| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fernanda L Basei, Ivan Rosa E Silva, Pedro R Firmino Dias, Camila C Ferezin, Andressa Peres de Oliveira, Luidy K Issayama, Livia A R Moura, Fernando Riback da Silva, Jörg Kobar. The Mitochondrial Connection: The Nek Kinases' New Functional Axis in Mitochondrial Homeostasis. Cells. vol 13. issue 6. 2024-03-27. PMID:38534317. |
nek1, nek5, and nek6 are connected to the stress response, including ros control, mtdna repair, autophagy, and apoptosis. |
2024-03-27 |
2024-03-29 |
Not clear |
| Isadora Carolina Betim Pavan, Fernanda Luisa Basei, Matheus Brandemarte Severino, Ivan Rosa E Silva, Luidy Kazuo Issayama, Mariana Camargo Silva Mancini, Mariana Marcela Góis, Luiz Guilherme Salvino da Silva, Rosangela Maria Neves Bezerra, Fernando Moreira Simabuco, Jörg Kobar. NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells. Cells. vol 12. issue 2. 2023-01-21. PMID:36672191. |
the depletion of nek6 also induces cell death by apoptosis and reduces the antiapoptotic bcl-2 protein. |
2023-01-21 |
2023-08-14 |
Not clear |
| Yifei Liu, Wenqiang Fu, Feng Yin, Lianjie Xia, Yubo Zhang, Baocun Wang, Tengfei Li, Tingting Zhang, Ling Cheng, Yanbing Wei, Bin Ga. miR-141-3p suppresses development of clear cell renal cell carcinoma by regulating NEK6. Anti-cancer drugs. 2021-08-13. PMID:34387594. |
mir-141-3p could regulate ccrcc cell proliferation, migration, invasion and apoptosis by targeting nek6. |
2021-08-13 |
2023-08-13 |
Not clear |
| Lina Wu, Zhen Chen, Yiqiao Xin. MiR-506-3p inhibits cell proliferation, induces cell cycle arrest and apoptosis in retinoblastoma by directly targeting NEK6. Cell biology international. 2019-11-20. PMID:30080301. |
enhanced expression of mir-506-3p significantly suppressed cell proliferation, induced g0/g1 cell cycle phase arrest and apoptosis in rb cells, which were attenuated by nek6 overexpression using mtt assay, colony formation and flow cytometry analysis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Lina Wu, Zhen Chen, Yiqiao Xin. MiR-506-3p inhibits cell proliferation, induces cell cycle arrest and apoptosis in retinoblastoma by directly targeting NEK6. Cell biology international. 2019-11-20. PMID:30080301. |
mir-506-3p inhibits cell proliferation, induces cell cycle arrest and apoptosis in retinoblastoma by directly targeting nek6. |
2019-11-20 |
2023-08-13 |
Not clear |
| Rounak Nassirpour, Lihua Shao, Peter Flanagan, Tinya Abrams, Bahija Jallal, Tod Smeal, Min-Jean Yi. Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target. Molecular cancer research : MCR. vol 8. issue 5. 2010-11-01. PMID:20407017. |
expression of exogenous wild-type nek6 increased anchorage-independent growth of a variety of human cancer cell lines, whereas overexpression of the kinase-dead nek6 and rnai knockdown of endogenous nek6 suppressed cancer cell transformation and induced apoptosis. |
2010-11-01 |
2023-08-12 |
mouse |
| Rounak Nassirpour, Lihua Shao, Peter Flanagan, Tinya Abrams, Bahija Jallal, Tod Smeal, Min-Jean Yi. Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target. Molecular cancer research : MCR. vol 8. issue 5. 2010-11-01. PMID:20407017. |
most importantly, knocking down endogenous nek6 levels or exogenous expression of the kinase-dead form did not inhibit cell proliferation, nor did it induce apoptosis in normal fibroblast cells. |
2010-11-01 |
2023-08-12 |
mouse |
| Laura O'Regan, Andrew M Fr. The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. Molecular and cellular biology. vol 29. issue 14. 2009-07-13. PMID:19414596. |
by generating specific antibodies, we show that both nek6 and nek7 are activated in mitosis and that interfering with their activity by either depletion or expression of reduced-activity mutants leads to mitotic arrest and apoptosis. |
2009-07-13 |
2023-08-12 |
human |
| Eun Jeoung Lee, Sung Hee Hyun, Jaesun Chun, Sang Sun Kan. Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins. Biochemical and biophysical research communications. vol 358. issue 3. 2007-07-20. PMID:17512906. |
thus, our observations indicated that nek6 binds to fe65 through its (267)pplp(270) motif and that the protein-protein interaction between nek6 and fe65 regulates their subcellular localization and cell apoptosis. |
2007-07-20 |
2023-08-12 |
human |
| Eun Jeoung Lee, Sung Hee Hyun, Jaesun Chun, Sang Sun Kan. Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins. Biochemical and biophysical research communications. vol 358. issue 3. 2007-07-20. PMID:17512906. |
finally, when transient transfection assays were performed, interaction of nek6 (wt) with fe65 induced substantial cell apoptosis, whereas interaction using the nek6 pplp mutant ((267)pplp(270) changes (267)apva(270)) did not. |
2007-07-20 |
2023-08-12 |
human |
| Min-Jean Yin, Lihua Shao, David Voehringer, Tod Smeal, Bahija Jalla. The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. The Journal of biological chemistry. vol 278. issue 52. 2004-02-10. PMID:14563848. |
time-lapse recording of the cell cycle progression of cells expressing kinase-inactive nek6 reveals mitotic arrest at the metaphase stage prior to cells entering apoptosis. |
2004-02-10 |
2023-08-12 |
human |
| Min-Jean Yin, Lihua Shao, David Voehringer, Tod Smeal, Bahija Jalla. The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. The Journal of biological chemistry. vol 278. issue 52. 2004-02-10. PMID:14563848. |
inhibition of nek6 function by either overexpression of an inactive nek6 mutant or elimination of endogenous nek6 by sirna arrests cells in m phase and triggers apoptosis. |
2004-02-10 |
2023-08-12 |
human |