| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia Pieńkowska, Margaret Fahnestock, Crystal Mahadeo, Izabela Zaborniak, Paweł Chmielarz, Grzegorz Bartosz, Izabela Sadowska-Bartos. Induction of Oxidative Stress in SH-SY5Y Cells by Overexpression of hTau40 and Its Mitigation by Redox-Active Nanoparticles. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613801. |
abnormally phosphorylated tau protein is the principal component of neurofibrillary tangles, accumulating in the brain in many neurodegenerative diseases, including alzheimer's disease. |
2023-01-08 |
2023-08-14 |
human |
| Young-Kook Kim, Yoon Seok Jung, Juhyun Son. Transcriptome Profile in the Mouse Brain of Hepatic Encephalopathy and Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614117. |
alzheimer's disease (ad), the most common neurodegenerative disease, is characterized by tau hyperphosphorylation, excessive amyloid beta (aβ) accumulation, the formation of fibrillary tangles, hippocampus atrophy, and neuroinflammation. |
2023-01-08 |
2023-08-14 |
mouse |
| Daniel Kirsch, Arsal Shah, Erin Dixon, Hunter Kelley, Jonathan D Cherry, Weiming Xia, Sarah Daley, Nurgul Aytan, Kerry Cormier, Carol Kubilus, Rebecca Mathias, Victor E Alvarez, Bertrand R Huber, Ann C McKee, Thor D Stei. Vascular injury is associated with repetitive head impacts and tau pathology in chronic traumatic encephalopathy. Journal of neuropathology and experimental neurology. 2023-01-08. PMID:36617181. |
chronic traumatic encephalopathy (cte) is a neurodegenerative disease linked to repetitive head impacts (rhi) and characterized by perivascular hyperphosphorylated tau (p-tau) deposits. |
2023-01-08 |
2023-08-14 |
human |
| Jiyoen Kim, Maria de Haro, Ismael Al-Ramahi, Lorena Laura Garaicoechea, Hyun-Hwan Jeong, Jun Young Sonn, Bakhos Tadros, Zhandong Liu, Juan Botas, Huda Yahya Zoghb. Evolutionarily conserved regulators of tau identify targets for new therapies. Neuron. 2023-01-07. PMID:36610398. |
tauopathies are neurodegenerative diseases that involve the pathological accumulation of tau proteins; in this family are alzheimer disease, corticobasal degeneration, and chronic traumatic encephalopathy, among others. |
2023-01-07 |
2023-08-14 |
mouse |
| b' \\xc5\\x9eenay G\\xc3\\xb6r\\xc3\\xbcc\\xc3\\xbc Y\\xc4\\xb1lmaz, Salam Almasri, Yasemin Yuyucu Karabulut, Murat Korkmaz, \\xc3\\x96znur Bucak, Sibel O\\xc4\\x9fuzkan Balc\\xc4\\xb. Okadaic Acid-Induced Alzheimer\'s in Rat Brain: Phytochemical Cucurbitacin E Contributes to Memory Gain by Reducing TAU Protein Accumulation. Omics : a journal of integrative biology. 2023-01-03. PMID:36594931.' |
alzheimer's disease (ad) is a neurodegenerative disease characterized by progressive memory loss and cognitive decline, with hallmark pathologies related to amyloid beta (aβ) and tau. |
2023-01-03 |
2023-08-14 |
rat |
| Shannon Faris, Weihua Jin, James Gibson, Anqesha Murray, Nathan Smith, Peng He, Fuming Zhang, Robert Linhardt, Chunyu Wan. Small-molecule compound from AlphaScreen disrupts tau-glycan interface. Frontiers in molecular biosciences. vol 9. 2023-01-02. PMID:36589242. |
tauopathies are neurodegenerative diseases characterized by intracellular abnormal tau deposits in the brain. |
2023-01-02 |
2023-08-14 |
Not clear |
| Louise Bryan, Saurabh Awasthi, Yuanjie Li, Peter Niraj Nirmalraj, Sandor Balog, Jerry Yang, Michael Maye. Site-Specific C-Terminal Fluorescent Labeling of Tau Protein. ACS omega. vol 7. issue 50. 2022-12-26. PMID:36570287. |
formation of tau protein aggregates in neurons is a pathological hallmark of several neurodegenerative diseases, including alzheimer's disease. |
2022-12-26 |
2023-08-14 |
Not clear |
| Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. Brain : a journal of neurology. 2022-12-26. PMID:36572122. |
furthermore, plasma brain-derived tau accurately distinguished autopsy-confirmed alzheimer's disease from other neurodegenerative diseases (area under the curve = 86.4%) while neurofilament light did not (area under the curve = 54.3%). |
2022-12-26 |
2023-08-14 |
human |
| Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. Brain : a journal of neurology. 2022-12-26. PMID:36572122. |
notably, plasma/serum brain-derived tau correlated with neurofilament light only in alzheimer's disease but not in the other neurodegenerative diseases. |
2022-12-26 |
2023-08-14 |
human |
| Yanan Zhu, Lauren Gandy, Fuming Zhang, Jian Liu, Chunyu Wang, Laura J Blair, Robert J Linhardt, Lianchun Wan. Heparan Sulfate Proteoglycans in Tauopathy. Biomolecules. vol 12. issue 12. 2022-12-23. PMID:36551220. |
tauopathies are a class of neurodegenerative diseases, including alzheimer's disease, and are characterized by intraneuronal tau inclusion in the brain and the patient's cognitive decline with obscure pathogenesis. |
2022-12-23 |
2023-08-14 |
Not clear |
| Ling Wu, Sidharth S Madhavan, Christopher Tan, Bin X. Hexameric Aggregation Nucleation Core Sequences and Diversity of Pathogenic Tau Strains. Pathogens (Basel, Switzerland). vol 11. issue 12. 2022-12-23. PMID:36558893. |
tau aggregation associates with multiple neurodegenerative diseases including alzheimer's disease and rare tauopathies such as pick's disease, progressive supranuclear palsy, and corticobasal degeneration. |
2022-12-23 |
2023-08-14 |
Not clear |
| Xibing He, Viet Hoang Man, Jie Gao, Junmei Wan. Investigation of the Structure of Full-Length Tau Proteins with Coarse-Grained and All-Atom Molecular Dynamics Simulations. ACS chemical neuroscience. 2022-12-23. PMID:36563129. |
tau proteins not only have many important biological functions but also are associated with several neurodegenerative diseases, such as parkinson's disease and alzheimer's disease (ad). |
2022-12-23 |
2023-08-14 |
Not clear |
| Goonho Park, Ke Xu, Leon Chea, Kyle Kim, Lance Safarta, Keon-Hyoung Song, Jian Wu, Soyoung Park, Hyejung Min, Nobuhiko Hiramatsu, Jaeseok Han, Jonathan H Li. Neurodegeneration Risk Factor, EIF2AK3 (PERK), Influences Tau Protein Aggregation. The Journal of biological chemistry. 2022-12-23. PMID:36563857. |
tauopathies are neurodegenerative diseases caused by pathologic misfolded tau protein aggregation in the nervous system. |
2022-12-23 |
2023-08-14 |
Not clear |
| Bo Qi, Yu Song, Chen Chen, Lina Zhao, Wanjie Ma, Shuqi Meng, Xiaoli Zhuang, Huayi Lin, Jing Liang, Yan Cui, Keliang Xi. Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation. International immunopharmacology. vol 114. 2022-12-20. PMID:36538853. |
hyperphosphorylated tau is considered to play a significant role in the progression of neurodegenerative disease and also contributes to cognitive dysfunction in septic mice. |
2022-12-20 |
2023-08-14 |
mouse |
| Itzhak Fische. Evolutionary perspective of Big tau structure: 4a exon variants of MAPT. Frontiers in molecular neuroscience. vol 15. 2022-12-19. PMID:36533137. |
tau plays important roles in modulating microtubule dynamics, axonal transport, synaptic plasticity, and dna repair, and has also been associated with neurodegenerative diseases (tauopathies) including alzheimer's disease and frontotemporal dementia. |
2022-12-19 |
2023-08-14 |
human |
| Júlia L B Simões, Leilane D Sobierai, Inayá F Leal, Miriam V R Dos Santos, João Victor Coiado, Margarete D Bagatin. Action of the purinergic and cholinergic anti-inflammatory pathways on oxidative stress in patients with Alzheimer's disease in the context of the COVID-19 pandemic. Neuroscience. 2022-12-16. PMID:36526078. |
this neurodegenerative disease is aggravated in cases involving sars-cov-2 and its inflammatory biomarkers, accelerating accumulation of β-amyloid peptide, hyperphosphorylation of tau protein, and production of reactive oxygen species, which lead to homeostasis imbalance. |
2022-12-16 |
2023-08-14 |
Not clear |
| Allwin Ebenezer Sahayaraj, Renjith Viswanathan, Faina Pinhero, Arshad Abdul Vahid, Vinesh Vijaya. Sequence-Dependent Conformational Properties of PGGG Motif in Tau Repeats: Insights from Molecular Dynamics Simulations of Narrow Pick Filament. ACS chemical neuroscience. 2022-12-13. PMID:36512636. |
tauopathies are a class of neurodegenerative diseases correlated with the presence of pathological tau fibrils as a diagnostic marker. |
2022-12-13 |
2023-08-14 |
Not clear |
| Tianqing Liu, Yuying Li, Yan Wang, Xiao-Xin Yan, Jiapei Dai, Mengchao Cu. Discovery and evaluation of aza-fused tricyclic derivatives for detection of Tau pathology in Alzheimer's disease. European journal of medicinal chemistry. vol 246. 2022-12-09. PMID:36493618. |
for various neurodegenerative diseases, including alzheimer's disease (ad), the abnormal aggregation of tau is not only the predominant contributing factor but also a major biomarker for disease diagnosis. |
2022-12-09 |
2023-08-14 |
Not clear |
| Anna Atlante, Giuseppina Amadoro, Valentina Latina, Daniela Valent. Therapeutic Potential of Targeting Mitochondria for Alzheimer's Disease Treatment. Journal of clinical medicine. vol 11. issue 22. 2022-11-26. PMID:36431219. |
alzheimer's disease (ad), a chronic and progressive neurodegenerative disease, is characterized by memory and cognitive impairment and by the accumulation in the brain of abnormal proteins, more precisely beta-amyloid (β-amyloid or aβ) and tau proteins. |
2022-11-26 |
2023-08-14 |
Not clear |
| Mehboob Hoque, Arijit Samanta, Syed Sahajada Mahafujul Alam, Torki A Zughaibi, Mohammad Amjad Kamal, Shams Tabre. Nanomedicine-based immunotherapy for Alzheimer's Disease. Neuroscience and biobehavioral reviews. 2022-11-26. PMID:36435391. |
alzheimer's disease (ad) is the most prevalent neurodegenerative disease caused by the deposition of amyloid β (aβ) fibrils forming extracellular plaques and the development of neurofibrillary tangles (nft) of intracellular hyperphosphorylated tau protein. |
2022-11-26 |
2023-08-14 |
Not clear |