| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongna Yuan, Xuqi Mao, Xiaohang Pan, Ruisheng Zhang, Wei S. Kinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis. Journal of chemical theory and computation. 2024-03-19. PMID:38501645. |
the ordered assembly of tau protein into filaments characterizes alzheimer's and other neurodegenerative diseases, and thus, stabilization of tau protein is a promising avenue for tauopathies therapy. |
2024-03-19 |
2024-03-21 |
Not clear |
| Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Steven A Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zo. Seeding Activity of Skin Misfolded Tau as a Biomarker for Tauopathies. Research square. 2024-03-18. PMID:38496453. |
background tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically phosphorylated tau protein in the brain, leading to prion-like propagation and aggregation. |
2024-03-18 |
2024-03-20 |
Not clear |
| Goonho Park, Angela Galdamez, Keon-Hyoung Song, Masako Le, Kyle Kim, Jonathan H Li. Ethnic variation and structure-function analysis of tauopathy-associated medRxiv : the preprint server for health sciences. 2024-03-18. PMID:38496636. |
in addition to its central position in intracellular stress regulation, human gwas identify eif2ak3 as a risk factor in tauopathies, neurodegenerative diseases caused by aberrant tau protein accumulation. |
2024-03-18 |
2024-03-20 |
human |
| Zhentao Zhan. Q&A with Zhentao Zhang. Cell reports. vol 43. issue 3. 2024-03-14. PMID:38483901. |
in this interview with zhentao zhang, we discuss his research focusing on the molecular mechanisms underlying the aggregation of prion-like proteins in neurodegenerative diseases and spotlight his recent work in cell reports that shows that a yeast prion protein interacts with tau and facilitates its aggregation. |
2024-03-14 |
2024-03-17 |
Not clear |
| Hong Xu, Qi Qiu, Peng Hu, Kevt'her Hoxha, Elliot Jang, Mia O'Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D Schellenberg, Brian Kraemer, Kelvin C Luk, Edward B Lee, John Q Trojanowski, Kurt R Brunden, Virginia M-Y Le. MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons. Acta neuropathologica. vol 147. issue 1. 2024-03-13. PMID:38472475. |
inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as tauopathies, that include alzheimer's disease (ad). |
2024-03-13 |
2024-03-15 |
mouse |
| Marina Han, Aleen Saxton, Heather Currey, Sarah M Waldherr, Nicole F Liachko, Brian C Kraeme. Transgenic Dendra2::tau expression allows in vivo monitoring of tau proteostasis in C. elegans. Disease models & mechanisms. 2024-03-12. PMID:38469687. |
protein homeostasis is perturbed in aging-related neurodegenerative diseases called tauopathies, which are pathologically characterized by aggregation of the microtubule-associated protein tau. |
2024-03-12 |
2024-03-14 |
caenorhabditis_elegans |
| Suzuko Ochi, Kumiko Yamada, Takashi Saito, Takaomi C Saido, Mitsuo Iinuma, Kagaku Azuma, Kin-Ya Kub. Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer's disease in adult Alzheimer's model Frontiers in aging neuroscience. vol 16. 2024-03-12. PMID:38469162. |
effects of early tooth loss on chronic stress and progression of neuropathogenesis of alzheimer's disease in adult alzheimer's model alzheimer's disease (ad), the most common neurodegenerative disease, is characterized by accumulated amyloid-β (aβ) plaques, aggregated phosphorylated tau protein, gliosis-associated neuroinflammation, synaptic dysfunction, and cognitive impairment. |
2024-03-12 |
2024-03-14 |
Not clear |
| Ruihua Liu, Linli Guo, Yanan Zhao, Dan Wu, Jiasi Yu, Ping Li. Study on multi-target effects of the novel HDAC6 inhibitor W5 on Aβ/Cu Brain research. 2024-03-05. PMID:38442843. |
study on multi-target effects of the novel hdac6 inhibitor w5 on aβ/cu histone deacetylase 6 (hdac6) is a key therapeutic target in neurodegenerative diseases such as alzheimer's disease (ad), which has been demonstrated to play an essential role in memory function and microtubule-associated tau physiology. |
2024-03-05 |
2024-03-08 |
rat |
| Shengyuan Wang, Bengang Chen, Minghao Yuan, Shu Liu, Haixia Fan, Xu Yang, Qian Zou, Yinshuang Pu, Zhiyou Ca. Enriched oxygen improves age-related cognitive impairment through enhancing autophagy. Frontiers in aging neuroscience. vol 16. 2024-03-04. PMID:38435399. |
moreover, the hyperphosphorylation of tau, a hallmark of many neurodegenerative diseases, was significantly reduced in the hbo-treated group, both |
2024-03-04 |
2024-03-06 |
mouse |
| Nadia El Mammeri, Aurelio J Dregni, Pu Duan, Mei Hon. Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 10. 2024-02-28. PMID:38408247. |
the microtubule-associated protein tau aggregates into amyloid fibrils in alzheimer's disease and other neurodegenerative diseases. |
2024-02-28 |
2024-03-01 |
Not clear |
| Abigail Alexander, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Jesse Mez, Yorghos Tripodis, Raymond Nicks, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Brett Martin, Joseph Palmisano, Lee E Goldstein, John F Crary, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Ivana Delalle, Ann C McKee, Thor D Stei. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta neuropathologica. vol 147. issue 1. 2024-02-26. PMID:38407651. |
chronic traumatic encephalopathy (cte) is a neurodegenerative disease caused by repetitive head impacts (rhi) and pathologically defined as neuronal phosphorylated tau aggregates around small blood vessels and concentrated at sulcal depths. |
2024-02-26 |
2024-02-28 |
human |
| Bo-Yu Kuang, Yu-Chen Zhu, Jin-Ping Liang, Shi-Feng Chu, Nai-Hong Chen, Yan-Tao Yan. [Exosome and prevention of Alzheimer's disease: based on theory of kidney storing essence]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 1. 2024-02-25. PMID:38403338. |
alzheimer's disease(ad) is one of the common neurodegenerative diseases, with the main pathological features of aβ deposition and tau phosphorylation, which activate neurotoxic reactions and eventually lead to neuronal dysfunction and cell death, severely impairing the patient's cognitive and memory functions. |
2024-02-25 |
2024-02-28 |
human |
| Ling-Ling Jiao, Hui-Lin Dong, Meng-Meng Liu, Peng-Lin Wu, Yi Cao, Yuan Zhang, Fu-Gao Gao, Huai-Yuan Zh. The potential roles of salivary biomarkers in neurodegenerative diseases. Neurobiology of disease. 2024-02-21. PMID:38382884. |
based on the available research, β-amyloid, tau protein, α-synuclein, dj-1, huntington protein in saliva profiles display reliability and validity as the biomarkers of neurodegenerative diseases. |
2024-02-21 |
2024-02-24 |
Not clear |
| Wentao Zhu, Wenqian Zhang, Jian Chen, Yichen Tong, Fang Xu, Jiyan Pan. Discovery of Effective Dual PROTAC Degraders for Neurodegenerative Disease-Associated Aggregates. Journal of medicinal chemistry. 2024-02-15. PMID:38356330. |
the aggregation of specific proteins is a histopathological hallmark in various neurodegenerative diseases (nds), among which alpha-synuclein (α-syn) and tau have received increased attention. |
2024-02-15 |
2024-02-17 |
Not clear |
| Gerard Ross. Novel Pyrrolo-pyrazol-one Ligands of Alpha-Synuclein for Diagnosis of Parkinson's Disease. ACS medicinal chemistry letters. vol 15. issue 2. 2024-02-14. PMID:38352848. |
many neurodegenerative diseases are characterized by cellular deposits such as abeta, tau, alpha-synuclein, and huntingtin. |
2024-02-14 |
2024-02-16 |
human |
| Ying-Chieh Wu, Tizibt Ashine Bogale, Jari Koistinaho, Marina Pizzi, Taisia Rolova, Arianna Bellucc. The contribution of β-amyloid, Tau and α-synuclein to blood-brain barrier damage in neurodegenerative disorders. Acta neuropathologica. vol 147. issue 1. 2024-02-12. PMID:38347288. |
central nervous system (cns) accumulation of fibrillary deposits made of amyloid β (aβ), hyperphosphorylated tau or α-synuclein (α-syn), present either alone or in the form of mixed pathology, characterizes the most common neurodegenerative diseases (ndds) as well as the aging brain. |
2024-02-12 |
2024-02-15 |
Not clear |
| Lukasz Joachimiak, Sofia Bali, Ruhar Singh, Pawel Wydorski, Aleksandra Wosztyl, Valerie Perez, Dailu Chen, Josep Riz. Ensemble-based design of tau to inhibit aggregation while preserving biological activity. Research square. 2024-02-05. PMID:38313287. |
the microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. |
2024-02-05 |
2024-02-07 |
Not clear |
| Michael L Alosco, Micaela White, Carter Bell, Farwa Faheem, Yorghos Tripodis, Eukyung Yhang, Zachary Baucom, Brett Martin, Joseph Palmisano, Kristen Dams-O'Connor, John F Crary, Lee E Goldstein, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Victor E Alvarez, Bertrand Russell Huber, Thor D Stein, Ann C McKee, Jesse Me. Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy. Molecular neurodegeneration. vol 19. issue 1. 2024-02-05. PMID:38317248. |
chronic traumatic encephalopathy (cte) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. |
2024-02-05 |
2024-02-09 |
Not clear |
| Carolina Lucía Facal, Iván Fernández Bessone, Javier Andrés Muñiz, A Ezequiel Pereyra, Olivia Pedroncini, Indiana Páez-Paz, Ramiro Clerici-Delville, Cayetana Arnaiz, Leandro Urrutia, Germán Falasco, Carla Verónica Argañaraz, Trinidad Saez, Antonia Marin-Burgin, Mariano Soiza-Reilly, Tomás Falzone, María Elena Aval. Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-02-04. PMID:38310353. |
abnormal tau accumulation is the hallmark of several neurodegenerative diseases, named tauopathies. |
2024-02-04 |
2024-02-06 |
mouse |
| Maria do Socorro do Nascimento Amorim, Álefe Roger Silva França, Ralph Santos-Oliveira, Jonas Rodrigues Sanches, Thamys Marinho Melo, Bruno Araújo Serra Pinto, Leandro R S Barbosa, Luciana Magalhães Rebelo Alenca. Atomic Force Microscopy Applied to the Study of Tauopathies. ACS chemical neuroscience. 2024-02-02. PMID:38305187. |
tauopathies are neurodegenerative diseases featured by aggregation of phosphorylated tau protein inside neurons, leading to functional loss and progressive neurotoxicity. |
2024-02-02 |
2024-02-04 |
Not clear |