| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eliot J Davidowitz, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G Mo. Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice. PloS one. vol 18. issue 8. 2023-08-09. PMID:37556474. |
advances in tau biology and the difficulties of amyloid-directed immunotherapeutics have heightened interest in tau as a target for small molecule drug discovery for neurodegenerative diseases. |
2023-08-09 |
2023-08-16 |
mouse |
| Jiayi Zhong, Xiaochen Zhang, Huanyu Xu, Xiaoran Zheng, Luyao Wang, Jiehui Jiang, Yunxia L. Unlocking the enigma: unraveling multiple cognitive dysfunction linked to glymphatic impairment in early Alzheimer's disease. Frontiers in neuroscience. vol 17. 2023-08-07. PMID:37547134. |
alzheimer's disease (ad) is one of the world's well-known neurodegenerative diseases, which is related to the balance mechanism of production and clearance of two proteins (amyloid-β and tau) regulated by the glymphatic system. |
2023-08-07 |
2023-08-14 |
Not clear |
| Sanghyun Ahn, Jung-Soo Suh, Yoon-Kwan Jang, Heonsu Kim, Kiseok Han, Yerim Lee, Gyuho Choi, Tae-Jin Ki. TAUCON and TAUCOM: A novel biosensor based on fluorescence resonance energy transfer for detecting tau hyperphosphorylation-associated cellular pathologies. Biosensors & bioelectronics. vol 237. 2023-07-30. PMID:37517333. |
tauopathies are neurodegenerative diseases characterized by abnormal conformational changes in tau protein. |
2023-07-30 |
2023-08-14 |
Not clear |
| George E Barret. Repurposing of Tibolone in Alzheimer's Disease. Biomolecules. vol 13. issue 7. 2023-07-29. PMID:37509151. |
alzheimer's disease (ad) is a debilitating neurodegenerative disease characterised by the accumulation of amyloid-beta and tau in the brain, leading to the progressive loss of memory and cognition. |
2023-07-29 |
2023-08-14 |
Not clear |
| Sarah E Torraville, Cassandra M Flynn, Tori L Kendall, Qi Yua. Life Experience Matters: Enrichment and Stress Can Influence the Likelihood of Developing Alzheimer's Disease via Gut Microbiome. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509523. |
alzheimer's disease (ad) is a chronic neurodegenerative disease, characterized by the presence of β-amyloid (aβ) plaques and neurofibrillary tangles (nfts) formed from abnormally phosphorylated tau proteins (ptau). |
2023-07-29 |
2023-08-14 |
Not clear |
| Zhikai Zeng, Vishnu Vijayan, Karen Tsay, Matthew P Frost, Athena Quddus, Alexa Albert, Michael Vigers, Amanda L Woerman, Songi Ha. CBD and PSP cell-passaged Tau Seeds Generate Heterogeneous Fibrils with A sub-population Adopting Disease Folds. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502998. |
the recent discovery by cryo-electron microscopy that the neuropatho-logical hallmarks of different tauopathies, including alzheimer's disease, corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), are caused by unique misfolded conformations of the protein tau is among the most profound developments in neurodegenerative disease research. |
2023-07-28 |
2023-08-14 |
Not clear |
| Xinlu Li, Jianfeng Chen, Wennuo Feng, Chao Wang, Minyu Chen, Yifan Li, Jinghong Chen, Xinwei Liu, Qiong Liu, Jing Tia. Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 118. 2023-07-28. PMID:37506403. |
ad is a neurodegenerative disease characterized by β-amyloid (aβ) deposition, hyperphosphorylated tau and other characters. |
2023-07-28 |
2023-08-14 |
mouse |
| Alisa Cario, Christopher L Berge. Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative disease. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 45. issue 8. 2023-07-25. PMID:37489532. |
tau, microtubule dynamics, and axonal transport: new paradigms for neurodegenerative disease. |
2023-07-25 |
2023-08-14 |
Not clear |
| Alisa Cario, Christopher L Berge. Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative disease. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 45. issue 8. 2023-07-25. PMID:37489532. |
the etiology of tauopathies, a diverse class of neurodegenerative diseases associated with the microtubule associated protein (map) tau, is usually described by a common mechanism in which tau dysfunction results in the loss of axonal microtubule stability. |
2023-07-25 |
2023-08-14 |
Not clear |
| Grace Rosen, Daniel Kirsch, Sarah Horowitz, Jonathan D Cherry, Raymond Nicks, Hunter Kelley, Madeline Uretsky, Kevin Dell'Aquila, Rebecca Mathias, Kerry A Cormier, Caroline A Kubilus, Jesse Mez, Yorghos Tripodis, Thor D Stein, Victor E Alvarez, Michael L Alosco, Ann C McKee, Bertrand R Hube. Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy. Acta neuropathologica communications. vol 11. issue 1. 2023-07-25. PMID:37491342. |
chronic traumatic encephalopathy (cte) is a neurodegenerative disease associated with exposure to repetitive head impacts (rhi) and characterized by perivascular accumulations of hyperphosphorylated tau protein (p-tau) at the depths of the cortical sulci. |
2023-07-25 |
2023-08-14 |
human |
| Sydney M A Juan, Maria Daglas, Phan H Truong, Celeste Mawal, Paul A Adlar. Alterations in iron content, iron-regulatory proteins and behaviour without tau pathology at one year following repetitive mild traumatic brain injury. Acta neuropathologica communications. vol 11. issue 1. 2023-07-18. PMID:37464280. |
repetitive mild traumatic brain injury (r-mtbi) has increasingly become recognised as a risk factor for the development of neurodegenerative diseases, many of which are characterised by tau pathology, metal dyshomeostasis and behavioural impairments. |
2023-07-18 |
2023-08-14 |
mouse |
| Marta Jorge-Oliva, Jan R T van Weering, Wiep Schepe. Structurally and Morphologically Distinct Pathological Tau Assemblies Differentially Affect GVB Accumulation. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446051. |
tau aggregation is central to the pathogenesis of a large group of neurodegenerative diseases termed tauopathies, but it is still unclear in which way neurons respond to tau pathology and how tau accumulation leads to neurodegeneration. |
2023-07-14 |
2023-08-14 |
Not clear |
| Enrique Estudillo, Adolfo López-Ornelas, Alejandro Rodríguez-Oviedo, Neptali Gutiérrez de la Cruz, Marco Antonio Vargas-Hernández, Adriana Jiméne. Thinking outside the black box: are the brain endothelial cells the new main target in Alzheimer's disease? Neural regeneration research. vol 18. issue 12. 2023-07-14. PMID:37449594. |
although brain endothelial cell function is crucial for brain homeostasis, their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia, astroglia, neurons, or even molecules such as amyloid beta, tau, or alpha-synuclein. |
2023-07-14 |
2023-08-14 |
Not clear |
| Marta Leńska-Mieciek, Natalia Madetko-Alster, Piotr Alster, Leszek Królicki, Urszula Fiszer, Dariusz Koziorowsk. Inflammation in multiple system atrophy. Frontiers in immunology. vol 14. 2023-07-10. PMID:37426656. |
among proteinopathies are neurodegenerative diseases with atypical parkinsonism and an accumulation of insoluble fibrillary alpha-synuclein (synucleinopathies) or hyperphosphorylated tau protein fragments (tauopathies). |
2023-07-10 |
2023-08-14 |
Not clear |
| Elly E Liao, Mu Yang, Noah Nathan Kochen, Nagamani Vunnam, Anthony R Braun, David M Ferguson, Jonathan N Sach. Proteasomal Stimulation by MK886 and Its Derivatives Can Rescue Tau-Induced Neurite Pathology. Molecular neurobiology. 2023-07-10. PMID:37428404. |
proteasomal degradation of intrinsically disordered proteins, such as tau, is a critical component of proteostasis in both aging and neurodegenerative diseases. |
2023-07-10 |
2023-08-14 |
Not clear |
| Mingxi Dang, Feng Sang, Shijie Long, Yaojing Che. The Aging Patterns of Brain Structure, Function, and Energy Metabolism. Advances in experimental medicine and biology. vol 1419. 2023-07-07. PMID:37418208. |
finally, we discussed the relationship between amyloid-β deposition and tau accumulation in the brain, as pathological manifestations of neurodegenerative disease and aging. |
2023-07-07 |
2023-08-14 |
Not clear |
| Leonora Szabo, Amandine Grimm, Juan Antonio García-León, Catherine M Verfaillie, Anne Ecker. Genetically Engineered Triple Cells. vol 12. issue 10. 2023-07-06. PMID:37408218. |
genetically engineered triple pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies. |
2023-07-06 |
2023-08-14 |
Not clear |
| Galina Limorenko, Meltem Tatli, Rajasekhar Kolla, Sergey Nazarov, Marie-Theres Weil, David C Schöndorf, Daniela Geist, Peter Reinhardt, Dagmar E Ehrnhoefer, Henning Stahlberg, Laura Gasparini, Hilal A Lashue. Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates. Nature communications. vol 14. issue 1. 2023-07-04. PMID:37402718. |
tau protein fibrillization is implicated in the pathogenesis of several neurodegenerative diseases collectively known as tauopathies. |
2023-07-04 |
2023-08-14 |
Not clear |
| Bryan T Hurtle, Longxin Xie, Christopher J Donnell. Disrupting pathologic phase transitions in neurodegeneration. The Journal of clinical investigation. vol 133. issue 13. 2023-07-03. PMID:37395272. |
this review explores the known mechanisms contributing to aberrant protein phase transitions in neurodegenerative diseases, focusing on tau and tdp-43 proteinopathies and outlining potential therapeutic strategies to regulate these pathologic events. |
2023-07-03 |
2023-08-14 |
human |
| Jasvinder Singh Bhatti, Satinder Kaur, Jayapriya Mishra, Harikrishnareddy Dibbanti, Arti Singh, Arubala P Reddy, Gurjit Kaur Bhatti, P Hemachandra Redd. Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-01. PMID:37392948. |
alzheimer's disease (ad) is a neurodegenerative disease that manifests its pathology through synaptic damage, mitochondrial abnormalities, microrna deregulation, hormonal imbalance, increased astrocytes & microglia, accumulation of amyloid β (aβ) and phosphorylated tau in the brains of ad patients. |
2023-07-01 |
2023-08-14 |
Not clear |