| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Wang, Haiquan Xu, Jianbo Shu, Dandan Yan, Dong Li, Chunquan Ca. Case Report: A developmental and epileptic encephalopathy 45 due to Frontiers in pediatrics. vol 12. 2024-04-18. PMID:38633326. |
case report: a developmental and epileptic encephalopathy 45 due to the gamma-aminobutyric acid (gaba) variant causes developmental and epileptic encephalopathy 45 (dee45), an autosomal dominant disorder that results in oculocortical visual impairment, reduced muscle tone, psychomotor retardation, and epilepsy. |
2024-04-18 |
2024-04-20 |
Not clear |
| Yong-Li Jiang, Liang Xia, Jing-Jing Zhao, Hui-Min Zhou, Dan Mi, Xuan Wang, Yuan-Yuan Wang, Chang-Geng Song, Wen Jian. Mice harboring the T316N variant in the GABA Experimental neurology. 2024-04-11. PMID:38604438. |
mice harboring the t316n variant in the gaba sleep-related hypermotor epilepsy (she) is a focal epilepsy syndrome characterized by seizures that predominantly occur during sleep. |
2024-04-11 |
2024-04-14 |
mouse |
| Züleyha Doğanyiğit, Aslı Okan, Seher Yılmaz, A Cihangir Uğuz, Enes Akyü. Gender-related variation expressions of neuroplastin TRAF6, GluA1, GABA(A) receptor, and PMCA in cortex, hippocampus, and brainstem in an experimental epilepsy model. Synapse (New York, N.Y.). vol 78. issue 2. 2024-03-04. PMID:38436644. |
gender-related variation expressions of neuroplastin traf6, glua1, gaba(a) receptor, and pmca in cortex, hippocampus, and brainstem in an experimental epilepsy model. |
2024-03-04 |
2024-03-06 |
rat |
| Graham A R Johnston, Philip M Bear. Milestone review: GABA, from chemistry, conformations, ionotropic receptors, modulators, epilepsy, flavonoids, and stress to neuro-nutraceuticals. Journal of neurochemistry. 2024-02-21. PMID:38383146. |
current interest in ionotropic gaba receptors includes the clinical development of subtype-specific agents and the role of gain-of-function receptor variants in epilepsy. |
2024-02-21 |
2024-02-24 |
human |
| Yuyang Liu, Ningkang Jia, Chuqi Tang, Hao Long, Jun Wan. Microglia in Microbiota-Gut-Brain Axis: A Hub in Epilepsy. Molecular neurobiology. 2024-02-17. PMID:38366306. |
essential axis signaling molecules, such as gamma-aminobutyric acid, 5-hydroxytryptamin, and short-chain fatty acids, are currently under investigation for their participation in drug-resistant epilepsy (dre). |
2024-02-17 |
2024-02-19 |
Not clear |
| Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-Xin Yang, Zhen-Zhen Ma, Lin Huang, Yan-Peng An, Yi-Yuan Yuan, Yan Lin, Wei Xu, Yao Li, Peng-Cheng Lin, Jing Cao, Jian-Yuan Zhao, Shi-Min Zha. Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy. Cell discovery. vol 10. issue 1. 2024-02-12. PMID:38346975. |
ketogenic diet-produced β-hydroxybutyric acid accumulates brain gaba and increases gaba/glutamate ratio to inhibit epilepsy. |
2024-02-12 |
2024-02-15 |
mouse |
| Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-Xin Yang, Zhen-Zhen Ma, Lin Huang, Yan-Peng An, Yi-Yuan Yuan, Yan Lin, Wei Xu, Yao Li, Peng-Cheng Lin, Jing Cao, Jian-Yuan Zhao, Shi-Min Zha. Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy. Cell discovery. vol 10. issue 1. 2024-02-12. PMID:38346975. |
herein, we report that kd-produced β-hydroxybutyric acid (bhb) augments brain gamma-aminobutyric acid (gaba) and the gaba/glutamate ratio to inhibit epilepsy. |
2024-02-12 |
2024-02-15 |
mouse |
| Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-Xin Yang, Zhen-Zhen Ma, Lin Huang, Yan-Peng An, Yi-Yuan Yuan, Yan Lin, Wei Xu, Yao Li, Peng-Cheng Lin, Jing Cao, Jian-Yuan Zhao, Shi-Min Zha. Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy. Cell discovery. vol 10. issue 1. 2024-02-12. PMID:38346975. |
bhb-mediated relief of epilepsy required high gaba level and gaba/glutamate ratio. |
2024-02-12 |
2024-02-15 |
mouse |
| Michal Novotny, Jan Bulla, Daniela Hubl, Sebastian Karl Maximilian Fischer, Martin Grosshans, Andreas Gutzeit, Oliver Bilke-Hentsch, Erich Seifritz, Jochen Mutschle. Pregabalin use in forensic hospitals and prisons in German speaking countries-a survey study of physicians. Frontiers in public health. vol 11. 2024-01-23. PMID:38259798. |
pregabalin is a gamma-aminobutyric acid (gaba) analog that was approved in the eu in 2004 for the treatment of neuropathic pain, generalized anxiety disorder and epilepsy. |
2024-01-23 |
2024-01-25 |
Not clear |
| Feba Benny, Sunil Kumar, Aiswarya Binu, Della Grace Thomas Parambi, Tariq G Alsahli, Abdullah G Al-Sehemi, Namitha Chandran, Deepthi S Manisha, Sarath Sreekumar, Akanksha Bhatt, Krishnadas Madhu, Bijo Mathe. Targeting GABA receptors with chalcone derivative compounds, what is the evidence? Expert opinion on therapeutic targets. 2023-12-19. PMID:38112471. |
epilepsy and gaba receptors are related. |
2023-12-19 |
2023-12-23 |
Not clear |
| Jun Wu, Miao Zhao, Yu-Chen Jin, Min Li, Ke-Xin Yu, Hai-Bo Y. Schisandrin B, a dual positive allosteric modulator of GABA Acta pharmacologica Sinica. 2023-11-28. PMID:38017298. |
schisandrin b, a dual positive allosteric modulator of gaba epilepsy is a prevalent and severe neurological disorder and approximately 30% of patients are resistant to existing medications. |
2023-11-28 |
2023-12-07 |
mouse |
| Kohei Matsubara, Ichiro Kuki, Risako Ishioka, Naoki Yamada, Masataka Fukuoka, Takeshi Inoue, Megumi Nukui, Nobuhiko Okamoto, Takeshi Mizuguchi, Naomichi Matsumoto, Shin Okazak. Abnormal axonal development and severe epileptic phenotype in Dynamin-1 (DNM1) encephalopathy. Epileptic disorders : international epilepsy journal with videotape. 2023-11-27. PMID:38009673. |
dnm1 is involved in the release of synaptic vesicles with the inhibitory transmitter gaba, suggesting that gabaergic neuron dysfunction is the mechanism of refractory epilepsy in dnm1 encephalopathy. |
2023-11-27 |
2023-11-29 |
Not clear |
| Kinga Borowicz-Reutt, Julia Czernia, Marlena Krawczy. Genetic Background of Epilepsy and Antiepileptic Treatments. International journal of molecular sciences. vol 24. issue 22. 2023-11-25. PMID:38003469. |
bearing in mind that seizures develop as a consequence of the predominance of excitatory over inhibitory processes, it seems reasonable that mutations in genes encoding sodium and potassium channels, as well as glutamatergic and gamma-aminobutyric (gaba) receptors, play a role in the pathogenesis of epilepsy. |
2023-11-25 |
2023-11-28 |
Not clear |
| Joana Fonte, Gonçalo Videira, Rui Chorão, Joel Freitas, Inês Carrilho, João Parente Freixo, Jorge Oliveira, João Chave. Familial occipital lobe epilepsy associated with GABA Seizure. vol 112. 2023-10-18. PMID:37852164. |
familial occipital lobe epilepsy associated with gaba |
2023-10-18 |
2023-11-08 |
Not clear |
| Trong Dao Nguyen, Masaru Ishibashi, Adya Saran Sinha, Miho Watanabe, Daisuke Kato, Hiroshi Horiuchi, Hiroaki Wake, Atsuo Fukud. Astrocytic NKCC1 inhibits seizures by buffering Cl- and antagonizing neuronal NKCC1 at GABAergic synapses. Epilepsia. 2023-10-02. PMID:37779224. |
a pathological excitatory action of the major inhibitory neurotransmitter γ-aminobutyric acid (gaba) has been observed in epilepsy. |
2023-10-02 |
2023-10-07 |
Not clear |
| Zhen-Fu Jiang, Li-Na Xuan, Xiao-Wan Sun, Shao-Bo Liu, Jian Yi. Knockdown of SIK3 in the CA1 Region can Reduce Seizure Susceptibility in Mice by Inhibiting Decreases in GABA Molecular neurobiology. 2023-09-16. PMID:37715891. |
knockdown of sik3 in the ca1 region can reduce seizure susceptibility in mice by inhibiting decreases in gaba imbalance between excitation and inhibition is an important cause of epilepsy. |
2023-09-16 |
2023-10-07 |
mouse |
| Zhen-Fu Jiang, Li-Na Xuan, Xiao-Wan Sun, Shao-Bo Liu, Jian Yi. Knockdown of SIK3 in the CA1 Region can Reduce Seizure Susceptibility in Mice by Inhibiting Decreases in GABA Molecular neurobiology. 2023-09-16. PMID:37715891. |
in mice, knockdown of sik3 reduced epilepsy susceptibility in a pentylenetetrazole (a gaba |
2023-09-16 |
2023-10-07 |
mouse |
| Pawan Kumar, Deepak Sheokand, Annu Grewal, Vandana Saini, Ajit Kuma. Drug repositioning for idiopathic epilepsy using gene expression signature data. Bioinformation. vol 18. issue 10. 2023-09-01. PMID:37654844. |
these compounds were docked against identified epilepsy targets- voltage-gated sodium channel subunit α2 (nav1.2); gaba receptor α1-β1; and voltage-gated calcium channel α1g (cav3.1)using carbamazepine, clonazepam, and pregabalin as standard drugs, respectively. |
2023-09-01 |
2023-09-07 |
human |
| Emilio Perucca, Meir Bialer, H Steve Whit. New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System. CNS drugs. 2023-08-21. PMID:37603262. |
γ-aminobutyric acid (gaba) is the most prevalent inhibitory neurotransmitter in the mammalian brain and has been found to play an important role in the pathogenesis or the expression of many neurological diseases, including epilepsy. |
2023-08-21 |
2023-09-07 |
Not clear |
| Nihan Çarçak, Filiz Onat, Evgenia Sitnikov. Astrocytes as a target for therapeutic strategies in epilepsy: current insights. Frontiers in molecular neuroscience. vol 16. 2023-08-16. PMID:37583518. |
several promising new strategies that attempted to modify astroglial functions for treating epilepsy are being developed: (1) selective targeting of glia-related molecular mechanisms of glutamate transport; (2) modulation of tonic gaba release from astrocytes; (3) gliotransmission; (4) targeting the astrocytic kir4.1-bdnf system; (5) astrocytic na |
2023-08-16 |
2023-09-07 |
human |