All Relations between Neurodegenerative Diseases and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
H Peter L. A Missing Origin of the Tau Protein Aggregation Pathway Triggered by Thermal and Biological Forces. Journal of integrative neuroscience. vol 22. issue 6. 2024-01-04. PMID:38176940. this article introduces our recent discovery of the missing tau protein property that is of significant relevance to the tau protein and neurodegenerative disease research and medical treatment, aiming to stimulate the collective observation and a new perspective on the tau aggregation mechanism and disease mechanism studies. 2024-01-04 2024-01-07 Not clear
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durran. p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. Acta neuropathologica. vol 147. issue 1. 2024-01-04. PMID:38175261. tau hyperphosphorylation and aggregation is a common feature of many dementia-causing neurodegenerative diseases. 2024-01-04 2024-01-06 mouse
Sofia Bali, Ruhar Singh, Pawel M Wydorski, Aleksandra Wosztyl, Valerie A Perez, Dailu Chen, Josep Rizo, Lukasz A Joachimia. Ensemble-based design of tau to inhibit aggregation while preserving biological activity. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168322. the microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. 2024-01-03 2024-01-06 Not clear
Morrie Lam, Szu-Yu Kuo, Surya Reis, Jason E Gestwicki, M Catarina Silva, Stephen J Haggart. Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168389. tauopathies are a class of neurodegenerative diseases characterized by the progressive misfolding and accumulation of pathological tau protein in focal regions of the brain, leading to insidious neurodegeneration. 2024-01-03 2024-01-06 Not clear
Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyma. Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau Biochemistry. 2023-12-28. PMID:38154792. reconstitution of the alzheimer's disease tau core structure from recombinant tau the protein tau misfolds into disease-specific fibrillar structures in more than 20 neurodegenerative diseases collectively referred to as tauopathies. 2023-12-28 2023-12-31 Not clear
Indalo Domene-Serrano, Raquel Cuadros, Felix Hernandez, Jesus Avila, Ismael Santa-Mari. Tridimensional Structural Analysis of Tau Isoforms Generated by Intronic Retention. Journal of Alzheimer's disease reports. vol 7. issue 1. 2023-12-25. PMID:38143771. tauopathies are a subset of neurodegenerative diseases characterized by abnormal tau inclusions. 2023-12-25 2023-12-27 human
Yamei Wang, Jianhao Wang, Hongyu Chen, Xiang Li, Ruifeng Xu, Feng Gao, Hang Yu, Fang Li, Dongdong Qin, Jiabei Wang, Yuke Shi, Yiyi Li, Songyan Liu, Xi Zhang, Shuai Ding, Yiqian Hu, Liqin Huang, Xin-Ya Gao, Zuneng Lu, Jin Luo, Zhi-Hao Wan. A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer's disease mouse models through attenuating mitochondrial function. Frontiers in aging neuroscience. vol 15. 2023-12-22. PMID:38131009. alzheimer's disease (ad) is the most prevalent neurodegenerative disease characterized by extracellular senile plaques including amyloid-β peptides and intracellular neurofibrillary tangles consisting of abnormal tau. 2023-12-22 2023-12-24 mouse
Joachim Strobel, Hans-Peter Müller, Albert C Ludolph, Ambros J Beer, Nico Sollmann, Jan Kassube. New Perspectives in Radiological and Radiopharmaceutical Hybrid Imaging in Progressive Supranuclear Palsy: A Systematic Review. Cells. vol 12. issue 24. 2023-12-22. PMID:38132096. progressive supranuclear palsy (psp) is a neurodegenerative disease characterized by four-repeat tau deposition in various cell types and anatomical regions, and can manifest as several clinical phenotypes, including the most common phenotype, richardson's syndrome. 2023-12-22 2023-12-24 Not clear
Joachim Strobel, Hans-Peter Müller, Albert C Ludolph, Ambros J Beer, Nico Sollmann, Jan Kassube. New Perspectives in Radiological and Radiopharmaceutical Hybrid Imaging in Progressive Supranuclear Palsy: A Systematic Review. Cells. vol 12. issue 24. 2023-12-22. PMID:38132096. specifically, combined pet and mri studies in psp highlight the potential of [18f]av-1451 to detect tau, but also the challenge in differentiating psp from other neurodegenerative diseases. 2023-12-22 2023-12-24 Not clear
Patrick W Cullinane, Sarah Wrigley, Jacy Bezerra Parmera, Fernanda Valerio, Thomas O Millner, Karen Shaw, Eduardo De Pablo-Fernandez, Thomas T Warner, Zane Jaunmuktan. Pathology of neurodegenerative disease for the general neurologist. Practical neurology. 2023-12-21. PMID:38124186. this review aims to elucidate the hallmark pathological features of neurodegenerative diseases commonly seen in general neurology clinics, such as alzheimer's disease and parkinson's disease; rare but well-known diseases, including progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy and more recently described entities such as chronic traumatic encephalopathy and age-related tau astrogliopathy. 2023-12-21 2023-12-23 Not clear
Vivian Hook, Sonia Podvin, Charles Mosier, Ben Boyarko, Laura Seyffert, Haley Stringer, Robert A Rissma. Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracellular vesicles and circulating nucleic acids. vol 4. issue 4. 2023-12-21. PMID:38125374. tau propagation, pathogenesis, and neurotoxicity are hallmarks of neurodegenerative diseases that result in cognitive impairment. 2023-12-21 2023-12-23 human
Khalid Iqba. Tau and Alzheimer's disease: Past, present and future. Cytoskeleton (Hoboken, N.J.). 2023-12-21. PMID:38126608. tau pathology, which without fail is made up of the aggregated hyperphosphorylated state of the protein, is also the hallmark lesion of a family of around 20 related neurodegenerative diseases, called tauopathies. 2023-12-21 2023-12-23 human
Lamiaa Bahnassawy, Nathalie Nicolaisen, Christopher Untucht, Benjamin Mielich-Süss, Lydia Reinhardt, Janina S Ried, Martina P Morawe, Daniela Geist, Anja Finck, Elke Käfer, Jürgen Korffmann, Matthew Townsend, Brinda Ravikumar, Viktor Lakics, Miroslav Cik, Peter Reinhard. Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations. SLAS discovery : advancing life sciences R & D. 2023-12-21. PMID:38128829. aberrant protein aggregation is a pathological cellular hallmark of many neurodegenerative diseases, such as alzheimer's disease (ad) and frontotemporal dementia (ftd), where the tau protein is aggregating, forming neurofibrillary tangles (nfts), and propagating from neuron to neuron. 2023-12-21 2023-12-24 human
Jie Yang, Naiting Shen, Jianying Shen, Ying Yang, Hong-Lian L. Complicated Role of Post-translational Modification and Protease-Cleaved Fragments of Tau in Alzheimer's Disease and Other Tauopathies. Molecular neurobiology. 2023-12-19. PMID:38114762. perturbations in tau's structure and function are implicated in the pathogenesis of neurodegenerative diseases collectively known as tauopathies, the most common disorder of which is alzheimer's disease (ad). 2023-12-19 2023-12-23 Not clear
Chao Qi, Bert M Verheijen, Yasumasa Kokubo, Yang Shi, Stephan Tetter, Alexey G Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki, Eleonora Aronica, Yoshifumi Hirokawa, Kiyomitsu Oyanagi, Akiyoshi Kakita, Benjamin Ryskeldi-Falcon, Mari Yoshida, Masato Hasegawa, Sjors H W Scheres, Michel Goeder. Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 51. 2023-12-15. PMID:38100415. the amyotrophic lateral sclerosis/parkinsonism-dementia complex (als/pdc) of the island of guam and the kii peninsula of japan is a fatal neurodegenerative disease of unknown cause that is characterized by the presence of abundant filamentous tau inclusions in brains and spinal cords. 2023-12-15 2023-12-18 Not clear
Michel Goedert, R Anthony Crowther, Sjors H W Scheres, Maria Grazia Spillantin. Tau and neurodegeneration. Cytoskeleton (Hoboken, N.J.). 2023-12-14. PMID:38073060. filamentous tangle inclusions were known to be made of hyperphosphorylated tau by 1991, with similar inclusions gaining recognition for being associated with other neurodegenerative diseases. 2023-12-14 2023-12-17 human
Neha, Zitin Wali, Pinky, Shaheenkousar H Hattiwale, Azfar Jamal, Suhel Parve. GLP-1/Sigma/RAGE receptors: An evolving picture of Alzheimer's disease pathology and treatment. Ageing research reviews. vol 93. 2023-12-14. PMID:38008402. the progressive neurodegenerative disease, ad is characterized by amyloid plaques and neurofibrillary tangles (nfts) of abnormally hyperphosphorylated tau protein and senile plaques (sps), which are brought on by the buildup of amyloid beta (aβ). 2023-12-14 2023-12-17 Not clear
Neelam Younas, Tayyaba Saleem, Abrar Younas, Inga Zer. Nuclear face of Tau: an inside player in neurodegeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-12-13. PMID:38087392. to complete the map of tau repertoire, understanding of various species of tau in the nucleus and cytoplasm, identification if specific transcripts of tau, isoforms and post-translational modifications could foretell tau's localizations and functions, and how they are modified in neurodegenerative diseases like ad, is urgently required. 2023-12-13 2023-12-17 human
Michael P Vigers, Samuel Lobo, Saeed Najafi, Austin Dubose, Karen Tsay, Pritam Ganguly, Andrew P Longhini, Yingying Jin, Steven K Buratto, Kenneth S Kosik, M Scott Shell, Joan-Emma Shea, Songi Ha. Tau P301L mutation promotes core 4R tauopathy fibril fold through near-surface water structuring and conformational rearrangement. bioRxiv : the preprint server for biology. 2023-12-11. PMID:38077065. tau forms toxic fibrillar aggregates in a family of neurodegenerative diseases known as tauopathies. 2023-12-11 2023-12-17 Not clear
Kerry T Sun, Tark Patel, Sang-Gyun Kang, Allan Yarahmady, Mahalashmi Srinivasan, Olivier Julien, Jónathan Heras, Sue-Ann Mo. Disease-Associated Mutations in Tau Encode for Changes in Aggregate Structure Conformation. ACS chemical neuroscience. 2023-12-06. PMID:38054595. the accumulation of tau fibrils is associated with neurodegenerative diseases, which are collectively termed tauopathies. 2023-12-06 2023-12-10 Not clear