All Relations between Autism Spectrum Disorder and serotonin

Publication Sentence Publish Date Extraction Date Species
Meagan A Quinlan, Danielle Krout, Rania M Katamish, Matthew J Robson, Catherine Nettesheim, Paul J Gresch, Deborah C Mash, L Keith Henry, Randy D Blakel. Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30668912. in a study of families with multiple individuals diagnosed with autism spectrum disorder (asd), we previously identified several, rare, missense coding variants that impart elevated 5-ht transport activity, relative to wild-type sert, upon heterologous expression as well as in asd subject lymphoblasts. 2020-06-11 2023-08-13 mouse
Magdalena Janecka, Sven Sandin, Abraham Reichenber. Autism Risk and Serotonin Reuptake Inhibitors-Reply. JAMA psychiatry. vol 76. issue 5. 2020-06-08. PMID:30840039. autism risk and serotonin reuptake inhibitors-reply. 2020-06-08 2023-08-13 Not clear
George M Anderso. Autism Risk and Serotonin Reuptake Inhibitors. JAMA psychiatry. vol 76. issue 5. 2020-06-08. PMID:30840041. autism risk and serotonin reuptake inhibitors. 2020-06-08 2023-08-13 Not clear
Anneke Wegener Sleeswijk, Reinout Heijungs, Sarah Dursto. Tackling Missing Heritability by Use of an Optimum Curve: A Systematic Review and Meta-Analysis. International journal of molecular sciences. vol 20. issue 20. 2020-02-20. PMID:31618836. this proof-of-concept study uses a systematic review and meta-analysis of the association between variants of the serotonin transporter promoter (5-httlpr) and autism to explore the hypothesis that some missing heritability can be explained using an optimum curve. 2020-02-20 2023-08-13 human
Lyon H Hough, Kalli Hill, Lindsay Staudt, Christine Grubb, Ashley Gree. Stereological Investigation of the Rat Ventral Thalamic Nuclei Following Developmental Hyperserotonemia. Neuroscience. vol 411. 2020-02-04. PMID:31170482. elevated blood serotonin in perinatal development is the most consistent neurochemical finding reported in autism spectrum disorder (asd), and has been implicated in the pathogenesis of the disorder. 2020-02-04 2023-08-13 rat
David P Laplante, Gabrielle Simcock, Lei Cao-Lei, Maya Mouallem, Guillaume Elgbeili, Alain Brunet, Vanessa Cobham, Sue Kildea, Suzanne Kin. The 5-HTTLPR polymorphism of the serotonin transporter gene and child's sex moderate the relationship between disaster-related prenatal maternal stress and autism spectrum disorder traits: The QF2011 Queensland flood study. Development and psychopathology. vol 31. issue 4. 2020-02-03. PMID:30394245. the 5-httlpr polymorphism of the serotonin transporter gene and child's sex moderate the relationship between disaster-related prenatal maternal stress and autism spectrum disorder traits: the qf2011 queensland flood study. 2020-02-03 2023-08-13 Not clear
Xiaoning Chen, Ran Ye, J Jay Gargus, Randy D Blakely, Kostantin Dobrenis, Ji Ying Sz. Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development. Cell reports. vol 10. issue 3. 2019-11-20. PMID:25600870. polymorphisms that alter serotonin transporter sert expression and functionality increase the risks for autism and psychiatric traits. 2019-11-20 2023-08-13 mouse
Josiane Hérault, Joëlle Martineau, Anne Perrot-Beaugerie, Jacqueline Jouve, Hervé Tournade, Catherine Barthelemy, Gilbert Lelord, Jean-Pierre Mu. Investigation of whole blood and urine monoamines in autism. European child & adolescent psychiatry. vol 2. issue 4. 2019-11-20. PMID:29871438. levels of serotonin (5-ht), dopamine (da), norepinephrine (ne) and epinephrine (e) were determined in the whole blood and urine of 23 children with autism and compared to those of normal children. 2019-11-20 2023-08-13 Not clear
Josiane Hérault, Joëlle Martineau, Anne Perrot-Beaugerie, Jacqueline Jouve, Hervé Tournade, Catherine Barthelemy, Gilbert Lelord, Jean-Pierre Mu. Investigation of whole blood and urine monoamines in autism. European child & adolescent psychiatry. vol 2. issue 4. 2019-11-20. PMID:29871438. very significant group effects (low whole blood 5-ht, high urinary 5-ht and high ne+e in autism) and age effects (urinary 5-ht and da decrease with age) were found. 2019-11-20 2023-08-13 Not clear
Alicia K Montgomery, Lauren C Shuffrey, Stephen J Guter, George M Anderson, Suma Jacob, Matthew W Mosconi, John A Sweeney, J Blake Turner, James S Sutcliffe, Edwin H Cook, Jeremy Veenstra-VanderWeel. Maternal Serotonin Levels Are Associated With Cognitive Ability and Core Symptoms in Autism Spectrum Disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 57. issue 11. 2019-11-18. PMID:30392628. maternal serotonin levels are associated with cognitive ability and core symptoms in autism spectrum disorder. 2019-11-18 2023-08-13 Not clear
Alicia K Montgomery, Lauren C Shuffrey, Stephen J Guter, George M Anderson, Suma Jacob, Matthew W Mosconi, John A Sweeney, J Blake Turner, James S Sutcliffe, Edwin H Cook, Jeremy Veenstra-VanderWeel. Maternal Serotonin Levels Are Associated With Cognitive Ability and Core Symptoms in Autism Spectrum Disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 57. issue 11. 2019-11-18. PMID:30392628. the serotonin (5-hydroxytryptamine [ht]) system has long been implicated in autism spectrum disorder (asd). 2019-11-18 2023-08-13 Not clear
Kimbra A Edwards, Amanda M K Madden, Susan L Zu. Serotonin receptor regulation as a potential mechanism for sexually dimorphic oxytocin dysregulation in a model of Autism. Brain research. vol 1701. 2019-11-04. PMID:30040918. perinatal administration of serotonin (5ht) agonist 5-methoxytryptamine (5mt) induces developmental hyperserotonemia (dhs; elevated blood serotonin) and produces behavioral and neurochemical changes in rats relevant to autism spectrum disorder (asd), such as oxytocin dysregulation. 2019-11-04 2023-08-13 rat
Michael C Monuteau. Methodological Challenges in Studying Autism Spectrum Disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 57. issue 11. 2019-08-27. PMID:30392622. evidence from genetic, animal, and epidemiologic studies have consistently implicated the serotonin (5-ht) system as an important risk factor for autism spectrum disorder (asd). 2019-08-27 2023-08-13 Not clear
Elizabeth Aaron, Alicia Montgomery, Xinguo Ren, Stephen Guter, George Anderson, Ana M D Carneiro, Suma Jacob, Matthew Mosconi, Ghanshyam N Pandey, Edwin Cook, Jeremy Veenstra-VanderWeel. Whole Blood Serotonin Levels and Platelet 5-HT Journal of autism and developmental disorders. vol 49. issue 6. 2019-08-06. PMID:30927179. whole blood serotonin levels and platelet 5-ht elevated whole blood serotonin (wb5-ht) is a well-replicated biomarker in autism spectrum disorder (asd). 2019-08-06 2023-08-13 Not clear
Nobuhiro Nakai, Masatoshi Nagano, Fumihito Saitow, Yasuhito Watanabe, Yoshinobu Kawamura, Akiko Kawamoto, Kota Tamada, Hiroshi Mizuma, Hirotaka Onoe, Yasuyoshi Watanabe, Hiromu Monai, Hajime Hirase, Jin Nakatani, Hirofumi Inagaki, Tomoyuki Kawada, Taisuke Miyazaki, Masahiko Watanabe, Yuka Sato, Shigeo Okabe, Kazuo Kitamura, Masanobu Kano, Kouichi Hashimoto, Hidenori Suzuki, Toru Takum. Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice. Science advances. vol 3. issue 6. 2019-07-01. PMID:28691086. serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 cnv mice. 2019-07-01 2023-08-13 mouse
Nobuhiro Nakai, Masatoshi Nagano, Fumihito Saitow, Yasuhito Watanabe, Yoshinobu Kawamura, Akiko Kawamoto, Kota Tamada, Hiroshi Mizuma, Hirotaka Onoe, Yasuyoshi Watanabe, Hiromu Monai, Hajime Hirase, Jin Nakatani, Hirofumi Inagaki, Tomoyuki Kawada, Taisuke Miyazaki, Masahiko Watanabe, Yuka Sato, Shigeo Okabe, Kazuo Kitamura, Masanobu Kano, Kouichi Hashimoto, Hidenori Suzuki, Toru Takum. Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice. Science advances. vol 3. issue 6. 2019-07-01. PMID:28691086. serotonin is a critical modulator of cortical function, and its metabolism is defective in autism spectrum disorder (asd) brain. 2019-07-01 2023-08-13 mouse
Stefano Gabriele, Marco Canali, Carla Lintas, Roberto Sacco, Maria Cristina Tirindelli, Arianna Ricciardello, Antonio M Persic. Evidence that ITGB3 promoter variants increase serotonin blood levels by regulating platelet serotonin transporter trafficking. Human molecular genetics. vol 28. issue 7. 2019-07-01. PMID:30535103. elevated serotonin (5-ht) blood levels, the first biomarker identified in autism research, has been consistently found in 20-30% of patients with autism spectrum disorder (asd). 2019-07-01 2023-08-13 Not clear
Joanna Kałużna-Czaplińska, Paulina Gątarek, Salvatore Chirumbolo, Max Stanley Chartrand, Geir Bjørklun. How important is tryptophan in human health? Critical reviews in food science and nutrition. vol 59. issue 1. 2019-06-13. PMID:28799778. reduced secretion of serotonin is associated with autism spectrum disorder, obesity, anorexia and bulimia nervosa, and other diseases presenting peripherals symptoms. 2019-06-13 2023-08-13 human
Valentina R Garbarino, T Lee Gilman, Lynette C Daws, Georgianna G Goul. Extreme enhancement or depletion of serotonin transporter function and serotonin availability in autism spectrum disorder. Pharmacological research. vol 140. 2019-05-13. PMID:30009933. extreme enhancement or depletion of serotonin transporter function and serotonin availability in autism spectrum disorder. 2019-05-13 2023-08-13 human
Valentina R Garbarino, T Lee Gilman, Lynette C Daws, Georgianna G Goul. Extreme enhancement or depletion of serotonin transporter function and serotonin availability in autism spectrum disorder. Pharmacological research. vol 140. 2019-05-13. PMID:30009933. a variety of human and animal studies support the hypothesis that serotonin (5-hydroxytryptamine or 5-ht) system dysfunction is a contributing factor to the development of autism in some patients. 2019-05-13 2023-08-13 human