| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fernanda L Basei, Ivan Rosa E Silva, Pedro R Firmino Dias, Camila C Ferezin, Andressa Peres de Oliveira, Luidy K Issayama, Livia A R Moura, Fernando Riback da Silva, Jörg Kobar. The Mitochondrial Connection: The Nek Kinases' New Functional Axis in Mitochondrial Homeostasis. Cells. vol 13. issue 6. 2024-03-27. PMID:38534317. |
nek1, nek5, and nek6 are connected to the stress response, including ros control, mtdna repair, autophagy, and apoptosis. |
2024-03-27 |
2024-03-29 |
Not clear |
| Georg Baumann, Tobias Meckel, Kevin Böhm, Yung-Hsin Shih, Mirco Dickhaut, Torben Reichardt, Johannes Pilakowski, Ulrich Pehl, Boris Schmid. Illuminating a Dark Kinase: Structure-Guided Design, Synthesis, and Evaluation of a Potent Nek1 Inhibitor and Its Effects on the Embryonic Zebrafish Pronephros. Journal of medicinal chemistry. vol 65. issue 2. 2022-01-27. PMID:35081715. |
nima-related kinase 1 (nek1) has lately garnered attention for its widespread function in ciliogenesis, apoptosis, and the dna-damage response. |
2022-01-27 |
2023-08-13 |
zebrafish |
| Huibing Wang, Weiwei Qi, Chengyu Zou, Zhangdan Xie, Mengmeng Zhang, Masanori Gomi Naito, Lauren Mifflin, Zhen Liu, Ayaz Najafov, Heling Pan, Bing Shan, Ying Li, Zheng-Jiang Zhu, Junying Yua. NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation. Nature communications. vol 12. issue 1. 2021-08-23. PMID:34376696. |
the metabolic and proteomic defects of nek1 deficiency disrupts the integrity of blood-brain barrier (bbb) by promoting lysosomal degradation of a20, a key modulator of ripk1, thus sensitizing cerebrovascular endothelial cells to ripk1-dependent apoptosis and necroptosis. |
2021-08-23 |
2023-08-13 |
mouse |
| Mariana Bonjiorno Martins, Arina Marina Perez, Vilhelm A Bohr, David M Wilson, Jörg Kobar. NEK1 deficiency affects mitochondrial functions and the transcriptome of key DNA repair pathways. Mutagenesis. vol 36. issue 3. 2021-08-12. PMID:33740813. |
our studies revealed that nek1 ko cells resulted in increased apoptosis and hypersensitivity to the alkylator methyl methanesulfonate, the radiomimetic bleomycin and uvc light, yet increased resistance to the crosslinker cisplatin. |
2021-08-12 |
2023-08-13 |
Not clear |
| Isabel Freund, Stephanie Hehlgans, Daniel Martin, Michael Ensminger, Emmanouil Fokas, Claus Rödel, Markus Löbrich, Franz Röde. Fractionation-Dependent Radiosensitization by Molecular Targeting of Nek1. Cells. vol 9. issue 5. 2021-02-24. PMID:32429458. |
stably transduced doxycycline (dox)-inducible nek1 shrna hela cervix and sirna-transfected hct-15 colorectal carcinoma cells were irradiated in vitro and 3d clonogenic radiation survival, residual dna damage, cell cycle distribution, and apoptosis were analyzed. |
2021-02-24 |
2023-08-13 |
mouse |
| Isabel Freund, Stephanie Hehlgans, Daniel Martin, Michael Ensminger, Emmanouil Fokas, Claus Rödel, Markus Löbrich, Franz Röde. Fractionation-Dependent Radiosensitization by Molecular Targeting of Nek1. Cells. vol 9. issue 5. 2021-02-24. PMID:32429458. |
nima (never-in-mitosis gene a)-related kinase 1 (nek1) is shown to impact on different cellular pathways such as dna repair, checkpoint activation, and apoptosis. |
2021-02-24 |
2023-08-13 |
mouse |
| Vibha Singh, Siddhant Bhoir, Rupesh V Chikhale, Javeena Hussain, Donard Dwyer, Richard A Bryce, Sivapriya Kirubakaran, Arrigo De Benedett. Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy. iScience. vol 23. issue 9. 2020-10-01. PMID:32905878. |
adt results in increased expression of tlk1b, a key kinase upstream of nek1 and atr and mediating the dna damage response that typically results in temporary cell-cycle arrest of androgen-responsive pca cells, whereas its abrogation leads to apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |
| Julian Spies, Anja Waizenegger, Olivia Barton, Michael Sürder, William D Wright, Wolf-Dietrich Heyer, Markus Löbric. Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability. Molecular cell. vol 62. issue 6. 2017-08-25. PMID:27264870. |
never-in-mitosis a-related kinase 1 (nek1) has established roles in apoptosis and cell cycle regulation. |
2017-08-25 |
2023-08-13 |
human |
| Jun Zhu, Yu Cai, Pin Liu, Weiguo Zha. Frequent Nek1 overexpression in human gliomas. Biochemical and biophysical research communications. vol 476. issue 4. 2017-05-22. PMID:27251576. |
nek1 sirna also sensitized u87-mg/u251-mg cells to temozolomide (tmz), causing a profound apoptosis induction and growth inhibition. |
2017-05-22 |
2023-08-13 |
human |
| Yumay Chen, Chi-Fen Chen, Rosaria Polci, Randy Wei, Daniel J Riley, Phang-Lang Che. Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment. Oncotarget. vol 5. issue 12. 2015-04-24. PMID:24970796. |
the association between nek1 and vdac1 is genotoxic dependent: prolonged nek1/vdac1 dissociation will lead to vdac1 dephosphorylation and initiate apoptosis. |
2015-04-24 |
2023-08-13 |
Not clear |
| Yumay Chen, Chi-Fen Chen, Rosaria Polci, Randy Wei, Daniel J Riley, Phang-Lang Che. Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment. Oncotarget. vol 5. issue 12. 2015-04-24. PMID:24970796. |
collectively, these results suggest that the increased nek1 expression in rcc cells maintain persistent vdac1 phosphorylation, closing its channel and preventing the onset of apoptosis under genotoxic insults. |
2015-04-24 |
2023-08-13 |
Not clear |