| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melanie M Pina, Dipanwita Pati, Lara S Hwa, Sarah Y Wu, Alexandra A Mahoney, Chiazam G Omenyi, Montserrat Navarro, Thomas L Kas. The kappa opioid receptor modulates GABA neuron excitability and synaptic transmission in midbrainprojections from the insular cortex. Neuropharmacology. vol 165. 2021-03-30. PMID:31870854. |
as an integrative hub, the insular cortex (ic) translates external cues into interoceptive states that generate complex physiological, affective, and behavioral responses. |
2021-03-30 |
2023-08-13 |
Not clear |
| Dominic Kargl, Joanna Kaczanowska, Sophia Ulonska, Florian Groessl, Lukasz Piszczek, Jelena Lazovic, Katja Buehler, Wulf Haubensa. The amygdala instructs insular feedback for affective learning. eLife. vol 9. 2021-03-22. PMID:33216712. |
using fmri in mice, we mapped a discrete cortico-limbic loop between insular cortex (ic), central amygdala (ce), and nucleus basalis of meynert (nbm), which decomposes the affective value of a conditioned stimulus (cs) into its salience and valence components. |
2021-03-22 |
2023-08-13 |
mouse |
| Vinod Menon, Guillermo Gallardo, Mark A Pinsk, Van-Dang Nguyen, Jing-Rebecca Li, Weidong Cai, Demian Wasserman. Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control. eLife. vol 9. 2021-03-03. PMID:32496190. |
quantitative modeling of multi-shell diffusion mri data from 413 participants revealed that human insula microstructure differs significantly across subdivisions that serve distinct cognitive and affective functions. |
2021-03-03 |
2023-08-13 |
human |
| Philip Gerran. Pain Asymbolia as Depersonalization for Pain Experience. An Interoceptive Active Inference Account. Frontiers in psychology. vol 11. 2020-11-17. PMID:33192765. |
a key component of this hierarchical processing system and hub of affective self-modeling is activity in the anterior insula cortex. |
2020-11-17 |
2023-08-13 |
Not clear |
| Luca Cerniglia, Letizia Bartolomeo, Micaela Capobianco, Sara Lucia M Lo Russo, Fabiana Festucci, Renata Tambelli, Walter Adriani, Silvia Cimin. Intersections and Divergences Between Empathizing and Mentalizing: Development, Recent Advancements by Neuroimaging and the Future of Animal Modeling. Frontiers in behavioral neuroscience. vol 13. 2020-10-01. PMID:31572143. |
as far as mirror-neuron processes are concerned, some structures (like anterior insula, ai; anterior cingulate cortex, acc) play a role both in the representation of one's own affective states and in comprehension of the same affective state when experienced by others. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yang Qu, Lynda C Lin, Eva H Telze. Culture Modulates the Neural Correlates Underlying Risky Exploration. Frontiers in human neuroscience. vol 13. 2020-09-30. PMID:31191278. |
moreover, while independent self-construal was not related to american individuals' behavioral performance and neural correlates of risky exploration, chinese participants who reported greater independent self-construal recruited greater activation in regions of the cognitive control system [e.g., dorsolateral prefrontal cortex (dlpfc)] and affective system [e.g., anterior insula (ai)], which was related to greater risky exploration. |
2020-09-30 |
2023-08-13 |
human |
| F Nees, K Usai, M Löffler, H Flo. The evaluation and brain representation of pleasant touch in chronic and subacute back pain. Neurobiology of pain (Cambridge, Mass.). vol 5. 2020-09-29. PMID:31194113. |
further, the insula responses in cbp were positively correlated with pain-related interference and the vs activation in sabp correlated negatively with affective distress. |
2020-09-29 |
2023-08-13 |
Not clear |
| Suk Won Han, Hana P Eaton, René Maroi. Functional Fractionation of the Cingulo-opercular Network: Alerting Insula and Updating Cingulate. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 6. 2020-09-22. PMID:29850839. |
the anterior insula (ai) and dorsal anterior cingulate cortex (dacc) are engaged in various cognitive and affective processes. |
2020-09-22 |
2023-08-13 |
Not clear |
| Olga Bednarska, Adriane Icenhour, Sofie Tapper, Suzanne T Witt, Anders Tisell, Peter Lundberg, Sigrid Elsenbruch, Maria Engström, Susanna Walte. Reduced excitatory neurotransmitter levels in anterior insulae are associated with abdominal pain in irritable bowel syndrome. Pain. vol 160. issue 9. 2020-07-27. PMID:31045748. |
brain imaging studies in ibs demonstrate altered function in anterior insula (ains), a key hub for integration of interoceptive, affective, and cognitive processes. |
2020-07-27 |
2023-08-13 |
human |
| Marina López-Solà, Stephan Geuter, Leonie Koban, James A Coan, Tor D Wage. Brain mechanisms of social touch-induced analgesia in females. Pain. vol 160. issue 9. 2020-07-27. PMID:31241496. |
brain correlates of touch-induced analgesia included reduced pain-related activation in (1) regions targeted by primary nociceptive afferents (eg, posterior insula, and anterior cingulate cortex); and (b) regions associated with affective value (orbitofrontal cortex), meaning (ventromedial prefrontal cortex [pfc]), and attentional regulation (dorsolateral pfc). |
2020-07-27 |
2023-08-13 |
Not clear |
| G Di Cesare, C Pinardi, C Carapelli, F Caruana, M Marchi, M Gerbella, G Rizzolatt. Insula Connections With the Parieto-Frontal Circuit for Generating Arm Actions in Humans and Macaque Monkeys. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 5. 2020-07-16. PMID:29741595. |
it has been recently found that the human dorso-central insular cortex contributes to the execution and recognition of the affective component of hand actions, most likely through modulation of the activity of the parieto-frontal circuits. |
2020-07-16 |
2023-08-13 |
human |
| Viridiana Mazzola, Giampiero Arciero, Leonardo Fazio, Tiziana Lanciano, Barbara Gelao, Alessandro Bertolino, Guido Bondolf. Emotion-body connection dispositions modify the insulae-midcingulate effective connectivity during anger processing. PloS one. vol 15. issue 2. 2020-04-30. PMID:32053605. |
in addition, from the perspective of a hierarchical model of neurovisceral integration, these findings add knowledge to the multiple ways which the insula and mcc dynamically integrate affective and bodily aspects of the human experience. |
2020-04-30 |
2023-08-13 |
human |
| Yang Zhang, Wenjing Zhou, Siyu Wang, Qin Zhou, Haixiang Wang, Bingqing Zhang, Juan Huang, Bo Hong, Xiaoqin Wan. The Roles of Subdivisions of Human Insula in Emotion Perception and Auditory Processing. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 2. 2020-04-03. PMID:29342237. |
our findings suggest different roles played by the two regions of the human insula and a transformation from sensory to affective representations in auditory modality along the posterior-to-anterior axis in the human insula. |
2020-04-03 |
2023-08-13 |
human |
| Ibai Diez, Laura Ortiz-Terán, Benjamin Williams, Rozita Jalilianhasanpour, Juan Pablo Ospina, Bradford C Dickerson, Matcheri S Keshavan, W Curt LaFrance, Jorge Sepulcre, David L Pere. Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder. Journal of neurology, neurosurgery, and psychiatry. vol 90. issue 8. 2020-03-17. PMID:30850473. |
given that the multimodal integration network (insula, dorsal cingulate, temporoparietal junction (tpj)) is implicated in convergent sensorimotor, affective and interoceptive processing, we hypothesised that patients with fnd would exhibit altered motor and amygdalar resting-state propagation to this network. |
2020-03-17 |
2023-08-13 |
Not clear |
| Markus Rütgen, Carolina Pletti, Martin Tik, Christoph Kraus, Daniela Melitta Pfabigan, Ronald Sladky, Manfred Klöbl, Michael Woletz, Thomas Vanicek, Christian Windischberger, Rupert Lanzenberger, Claus Lam. Antidepressant treatment, not depression, leads to reductions in behavioral and neural responses to pain empathy. Translational psychiatry. vol 9. issue 1. 2020-02-06. PMID:31175273. |
moreover, functional connectivity during the empathy task between areas associated with affective (anterior insula) and cognitive (precuneus) empathy decreased between sessions in the mdd group. |
2020-02-06 |
2023-08-13 |
human |
| Namik Kirlic, Robin L Aupperle, Jamie L Rhudy, Masaya Misaki, Rayus Kuplicki, Anne Sutton, Ruben P Alvare. Latent variable analysis of negative affect and its contributions to neural responses during shock anticipation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 4. 2019-12-13. PMID:30181595. |
pna, via insula activity, may relate to arousal in ways that could contribute to affective dysregulation, and thus may be an important treatment target. |
2019-12-13 |
2023-08-13 |
human |
| J S Nomi, E Schettini, I Broce, A S Dick, L Q Uddi. Structural Connections of Functionally Defined Human Insular Subdivisions. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 10. 2019-11-06. PMID:28968768. |
studies examining unique profiles show that the dorsal anterior insula (dai) has connections with frontal areas supporting higher-level cognitive processes, the ventral anterior insula (vai) has connections with limbic areas supporting affective processes, and the posterior insula (pi) has connections with sensorimotor areas supporting interoceptive processes. |
2019-11-06 |
2023-08-13 |
human |
| Merideth A Addicott, Stacey B Daughters, Timothy J Strauman, L Gregory Appelbau. Distress tolerance to auditory feedback and functional connectivity with the auditory cortex. Psychiatry research. Neuroimaging. vol 282. 2019-07-25. PMID:30384144. |
the results provide initial evidence of the role of the anterior insula as a mediating link between the bottom-up generation of affective distress and top-down behavioral avoidance of distress. |
2019-07-25 |
2023-08-13 |
human |
| Charlotte L Rae, Liliana Polyanska, Cassandra D Gould van Praag, Jim Parkinson, Samira Bouyagoub, Yoko Nagai, Anil K Seth, Neil A Harrison, Sarah N Garfinkel, Hugo D Critchle. Face perception enhances insula and motor network reactivity in Tourette syndrome. Brain : a journal of neurology. vol 141. issue 11. 2019-07-15. PMID:30346484. |
these findings highlight a potential mechanism in tourette syndrome through which heightened representation within insular cortex of embodied affective social information may impact the reactivity of subcortical motor pathways, supporting programmed motor actions that are causally implicated in tic generation. |
2019-07-15 |
2023-08-13 |
human |
| Carlotta Cogoni, Andrea Carnaghi, Giorgia Silan. Reduced empathic responses for sexually objectified women: An fMRI investigation. Cortex; a journal devoted to the study of the nervous system and behavior. vol 99. 2019-06-10. PMID:29294431. |
at the brain level, empathy for social exclusion of personalized women recruited areas coding the affective component of pain (i.e., anterior insula and cingulate cortex), the somatosensory components of pain (i.e., posterior insula and secondary somatosensory cortex) together with the mentalizing network (i.e., middle frontal cortex) to a greater extent than for the sexually objectified women. |
2019-06-10 |
2023-08-13 |
human |