| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrícia Maidana Miguel, Bruna Ferrary Deniz, Heloísa Deola Confortim, Loise Peres Bronauth, Bruna Chaves de Oliveira, Márcio Bonesso Alves, Patrícia Pelufo Silveira, Lenir Orlandi Pereir. Methylphenidate administration reverts attentional inflexibility in adolescent rats submitted to a model of neonatal hypoxia-ischemia: Predictive validity for ADHD study. Experimental neurology. vol 315. 2020-02-24. PMID:30771298. |
data from a rat model of neonatal hypoxia-ischemia (hi) have revealed inattention, impulsive behavior and dopamine (da) disturbances in the prefrontal cortex (pfc), confirming the face validity and construct validity for adhd study. |
2020-02-24 |
2023-08-13 |
rat |
| Patrícia Maidana Miguel, Bruna Ferrary Deniz, Heloísa Deola Confortim, Loise Peres Bronauth, Bruna Chaves de Oliveira, Márcio Bonesso Alves, Patrícia Pelufo Silveira, Lenir Orlandi Pereir. Methylphenidate administration reverts attentional inflexibility in adolescent rats submitted to a model of neonatal hypoxia-ischemia: Predictive validity for ADHD study. Experimental neurology. vol 315. 2020-02-24. PMID:30771298. |
therefore, we aimed to investigate the effects of methylphenidate (mph) - the treatment of choice for adhd - on exploratory and attentional flexibility behaviors and da-related proteins in the pfc of animals submitted to neonatal hi. |
2020-02-24 |
2023-08-13 |
rat |
| Ali Khaleghi, Hadi Zarafshan, Mohammad Reza Mohammad. Visual and auditory steady-state responses in attention-deficit/hyperactivity disorder. European archives of psychiatry and clinical neuroscience. vol 269. issue 6. 2020-02-04. PMID:29789937. |
in conclusion, poorer task performance (especially inattention) and neurophysiological results in adhd demonstrate a possible impairment in the interconnection of the association cortices in the parietal and temporal lobes and the prefrontal cortex. |
2020-02-04 |
2023-08-13 |
Not clear |
| Sidish S Venkataraman, Michael Joseph, Nachum Dafn. Concomitant behavioral and prefrontal cortex neuronal responses following acute and chronic methylphenidate exposure in adolescent and adult rats. Brain research bulletin. vol 144. 2020-01-16. PMID:30502401. |
the pfc is one of the primary brain areas affected by mpd and the drug of choice for treating adhd. |
2020-01-16 |
2023-08-13 |
rat |
| Akira Yasumura, Mikimasa Omori, Ayako Fukuda, Junichi Takahashi, Yukiko Yasumura, Eiji Nakagawa, Toshihide Koike, Yushiro Yamashita, Tasuku Miyajima, Tatsuya Koeda, Masao Aihara, Masumi Inagak. Age-related differences in frontal lobe function in children with ADHD. Brain & development. vol 41. issue 7. 2020-01-06. PMID:30952459. |
thus, this study aimed to explore changes in pfc function in children with adhd. |
2020-01-06 |
2023-08-13 |
Not clear |
| Amy Ft Arnsten, Anne G Dudle. Methylphenidate improves prefrontal cortical cognitive function through alpha2 adrenoceptor and dopamine D1 receptor actions: Relevance to therapeutic effects in Attention Deficit Hyperactivity Disorder. Behavioral and brain functions : BBF. vol 1. issue 1. 2019-11-20. PMID:15916700. |
the current study examined the effects of these low, orally-administered doses of mph in rats performing a delayed alternation task dependent on prefrontal cortex (pfc), a brain region that is dysfunctional in adhd, and is highly sensitive to levels of catecholamines. |
2019-11-20 |
2023-08-12 |
rat |
| Amy Ft Arnsten, Anne G Dudle. Methylphenidate improves prefrontal cortical cognitive function through alpha2 adrenoceptor and dopamine D1 receptor actions: Relevance to therapeutic effects in Attention Deficit Hyperactivity Disorder. Behavioral and brain functions : BBF. vol 1. issue 1. 2019-11-20. PMID:15916700. |
conclusion: the administration of low, oral doses of mph to rats has effects on pfc cognitive function similar to those seen in humans and patients with adhd. |
2019-11-20 |
2023-08-12 |
rat |
| Yuncheng Zhu, Daoliang Yang, Weidong Ji, Tianming Huang, Lianxue Xue, Xixi Jiang, Liangliang Chen, Fang Wan. The Relationship between Neurocircuitry Dysfunctions and Attention Deficit Hyperactivity Disorder: A Review. BioMed research international. vol 2016. 2019-11-20. PMID:27689077. |
the prefrontal cortex is the superlative structure of brain that needs the longest developmental and maturational duration that highlights the region of attention deficit hyperactivity disorder (adhd) in neuroimaging studies. |
2019-11-20 |
2023-08-13 |
Not clear |
| Gunhyuk Park, Young-Suk Jung, Moon-Ki Park, Chae Ha Yang, Yong-Ung Ki. Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model. Scientific reports. vol 8. issue 1. 2019-10-24. PMID:30297827. |
ad-related psychological stress caused an increase in the levels of dopamine beta-hydroxylase and tyrosine hydroxylase, degradation of melatonin, hyper-activity of the hypothalamic-pituitary-adrenal axis, and dysregulation of dopamine and noradrenaline levels (adhd phenomena) in the locus coeruleus, prefrontal cortex, and striatum of the ad mouse brain. |
2019-10-24 |
2023-08-13 |
mouse |
| Néstor I Martínez-Torres, David González-Tapia, Nallely Vázquez-Hernández, Ignacio González-Burgo. Atomoxetine prevents working memory loss in hyperactive rats, mediating plastic changes in prefrontal cortex pyramidal neurons. Pharmacology, biochemistry, and behavior. vol 175. 2019-09-30. PMID:30267796. |
attention deficit hyperactivity disorder (adhd) causes impaired visuospatial working memory (vwm), which primarily maps to the prefrontal cortex. |
2019-09-30 |
2023-08-13 |
rat |
| Hai-Xia Yuan, Xin-Qiang Ni, Zheng-Zhi Wu, Xin-Min Han, Dan-Gui Xu, Yu-Chen Song, Tian-Yi Che. [Regulatory effect of Shudihuang on expressions of BDNF/TrkB and NRG-3 in prefrontal cortex and striatum of ADHD model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 17. 2019-07-29. PMID:30347924. |
[regulatory effect of shudihuang on expressions of bdnf/trkb and nrg-3 in prefrontal cortex and striatum of adhd model rats]. |
2019-07-29 |
2023-08-13 |
rat |
| Hai-Xia Yuan, Xin-Qiang Ni, Zheng-Zhi Wu, Xin-Min Han, Dan-Gui Xu, Yu-Chen Song, Tian-Yi Che. [Regulatory effect of Shudihuang on expressions of BDNF/TrkB and NRG-3 in prefrontal cortex and striatum of ADHD model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 17. 2019-07-29. PMID:30347924. |
to observe the effect of shudihuang on behaviors and expression of bdnf/trkb and nrg-3 in prefrontal cortex and striatum of attention deficit hyperactivity disorder (adhd) model rats. |
2019-07-29 |
2023-08-13 |
rat |
| Francisco Zamorano, Pablo Billeke, Leonie Kausel, Josefina Larrain, Ximena Stecher, Jose M Hurtado, Vladimir López, Ximena Carrasco, Francisco Aboiti. Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder. Scientific reports. vol 7. issue 1. 2019-06-04. PMID:28775285. |
associated to the msit effect, neuroimaging results showed a significant enhancement in the activation of the right lateral prefrontal cortex (rlpfc) in adhd than in td subjects. |
2019-06-04 |
2023-08-13 |
human |
| Chao Wang, Binrang Yang, Diangang Fang, Hongwu Zeng, Xiaowen Chen, Gang Peng, Qiuying Cheng, Guohua Lian. The impact of SNAP25 on brain functional connectivity density and working memory in ADHD. Biological psychology. vol 138. 2019-05-01. PMID:30092259. |
compared with rs3746544 g-allele carriers, tt homozygous, which confers a high risk for adhd, exhibited significantly decreased local and long-range fcd in anterior cingulate cortex, and decreased local fcd in the dorsal lateral prefrontal cortex. |
2019-05-01 |
2023-08-13 |
Not clear |
| Irene Joy I Dela Peña, Chrislean Jun Botanas, June Bryan de la Peña, Raly James Custodio, Ike Dela Peña, Zae Young Ryoo, Bung-Nyun Kim, Jong Hoon Ryu, Hee Jin Kim, Jae Hoon Cheon. The Atxn7-overexpressing mice showed hyperactivity and impulsivity which were ameliorated by atomoxetine treatment: A possible animal model of the hyperactive-impulsive phenotype of ADHD. Progress in neuro-psychopharmacology & biological psychiatry. vol 88. 2019-03-18. PMID:30125623. |
interestingly, treatment with the adhd drug, atomoxetine (3 mg/kg, intraperitoneal), attenuated adhd-like behaviors and reduced atxn7 gene expression in the pfc and str of these mice. |
2019-03-18 |
2023-08-13 |
mouse |
| Cheyenne Allenby, Mary Falcone, Leah Bernardo, E Paul Wileyto, Anthony Rostain, J Russell Ramsay, Caryn Lerman, James Loughea. Transcranial direct current brain stimulation decreases impulsivity in ADHD. Brain stimulation. vol 11. issue 5. 2019-03-11. PMID:29885858. |
transcranial direct current stimulation (tdcs) of the dorsolateral prefrontal cortex (dlpfc) has been shown to modulate cognitive control circuits and could enhance dlpfc activity, leading to improved impulse control in adhd. |
2019-03-11 |
2023-08-13 |
Not clear |
| Yoshifumi Mizuno, Minyoung Jung, Takashi X Fujisawa, Shinichiro Takiguchi, Koji Shimada, Daisuke N Saito, Hirotaka Kosaka, Akemi Tomod. Catechol-O-methyltransferase polymorphism is associated with the cortico-cerebellar functional connectivity of executive function in children with attention-deficit/hyperactivity disorder. Scientific reports. vol 7. issue 1. 2019-01-29. PMID:28687733. |
relative to td controls, children with adhd showed significantly lower functional connectivity of the right crus i/ii with the left dorsolateral prefrontal cortex. |
2019-01-29 |
2023-08-13 |
Not clear |
| Johanna Inhyang Kim, Jae-Won Kim, Jong-Min Lee, Hyuk Jin Yun, Chul-Ho Sohn, Min-Sup Shin, Bongseog Kim, Jonghee Chae, Jaewoo Roh, Bung-Nyun Ki. Interaction between DRD2 and lead exposure on the cortical thickness of the frontal lobe in youth with attention-deficit/hyperactivity disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 82. 2019-01-22. PMID:29169998. |
adhd is characterized by delay in brain maturation, most prominent in the prefrontal cortex (pfc). |
2019-01-22 |
2023-08-13 |
Not clear |
| Johanna Inhyang Kim, Jae-Won Kim, Jong-Min Lee, Hyuk Jin Yun, Chul-Ho Sohn, Min-Sup Shin, Bongseog Kim, Jonghee Chae, Jaewoo Roh, Bung-Nyun Ki. Interaction between DRD2 and lead exposure on the cortical thickness of the frontal lobe in youth with attention-deficit/hyperactivity disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 82. 2019-01-22. PMID:29169998. |
the d2 receptor is also mainly located in the pfc, and animal studies show that lead exposure affects the dopaminergic system of the frontal lobe, indicating an overlap in neural correlates of adhd, drd2, and lead exposure. |
2019-01-22 |
2023-08-13 |
Not clear |
| Jochen Bauer, Anne Werner, Waldemar Kohl, Harald Kugel, Anna Shushakova, Anya Pedersen, Patricia Ohrman. Hyperactivity and impulsivity in adult attention-deficit/hyperactivity disorder is related to glutamatergic dysfunction in the anterior cingulate cortex. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 19. issue 7. 2019-01-14. PMID:27973969. |
attention-deficit/hyperactivity disorder (adhd) is closely linked to the dysregulation of dopaminergic and noradrenergic neurotransmission in the fronto-striatal neural network, including the anterior cingulate cortex (acc) and the dorsolateral prefrontal cortex (dlpfc). |
2019-01-14 |
2023-08-13 |
Not clear |