| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Artero Castro, C Machuca, F J Rodriguez Jimenez, P Jendelova, S Erce. Short Review: Investigating ARSACS: models for understanding cerebellar degeneration. Neuropathology and applied neurobiology. vol 45. issue 6. 2020-08-31. PMID:30636067. |
autosomal recessive spastic ataxia of charlevoix-saguenay (arsacs) is an early-onset neurodegenerative disease that includes progressive cerebellar dysfunction. |
2020-08-31 |
2023-08-13 |
human |
| He-Jin Lee, Diadem Ricarte, Darlene Ortiz, Seung-Jae Le. Models of multiple system atrophy. Experimental & molecular medicine. vol 51. issue 11. 2020-06-15. PMID:31740682. |
multiple system atrophy (msa) is a neurodegenerative disease with diverse clinical manifestations, including parkinsonism, cerebellar syndrome, and autonomic failure. |
2020-06-15 |
2023-08-13 |
mouse |
| Francesca Prestori, Francesco Moccia, Egidio D'Angel. Disrupted Calcium Signaling in Animal Models of Human Spinocerebellar Ataxia (SCA). International journal of molecular sciences. vol 21. issue 1. 2020-05-14. PMID:31892274. |
spinocerebellar ataxias (scas) constitute a heterogeneous group of more than 40 autosomal-dominant genetic and neurodegenerative diseases characterized by loss of balance and motor coordination due to dysfunction of the cerebellum and its efferent connections. |
2020-05-14 |
2023-08-13 |
human |
| Hiroaki Sekiya, Hisatomo Kowa, Hinako Koga, Mariko Takata, Wataru Satake, Naonobu Futamura, Itaru Funakawa, Kenji Jinnai, Motonori Takahashi, Takeshi Kondo, Yasuhiro Ueno, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Tod. Wide distribution of alpha-synuclein oligomers in multiple system atrophy brain detected by proximity ligation. Acta neuropathologica. vol 137. issue 3. 2020-04-20. PMID:30721406. |
multiple system atrophy (msa) is a fatal adult-onset neurodegenerative disease that is characterized by varying degrees of cerebellar dysfunction and parkinsonism. |
2020-04-20 |
2023-08-13 |
Not clear |
| Maryam Rahimi-Balaei, Matthew Buchok, Pirkko Vihko, Fiona E Parkinson, Hassan Marzba. Loss of prostatic acid phosphatase and α-synuclein cause motor circuit degeneration without altering cerebellar patterning. PloS one. vol 14. issue 9. 2020-04-02. PMID:31509576. |
these data indicate that although aggregation of pap and snca causes severe neurodegenerative diseases, pap -/- with absence of the snca does not appear to interrupt the cerebellar architecture development and zone and stripe pattern formation. |
2020-04-02 |
2023-08-13 |
mouse |
| Austin Ferro, Carrie Sheeler, Juao-Guilherme Rosa, Marija Cvetanovi. Role of Microglia in Ataxias. Journal of molecular biology. vol 431. issue 9. 2020-03-19. PMID:30660620. |
ataxias are a class of neurodegenerative diseases characterized by motor discoordination and predominant cerebellar involvement. |
2020-03-19 |
2023-08-13 |
Not clear |
| Jan Cendelin, Annalisa Buffo, Hirokazu Hirai, Lorenzo Magrassi, Hiroshi Mitoma, Rachel Sherrard, Frantisek Vozeh, Mario Mant. Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy? Cerebellum (London, England). vol 18. issue 3. 2019-12-06. PMID:30607797. |
restoration of damaged central nervous system structures, functional recovery, and prevention of neuronal loss during neurodegenerative diseases are major objectives in cerebellar research. |
2019-12-06 |
2023-08-13 |
Not clear |
| Michela Lupo, Giusy Olivito, Claudia Iacobacci, Silvia Clausi, Silvia Romano, Marcella Masciullo, Marco Molinari, Mara Cercignani, Marco Bozzali, Maria Leggi. The cerebellar topography of attention sub-components in spinocerebellar ataxia type 2. Cortex; a journal devoted to the study of the nervous system and behavior. vol 108. 2019-11-26. PMID:30121445. |
spinocerebellar ataxia type 2 (sca2) is an autosomal dominant neurodegenerative disease characterized by a progressive cerebellar syndrome and multiple-domain cognitive impairments. |
2019-11-26 |
2023-08-13 |
human |
| Kathrin Reetz, Roberto Rodríguez-Labrada, Imis Dogan, Shahram Mirzazade, Sandro Romanzetti, Jörg B Schulz, Edilia M Cruz-Rivas, Jose A Alvarez-Cuesta, Raul Aguilera Rodríguez, Yanetza Gonzalez Zaldivar, Georg Auburger, Luis Velázquez-Pére. Brain atrophy measures in preclinical and manifest spinocerebellar ataxia type 2. Annals of clinical and translational neurology. vol 5. issue 2. 2019-11-20. PMID:29468174. |
spinocerebellar ataxia type 2 (sca2) is an autosomal dominantly inherited neurodegenerative disease mainly affecting the cerebellum and brainstem. |
2019-11-20 |
2023-08-13 |
Not clear |
| E Otero-Dominguez, C Gomez-Lado, P Fuentes-Pita, D Dacruz, F Barros-Angueira, J Eiris-Puna. [Hypomyelinating leukodystrophy type 6. Clinical and neuroimaging key features in the detection of a new case]. Revista de neurologia. vol 67. issue 9. 2019-10-30. PMID:30350845. |
hypomyelinating leukodystrophy-6 is a rare and early onset neurodegenerative disease which entails a clinical pattern of pyramidal-extrapyramidal and cerebellar involvement and it comes with a neuroimaging consisting of hypomielination, cerebellar hypoplasia and specific abnormalities in basal ganglia, particularly the absence or nearly absence of putamen and the possible loss of caudate's volume. |
2019-10-30 |
2023-08-13 |
Not clear |
| B Ferreira, M Palinkas, L Gonçalves, G da Silva, V Arnoni, I Regalo, P Vasconcelos, W-M Júnior, J Hallak, S Regalo, S Siésser. Spinocerebellar ataxia: Functional analysis of the stomatognathic system. Medicina oral, patologia oral y cirugia bucal. vol 24. issue 2. 2019-09-30. PMID:30818308. |
neurodegenerative diseases that affect the cerebellum, especially in elderly individuals, cause impairment of motor coordination and quality of life. |
2019-09-30 |
2023-08-13 |
Not clear |
| Arno Olthof. [Speech and Language Disorders in the Elderly]. Laryngo- rhino- otologie. vol 97. issue 12. 2019-09-16. PMID:30536283. |
vascular insults and neurodegenerative diseases are also causes of brainstem and cerebellar disorders that affect motor speech. |
2019-09-16 |
2023-08-13 |
Not clear |
| Shin-Wu Liu, Jui-Chih Chang, Sheng-Fei Chuang, Ko-Hung Liu, Wen-Ling Cheng, Hui-Ju Chang, Huei-Shin Chang, Ta-Tsung Lin, Ching-Liang Hsieh, Wei-Yong Lin, Mingli Hsieh, Shou-Jen Kuo, Chin-San Li. Far-infrared Radiation Improves Motor Dysfunction and Neuropathology in Spinocerebellar Ataxia Type 3 Mice. Cerebellum (London, England). vol 18. issue 1. 2019-05-20. PMID:29725949. |
spinocerebellar ataxia type 3 (sca3) is a polyglutamine neurodegenerative disease resulting from the misfolding and accumulation of a pathogenic protein, causing cerebellar dysfunction, and this disease currently has no effective treatments. |
2019-05-20 |
2023-08-13 |
mouse |
| Yu-Ling Wu, Jui-Chih Chang, Wei-Yong Lin, Chien-Chun Li, Mingli Hsieh, Haw-Wen Chen, Tsu-Shing Wang, Wen-Tzu Wu, Chin-San Liu, Kai-Li Li. Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway. Free radical biology & medicine. vol 115. 2019-05-03. PMID:29247688. |
polyglutamine (polyq)-expanded mutant ataxin-3 protein, which is prone to misfolding and aggregation, leads to cerebellar neurotoxicity in spinocerebellar ataxia type 3 (sca3), an inherited polyq neurodegenerative disease. |
2019-05-03 |
2023-08-13 |
drosophila_melanogaster |
| Guido Rohrer, Günter U Höglinger, Johannes Levi. Symptomatic therapy of multiple system atrophy. Autonomic neuroscience : basic & clinical. vol 211. 2019-04-12. PMID:29104019. |
multiple system atrophy is a progressive neurodegenerative disease characterized by the association of autonomic failure and a movement disorder that consist of either a hypokinetic movement disorder or a cerebellar syndrome or both. |
2019-04-12 |
2023-08-13 |
Not clear |
| Gustavo A Higuera, Grazia Iaffaldano, Meiwand Bedar, Guy Shpak, Robin Broersen, Shashini T Munshi, Catherine Dupont, Joost Gribnau, Femke M S de Vrij, Steven A Kushner, Chris I De Zeeu. An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum. Scientific reports. vol 7. issue 1. 2019-03-21. PMID:28821816. |
we conclude that this protocol may be useful for the generation and maturation of pns, highlighting the potential for development of a regenerative medicine approach to the treatment of cerebellar neurodegenerative diseases. |
2019-03-21 |
2023-08-13 |
mouse |
| Hirokazu Hirai, Masanobu Kan. Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders. Current opinion in pharmacology. vol 38. 2019-03-14. PMID:29525719. |
neurodegenerative diseases such as spinocerebellar ataxias and autoantibody-associated disorders of the central nervous system often affect the cerebellum, resulting in motor deficits. |
2019-03-14 |
2023-08-13 |
Not clear |
| Carlos R Hernandez-Castillo, Maedbh King, Jörn Diedrichsen, Juan Fernandez-Rui. Unique degeneration signatures in the cerebellar cortex for spinocerebellar ataxias 2, 3, and 7. NeuroImage. Clinical. vol 20. 2019-02-05. PMID:30308379. |
spinocerebellar ataxias (scas) are a heterogeneous group of neurodegenerative diseases that selectively affect vulnerable neuronal populations in the cerebellum and other subcortical regions. |
2019-02-05 |
2023-08-13 |
Not clear |
| D Heidelberg, S Ronsin, F Bonneville, S Hannoun, C Tilikete, F Cotto. Main inherited neurodegenerative cerebellar ataxias, how to recognize them using magnetic resonance imaging? Journal of neuroradiology = Journal de neuroradiologie. vol 45. issue 5. 2018-11-26. PMID:29920348. |
ataxia is a neurodegenerative disease resulting from brainstem, cerebellar, and/or spinocerebellar tracts impairments. |
2018-11-26 |
2023-08-13 |
Not clear |
| Farahnaz Rezaei Makhouri, Jahan B Ghasem. In Silico Studies in Drug Research Against Neurodegenerative Diseases. Current neuropharmacology. vol 16. issue 6. 2018-10-04. PMID:28831921. |
neurodegenerative diseases such as alzheimer's disease (ad), amyotrophic lateral sclerosis, parkinson's disease (pd), spinal cerebellar ataxias, and spinal and bulbar muscular atrophy are described by slow and selective degeneration of neurons and axons in the central nervous system (cns) and constitute one of the major challenges of modern medicine. |
2018-10-04 |
2023-08-13 |
Not clear |