All Relations between Neurodegenerative Diseases and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Gabriele Saretzk. The telomerase connection of the brain and its implications for neurodegenerative diseases. Stem cells (Dayton, Ohio). 2022-11-04. PMID:36330760. protein degradation processes are prominently involved in degrading toxic proteins in the brain like amyloid-β, pathological tau and α-synuclein that are responsible for various neurodegenerative diseases. 2022-11-04 2023-08-14 human
Ling Chen, Mingxia Bi, Zhen Zhang, Xixun Du, Xi Chen, Qian Jiao, Hong Jian. The functions of IRE1α in neurodegenerative diseases: Beyond ER stress. Ageing research reviews. 2022-11-04. PMID:36332756. furthermore, ire1α is a significant factor in the regulation of neurodegenerative diseases that are caused by the phosphorylation of tau protein, the accumulation of α-synuclein (α-syn) and the toxic effects of mutant htt (mhtt). 2022-11-04 2023-08-14 Not clear
Gabriel A Marx, Daniel G Koenigsberg, Andrew T McKenzie, Justin Kauffman, Russell W Hanson, Kristen Whitney, Maxim Signaevsky, Marcel Prastawa, Megan A Iida, Charles L White, Jamie M Walker, Timothy E Richardson, John Koll, Gerardo Fernandez, Jack Zeineh, Carlos Cordon-Cardo, John F Crary, Kurt Farrel. Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment. Acta neuropathologica communications. vol 10. issue 1. 2022-11-01. PMID:36316708. tauopathies are a category of neurodegenerative diseases characterized by the presence of abnormal tau protein-containing neurofibrillary tangles (nfts). 2022-11-01 2023-08-14 human
Long Feng, Shihui Fu, Yao Yao, Yulong Li, Longhe Xu, Yali Zhao, Leiming Lu. Roles for c-Abl in postoperative neurodegeneration. International journal of medical sciences. vol 19. issue 12. 2022-10-31. PMID:36313229. c-abl also plays a crucial role in neurodevelopment and neurodegenerative diseases, mainly through mechanisms such as neuroinflammation, oxidative stress (os), and tau protein phosphorylation. 2022-10-31 2023-08-14 Not clear
Javier Andrés Muñiz, Carolina Lucía Facal, Leandro Urrutia, Ramiro Clerici-Delville, Ana Damianich, Juan E Ferrario, Germán Falasco, María Elena Aval. SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy. Frontiers in bioengineering and biotechnology. vol 10. 2022-10-24. PMID:36277399. abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as alzheimer's disease and frontotemporal dementia. 2022-10-24 2023-08-14 human
E A Kovalenko, E V Makhnovich, N A Osinovskaya, A N Bogolepov. [Focused ultrasound as a non-invasive method with therapeutic potential in patients with Alzheimer's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 122. issue 10. 2022-10-24. PMID:36279227. alzheimer's disease (ad) is a common, progressive neurodegenerative disease characterized by abnormal deposition of β-amyloid (aβ) and hyperphosphorylated tau protein. 2022-10-24 2023-08-14 Not clear
Ashley C Knight, Christopher D Morrone, Cassis Varlow, Wai Haung Yu, Paul McQuade, Neil Vasde. Head-to-Head Comparison of Tau-PET Radioligands for Imaging TDP-43 in Post-Mortem ALS Brain. Molecular imaging and biology. 2022-10-18. PMID:36258099. in vivo detection of transactivation response element dna binding protein-43 kda (tdp-43) aggregates through positron emission tomography (pet) would impact the ability to successfully develop therapeutic interventions for a variety of neurodegenerative diseases, including amyotrophic lateral sclerosis (als).  the purpose of the present study is to evaluate the ability of six tau pet radioligands to bind to tdp-43 aggregates in post-mortem brain tissues from als patients. 2022-10-18 2023-08-14 Not clear
Pijush Chakraborty, Markus Zweckstette. Phase separation of the microtubule-associated protein tau. Essays in biochemistry. 2022-10-17. PMID:36251053. the aggregation and misfolding of the neuronal microtubule-associated protein tau is closely linked to the pathology of alzheimer's disease and several other neurodegenerative diseases. 2022-10-17 2023-08-14 Not clear
Tomas Kavanagh, Aditi Halder, Eleanor Drummon. Tau interactome and RNA binding proteins in neurodegenerative diseases. Molecular neurodegeneration. vol 17. issue 1. 2022-10-17. PMID:36253823. tau interactome and rna binding proteins in neurodegenerative diseases. 2022-10-17 2023-08-14 human
Tomas Kavanagh, Aditi Halder, Eleanor Drummon. Tau interactome and RNA binding proteins in neurodegenerative diseases. Molecular neurodegeneration. vol 17. issue 1. 2022-10-17. PMID:36253823. pathological tau aggregation is a primary neuropathological feature of many neurodegenerative diseases. 2022-10-17 2023-08-14 human
Lenka Hromadkova, Mohammad Khursheed Siddiqi, He Liu, Jiri G Safa. Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer's Disease and Related Dementias. Cells. vol 11. issue 19. 2022-10-14. PMID:36230957. recent findings of diverse populations of prion-like conformers of misfolded tau protein expand the prion concept to alzheimer's disease (ad) and monogenic frontotemporal lobar degeneration (ftld)-mapt p301l, and suggest that distinct strains of misfolded proteins drive the phenotypes and progression rates in many neurodegenerative diseases. 2022-10-14 2023-08-14 human
Julia Sala-Jarque, Karolina Zimkowska, Jesús Ávila, Isidro Ferrer, José Antonio Del Rí. Towards a Mechanistic Model of Tau-Mediated Pathology in Tauopathies: What Can We Learn from Cell-Based In Vitro Assays? International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232835. tauopathies are a group of neurodegenerative diseases characterized by the hyperphosphorylation and deposition of tau proteins in the brain. 2022-10-14 2023-08-14 Not clear
Cody McKee, Peter Shrager, Arindam Gosh Mazumder, Archan Ganguly, Abigail Mayer, Karl Foley, Nancy Ward, Margaret Youngman, Hailong Hou, Houhui Xi. Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development. Molecular neurobiology. 2022-10-05. PMID:36198882. our study suggests that nipp1 in neural precursor cells regulates phosphorylation of tau and cns myelination and may represent a novel therapeutic target for neurodegenerative diseases. 2022-10-05 2023-08-14 mouse
Charline Fagnen, Johanna Giovannini, Marco Catto, Anne Sophie Voisin-Chiret, Jana Sopkova-de Oliveira Santo. On the Tracks of the Aggregation Mechanism of the PHF6 Peptide from Tau Protein: Molecular Dynamics, Energy, and Interaction Network Investigations. ACS chemical neuroscience. 2022-09-26. PMID:36153969. the formation of neurofibrillary tangles (nfts), composed of tau protein aggregates, is a hallmark of some neurodegenerative diseases called tauopathies. 2022-09-26 2023-08-14 Not clear
Alisa Cario, Sanjula P Wickramasinghe, Elizabeth Rhoades, Christopher L Berge. The N-terminal disease-associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches. The Journal of biological chemistry. 2022-09-26. PMID:36162501. tau misregulation is associated with a class of neurodegenerative diseases, known as tauopathies, including progressive supranuclear palsy (psp), pick's disease, and alzheimer's disease. 2022-09-26 2023-08-14 Not clear
Gemma Shireby, Emma L Dempster, Stefania Policicchio, Rebecca G Smith, Ehsan Pishva, Barry Chioza, Jonathan P Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame, Seth Love, Alan Thomas, Keeley Brookes, Kevin Morgan, Paul Francis, Eilis Hannon, Jonathan Mil. DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. Nature communications. vol 13. issue 1. 2022-09-24. PMID:36153390. alzheimer's disease (ad) is a chronic neurodegenerative disease characterized by the progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex. 2022-09-24 2023-08-14 Not clear
Tingting Yao, Heng Xiao, Hong Wang, Xiaowei X. Recent Advances in PROTACs for Drug Targeted Protein Research. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142231. for example, protacs targeting ar, br, btk, tau, irak4, and other proteins have shown unprecedented clinical efficacy in cancers, neurodegenerative diseases, inflammations, and other fields. 2022-09-23 2023-08-14 Not clear
Javad Sharifi-Rad, Simona Rapposelli, Simona Sestito, Jesús Herrera-Bravo, Alejandra Arancibia-Diaz, Luis A Salazar, Balakyz Yeskaliyeva, Ahmet Beyatli, Gerardo Leyva-Gómez, Carlos González-Contreras, Eda Sönmez Gürer, Miquel Martorell, Daniela Calin. Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation. Journal of personalized medicine. vol 12. issue 9. 2022-09-23. PMID:36143299. alzheimer's disease (ad) is a neurodegenerative disease characterized by a tangle-shaped accumulation of beta-amyloid peptide fragments and tau protein in brain neurons. 2022-09-23 2023-08-14 Not clear
Andrea Arighi, Marina Arcaro, Giorgio Giulio Fumagalli, Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Giovanni Isgrò, Federico Turkheimer, Elio Scarpini, Daniela Galimbert. Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation. Alzheimer's research & therapy. vol 14. issue 1. 2022-09-17. PMID:36115967. significantly higher levels of aqp4 were found in ad and ftd patients compared to subjects not affected by neurodegenerative diseases, and a significant, positive correlation between aqp4 and total tau levels was found. 2022-09-17 2023-08-14 human
Masoume Alipour, Majid Tebianian, Nahid Tofigh, Reyhaneh Sadat Taheri, Sayed Alireza Mousavi, Asal Naseri, Amin Ahmadi, Nayla Munawar, Koorosh Shahpasan. Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models. Neuropeptides. vol 96. 2022-09-10. PMID:36087426. traumatic brain injury (tbi), characterized by acute neurological impairment, is associated with a higher incidence of neurodegenerative diseases, particularly chronic traumatic encephalopathy (cte), alzheimer's disease (ad), and parkinson's disease (pd), whose hallmarks include hyperphosphorylated tau protein. 2022-09-10 2023-08-14 mouse