| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-Shuang Zhao, Ding-Xi Liu, Fu-Qing Tan, Wan-Xi Yan. KIF2A Upregulates PI3K/AKT Signaling through Polo-like Kinase 1 (PLK1) to Affect the Proliferation and Apoptosis Levels of Biology. vol 13. issue 3. 2024-03-27. PMID:38534420. |
kif2a upregulates pi3k/akt signaling through polo-like kinase 1 (plk1) to affect the proliferation and apoptosis levels of |
2024-03-27 |
2024-03-29 |
Not clear |
| Jiayan Chen, Junmiao Wen, Di Liu, Xinyan Xu, Min Fan, Zhen Zhan. The molecular mechanism of kinesin family member 2A (KIF2A) underlying non-small cell lung cancer: the effect of its knockdown on malignant behaviors, stemness, chemosensitivity, and potential regulated signaling pathways. American journal of translational research. vol 14. issue 1. 2022-02-17. PMID:35173830. |
the effect of kif2a knockdown on cell proliferation, apoptosis, invasion, epithelial-mesenchymal transition (emt) markers, stemness, chemosensitivity was detected after transfecting kif2a short hairpin rna (shrna) plasmids into a549 and nci-h1975 cells. |
2022-02-17 |
2023-08-13 |
Not clear |
| Hong-Cheng Lv, Yan-Yan Lv, Gang Wang, Xie-Hua Zhang, Sheng-Nan Li, Xiao-Fen Yue, Wei L. Mechanism of miR-424-5p promoter methylation in promoting epithelial-mesenchymal transition of hepatocellular carcinoma cells. The Kaohsiung journal of medical sciences. 2022-01-20. PMID:35049148. |
in addition, kif2a overexpression reversed the mir-424-5p-driven changes in terms of cell viability, apoptosis and emt-related protein levels. |
2022-01-20 |
2023-08-13 |
Not clear |
| Xinglin Liang, Ruixiang Xi. Kinesin family member 2A acts as a potential prognostic marker and treatment target via interaction with PI3K/AKT and RhoA/ROCK pathways in acute myeloid leukemia. Oncology reports. vol 47. issue 1. 2021-11-18. PMID:34792179. |
kif2a sirna inhibited proliferation but enhanced apoptosis and chemosensitivity to adr and arac in kg‑1 and kasumi‑1 cells, which also inactivated pi3k/akt and rhoa/rock pathways. |
2021-11-18 |
2023-08-13 |
human |
| Xinglin Liang, Ruixiang Xi. Kinesin family member 2A acts as a potential prognostic marker and treatment target via interaction with PI3K/AKT and RhoA/ROCK pathways in acute myeloid leukemia. Oncology reports. vol 47. issue 1. 2021-11-18. PMID:34792179. |
kif2a was correlated with worse clinical features and survival in patients with aml; its knockdown promoted apoptosis and chemosensitivity by inactivating pi3k/akt and rhoa/rock signaling pathways in aml cells. |
2021-11-18 |
2023-08-13 |
human |
| Jin Zhao, Liping Su, Jianjun Jian. Long Non-Coding RNA Paternally Expressed Imprinted Gene 10 (PEG10) Elevates Diffuse Large B-Cell Lymphoma Progression by Regulating Kinesin Family Member 2A (KIF2A) via Targeting MiR-101-3p. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32976381. |
peg10, or kif2a deletion significantly inhibited the proliferative, migratory, and invasive abilities of dlbcl cells and elevated cell apoptosis in dlbcl cells. |
2021-05-20 |
2023-08-13 |
Not clear |
| Jin Zhao, Liping Su, Jianjun Jian. Long Non-Coding RNA Paternally Expressed Imprinted Gene 10 (PEG10) Elevates Diffuse Large B-Cell Lymphoma Progression by Regulating Kinesin Family Member 2A (KIF2A) via Targeting MiR-101-3p. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32976381. |
kif2a upregulation partially reversed the effects of peg10 downregulation on cell growth, metastasis, and apoptosis in dlbcl. |
2021-05-20 |
2023-08-13 |
Not clear |
| Tianling Ding, Jialing Li, Jianhong Sun, Xiaoman Fan, Chunli Shi, Dong Zhou, Ruoyu Den. Association of kinesin family member 2A with increased disease risk, deteriorative clinical characteristics, and shorter survival profiles in acute myeloid leukemia. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 2. 2021-02-02. PMID:33331418. |
in vitro experiments showed that kif2a was overexpressed in aml cell lines (kg-1, hl-60, me-1, and ht-93) compared to cd34+ cells, moreover, cell proliferation was reduced but apoptosis was increased by kif2a knockdown in hl-60 and kg-1 cells. |
2021-02-02 |
2023-08-13 |
Not clear |
| Tianling Ding, Jialing Li, Jianhong Sun, Xiaoman Fan, Chunli Shi, Dong Zhou, Ruoyu Den. Association of kinesin family member 2A with increased disease risk, deteriorative clinical characteristics, and shorter survival profiles in acute myeloid leukemia. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 2. 2021-02-02. PMID:33331418. |
in vitro, kif2a expression in aml cell lines and cd34+ cells (from healthy donors) was measured, and the effect of kif2a knockdown on aml cell proliferation and apoptosis in hl-60 and kg-1 cells was detected. |
2021-02-02 |
2023-08-13 |
Not clear |
| Xin Zhang, Yuyan Wang, Xiumei Liu, Anqi Zhao, Zhongheng Yang, Fanshuang Kong, Lili Sun, Yingyu Yu, Lipeng Jian. KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2021-01-19. PMID:32106376. |
it was found that silencing kif2a effectively induced the apoptosis, and inhibited the proliferation, migration and invasion capacities of gc cells. |
2021-01-19 |
2023-08-13 |
human |
| Xin Zhang, Yuyan Wang, Xiumei Liu, Anqi Zhao, Zhongheng Yang, Fanshuang Kong, Lili Sun, Yingyu Yu, Lipeng Jian. KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2021-01-19. PMID:32106376. |
furthermore, the effects of kif2a on the growth, migration, invasion, and apoptosis of gc cell were evaluated in vitro and the underlying mechanisms were explored. |
2021-01-19 |
2023-08-13 |
human |
| Xin Zhang, Yuyan Wang, Xiumei Liu, Anqi Zhao, Zhongheng Yang, Fanshuang Kong, Lili Sun, Yingyu Yu, Lipeng Jian. KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2021-01-19. PMID:32106376. |
in summary, kif2a is upregulated by transcription factor etv4, and its knockdown can effectively inhibit the proliferation and induce the apoptosis of gc cells through the akt signaling pathway in gc cells, implying that the inhibition of kif2a expression is a potential target for gc therapy. |
2021-01-19 |
2023-08-13 |
human |
| Tian Xie, Xingyu Li, Fei Ye, Chenxi Lu, Haitao Huang, Fei Wang, Xiaolei Cao, Chongjun Zhon. High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma. Biochemical and biophysical research communications. vol 497. issue 1. 2018-03-23. PMID:29427669. |
furthermore, silencing kif2a inhibited cell proliferation and induced apoptosis in lung adenocarcinoma(luad) cells. |
2018-03-23 |
2023-08-13 |
Not clear |
| Tian Xie, Xingyu Li, Fei Ye, Chenxi Lu, Haitao Huang, Fei Wang, Xiaolei Cao, Chongjun Zhon. High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma. Biochemical and biophysical research communications. vol 497. issue 1. 2018-03-23. PMID:29427669. |
the kinesin family member 2a (kif2a), that belongs to the kinesin-13 microtubule depolymerases, plays an important role in cancer cell proliferation, migration and apoptosis in various types of cancer such as gastric cancer, breast cancer, and squamous cell carcinoma of the oral tongue, but, its role and mechanism in lung adenocarcinoma (luad) is largely unknown. |
2018-03-23 |
2023-08-13 |
Not clear |
| Xin Zhang, Chao Ma, Qingjie Wang, Jia Liu, Mingyi Tian, Yuchang Yuan, Xingang Li, Xun Q. Role of KIF2A in the progression and metastasis of human glioma. Molecular medicine reports. vol 13. issue 2. 2016-10-31. PMID:26707290. |
in vitro, kif2a gene silencing inhibited the proliferation, migration and invasion, and induced apoptosis in cancer cells. |
2016-10-31 |
2023-08-13 |
human |
| Xin Zhang, Chao Ma, Qingjie Wang, Jia Liu, Mingyi Tian, Yuchang Yuan, Xingang Li, Xun Q. Role of KIF2A in the progression and metastasis of human glioma. Molecular medicine reports. vol 13. issue 2. 2016-10-31. PMID:26707290. |
the biological functions of kif2a on the proliferation, apoptosis, migration and invasion of glioma cells were investigated using an a172 cell line. |
2016-10-31 |
2023-08-13 |
human |
| Ketao Wang, Changlong Lin, Chengqin Wang, Qianqian Shao, Wenjuan Gao, Bingfeng Song, Lei Wang, Xiaobin Song, Xun Qu, Fengcai We. Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3K/Akt signaling pathway. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24248467. |
few studies have reported the correlation between kif2a and apoptosis of tumor cells and which signaling pathways kif2a is involved in remains unclear. |
2014-07-29 |
2023-08-12 |
human |
| Ketao Wang, Changlong Lin, Chengqin Wang, Qianqian Shao, Wenjuan Gao, Bingfeng Song, Lei Wang, Xiaobin Song, Xun Qu, Fengcai We. Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3K/Akt signaling pathway. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24248467. |
the results suggest that silencing kif2a induces tumor cell apoptosis, at least partially, through the pi3k/akt signaling pathway. |
2014-07-29 |
2023-08-12 |
human |
| Ketao Wang, Changlong Lin, Chengqin Wang, Qianqian Shao, Wenjuan Gao, Bingfeng Song, Lei Wang, Xiaobin Song, Xun Qu, Fengcai We. Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3K/Akt signaling pathway. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24248467. |
silencing kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the pi3k/akt signaling pathway. |
2014-07-29 |
2023-08-12 |
human |
| Ketao Wang, Changlong Lin, Chengqin Wang, Qianqian Shao, Wenjuan Gao, Bingfeng Song, Lei Wang, Xiaobin Song, Xun Qu, Fengcai We. Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3K/Akt signaling pathway. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24248467. |
the results revealed that silencing kif2a induces apoptosis and decreases the mrna and protein level of pi3k, akt and b‑cell lymphoma 2 (bcl‑2) in tca8113 cells. |
2014-07-29 |
2023-08-12 |
human |