| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fernando Rodríguez de Fonseca, Francisco Medina-Paz, Mira Sapozhnikov, Isaac Hurtado-Guerrero, Leticia Rubio, Stella Martín-de-Las-Heras, Nerea Requena-Ocaña, María Flores-López, María Del Mar Fernández-Arjona, Patricia Rivera, Antonia Serrano, Pedro Serrano, Sara C Zapico, Juan Suáre. Plasma Concentrations of High Mobility Group Box 1 Proteins and Soluble Receptors for Advanced Glycation End-Products Are Relevant Biomarkers of Cognitive Impairment in Alcohol Use Disorder: A Pilot Study. Toxics. vol 12. issue 3. 2024-03-27. PMID:38535924. |
underlying mechanisms by which long-term alcohol abuse causes cognitive dysfunction include excessive oxidative stress and inflammation in the brain, activated by increased reactive oxygen/nitrogen species (ros/rns), advanced glycation end-products (ages) and high-mobility group box 1 protein (hmgb1). |
2024-03-27 |
2024-03-29 |
Not clear |
| Norimitsu Morioka, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakat. High mobility group box-1: A therapeutic target for analgesia and associated symptoms in chronic pain. Biochemical pharmacology. 2024-02-17. PMID:38367818. |
in addition, hmgb1 can function in the brain, and is involved in the symptoms of depression, anxiety and cognitive dysfunction that accompany chronic pain. |
2024-02-17 |
2024-02-20 |
Not clear |
| Seung Hee Yoo, Mi Jin Jue, Yu-Hee Kim, Sooyoung Cho, Won-Joong Kim, Kye-Min Kim, Jong In Han, Heeseung Le. The Effect of Dexmedetomidine on the Mini-Cog Score and High-Mobility Group Box 1 Levels in Elderly Patients with Postoperative Neurocognitive Disorders Undergoing Orthopedic Surgery. Journal of clinical medicine. vol 12. issue 20. 2023-10-30. PMID:37892748. |
dexmedetomidine prevents postoperative cognitive dysfunction by inhibiting high-mobility group box 1 (hmgb1), which acts as an inflammatory marker. |
2023-10-30 |
2023-11-08 |
Not clear |
| Yangyang Shan, Panmiao Liu, Yanbo Zhou, Xin Ding, Hongtao Liu, Jianjun Yan. Prenatal Sevoflurane Exposure Impairs the Learning and Memory of Rat Offspring via HMGB1-Induced NLRP3/ASC Inflammasome Activation. ACS chemical neuroscience. 2023-01-31. PMID:36718586. |
we concluded that the hmgb1 inhibitor may repress the sevoflurane-induced activation of the nlrp3/asc inflammasome and cognitive dysfunction and that tlr4/nf-κb signaling maybe the key pathway, at least in part. |
2023-01-31 |
2023-08-14 |
rat |
| Devlina Ghosh, Aditi Singh, Alok Kumar, Neeraj Sinh. High mobility group box 1 (HMGB1) inhibition attenuates lipopolysaccharide-induced cognitive dysfunction and sickness-like behavior in mice. Immunologic research. 2022-06-07. PMID:35670903. |
together, these results show that blocking hmgb1 using gcy abrogated the cognitive dysfunction, sickness-like behavior of anxiety and depression induced by lps which can be a promising avenue for crucial neurobehavioral dysfunction. |
2022-06-07 |
2023-08-14 |
mouse |
| Devlina Ghosh, Aditi Singh, Alok Kumar, Neeraj Sinh. High mobility group box 1 (HMGB1) inhibition attenuates lipopolysaccharide-induced cognitive dysfunction and sickness-like behavior in mice. Immunologic research. 2022-06-07. PMID:35670903. |
high mobility group box 1 (hmgb1) inhibition attenuates lipopolysaccharide-induced cognitive dysfunction and sickness-like behavior in mice. |
2022-06-07 |
2023-08-14 |
mouse |
| Devlina Ghosh, Aditi Singh, Alok Kumar, Neeraj Sinh. High mobility group box 1 (HMGB1) inhibition attenuates lipopolysaccharide-induced cognitive dysfunction and sickness-like behavior in mice. Immunologic research. 2022-06-07. PMID:35670903. |
here we focus on determining the relationship between lipopolysaccharide (lps)-induced neuroinflammation (in both in vitro and in vivo models), cognitive dysfunction, sickness-like behavior and thus decode the impact of hmgb1 inhibition (using glycyrrhizin; gcy as an antagonist). |
2022-06-07 |
2023-08-14 |
mouse |
| Chen Qiu, Min Wang, Wen Yu, Zheng Rong, He-Sheng Zheng, Ting Sun, Shui-Bing Liu, Ming-Gao Zhao, Yu-Mei W. Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34278533. |
this study correlates a deficit of lxrβ in cognitive dysfunction in sd associated with hmgb1 inflammatory pathway in hippocampus, and lxrs may serve as a potential therapeutic target for cognitive impairment with anti-inflammation. |
2021-10-08 |
2023-08-13 |
mouse |
| Yam Nath Paudel, Mohd Farooq Shaikh, Ayanabha Chakraborti, Yatinesh Kumari, Ángel Aledo-Serrano, Katina Aleksovska, Marina Koutsodontis Machado Alvim, Iekhsan Othma. HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30271319. |
the current review discusses the contribution of hmgb1/tlr4/rage signaling in several brain injury, neuroinflammation mediated disorders, epileptogenesis and cognitive dysfunctions and in the light of available evidence, argued the possibilities of hmgb1 as a common viable biomarker of the above mentioned neurological dysfunctions. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yam Nath Paudel, Mohd Farooq Shaikh, Ayanabha Chakraborti, Yatinesh Kumari, Ángel Aledo-Serrano, Katina Aleksovska, Marina Koutsodontis Machado Alvim, Iekhsan Othma. HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30271319. |
hmgb1: a common biomarker and potential target for tbi, neuroinflammation, epilepsy, and cognitive dysfunction. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yam Nath Paudel, Mohd Farooq Shaikh, Ayanabha Chakraborti, Yatinesh Kumari, Ángel Aledo-Serrano, Katina Aleksovska, Marina Koutsodontis Machado Alvim, Iekhsan Othma. HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30271319. |
these findings suggest hmgb1 as a potential candidate to be a common biomarker of tbi, neuroinflammation, epileptogenesis, and cognitive dysfunctions which can be used for early prediction and progression of those neurological diseases. |
2020-10-01 |
2023-08-13 |
Not clear |
| Leelavathi N Madhu, Sahithi Attaluri, Maheedhar Kodali, Bing Shuai, Raghavendra Upadhya, Daniel Gitai, Ashok K Shett. Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31255677. |
the results provide new evidence that persistent cognitive dysfunction and chronic neuroinflammation in a model of gwi are linked with elevated hmgb1 concentration and complement activation. |
2020-08-14 |
2023-08-13 |
rat |
| Teresa Ravizza, Gaetano Terrone, Alessia Salamone, Federica Frigerio, Silvia Balosso, Daniel J Antoine, Annamaria Vezzan. High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy. Brain, behavior, and immunity. vol 72. 2019-07-15. PMID:29031614. |
hmgb1 isoforms reflect different pathophysiological processes, and the disulfide isoform, which is generated in the brain during oxidative stress, is implicated in seizures, cell loss and cognitive dysfunctions. |
2019-07-15 |
2023-08-13 |
Not clear |
| Rui-Lin Li, Zong-Ze Zhang, Mian Peng, Yun Wu, Jun-Jian Zhang, Cheng-Yao Wang, Yan-Lin Wan. Postoperative impairment of cognitive function in old mice: a possible role for neuroinflammation mediated by HMGB1, S100B, and RAGE. The Journal of surgical research. vol 185. issue 2. 2014-01-07. PMID:23899512. |
the present study sought to investigate the role of neuroinflammation mediated by high-mobility group box 1 (hmgb1), s100b, and the receptor for advanced glycation end product (rage) in cognitive dysfunction after partial hepatectomy in aged mice. |
2014-01-07 |
2023-08-12 |
mouse |