| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hira Sayed, Qiongqiong Zhang, Yu Tang, Yanan Wang, Yongpeng Guo, Jianyun Zhang, Cheng Ji, Qiugang Ma, Lihong Zha. Alleviative Effect of Rutin on Zearalenone-Induced Reproductive Toxicity in Male Mice by Preventing Spermatogenic Cell Apoptosis and Modulating Gene Expression in the Hypothalamic-Pituitary-Gonadal Axis. Toxins. vol 16. issue 3. 2024-03-27. PMID:38535787. |
moreover, rut mitigated zen-induced apoptosis by increasing the mrna expression level of |
2024-03-27 |
2024-03-29 |
mouse |
| Yong He, Hong-Hong Liu, Xue-Lin Zhou, Ting-Ting He, Ao-Zhe Zhang, Xin Wang, Shi-Zhang Wei, Hao-Tian Li, Li-Sheng Chen, Lei Chang, Yan-Ling Zhao, Man-Yi Jin. Rutaecarpine Ameliorates Murine N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway. Molecules (Basel, Switzerland). vol 28. issue 17. 2023-09-09. PMID:37687125. |
the qrt-pcr and wb analyses indicated that the protective effect of rut is related to the upregulation of the shh pathway and downregulation of the downstream of apoptosis to improve gastric cellular survival. |
2023-09-09 |
2023-10-07 |
rat |
| Haosu Huang, Meng Wang, Zimeng Guo, Di Wu, Hanyue Wang, Yan Jia, Honghui Liu, Junjie Ding, Jie Pen. Rutaecarpine alleviates acute pancreatitis in mice and AR42J cells by suppressing the MAPK and NF-κB signaling pathways via calcitonin gene-related peptide. Phytotherapy research : PTR. vol 35. issue 11. 2021-11-25. PMID:34661951. |
cell-based studies revealed that rut significantly improved cell viability while suppressing the apoptosis of ar42j cells with cerulein-induced ap, downregulating il-6 and tnf-α, stimulating il-10 release, and inhibiting mapk, nf-κb, and stat3 signaling activation, all in a cgrp-dependent manner. |
2021-11-25 |
2023-08-13 |
mouse |
| Meng Qin, Qi Li, Yadi Wang, Tengteng Li, Zehui Gu, Peng Huang, Liqun Re. Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway. Journal of biochemical and molecular toxicology. vol 35. issue 1. 2021-06-08. PMID:32864822. |
mir-22-5p overexpression in cardiomyocytes can affect the rap1/erk pathway and reduce reactive oxygen species production and cardiomyocyte apoptosis caused by thp (p < .01), which is consistent with the effect of rut. |
2021-06-08 |
2023-08-13 |
rat |
| Zubeyir Elmazoglu, Volkan Ergin, Ergin Sahin, Handan Kayhan, Cimen Karas. Oleuropein and rutin protect against 6-OHDA-induced neurotoxicity in PC12 cells through modulation of mitochondrial function and unfolded protein response. Interdisciplinary toxicology. vol 10. issue 4. 2020-09-30. PMID:30147420. |
ole or rut pretreatment (24 h) at low doses (1-50 μm) protected the differentiated pc12 cells from 6-ohda-induced cytotoxicity as assessed by increased viability, improved ΔΨm and inhibited apoptosis, whereas relatively high doses of ole or rut (>50 μm) inhibited cell growth and proliferation, indicating a typical hormetic effect. |
2020-09-30 |
2023-08-13 |
rat |
| Y Zhang, Q Wang, Y-D Wang, B Sun, X-W Leng, Q Li, L-Q Re. Effect of rutin on cisplatin-induced damage in human mesangial cells via apoptotic pathway. Human & experimental toxicology. vol 38. issue 1. 2019-03-28. PMID:29962303. |
treatment with rut suppressed intracellular reactive oxygen species and malonic dialdehyde levels and inhibited cell apoptosis. |
2019-03-28 |
2023-08-13 |
human |
| Kpobari W Nkpaa, Godspower I Onyes. Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats. Neuroscience letters. vol 682. 2019-03-11. PMID:29908257. |
collectively, the present study demonstrated that rut attenuates naf - induced toxicity in the cerebrum and striatum of rats via mechanisms involving enhancement of ache activity, antioxidant status with concomitant inhibition of lipid peroxidation, neuro-inflammation and apoptosis in rats. |
2019-03-11 |
2023-08-13 |
rat |
| Kpobari W Nkpaa, Godspower I Onyes. Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats. Neuroscience letters. vol 682. 2019-03-11. PMID:29908257. |
moreover, rut attenuated the naf - induced inhibition of antioxidant enzymes and ache activity and inhibits lipid peroxidation, neuro-inflammation and apoptosis in the cerebrum and striatum of the rats. |
2019-03-11 |
2023-08-13 |
rat |
| Grandhi Venkata Ramalingayya, Sri Pragnya Cheruku, Pawan G Nayak, Anoop Kishore, Rekha Shenoy, Chamallamudi Mallikarjuna Rao, Nandakumar Krishnada. Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats. Drug design, development and therapy. vol 11. 2017-05-05. PMID:28408800. |
dox exposure resulted in increased cellular death, apoptosis, and intracellular ros generation with inhibition of neurite growth in differentiated imr32 cells, which was significantly ameliorated by rut. |
2017-05-05 |
2023-08-13 |
human |
| Catalina Carrasco-Pozo, Edgar Pastene, Carola Vergara, Moises Zapata, Cristian Sandoval, Martin Gottelan. Stimulation of cytosolic and mitochondrial calcium mobilization by indomethacin in Caco-2 cells: modulation by the polyphenols quercetin, resveratrol and rutin. Biochimica et biophysica acta. vol 1820. issue 12. 2013-01-10. PMID:23022152. |
the effect of indomethacin (indo) on ca(2+) mobilization, cytotoxicity, apoptosis and caspase activation and the potential protective effect of quercetin (que), resveratrol (res) and rutin (rut) were determined in caco-2 cells. |
2013-01-10 |
2023-08-12 |
Not clear |
| Mei-Hua Bao, Wen Dai, Yuan-Jian Li, Chang-Ping H. Rutaecarpine prevents hypoxia-reoxygenation-induced myocardial cell apoptosis via inhibition of NADPH oxidases. Canadian journal of physiology and pharmacology. vol 89. issue 3. 2012-02-13. PMID:21423291. |
the aim of the present study was to determine the effects of rutaecarpine (rut) on hypoxia-reoxygenation (h-r)-induced apoptosis in myocardial cell line h9c2, as well as the underlying mechanisms. |
2012-02-13 |
2023-08-12 |
Not clear |
| Mei-Hua Bao, Wen Dai, Yuan-Jian Li, Chang-Ping H. Rutaecarpine prevents hypoxia-reoxygenation-induced myocardial cell apoptosis via inhibition of NADPH oxidases. Canadian journal of physiology and pharmacology. vol 89. issue 3. 2012-02-13. PMID:21423291. |
these results suggest that the protective effects of rut against h-r-induced myocardial cell injury and apoptosis might, at least partly, be due to the inhibition of the nadph oxidase - ros pathway. |
2012-02-13 |
2023-08-12 |
Not clear |
| Zhong Dai, Jian Xiao, Si-Yu Liu, Liao Cui, Gao-Yun Hu, De-Jian Jian. Rutaecarpine inhibits hypoxia/reoxygenation-induced apoptosis in rat hippocampal neurons. Neuropharmacology. vol 55. issue 8. 2009-04-15. PMID:18809421. |
however, pretreatment with rut (1-10microm) or caspase-3 specific inhibitor devd-cho could markedly attenuate h/r-induced apoptosis in neurons. |
2009-04-15 |
2023-08-12 |
rat |
| Zhong Dai, Jian Xiao, Si-Yu Liu, Liao Cui, Gao-Yun Hu, De-Jian Jian. Rutaecarpine inhibits hypoxia/reoxygenation-induced apoptosis in rat hippocampal neurons. Neuropharmacology. vol 55. issue 8. 2009-04-15. PMID:18809421. |
the present study was to investigate the effect of rut on hypoxia/reoxygenation (h/r)-induced apoptosis in primary rat hippocampal neurons. |
2009-04-15 |
2023-08-12 |
rat |
| Zhong Dai, Jian Xiao, Si-Yu Liu, Liao Cui, Gao-Yun Hu, De-Jian Jian. Rutaecarpine inhibits hypoxia/reoxygenation-induced apoptosis in rat hippocampal neurons. Neuropharmacology. vol 55. issue 8. 2009-04-15. PMID:18809421. |
in summary, the present data suggest that rut inhibits h/r-induced apoptosis of hippocampal neurons via trpv1-[ca2+]i-dependent and pi3k/akt signaling pathway, which is related to inhibiting oxidative stress and caspase-3 activation. |
2009-04-15 |
2023-08-12 |
rat |
| Steffen Blottner, Jennifer Schön, Hannelore Roelant. Apoptosis is not the cause of seasonal testicular involution in roe deer. Cell and tissue research. vol 327. issue 3. 2007-05-01. PMID:17093922. |
the maximum level of apoptosis during the rut in roe deer was similar to the values obtained during the invariably high spermatogenic activity in cattle. |
2007-05-01 |
2023-08-12 |
cattle |
| Shing-Chuan Shen, Yen-Chou Chen, Feng-Lin Hsu, Woan-Rouh Le. Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade. Journal of cellular biochemistry. vol 89. issue 5. 2003-11-18. PMID:12874837. |
results of the mtt assay showed that que, but not rut and qui, exhibits significant cytotoxic effect on hl-60 cells, accompanied by the dose- and time-dependent appearance of characteristics of apoptosis including an increase in dna ladder intensity, morphological changes, apoptotic bodies, and an increase in hypodiploid cells by flow cytometry analysis. |
2003-11-18 |
2023-08-12 |
human |
| S Blottner, K Frölich, H Roelants, J Streich, F Tataruc. Influence of environmental cadmium on testicular proliferation in roe deer. Reproductive toxicology (Elmsford, N.Y.). vol 13. issue 4. 1999-10-20. PMID:10453910. |
during the rut, testicular proliferation and spermatozoa/g testis as well as apoptosis showed no significant changes with increased cadmium contamination. |
1999-10-20 |
2023-08-12 |
Not clear |
| S Blottner, O Hingst, H H Meye. Seasonal spermatogenesis and testosterone production in roe deer (Capreolus capreolus). Journal of reproduction and fertility. vol 108. issue 2. 1997-03-17. PMID:9038789. |
interrupted proliferation and stimulated apoptosis promote testis involution after the rut, and testosterone seems to play a role in the regulation of both processes. |
1997-03-17 |
2023-08-12 |
Not clear |