08-13 |
human |
| Yasunori Nishimura, Mitsuaki Moriyama, Kenji Kawabe, Hideyo Satoh, Katsura Takano, Yasu-Taka Azuma, Yoichi Nakamur. Lauric Acid Alleviates Neuroinflammatory Responses by Activated Microglia: Involvement of the GPR40-Dependent Pathway. Neurochemical research. vol 43. issue 9. 2018-11-21. PMID:29947014. |
in several neurodegenerative diseases such as alzheimer's disease (ad), microglia are hyperactivated and release nitric oxide (no) and proinflammatory cytokines, resulting its neuropathology. |
2018-11-21 |
2023-08-13 |
mouse |
| Do Hee Kim, Hua Li, Yeong Eun Han, Ji Hye Jeong, Hwa Jin Lee, Jae-Ha Ry. Modulation of Inducible Nitric Oxide Synthase Expression in LPS-Stimulated BV-2 Microglia by Prenylated Chalcones from Cullen corylifolium (L.) Medik. through Inhibition of I-κBα Degradation. Molecules (Basel, Switzerland). vol 23. issue 1. 2018-09-03. PMID:29300354. |
the overproduction of nitric oxide (no) and prostaglandin e₂ (pge₂) by microglia may cause neurodegenerative diseases, such as alzheimer's disease and parkinson's disease. |
2018-09-03 |
2023-08-13 |
Not clear |
| Hai M Nguyen, Eva M Grössinger, Makoto Horiuchi, Kyle W Davis, Lee-Way Jin, Izumi Maezawa, Heike Wulf. Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia. Glia. vol 65. issue 1. 2018-02-01. PMID:27696527. |
lipopolysaccharide (lps) and interferon-γ (ifn-γ) promote differentiation into classically activated m1-like microglia, which produce high levels of pro-inflammatory cytokines and nitric oxide and are thought to contribute to neurological damage in ischemic stroke and alzheimer's disease. |
2018-02-01 |
2023-08-13 |
Not clear |
| Andrew M Roberts, Rekha Jagadapillai, Radhika A Vaishnav, Robert P Friedland, Robert Drinovac, Xingyu Lin, Evelyne Goza. Increased pulmonary arteriolar tone associated with lung oxidative stress and nitric oxide in a mouse model of Alzheimer's disease. Physiological reports. vol 4. issue 17. 2017-10-24. PMID:27604401. |
increased pulmonary arteriolar tone associated with lung oxidative stress and nitric oxide in a mouse model of alzheimer's disease. |
2017-10-24 |
2023-08-13 |
mouse |
| Cândida Dias, Cátia F Lourenço, Elisabete Ferreiro, Rui M Barbosa, João Laranjinha, Ana Led. Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation. Neurobiology of aging. vol 46. 2017-09-28. PMID:27460153. |
age-dependent changes in nitric oxide ((•)no) concentration dynamics may play a significant role in both decaying synaptic and metabolic functions in alzheimer's disease (ad). |
2017-09-28 |
2023-08-13 |
mouse |
| Mario Merlini, Yi Shi, Stephan Keller, Gianluigi Savarese, Alexander Akhmedov, Rebecca Derungs, Remo D Spescha, Luka Kulic, Roger M Nitsch, Thomas F Lüscher, Giovanni G Camic. Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer's disease. American journal of physiology. Heart and circulatory physiology. vol 312. issue 2. 2017-06-26. PMID:27836896. |
reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of alzheimer's disease. |
2017-06-26 |
2023-08-13 |
mouse |
| Cátia F Lourenço, Ana Ledo, Rui M Barbosa, João Laranjinh. Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling. Experimental neurology. vol 291. 2017-05-16. PMID:28161255. |
neurovascular uncoupling in the triple transgenic model of alzheimer's disease: impaired cerebral blood flow response to neuronal-derived nitric oxide signaling. |
2017-05-16 |
2023-08-13 |
mouse |
| Cátia F Lourenço, Ana Ledo, Rui M Barbosa, João Laranjinh. Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling. Experimental neurology. vol 291. 2017-05-16. PMID:28161255. |
nitric oxide (no)-dependent pathways and cerebrovascular dysfunction have been shown to contribute to the cognitive decline and neurodegeneration observed in alzheimer's disease (ad) but whether they represent initial factors or later changes of the disease is still a matter of debate. |
2017-05-16 |
2023-08-13 |
mouse |
| Nicholas Asiimwe, Seung Geun Yeo, Min-Sik Kim, Junyang Jung, Na Young Jeon. Nitric Oxide: Exploring the Contextual Link with Alzheimer's Disease. Oxidative medicine and cellular longevity. vol 2016. 2017-03-06. PMID:28096943. |
nitric oxide: exploring the contextual link with alzheimer's disease. |
2017-03-06 |
2023-08-13 |
Not clear |
| Mohammed Ragab Abdel-Aziz Ali, Amira Morad Hussein Abo-Youssef, Basim Anwar Shehata Messiha, Mahmoud Mohamed Khatta. Tempol and perindopril protect against lipopolysaccharide-induced cognition impairment and amyloidogenesis by modulating brain-derived neurotropic factor, neuroinflammation and oxido-nitrosative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 6. 2017-02-21. PMID:27026404. |
a behavioral study was conducted to evaluate spatial and nonspatial memory in mice, followed by a biochemical study involving assessment of brain levels of aβ and bdnf as alzheimer and neuroplasticity markers; tumor necrosis factor-alpha (tnf-α), nitric oxide end-products (nox), neuronal nitric oxide synthase (nnos), and inducible nitric oxide synthase (inos) as inflammatory markers; and superoxide dismutase (sod), malondialdehyde (mda), glutathione reduced (gsh), and nitrotyrosine (nt) as oxido-nitrosative stress markers. |
2017-02-21 |
2023-08-13 |
mouse |
| Felicity Ockelford, Louis Saada, Ehud Gazit, Achala de Me. Is Nitric Oxide Assuming a Janus-Face in The Central Nervous System? Current medicinal chemistry. vol 23. issue 16. 2017-01-31. PMID:26980566. |
an aging population faces an increasing incidence of neurodegenerative disease and the pathological action of nitric oxide in alzheimer's and parkinson's diseases may be important therapeutic targets for the future. |
2017-01-31 |
2023-08-13 |
human |
| Namki Cho, Eun Hye Moon, Hyun Woo Kim, Jaewoo Hong, John A Beutler, Sang Hyun Sun. Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus. Molecules (Basel, Switzerland). vol 21. issue 4. 2016-12-14. PMID:27070561. |
it is well known that activated microglia produce nitric oxide (no), which has an important role in the pathophysiology of several neurodegenerative diseases such as alzheimer's disease. |
2016-12-14 |
2023-08-13 |
Not clear |
| Christina Alves Peixoto, Ana Karolina Santana Nunes, Ana Garcia-Ost. Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of inflammation. vol 2015. 2016-11-02. PMID:26770022. |
mechanistically, pde5-is produce an anti-inflammatory and neuroprotection effect by increasing expression of nitric oxide synthases and accumulation of cgmp and activating protein kinase g (pkg), the signaling pathway of which is thought to play an important role in the development of several neurodiseases, such as alzheimer's disease (ad), parkinson's disease (pd), and multiple sclerosis (ms). |
2016-11-02 |
2023-08-13 |
Not clear |
| Luciana Hanniba. Nitric Oxide Homeostasis in Neurodegenerative Diseases. Current Alzheimer research. vol 13. issue 2. 2016-10-05. PMID:26391043. |
the role of nitric oxide in the pathogenesis and progression of neurodegenerative illnesses such as parkinson's and alzheimer's diseases has become prominent over the years. |
2016-10-05 |
2023-08-13 |
human |
| Rachelle Balez, Lezanne Oo. Getting to NO Alzheimer's Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide. Oxidative medicine and cellular longevity. vol 2016. 2016-09-12. PMID:26697132. |
getting to no alzheimer's disease: neuroprotection versus neurotoxicity mediated by nitric oxide. |
2016-09-12 |
2023-08-13 |
Not clear |
| Rachelle Balez, Lezanne Oo. Getting to NO Alzheimer's Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide. Oxidative medicine and cellular longevity. vol 2016. 2016-09-12. PMID:26697132. |
nitric oxide (no) has long been considered part of the neurotoxic insult caused by neuroinflammation in the alzheimer's brain. |
2016-09-12 |
2023-08-13 |
Not clear |
| Nassima Behairi, Mourad Belkhelfa, Hamida Mesbah-Amroun, Hayet Rafa, Soreya Belarbi, Meriem Tazir, Chafia Touil-Boukoff. All-trans-retinoic acid modulates nitric oxide and interleukin-17A production by peripheral blood mononuclear cells from patients with Alzheimer's disease. Neuroimmunomodulation. vol 22. issue 6. 2016-08-15. PMID:26278415. |
all-trans-retinoic acid modulates nitric oxide and interleukin-17a production by peripheral blood mononuclear cells from patients with alzheimer's disease. |
2016-08-15 |
2023-08-13 |
Not clear |
| Namki Cho, Heejung Yang, Jung Wha Kim, Young Choong Kim, Sang Hyun Sun. Chemical constituents isolated from Disporum viridescens leaves and their inhibitory effect on nitric oxide production in BV2 microglial cells. Bioorganic & medicinal chemistry letters. vol 24. issue 24. 2015-08-04. PMID:25467159. |
excessive no (nitric oxide) has been associated with the pathogenesis of various neurodegenerative diseases including alzheimer's disease (ad). |
2015-08-04 |
2023-08-13 |
Not clear |