| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mary R Dusing, Candi L LaSarge, Austin W Drake, Grace C Westerkamp, Carlie McCoy, Shelby M Hetzer, Kimberly L Kraus, Ernest V Pedapati, Steve C Danze. Transient seizure clusters and epileptiform activity following widespread bilateral hippocampal interneuron ablation. eNeuro. 2024-04-04. PMID:38575351. |
interneuron loss is a prominent feature of temporal lobe epilepsy in both animals and humans and is hypothesized to be critical for epileptogenesis. |
2024-04-04 |
2024-04-07 |
mouse |
| Alexander C Whitebirch, Bina Santoro, Anastasia Barnett, Christos Panagiotis Lisgaras, Helen E Scharfman, Steven A Siegelbau. Reduced cholecystokinin-expressing interneuron input contributes to disinhibition of the hippocampal CA2 region in a mouse model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-29. PMID:37643861. |
reduced cholecystokinin-expressing interneuron input contributes to disinhibition of the hippocampal ca2 region in a mouse model of temporal lobe epilepsy. |
2023-08-29 |
2023-09-07 |
mouse |
| Paolo Scalmani, Rosina Paterra, Massimo Mantegazza, Massimo Avoli, Marco de Curti. Involvement of GABAergic interneuron subtypes in 4-aminopyridine-induced seizure-like events in mouse entorhinal cortex The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-02-22. PMID:36810229. |
involvement of gabaergic interneuron subtypes in 4-aminopyridine-induced seizure-like events in mouse entorhinal cortex single unit recordings performed in temporal lobe epilepsy patients and in models of temporal lobe seizures have shown that interneurons are active at focal seizure onset. |
2023-02-22 |
2023-08-14 |
mouse |
| Dinesh Upadhya, Sahithi Attaluri, Yan Liu, Bharathi Hattiangady, Olagide W Castro, Bing Shuai, Yi Dong, Su-Chun Zhang, Ashok K Shett. Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy. NPJ Regenerative medicine. vol 7. issue 1. 2022-08-01. PMID:35915118. |
interneuron loss/dysfunction contributes to spontaneous recurrent seizures (srs) in chronic temporal lobe epilepsy (tle), and interneuron grafting into the epileptic hippocampus reduces srs and improves cognitive function. |
2022-08-01 |
2023-08-14 |
human |
| István Mihály, Tímea Molnár, Ádám-József Berki, Réka-Barbara Bod, Károly Orbán-Kis, Zsolt Gáll, Tibor Szilágy. Short-Term Amygdala Low-Frequency Stimulation Does not Influence Hippocampal Interneuron Changes Observed in the Pilocarpine Model of Epilepsy. Cells. vol 10. issue 3. 2021-11-19. PMID:33804543. |
temporal lobe epilepsy (tle) is characterized by changes in interneuron numbers in the hippocampus. |
2021-11-19 |
2023-08-13 |
rat |
| Megan Wyeth, Monica Nagendran, Paul S Buckmaste. Ictal onset sites and γ-aminobutyric acidergic neuron loss in epileptic pilocarpine-treated rats. Epilepsia. vol 61. issue 5. 2020-11-30. PMID:32242932. |
the present study tested whether ictal onset sites are regions of more severe interneuron loss in epileptic pilocarpine-treated rats, a model of human temporal lobe epilepsy. |
2020-11-30 |
2023-08-13 |
human |
| Archie A Khan, Tawfeeq Shekh-Ahmad, Ayatakin Khalil, Matthew C Walker, Afia B Al. Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model. British journal of pharmacology. vol 175. issue 11. 2019-08-06. PMID:29574880. |
cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model. |
2019-08-06 |
2023-08-13 |
Not clear |
| Nickesha C Anderson, Meghan A Van Zandt, Swechhya Shrestha, Daniel B Lawrence, Jyoti Gupta, Christopher Y Chen, Felicia A Harrsch, Trinithas Boyi, Carolyn E Dundes, Gloster Aaron, Janice R Naegele, Laura Grabe. Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain. Stem cell research. vol 33. 2019-07-30. PMID:30340090. |
gabaergic interneuron dysfunction has been implicated in temporal lobe epilepsy (tle), autism, and schizophrenia. |
2019-07-30 |
2023-08-13 |
mouse |
| Dinesh Upadhya, Bharathi Hattiangady, Olagide W Castro, Bing Shuai, Maheedhar Kodali, Sahithi Attaluri, Adrian Bates, Yi Dong, Su-Chun Zhang, Darwin J Prockop, Ashok K Shett. Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 1. 2019-03-18. PMID:30559206. |
medial ganglionic eminence (mge)-like interneuron precursors derived from human induced pluripotent stem cells (hipscs) are ideal for developing patient-specific cell therapy in temporal lobe epilepsy (tle). |
2019-03-18 |
2023-08-13 |
human |
| Lim-Anna Sieu, Emmanuel Eugène, Agnès Bonnot, Ivan Cohe. Disrupted Co-activation of Interneurons and Hippocampal Network after Focal Kainate Lesion. Frontiers in neural circuits. vol 11. 2018-08-07. PMID:29180954. |
in temporal lobe epilepsy interneuron loss and consecutive network imbalance could favor pathological hypersynchronous epileptic discharges. |
2018-08-07 |
2023-08-13 |
mouse |
| Gabrielle Hofmann, Laura Balgooyen, Joanna Mattis, Karl Deisseroth, Paul S Buckmaste. Hilar somatostatin interneuron loss reduces dentate gyrus inhibition in a mouse model of temporal lobe epilepsy. Epilepsia. vol 57. issue 6. 2017-06-02. PMID:27030321. |
hilar somatostatin interneuron loss reduces dentate gyrus inhibition in a mouse model of temporal lobe epilepsy. |
2017-06-02 |
2023-08-13 |
mouse |
| Ethan M Goldberg, Douglas A Coulte. Seizing the opportunity: stem cells take on epilepsy. Cell stem cell. vol 15. issue 5. 2015-07-17. PMID:25517456. |
(2014) use cortical gabaergic interneuron progenitors derived from human embryonic stem cells to treat chronic temporal lobe epilepsy in a mouse model. |
2015-07-17 |
2023-08-13 |
mouse |
| Robert Nunan, Harri Sivasathiaseelan, Damla Khan, Malik Zaben, William Gra. Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release. Glia. vol 62. issue 8. 2015-02-04. PMID:24801739. |
this demonstrates a potential neuro-immuno-neurogenic pathway, disruption of which may have significant implications in conditions where combined cognitive impairments, interneuron loss, and immune system activation occurs, such as temporal lobe epilepsy and alzheimer's disease. |
2015-02-04 |
2023-08-13 |
Not clear |
| Katharine W Henderson, Jyoti Gupta, Stephanie Tagliatela, Elizabeth Litvina, XiaoTing Zheng, Meghan A Van Zandt, Nicholas Woods, Ethan Grund, Diana Lin, Sara Royston, Yuchio Yanagawa, Gloster B Aaron, Janice R Naegel. Long-term seizure suppression and optogenetic analyses of synaptic connectivity in epileptic mice with hippocampal grafts of GABAergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 40. 2015-01-20. PMID:25274826. |
studies in rodent epilepsy models suggest that gabaergic interneuron progenitor grafts can reduce hyperexcitability and seizures in temporal lobe epilepsy (tle). |
2015-01-20 |
2023-08-13 |
mouse |
| Kinga Tóth, Zsófia Maglóczk. The vulnerability of calretinin-containing hippocampal interneurons to temporal lobe epilepsy. Frontiers in neuroanatomy. vol 8. 2014-10-17. PMID:25324731. |
this review focuses on the vulnerability of a special interneuron type-the calretinin (cr)-containing interneurons-in temporal lobe epilepsy (tle). |
2014-10-17 |
2023-08-13 |
human |
| Xu Maisano, Elizabeth Litvina, Stephanie Tagliatela, Gloster B Aaron, Laura B Grabel, Janice R Naegel. Differentiation and functional incorporation of embryonic stem cell-derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 1. 2012-02-22. PMID:22219269. |
in many patients with severe acquired temporal lobe epilepsy (tle), the dentate gyrus exhibits sclerosis and gabaergic interneuron degeneration. |
2012-02-22 |
2023-08-12 |
mouse |
| Janice R Naegel. Tangled roots: digging deeper into astrocyte or interneuron dysfunction in temporal lobe epilepsy. Epilepsy currents. vol 11. issue 1. 2011-11-10. PMID:21852863. |
tangled roots: digging deeper into astrocyte or interneuron dysfunction in temporal lobe epilepsy. |
2011-11-10 |
2023-08-12 |
Not clear |
| A K Shetty, D A Turne. Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102487. |
fetal hippocampal grafts containing ca3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. |
2001-02-08 |
2023-08-12 |
rat |
| N C de Lanerolle, J H Kim, R J Robbins, D D Spence. Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. Brain research. vol 495. issue 2. 1989-10-12. PMID:2569920. |
hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. |
1989-10-12 |
2023-08-11 |
human |