| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sjors H W Scheres, Benjamin Ryskeldi-Falcon, Michel Goeder. Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids. Nature. vol 621. issue 7980. 2023-09-27. PMID:37758888. |
abnormal assembly of tau, α-synuclein, tdp-43 and amyloid-β proteins into amyloid filaments defines most human neurodegenerative diseases. |
2023-09-27 |
2023-10-07 |
human |
| Genevieve L Stein-O'Brien, Ryan Palaganas, Ernest M Meyer, Javier Redding-Ochoa, Olga Pletnikova, Haidan Guo, William R Bell, Juan C Troncoso, Richard L Huganir, Meaghan Morri. Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer's Disease. medRxiv : the preprint server for health sciences. 2023-09-25. PMID:37745408. |
tau pathology is common in age-related neurodegenerative diseases. |
2023-09-25 |
2023-10-07 |
Not clear |
| Naruhiko Sahara, Makoto Higuch. Diagnostic and therapeutic targeting of pathological tau proteins in neurodegenerative disorders. FEBS open bio. 2023-09-25. PMID:37746832. |
tauopathies, characterized by fibrillar tau accumulation in neurons and glial cells, constitute a major neuropathological category of neurodegenerative diseases. |
2023-09-25 |
2023-10-07 |
mouse |
| Wyatt C Powell, Ruiheng Jing, Maciej A Walcza. Chemical Synthesis of Microtubule-Associated Protein Tau. Journal of the American Chemical Society. 2023-09-22. PMID:37737824. |
deposits of the microtubule-associated protein tau (mapt) serve as a hallmark of neurodegenerative diseases known as tauopathies. |
2023-09-22 |
2023-10-07 |
Not clear |
| Pijush Chakraborty, Gwladys Rivière, Alina Hebestreit, Alain Ibáñez de Opakua, Ina M Vorberg, Loren B Andreas, Markus Zweckstette. Acetylation discriminates disease-specific tau deposition. Nature communications. vol 14. issue 1. 2023-09-22. PMID:37739953. |
the results implicate acetylation as a critical regulator that guides the selective aggregation of three-repeat tau and the development of tau isoform-specific neurodegenerative diseases. |
2023-09-22 |
2023-10-07 |
Not clear |
| Carmen Gasca-Salas, Clara Trompeta, Miguel López-Aguirre, Rafael Rodríguez Rojas, Jordi Clarimon, Oriol Dols-Icardo, Shaimaa El Bounasri, Pasqualina Guida, David Mata-Marín, Frida Hernández-Fernández, Connie Marras, Lina García-Cañamaque, Isabel Plaza de Las Heras, Ignacio Obeso, Lydia Vela, Beatriz Fernández-Rodrígue. Brain hypometabolism in non-demented microtubule-associated protein tau H1 carriers with Parkinson's disease. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2023-09-20. PMID:37726927. |
the microtubule-associated protein tau (mapt) h1 homozygosity (h1/h1 haplotype) is a genetic risk factor for neurodegenerative diseases, such as parkinson's disease (pd). |
2023-09-20 |
2023-10-07 |
Not clear |
| Maurizio Callari, Martina Sola, Claudia Magrin, Andrea Rinaldi, Marco Bolis, Paolo Paganetti, Luca Colnaghi, Stéphanie Papi. Cancer-specific association between Tau (MAPT) and cellular pathways, clinical outcome, and drug response. Scientific data. vol 10. issue 1. 2023-09-20. PMID:37730697. |
tau (mapt) is a microtubule-associated protein causing common neurodegenerative diseases or rare inherited frontotemporal lobar degenerations. |
2023-09-20 |
2023-10-07 |
Not clear |
| Lovedeep Singh, Harpreet Kaur, Girish Chandra Arya, Rajbir Bhatt. Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen. Chemical biology & drug design. 2023-09-18. PMID:37722967. |
furthermore, formononetin also increases the expression of adam-10, which affects the pathology of neurodegenerative disease by lowering tau phosphorylation, maintaining synaptic plasticity, and boosting hippocampus neurogenesis. |
2023-09-18 |
2023-10-07 |
Not clear |
| Xinyi Zhao, Wen Zeng, Hong Xu, Zihan Sun, Yingxin Hu, Beibei Peng, Jennifer D McBride, Jiangtao Duan, Juan Deng, Bin Zhang, Soo-Jung Kim, Bryan Zoll, Takashi Saito, Hiroki Sasaguri, Takaomi C Saido, Carlo Ballatore, Haishan Yao, Zhaoyin Wang, John Q Trojanowski, Kurt R Brunden, Virginia M-Y Lee, Zhuohao H. A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury. Science translational medicine. vol 15. issue 713. 2023-09-13. PMID:37703352. |
tau pathogenesis is a hallmark of many neurodegenerative diseases, including alzheimer's disease (ad). |
2023-09-13 |
2023-10-07 |
mouse |
| Maxwell Eisenbaum, Andrew Pearson, Camila Ortiz, Michael Mullan, Fiona Crawford, Joseph Ojo, Corbin Bachmeie. ApoE4 expression disrupts tau uptake, trafficking, and clearance in astrocytes. Glia. 2023-09-05. PMID:37668005. |
tauopathies are a collection of neurodegenerative diseases characterized by the accumulation of pathogenic aggregates of the microtubule-associated protein tau. |
2023-09-05 |
2023-09-07 |
mouse |
| Maxwell Eisenbaum, Andrew Pearson, Camila Ortiz, Michael Mullan, Fiona Crawford, Joseph Ojo, Corbin Bachmeie. ApoE4 expression disrupts tau uptake, trafficking, and clearance in astrocytes. Glia. 2023-09-05. PMID:37668005. |
in total, our findings suggest that the apoe4 isoform lowers the threshold of astrocytic resilience to pathogenic tau, rendering them susceptible to bioenergetic deficits in the early stages of neurodegenerative diseases such as traumatic brain injury, potentially contributing to neurological decline. |
2023-09-05 |
2023-09-07 |
mouse |
| Bassel Eldeen Makki, Sarah Rahma. Alzheimer's Disease in Diabetic Patients: A Lipidomic Prospect. Neuroscience. 2023-08-31. PMID:37652288. |
type 2 dm (t2dm) is a metabolic disease depicted by insulin resistance, dyslipidemia, and chronic hyperglycemia while ad is a neurodegenerative disease marked by amyloid β (aβ) accumulation, neurofibrillary tangles aggregation, and tau phosphorylation. |
2023-08-31 |
2023-09-07 |
Not clear |
| Cory M Nadel, Kristin Wucherer, Abby Oehler, Aye C Thwin, Koli Basu, Matthew D Callahan, Daniel R Southworth, Daniel A Mordes, Charles S Craik, Jason E Gestwick. Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645969. |
microtubule-associated protein tau (mapt/tau) accumulates in a family of neurodegenerative diseases, including alzheimer's disease (ad). |
2023-08-30 |
2023-09-07 |
Not clear |
| Jafar Sadeghzadeh, Parviz Shahabi, Mehdi Farhoudi, Abbas Ebrahimi-Kalan, Ahmad Mobed, Kourosh Shahpasan. Tau Protein Biosensors in the Diagnosis of Neurodegenerative Diseases. Advanced pharmaceutical bulletin. vol 13. issue 3. 2023-08-30. PMID:37646056. |
tau protein biosensors in the diagnosis of neurodegenerative diseases. |
2023-08-30 |
2023-09-07 |
human |
| Jafar Sadeghzadeh, Parviz Shahabi, Mehdi Farhoudi, Abbas Ebrahimi-Kalan, Ahmad Mobed, Kourosh Shahpasan. Tau Protein Biosensors in the Diagnosis of Neurodegenerative Diseases. Advanced pharmaceutical bulletin. vol 13. issue 3. 2023-08-30. PMID:37646056. |
tau protein plays a crucial role in diagnosing neurodegenerative diseases. |
2023-08-30 |
2023-09-07 |
human |
| Tong Zhang, Nshunge Musheshe, Christina H J T M van der Veen, Helmut W Kessels, Amalia Dolga, Peter De Deyn, Ulrich Eisel, Martina Schmid. The Expression of Epac2 and GluA3 in an Alzheimer's Disease Experimental Model and Postmortem Patient Samples. Biomedicines. vol 11. issue 8. 2023-08-26. PMID:37626593. |
alzheimer's disease (ad) is one of the most prevalent neurodegenerative diseases, characterized by amyloid beta (aβ) and hyperphosphorylated tau accumulation in the brain. |
2023-08-26 |
2023-09-07 |
Not clear |
| Michal J Halicki, Karen Hind, Paul L Chazo. Blood-Based Biomarkers in the Diagnosis of Chronic Traumatic Encephalopathy: Research to Date and Future Directions. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628736. |
however, several molecules, such as different phosphorylated tau isoforms, were able to discern cte from different neurodegenerative diseases. |
2023-08-26 |
2023-09-07 |
Not clear |
| Jiyeon Lee, Julie M Dimitry, Jong Hee Song, Minsoo Son, Patrick W Sheehan, Melvin W King, G Travis Tabor, Young Ah Goo, Mitchell A Lazar, Leonard Petrucelli, Erik S Musie. Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice. Nature communications. vol 14. issue 1. 2023-08-25. PMID:37626048. |
alzheimer's disease, the most common age-related neurodegenerative disease, is characterized by tau aggregation and associated with disrupted circadian rhythms and dampened clock gene expression. |
2023-08-25 |
2023-09-07 |
mouse |
| Lijuan Shu, Chunfu Du, Yunxia Zu. Abnormal phosphorylation of protein tyrosine in neurodegenerative diseases. Journal of neuropathology and experimental neurology. 2023-08-17. PMID:37589710. |
in the cns of patients with neurodegenerative diseases, a variety of abnormally phosphorylated proteins play important roles in pathological processes such as neuroinflammation and intracellular accumulation of β-amyloid plaques and tau. |
2023-08-17 |
2023-09-07 |
Not clear |
| Ryan J Keenan, Heather Daykin, Jeremy Metha, Linda Cornthwaite-Duncan, David K Wright, Kyra Clarke, Sara Oberrauch, Maddison Brian, Sarah Stephenson, Cameron J Nowell, Giancarlo Allocca, Kevin J Barnham, Daniel Hoyer, Laura H Jacobso. Orexin 2 receptor antagonism sex-dependently improves sleep/wakefulness and cognitive performance in tau transgenic mice. British journal of pharmacology. 2023-08-09. PMID:37553894. |
tau pathology contributes to a bidirectional relationship between sleep disruption and neurodegenerative disease. |
2023-08-09 |
2023-08-16 |
mouse |